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Original Article

Dexamethasone Intravitreal Implant for Chronic Diabetic Macular Edema Resistant to Intravitreal Bevacizumab Treatment

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Pages 107-113 | Received 28 Aug 2014, Accepted 17 Dec 2014, Published online: 22 Jan 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Kamal Kishore, Pooja V Bhat, Pradeep Venkatesh & Cecilia C Canizela. (2022) Dexamethasone Intravitreal Implant for the Treatment of Macular Edema and Uveitis: A Comprehensive Narrative Review. Clinical Ophthalmology 16, pages 1019-1045.
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Maria Elisa Luís, Filipa Sampaio, José Costa, Diogo Cabral, Carla Teixeira & Joana Tavares Ferreira. (2021) Dril Influences Short-term Visual Outcome after Intravitreal Corticosteroid Injection for Refractory Diabetic Macular Edema. Current Eye Research 46:9, pages 1378-1386.
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Benjamin J Thomas, Yoshihiro Yonekawa, Jeremy D Wolfe & Tarek S Hassan. (2016) Contralateral eye-to-eye comparison of intravitreal ranibizumab and a sustained-release dexamethasone intravitreal implant in recalcitrant diabetic macular edema. Clinical Ophthalmology 10, pages 1679-1684.
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Giuseppe Giannaccare, Michela Fresina, Alberto Pazzaglia & Piera Versura. (2016) Long-lasting corneal endothelial graft rejection successfully reversed after dexamethasone intravitreal implant. International Medical Case Reports Journal 9, pages 187-191.
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Articles from other publishers (31)

Hakan Koc, Atilla Alpay & Suat Hayri Ugurbas. (2023) Comparison of the efficacy of intravitreal Anti-VEGF versus intravitreal dexamethasone implant in treatment resistant diabetic Macular Edema. BMC Ophthalmology 23:1.
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Osama A. Sorour, Emily S. Levine, Caroline R. Baumal, Ayman G. Elnahry, Phillip Braun, Jessica Girgis & Nadia K. Waheed. (2023) Persistent diabetic macular edema: Definition, incidence, biomarkers, and treatment methods. Survey of Ophthalmology 68:2, pages 147-174.
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Qiongzhen Yuan, Yilin Liu, Hanyue Xu, Yunxia Gao, Ling Qin, Yueqin Gou, Mengying Tao & Ming Zhang. (2021) Efficacy and safety of single-dose dexamethasone implantation for patients with persistent diabetic macular edema: a systematic review and meta-analysis. Graefe's Archive for Clinical and Experimental Ophthalmology 260:2, pages 405-413.
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Mouna Al Saad, Amin Shehadeh, Asem Hizzani, Abdulla Alzibdeh, Amani A. Alsubhi, Dina Hamdan, Ebtehal Alkubati, Jehad Meqbil, Lina Hamadneh & Osama Ababneh. (2022) Effects of Smoking on Outcomes of Anti-Vascular Endothelial Growth Factor Therapy in Patients with Diabetic Macular Edema: A Retrospective Case-Control Study. Middle East African Journal of Ophthalmology 29:3, pages 116-121.
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Yohei Tomita, Deokho Lee, Kazuo Tsubota, Kazuno Negishi & Toshihide Kurihara. (2021) Updates on the Current Treatments for Diabetic Retinopathy and Possibility of Future Oral Therapy. Journal of Clinical Medicine 10:20, pages 4666.
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Ning-Yi Hsia, Chun-Ju Lin, Huan-Sheng Chen, Cheng-Hsien Chang, Henry Bair, Chun-Ting Lai, Jane-Ming Lin, Wen-Lu Chen, Peng-Tai Tien, Wen-Chuan Wu & Yi-Yu Tsai. (2021) Short-Term Outcomes of Refractory Diabetic Macular Edema Switch From Ranibizumab to Dexamethasone Implant and the Influential Factors: A Retrospective Real World Experience. Frontiers in Medicine 8.
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Josh O. Wallsh & Ron P. Gallemore. (2021) Anti-VEGF-Resistant Retinal Diseases: A Review of the Latest Treatment Options. Cells 10:5, pages 1049.
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Javier Zarranz-Ventura, Barbara Romero-Núñez, Carolina Bernal-Morales, Daniel Velazquez-Villoria, Anna Sala-Puigdollers, Marc Figueras-Roca, Sergio Copete, Laura Distefano, Anna Boixadera, Jose García-Arumi & Alfredo Adan. (2020) Differential response to intravitreal dexamethasone implant in naïve and previously treated diabetic macular edema eyes. BMC Ophthalmology 20:1.
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Havva Kaldırım, Fatma Savur, Ahmet Kırgız & Kürşat Atalay. (2020) Comparison of Anatomical and Functional Outcomes of Intravitreal Dexamethasone Implant between Phakic and Pseudophakic Eyes with Diabetic Macular Edema. Korean Journal of Ophthalmology 34:5, pages 383-391.
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Victor. A. de Vries, Fabiana L. Bassil & Wishal. D. Ramdas. (2020) The effects of intravitreal injections on intraocular pressure and retinal nerve fiber layer: a systematic review and meta-analysis. Scientific Reports 10:1.
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Emrah ÖZTÜRK, Burak ESENER & Abuzer GÜNDÜZ. (2020) Efficacy of dexamethasone implant in the treatment of macular edema due to different etiologiesFarklı etyolojilere bağlı maküler ödem tedavisinde deksametazon implantın etkinliği. Cukurova Medical Journal 45:2, pages 568-573.
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Gokhan Demir, Abdullah Ozkaya, Elmas Yuksel, Gurkan Erdogan, Ugur Tunc, Mevlut Celal Ocal & Yasin Sakır Goker. (2019) Early and Late Switch from Ranibizumab to an Intravitreal Dexamethasone Implant in Patients with Diabetic Macular Edema in the Event of a Poor Anatomical Response. Clinical Drug Investigation 40:2, pages 119-128.
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Verónica Castro-Navarro, Enrique Cervera-Taulet, Catalina Navarro-Palop, Clara Monferrer-Adsuara, Laura Hernández-Bel & Javier Montero-Hernández. (2019) Intravitreal dexamethasone implant Ozurdex® in naïve and refractory patients with different subtypes of diabetic macular edema. BMC Ophthalmology 19:1.
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Laurent Kodjikian, David Bellocq, Francesco Bandello, Anat Loewenstein, Usha Chakravarthy, Adrian Koh, Albert Augustin, Marc D de Smet, Jay Chhablani, Adnan Tufail, Alfredo García-Layana, Aditya Sudhalkar & Thibaud Mathis. (2019) First-line treatment algorithm and guidelines in center-involving diabetic macular edema. European Journal of Ophthalmology 29:6, pages 573-584.
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O. Sever & F. Horozoglu. (2019) The effect of single dose adjunctive dexamethasone implant on diabetic macular edema in patients on anti-vascular endothelial growth factor treatment: 1 year follow-up from a real-life practice. Journal Français d'Ophtalmologie 42:9, pages 993-1000.
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Laurent Kodjikian, David Bellocq & Thibaud Mathis. (2018) Pharmacological Management of Diabetic Macular Edema in Real-Life Observational Studies. BioMed Research International 2018, pages 1-16.
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Havva Kaldırım, Serpil YazganKursat Atalay, Ceren Gurez & Fatma Savur. (2018) INTRAVITREAL DEXAMETHASONE IMPLANTATION IN PATIENTS WITH DIFFERENT MORPHOLOGICAL DIABETIC MACULAR EDEMA HAVING INSUFFICIENT RESPONSE TO RANIBIZUMAB. Retina 38:5, pages 986-992.
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G Srividya, M Jain, K Mahalakshmi, S Gayathri, R Raman & N Angayarkanni. (2018) A novel and less invasive technique to assess cytokine profile of vitreous in patients of diabetic macular oedema. Eye 32:4, pages 820-829.
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Katja Hatz, Andreas Ebneter, Cengiz Tuerksever, Christian Pruente & Martin Zinkernagel. (2018) Repeated Dexamethasone Intravitreal Implant for the Treatment of Diabetic Macular Oedema Unresponsive to Anti-VEGF Therapy: Outcome and Predictive SD-OCT Features. Ophthalmologica 239:4, pages 205-214.
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Rita Laiginhas, Marta Inês Silva, Vitor Rosas, Susana Penas, Vitor Adriano Fernandes, Amândio Rocha-Sousa, Ângela Carneiro, Fernando Falcão-Reis & Manuel Sousa Falcão. (2017) Aflibercept in diabetic macular edema refractory to previous bevacizumab: outcomes and predictors of success. Graefe's Archive for Clinical and Experimental Ophthalmology 256:1, pages 83-89.
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Donghyoun Noh, Jang Hwan Ahn, Junyeop Lee & Min Sagong. (2017) Short-term Effect of Intravitreal Dexamethasone Implant on Diabetic Macular Edema with Epiretinal Membrane. Journal of Retina 2:2, pages 68-75.
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Ahmed Hosni Abd Elhamid. (2017) Combined Intravitreal Dexamethasone Implant And Micropulse Yellow Laser For Treatment Of Anti-VEGF Resistant Diabetic Macular Edema. The Open Ophthalmology Journal 11:1, pages 164-172.
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Carl D. Regillo, David G. Callanan, Diana V. Do, Howard F. Fine, Nancy M. Holekamp, Baruch D. Kuppermann, Michael A. Singer & Rishi P. Singh. (2017) Use of Corticosteroids in the Treatment of Patients With Diabetic Macular Edema Who Have a Suboptimal Response to Anti-VEGF: Recommendations of an Expert Panel. Ophthalmic Surgery, Lasers and Imaging Retina 48:4, pages 291-301.
Crossref
Ariane Malclès, Corinne Dot, Nicolas Voirin, Émilie Agard, Anne-Laure Vié, David Bellocq, Philippe Denis & Laurent Kodjikian. (2017) REAL-LIFE STUDY IN DIABETIC MACULAR EDEMA TREATED WITH DEXAMETHASONE IMPLANT. Retina 37:4, pages 753-760.
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David G. Callanan, Anat Loewenstein, Sunil S. Patel, Pascale Massin, Borja Corcóstegui, Xiao-Yan Li, Jenny Jiao, Yehia Hashad & Scott M. Whitcup. (2016) A multicenter, 12-month randomized study comparing dexamethasone intravitreal implant with ranibizumab in patients with diabetic macular edema. Graefe's Archive for Clinical and Experimental Ophthalmology 255:3, pages 463-473.
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Zainab Khan, Robin K. Kuriakose, Maryam Khan, Eric K Chin & David R. P. Almeida. (2017) Efficacy of the Intravitreal Sustained-Release Dexamethasone Implant for Diabetic Macular Edema Refractory to Anti-Vascular Endothelial Growth Factor Therapy: Meta-Analysis and Clinical Implications. Ophthalmic Surgery, Lasers and Imaging Retina 48:2, pages 160-166.
Crossref
M Ashraf, A Souka, R Adelman & S H Forster. (2016) Aflibercept in diabetic macular edema: evaluating efficacy as a primary and secondary therapeutic option. Eye 31:2, pages 342-345.
Crossref
. (2017) Intravitreal Aflibercept for Patients With Diabetic Macular Edema Refractory to Bevacizumab or Ranibizumab: Analysis of Response to Aflibercept. Asia-Pacific Journal of Ophthalmology.
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Sanket U. Shah, Ashley Harless, Laura Bleau & Raj K. Maturi. (2016) PROSPECTIVE RANDOMIZED SUBJECT-MASKED STUDY OF INTRAVITREAL BEVACIZUMAB MONOTHERAPY VERSUS DEXAMETHASONE IMPLANT MONOTHERAPY IN THE TREATMENT OF PERSISTENT DIABETIC MACULAR EDEMA. Retina 36:10, pages 1986-1996.
Crossref
Bobak Bahrami, Meidong Zhu, Thomas Hong & Andrew Chang. (2016) Diabetic macular oedema: pathophysiology, management challenges and treatment resistance. Diabetologia 59:8, pages 1594-1608.
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Bo Ram LeeJae Moon AhnJae Ryung Oh. (2015) The Characteristics of Non-Retinal Lesions in the Ultra-Wide Field Scanning Laser Ophthalmoscope Image. Journal of the Korean Ophthalmological Society 56:11, pages 1742.
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