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Current Eye Research Volume 41, 2016 - Issue 2
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Original Article

Increased O-GlcNAcylation of NF-κB Enhances Retinal Ganglion Cell Death in Streptozotocin-induced Diabetic Retinopathy

Seong-Jae KimDepartment of Ophthalmology, School of Medicine, Gyeongsang National University, Jinju, Korea, ;Institute of Health Science, Gyeongsang National University, Jinju, South Korea and
,
Woong-Sun YooDepartment of Ophthalmology, School of Medicine, Gyeongsang National University, Jinju, Korea,
,
Meeyoung ChoiInstitute of Health Science, Gyeongsang National University, Jinju, South Korea and ;Department of Anatomy and Neurobiology, School of Medicine, Gyeongsang National University, Jinju, Korea
,
Inyoung ChungDepartment of Ophthalmology, School of Medicine, Gyeongsang National University, Jinju, Korea, ;Institute of Health Science, Gyeongsang National University, Jinju, South Korea and
,
Ji-Myong YooDepartment of Ophthalmology, School of Medicine, Gyeongsang National University, Jinju, Korea, ;Institute of Health Science, Gyeongsang National University, Jinju, South Korea and Correspondence[email protected]
&
Wan-Sung ChoiInstitute of Health Science, Gyeongsang National University, Jinju, South Korea and ;Department of Anatomy and Neurobiology, School of Medicine, Gyeongsang National University, Jinju, KoreaCorrespondence[email protected]
Pages 249-257 | Received 19 Sep 2014, Accepted 30 Dec 2014, Published online: 02 Apr 2015

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Baohua Li, Bobiao Ning, Fan Yang & Chengwei Guo. (2022) Nerve Growth Factor Promotes Retinal Neurovascular Unit Repair: A Review. Current Eye Research 47:8, pages 1095-1105.
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Articles from other publishers (30)

Christopher R. Starr, Assylbek Zhylkibayev, James A. Mobley & Marina S. Gorbatyuk. (2023) Proteomic analysis of diabetic retinas. Frontiers in Endocrinology 14.
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Drew Garber & Shu Zhu. (2023) Implications of Caspase 1/ Interleukin-1 Beta (IL-1β) Signaling and Hypoxia-Inducible Factor 1-Alpha (HIF-1α) on Diabetic Retinopathy Pathology. Cureus.
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Yixin Wang, Rachana Eshwaran, Susanne C. Beck, Hans-Peter Hammes, Thomas Wieland & Yuxi Feng. (2023) Contribution of the hexosamine biosynthetic pathway in the hyperglycemia-dependent and -independent breakdown of the retinal neurovascular unit. Molecular Metabolism 73, pages 101736.
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Yuxuan Yang, Gengchen Jiang, Runchun Huang, Yi Liu, Xingyu Chang & Songbo Fu. (2023) Targeting the NLRP3 inflammasome in diabetic retinopathy: From pathogenesis to therapeutic strategies. Biochemical Pharmacology 212, pages 115569.
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Dimitris Spyridakos, Niki Mastrodimou, Kiran Vemuri, Thanh C. Ho, Spyros P. Nikas, Alexandros Makriyannis & Kyriaki Thermos. (2022) Blockade of CB1 or Activation of CB2 Cannabinoid Receptors Is Differentially Efficacious in the Treatment of the Early Pathological Events in Streptozotocin-Induced Diabetic Rats. International Journal of Molecular Sciences 24:1, pages 240.
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Xin Zhao, Feng Ling, Guang wei Zhang, Na Yu, Jing Yang & Xiang yang Xin. (2022) The Correlation Between MicroRNAs and Diabetic Retinopathy. Frontiers in Immunology 13.
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Sadie K. Dierschke & Michael D. Dennis. (2022) Retinal Protein O-GlcNAcylation and the Ocular Renin-angiotensin System: Signaling Cross-roads in Diabetic Retinopathy. Current Diabetes Reviews 18:2.
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Oleg S. Gorbatyuk, Priyamvada M. Pitale, Irina V. Saltykova, Iuliia B. Dorofeeva, Assylbek A. Zhylkibayev, Mohammad Athar, Preston A. Fuchs, Brian C. Samuels & Marina S. Gorbatyuk. (2022) A Novel Tree Shrew Model of Diabetic Retinopathy. Frontiers in Endocrinology 12.
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Dhaval K Shukal, Pooja B Malaviya & Tusha Sharma. (2022) Role of the AMPK signalling pathway in the aetiopathogenesis of ocular diseases. Human & Experimental Toxicology 41, pages 096032712110631.
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Mira M. Sachdeva. (2021) Retinal Neurodegeneration in Diabetes: an Emerging Concept in Diabetic Retinopathy. Current Diabetes Reports 21:12.
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Chunren Meng, Chufeng Gu, Shuai He, Tong Su, Thashi Lhamo, Deji Draga & Qinghua Qiu. (2021) Pyroptosis in the Retinal Neurovascular Unit: New Insights Into Diabetic Retinopathy. Frontiers in Immunology 12.
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John C. Chatham, Jianhua Zhang & Adam R. Wende. (2021) Role of O -linked N -acetylglucosamine protein modification in cellular (patho)physiology . Physiological Reviews 101:2, pages 427-493.
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Thekkuttuparambil A. Ajith. (2020) Alpha‐lipoic acid: A possible pharmacological agent for treating dry eye disease and retinopathy in diabetes. Clinical and Experimental Pharmacology and Physiology 47:12, pages 1883-1890.
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Xiaopeng Ai, Peiling Yu, Ya Hou, Xinchen Song, Jie Luo, Ning Li, Xianrong Lai, Xiaobo Wang & Xianli Meng. (2020) A review of traditional Chinese medicine on treatment of diabetic retinopathy and involved mechanisms. Biomedicine & Pharmacotherapy 132, pages 110852.
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Vienna Mazzoli, Lexy H. Zhong, Vi T. Dang, Yuanyuan Shi & Geoff H. Werstuck. (2020) Characterization of Retinal Microvascular Complications and the Effects of Endoplasmic Reticulum Stress in Mouse Models of Diabetic Atherosclerosis. Investigative Opthalmology & Visual Science 61:10, pages 49.
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Sadie K. Dierschke, Allyson L. Toro, William P. Miller, Siddharth Sunilkumar & Michael D. Dennis. (2020) Diabetes enhances translation of Cd40 mRNA in murine retinal Müller glia via a 4E-BP1/2–dependent mechanism. Journal of Biological Chemistry 295:31, pages 10831-10841.
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María Constanza Potilinski, Valeria Lorenc, Sofía Perisset & Juan Eduardo Gallo. (2020) Mechanisms behind Retinal Ganglion Cell Loss in Diabetes and Therapeutic Approach. International Journal of Molecular Sciences 21:7, pages 2351.
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Qing Xiao, Yinu Zhao, Jia Xu, Wen-Jie Li, Yu Chen & Hong-Jing Sun. (2019) NFE2/miR-423-5p/TFF1 axis regulates high glucose-induced apoptosis in retinal pigment epithelial cells. BMC Molecular and Cell Biology 20:1.
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Hongxia Xiao & Zhen Liu. (2019) Effects of microRNA‑217 on high glucose‑induced inflammation and apoptosis of human retinal pigment epithelial cells (ARPE‑19) and its underlying mechanism. Molecular Medicine Reports.
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Peng-Fei Tao & Han-Chang Huang. (2019) Regulation of AβPP Glycosylation Modification and Roles of Glycosylation on AβPP Cleavage in Alzheimer’s Disease. ACS Chemical Neuroscience 10:5, pages 2115-2124.
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Maria Grazia Rossino & Giovanni Casini. (2019) Nutraceuticals for the Treatment of Diabetic Retinopathy. Nutrients 11:4, pages 771.
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Sadie K. Dierschke, William P. Miller, John S. Favate, Premal Shah, Yuka Imamura Kawasawa, Anna C. Salzberg, Scot R. Kimball, Leonard S. Jefferson & Michael D. Dennis. (2019) O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1–dependent mitochondrial dysfunction in the retina. Journal of Biological Chemistry 294:14, pages 5508-5520.
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Nidhi Mahajan, Palkin Arora & Rajat Sandhir. (2019) Perturbed Biochemical Pathways and Associated Oxidative Stress Lead to Vascular Dysfunctions in Diabetic Retinopathy. Oxidative Medicine and Cellular Longevity 2019, pages 1-16.
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Gerald W. Hart. (2019) Nutrient regulation of signaling and transcription. Journal of Biological Chemistry 294:7, pages 2211-2231.
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Weiwei Dai, Sadie K. Dierschke, Allyson L. Toro & Michael D. Dennis. (2018) Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:12, pages 3568-3576.
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Zafer GurelNader Sheibani. (2018) O-Linked β- N -acetylglucosamine (O-GlcNAc) modification: a new pathway to decode pathogenesis of diabetic retinopathy . Clinical Science 132:2, pages 185-198.
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Xiaofeng Ma, He Li, Yating He & Junwei Hao. (2017) The emerging link between O-GlcNAcylation and neurological disorders. Cellular and Molecular Life Sciences 74:20, pages 3667-3686.
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Willayat Y. Wani, John C. Chatham, Victor Darley-Usmar, Lori L. McMahon & Jianhua Zhang. (2017) O-GlcNAcylation and neurodegeneration. Brain Research Bulletin 133, pages 80-87.
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Jing Zhang, Rong Liu, Hong-Yu Kuang, Xin-Yuan Gao & Hao-Ling Liu. (2017) Protective treatments and their target retinal ganglion cells in diabetic retinopathy. Brain Research Bulletin 132, pages 53-60.
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Cheng Li, Xiao Miao, Fengsheng Li, Shudong Wang, Quan Liu, Yonggang Wang & Jian Sun. (2017) Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Diabetic Retinopathy. Oxidative Medicine and Cellular Longevity 2017, pages 1-15.
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