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Journal of Asthma Volume 48, 2011 - Issue 10
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Biomarkers

Eosinophil Degranulation Is More Important than Eosinophilia in Identifying Asthma in Chronic Cough

Chang-Keun KimDepartment of Pediatrics, Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea
, M.D.,
Zak CallawayDepartment of Pediatrics, Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea;School of Biological Sciences, College of Natural Sciences, University of Ulsan, Ulsan, Korea
, Ph.D.,
Dong Won KimDepartment of Pediatrics, Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea
, M.D. &
Hirohito KitaDivision of Allergy, Department of Immunology and Medicine, Mayo Clinic and Foundation, Rochester, MN, USACorrespondence[email protected]
, M.D.
Pages 994-1000 | Published online: 24 Oct 2011

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Akshay Sood, JeanClare Seagrave, Guy Herbert, Michelle Harkins, Yasir Alam, Annalisa Chiavaroli, Rugia Shohreh, Paolo Montuschi, Matthew Campen, Molly Harmon, Clifford Qualls, Marianne Berwick & Mark Schuyler. (2014) High sputum total adiponectin is associated with low odds for asthma. Journal of Asthma 51:5, pages 459-466.
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Chang-Keun Kim, Jeong Koo Seo, Seong Hwan Ban, Takao Fujisawa, Dong Won Kim & Zak Callaway. (2013) Eosinophil-derived neurotoxin levels at 3 months post-respiratory syncytial virus bronchiolitis are a predictive biomarker of recurrent wheezing. Biomarkers 18:3, pages 230-235.
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Articles from other publishers (19)

Yoshihide Terashi, Chang-Keun Kim, Zak Callaway, Jin-Sung Park, Shinya Yoshihara, Masaya Kato & Shigemi Yoshihara. (2023) Natural history of eosinophil‑derived neurotoxin levels and the onset of allergic airway disease in preschool children. Experimental and Therapeutic Medicine 26:6.
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Huijia Hu, Xiaoyan Hu, Zhuoping Wang, Liping Gao, Jun Jin, Junbo Xia, Linfeng Huang & Senhua Li. (2023) Clinical value of serum soluble receptor for advanced glycation end products in evaluating the condition of patients with bronchial asthma. Allergy and Asthma Proceedings 44:4, pages 258-264.
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Shougang Kuai & Peipei Zhao. (2023) Association of EDN levels in patients with asthma and correlation with FEV 1 %: A meta-analysis . Allergy and Asthma Proceedings 44:4, pages 244-251.
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Maciej Tota, Julia Łacwik, Julia Laska, Łukasz Sędek & Krzysztof Gomułka. (2023) The Role of Eosinophil-Derived Neurotoxin and Vascular Endothelial Growth Factor in the Pathogenesis of Eosinophilic Asthma. Cells 12:9, pages 1326.
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Andrei Malinovschi, Niclas Rydell, Takao Fujisawa, Magnus P. Borres & Chang-Keun Kim. (2023) Clinical Potential of Eosinophil-Derived Neurotoxin in Asthma Management. The Journal of Allergy and Clinical Immunology: In Practice 11:3, pages 750-761.
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Desen Sun, Chenjie Han & Jinghao Sheng. (2022) The role of human ribonuclease A family in health and diseases: A systematic review. iScience 25:11, pages 105284.
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Pablo Rodriguez del Rio, Andrew H. Liu, Magnus P. Borres, Eva Södergren, Fabio Iachetti & Thomas B. Casale. (2022) Asthma and Allergy: Unravelling a Tangled Relationship with a Focus on New Biomarkers and Treatment. International Journal of Molecular Sciences 23:7, pages 3881.
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Hwan Soo KimHyeon-Jong YangDae Jin SongYong Ju LeeDong In SuhJung Yeon ShimYoung YooChang Keun Kim, Young Min Ahn & Jin Tack Kim. (2022) Eosinophil-derived neurotoxin: An asthma exacerbation biomarker in children. Allergy and Asthma Proceedings 43:2, pages 133-139.
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Bert Rutten, Simon Young, Magdalena Rhedin, Marita Olsson, Nisha Kurian, Farhat Syed, Augusta Beech, Mark Fidock, Paul Newbold, Dave Singh, Adam Platt & Glen Hughes. (2021) Eosinophil-derived neurotoxin: A biologically and analytically attractive asthma biomarker. PLOS ONE 16:2, pages e0246627.
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Chang-Keun Kim, Zak Callaway, Jin-Sung Park & Eunmi Kwon. (2017) Utility of serum eosinophil-derived neurotoxin (EDN) measurement by ELISA in young children with asthma. Allergology International 66:1, pages 70-74.
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I. Agache, D. S. Strasser, A. Klenk, C. Agache, H. Farine, C. Ciobanu, P. M. A. Groenen & C. A. Akdis. (2016) Serum IL-5 and IL-13 consistently serve as the best predictors for the blood eosinophilia phenotype in adult asthmatics. Allergy 71:8, pages 1192-1202.
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Christopher F. Thompson, Caroline P.E. Price, Julia He Huang, Jin-Young Min, Lydia A. Suh, Stephanie Shintani-Smith, David B. Conley, Robert P. Schleimer, Robert C. Kern & Bruce K. Tan. (2016) A pilot study of symptom profiles from a polyp vs an eosinophilic-based classification of chronic rhinosinusitis. International Forum of Allergy & Rhinology 6:5, pages 500-507.
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Rafael Martínez-Girón & Cristina Martínez-Torre. (2016) Cytolytic degranulation of eosinophils in sputum smears. Diagnostic Cytopathology 44:3, pages 220-222.
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E. A. Jacobsen, A. D. Doyle, D. C. Colbert, K. R. Zellner, C. A. Protheroe, W. E. LeSuer, N. A. Lee & J. J. Lee. (2015) Differential activation of airway eosinophils induces IL-13-mediated allergic Th2 pulmonary responses in mice. Allergy 70:9, pages 1148-1159.
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P. Panzner, I. Malkusová, M. Vachová, M. Liška, P. Brodská, O. Růžičková & M. Malý. (2015) Bronchial inflammation in seasonal allergic rhinitis with or without asthma in relation to natural exposure to pollen allergens. Allergologia et Immunopathologia 43:1, pages 3-9.
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Ting Wen & Marc E. Rothenberg. 2015. Mucosal Immunology. Mucosal Immunology 883 914 .
Sergei I. Ochkur, Cheryl A. Protheroe, Wen Li, Dana C. Colbert, Katie R. Zellner, Hua-Hao Shen, Andrew D. Luster, Charles G. Irvin, James J. Lee & Nancy A. Lee. (2013) Cys-Leukotrienes Promote Fibrosis in a Mouse Model of Eosinophil-Mediated Respiratory Inflammation. American Journal of Respiratory Cell and Molecular Biology 49:6, pages 1074-1084.
Crossref
Paul M. Dias & Gautam Banerjee. (2013) The Role of Th17/IL-17 on Eosinophilic Inflammation. Journal of Autoimmunity 40, pages 9-20.
Crossref
Chang-Keun Kim. (2013) Eosinophil-derived neurotoxin: a novel biomarker for diagnosis and monitoring of asthma. Korean Journal of Pediatrics 56:1, pages 8.
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