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Acta Oncologica Volume 49, 2010 - Issue 4
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ORIGINAL ARTICLE

Influence of complex variant chromosomal translocations in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

Fabio Stagno Department of Biomedical Sciences, Sections of Hematology; *These authors contributed equally to this workCorrespondence[email protected]
,
Paolo Vigneri Department of Biomedical Sciences, General Pathology, University of Catania, Italy; *These authors contributed equally to this work
,
Vittorio Del Fabro Department of Biomedical Sciences, Sections of Hematology
,
Stefania Stella Department of Biomedical Sciences, General Pathology, University of Catania, Italy
,
Alessandra Cupri Department of Biomedical Sciences, Sections of Hematology
,
Michele Massimino Department of Biomedical Sciences, General Pathology, University of Catania, Italy
,
Carla Consoli Department of Biomedical Sciences, Sections of Hematology
,
Loredana Tambè Department of Biomedical Sciences, Sections of Hematology
,
Maria Letizia Consoli Department of Biomedical Sciences, General Pathology, University of Catania, Italy
,
Agostino Antolino Department of Transfusional Medicine, A.O. “Maria Paternò Arezzo”, Ragusa, Italy
&
Francesco Di Raimondo Department of Biomedical Sciences, Sections of Hematology
 show all
Pages 506-508 | Received 15 Oct 2009, Accepted 28 Jan 2010, Published online: 24 Mar 2010

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Enaam Alsobhi, Mohammed Burhan Abrar, Mohammed Abdelaal, Ahmed Alsaeed, Ahmed Absi, Zayed Alzahrani, Ihab El-Hemaidi, Mohammed Ali Alshehri, Ashraf Warsi, Safaa Bayashoot, Heba Hashem, Anas Merdad, Suhaib Radi, Hanadi Shiekhi & Abdulfattah Al-Amri. (2015) Response to imatinib therapy in adult patients with chronic myeloid leukemia in Saudi population: a single-center study. Leukemia & Lymphoma 56:4, pages 882-886.
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Adriana Zámecˇníkova, Soad Al Bahar & Ramesh Pandita. (2012) Unusual location of BCR-ABL1 fusion sequences in a chronic myeloid leukemia patient. Hematology 17:6, pages 321-324.
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Chuanyi M. Lu, Lukun Zhou, Sizhou Feng, Peter H. Kohn, Zhongxia Qi & Jingwei Yu. (2011) Presence of complex t(6;9;22;15) four-way chromosome rearrangement plus rare t(1;6) translocation with favorable response to imatinib therapy in chronic myelogenous leukemia. Leukemia & Lymphoma 52:11, pages 2182-2184.
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Adelina Fernandes, Naranie Shanmuganathan & Susan Branford. (2022) Genomic Mechanisms Influencing Outcome in Chronic Myeloid Leukemia. Cancers 14:3, pages 620.
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Irena Ćojbašić, Lana Mačukanović-Golubović, Dragan Mihailović, Miodrag Vučić & Stevo Lukić. (2014) Improved prediction of clinical outcome in chronic myeloid leukemia. International Journal of Hematology 101:2, pages 173-183.
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Vijaya V. Mysorekar, Murali Subramanian, Nalini Kilara & Tambarahalli S. Sundareshan. (2015) Variant Philadelphia translocations in chronic myeloid leukemia. Journal of Cancer Research and Therapeutics 11:3, pages 654.
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Woo-Seong KimGeon ParkSook-Jin JangDae-Soo MoonSeong-Ho Kang. (2015) A Novel Four-Way Translocation t(5;9;22;18)(q31;q34;q11.2;q21) in a Patient with Chronic Myelogenous Leukemia. Laboratory Medicine Online 5:2, pages 101.
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Kendra Sweet, Ling Zhang & Javier Pinilla-Ibarz. (2013) Biomarkers for determining the prognosis in chronic myelogenous leukemia. Journal of Hematology & Oncology 6:1.
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Shantashri Vaidya, Dolly Joshi, Kanjaksha Ghosh, Prantar Chakrabarti & Babu Rao Vundinti. (2013) A novel 5-way translocation t(9;11;13;19;22) in a case of chronic-phase chronic myeloid leukemia. Human Pathology 44:10, pages 2365-2369.
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Giuseppe Saglio & Carmen FavaGiovanna Rege-Cambrin, Emilia Giugliano & Patrizia Scaravaglio. 2013. The Treatment of Chronic Myeloid Leukemia. The Treatment of Chronic Myeloid Leukemia 20 36 .
Dayane B. Koshiyama, Marcelo E. Z. Capra, Giorgio A. Paskulin, Rafael F. M. Rosa, Ceres A. V. Oliveira, Tito Vanelli, Laura M. Fogliatto & Paulo R. G. Zen. (2012) Cytogenetic response to imatinib treatment in Southern Brazilian patients with chronic myelogenous leukemia and variant Philadelphia chromosome. Annals of Hematology 92:2, pages 185-189.
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Sho Yokota, Yuichi Nakamura & Masami Bessho. (2012) A novel five-way translocation t(7;11;9;22;9)(q22;q13;q34;q11.2;q34) involving Ph chromosome in a patient of chronic myeloid leukemia: a case report. Molecular Cytogenetics 5:1.
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Masahiro Manabe, Yumi Yoshii, Satoru Mukai, Erina Sakamoto, Hiroshi Kanashima, Takeshi Inoue & Hirofumi Teshima. (2011) A Rare t(9;22;16)(q34;q11;q24) Translocation in Chronic Myeloid Leukemia for Which Imatinib Mesylate Was Effective: A Case Report. Leukemia Research and Treatment 2011, pages 1-3.
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François Guilhot. (2011) Ph: not bad at all. Blood 117:25, pages 6741-6742.
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