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Acta Oncologica Volume 28, 1989 - Issue 3
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Original Article

Chromogranins — New Sensitive Markers for Neuroendocrine Tumors

B. Eriksson LUDWIG INSTITUTE FOR CANCER RESEARCH, AND THE DEPARTMENTS OF CLINICAL CHEMISTRY AND PATHOLOGY, UPPSALA HOSPITAL, AND THE LUDWIG INSTITUTE FOR CANCER RESEARCH, BIOMEDICAL CENTER, UPPSALA, SWEDEN
,
H. Arnberg LUDWIG INSTITUTE FOR CANCER RESEARCH, AND THE DEPARTMENTS OF CLINICAL CHEMISTRY AND PATHOLOGY, UPPSALA HOSPITAL, AND THE LUDWIG INSTITUTE FOR CANCER RESEARCH, BIOMEDICAL CENTER, UPPSALA, SWEDEN
,
K. Ouberg LUDWIG INSTITUTE FOR CANCER RESEARCH, AND THE DEPARTMENTS OF CLINICAL CHEMISTRY AND PATHOLOGY, UPPSALA HOSPITAL, AND THE LUDWIG INSTITUTE FOR CANCER RESEARCH, BIOMEDICAL CENTER, UPPSALA, SWEDEN
,
U. Hellman LUDWIG INSTITUTE FOR CANCER RESEARCH, AND THE DEPARTMENTS OF CLINICAL CHEMISTRY AND PATHOLOGY, UPPSALA HOSPITAL, AND THE LUDWIG INSTITUTE FOR CANCER RESEARCH, BIOMEDICAL CENTER, UPPSALA, SWEDEN
,
G. Lundqvist LUDWIG INSTITUTE FOR CANCER RESEARCH, AND THE DEPARTMENTS OF CLINICAL CHEMISTRY AND PATHOLOGY, UPPSALA HOSPITAL, AND THE LUDWIG INSTITUTE FOR CANCER RESEARCH, BIOMEDICAL CENTER, UPPSALA, SWEDEN
,
C. Wernstedt LUDWIG INSTITUTE FOR CANCER RESEARCH, AND THE DEPARTMENTS OF CLINICAL CHEMISTRY AND PATHOLOGY, UPPSALA HOSPITAL, AND THE LUDWIG INSTITUTE FOR CANCER RESEARCH, BIOMEDICAL CENTER, UPPSALA, SWEDEN
&
E. Wilander LUDWIG INSTITUTE FOR CANCER RESEARCH, AND THE DEPARTMENTS OF CLINICAL CHEMISTRY AND PATHOLOGY, UPPSALA HOSPITAL, AND THE LUDWIG INSTITUTE FOR CANCER RESEARCH, BIOMEDICAL CENTER, UPPSALA, SWEDEN
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Pages 325-329 | Published online: 08 Jul 2009

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Kjell Öberg. (2015) Neuroendocrine gastro-enteropancreatic tumors – from eminence based to evidence-based medicine – A Scandinavian view. Scandinavian Journal of Gastroenterology 50:6, pages 727-739.
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Marie-Louise Fjällskog & Eva Tiensuu Janson. (2005) Treatment of endocrine pancreatic tumors. Acta Oncologica 44:4, pages 329-338.
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Emilio Bajetta, Giuseppe Procopio, Roberto Buzzoni, Laura Catena, Leonardo Ferrari & Michele Del Vecchio. (2001) Advances in diagnosis and therapy of neuroendocrine tumors. Expert Review of Anticancer Therapy 1:3, pages 371-381.
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Mats Stridsberg. (1995) The Use of Chromogranin, Synaptophysin and Islet Amyloid Polypeptide as Markers for Neuroendocrine Tumours. Upsala Journal of Medical Sciences 100:3, pages 169-199.
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Unni Syversen, Michel Mignon, Serge Bonfils, Anne Kristensen & Helge L Waldum. (1993) Chromogranin a and Pancreastatin-Like Immunoreactivity in Serum of Gastrinoma Patients. Acta Oncologica 32:2, pages 161-165.
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V.-P. Lehto & J. Pontén. (1989) Tumor Markers in Human Biopsy Material. Acta Oncologica 28:5, pages 743-763.
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Anthony J. Gill, Lori A. Erickson & Talia L. Fuchs. 2022. Non-Neoplastic Disorders of the Endocrine System. Non-Neoplastic Disorders of the Endocrine System 275 302 .
Jiayun M Fang, Jay Li & Jiaqi Shi. (2022) An update on the diagnosis of gastroenteropancreatic neuroendocrine neoplasms. World Journal of Gastroenterology 28:10, pages 1009-1023.
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Anna Malczewska, Mark Kidd, Somer Matar, Beata Kos-Kudła, Lisa Bodei, Kjell Oberg & Irvin M. Modlin. (2020) An Assessment of Circulating Chromogranin A as a Biomarker of Bronchopulmonary Neuroendocrine Neoplasia: A Systematic Review and Meta-Analysis. Neuroendocrinology 110:3-4, pages 198-216.
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Somer Matar, Anna Malczewska, Kjell Oberg, Lisa Bodei, Harry Aslanian, Anna Lewczuk-Myślicka, Pier Luigi Filosso, Alejandro L. Suarez, Agnieszka Kolasińska-Ćwikła, Matteo Roffinella, Beata Kos-Kudła, Jarosław B. Ćwikła, Ignat A. Drozdov, Mark  Kidd & Irvin M. Modlin. (2020) Blood Chromogranin A Is Not Effective as a Biomarker for Diagnosis or Management of Bronchopulmonary Neuroendocrine Tumors/Neoplasms. Neuroendocrinology 110:3-4, pages 185-197.
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Andrea Sansone, Rosa Lauretta, Sebastiano Vottari, Alfonsina Chiefari, Agnese Barnabei, Francesco Romanelli & Marialuisa Appetecchia. (2019) Specific and Non-Specific Biomarkers in Neuroendocrine Gastroenteropancreatic Tumors. Cancers 11:8, pages 1113.
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Johannes Hofland, Wouter T. Zandee & Wouter W. de Herder. (2018) Role of biomarker tests for diagnosis of neuroendocrine tumours. Nature Reviews Endocrinology 14:11, pages 656-669.
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Kjell Öberg. (2018) The Genesis of the Neuroendocrine Tumors Concept. Endocrinology and Metabolism Clinics of North America 47:3, pages 711-731.
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Stavros Gkolfinopoulos, Konstantinos Tsapakidis, Konstantinos Papadimitriou, Demetris Papamichael & Panteleimon Kountourakis. (2017) Chromogranin A as a valid marker in oncology: Clinical application or false hopes?. World Journal of Methodology 7:1, pages 9.
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Raymond M Fertig, Adam Alperstein, Carlos Diaz, Kyle D Klingbeil, Sameera S. Vangara, Ryosuke Misawa, Jennifer Reed & Sudeep Gaudi. (2017) Metastatic neuroendocrine tumor of the esophagus with features of medullary thyroid carcinoma. Intractable & Rare Diseases Research 6:3, pages 224-229.
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P.J. Monaghan, A. Lamarca, J.W. Valle, R.A. Hubner, W. Mansoor, P.J. Trainer & D. Darby. (2015) Routine measurement of plasma chromogranin B has limited clinical utility in the management of patients with neuroendocrine tumours. Clinical Endocrinology 84:3, pages 348-352.
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Kjell Öberg. 2015. Neuroendocrine Tumours. Neuroendocrine Tumours 77 95 .
Anneke P.J. Jilesen, Olivier R.C. Busch, Thomas M. van Gulik, Dirk J. Gouma & Els J.M. Nieveen van Dijkum. (2014) Standard Pre- and Postoperative Determination of Chromogranin A in Resectable Non-Functioning Pancreatic Neuroendocrine Tumors - Diagnostic Accuracy: NF-pNET and Low Tumor Burden. Digestive Surgery 31:6, pages 407-414.
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José Ángel Díaz Pérez & Maria Currás Freixes. (2013) Cromogranina A y tumores neuroendocrinos. Endocrinología y Nutrición 60:7, pages 386-395.
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José Ángel Díaz Pérez & Maria Currás Freixes. (2013) Chromogranin A and neuroendocrine tumors. Endocrinología y Nutrición (English Edition) 60:7, pages 386-395.
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George Kanakis & Gregory Kaltsas. (2012) Biochemical markers for gastroenteropancreatic neuroendocrine tumours (GEP-NETs). Best Practice & Research Clinical Gastroenterology 26:6, pages 791-802.
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Kjell Öberg. (2012) Diagnostic work-up of gastroenteropancreatic neuroendocrine tumors. Clinics 67, pages 109-112.
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Ben Lawrence, Bjorn I. Gustafsson, Mark Kidd, Marianne Pavel, Bernhard Svejda & Irvin M. Modlin. (2011) The Clinical Relevance of Chromogranin A as a Biomarker for Gastroenteropancreatic Neuroendocrine Tumors. Endocrinology and Metabolism Clinics of North America 40:1, pages 111-134.
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Kjell Öberg & Daniel Castellano. (2011) Current knowledge on diagnosis and staging of neuroendocrine tumors. Cancer and Metastasis Reviews 30:S1, pages 3-7.
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Sylvia L Asa. (2011) Pancreatic endocrine tumors. Modern Pathology 24, pages S66-S77.
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Irvin M. Modlin, Bjorn I. Gustafsson, Steven F. Moss, Marianne Pavel, Apostolos V. Tsolakis & Mark Kidd. (2010) Chromogranin A—Biological Function and Clinical Utility in Neuro Endocrine Tumor Disease. Annals of Surgical Oncology 17:9, pages 2427-2443.
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Shahrad Taheri, Mohammad A. Ghatei & Stephen R. Bloom. 2010. Endocrinology. Endocrinology 2759 2773 .
Sara Ekeblad, Britt Skogseid, Kristina Dunder, Kjell Öberg & Barbro Eriksson. (2008) Prognostic Factors and Survival in 324 Patients with Pancreatic Endocrine Tumor Treated at a Single Institution. Clinical Cancer Research 14:23, pages 7798-7803.
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Paulus G. Schurr, Tim Strate, Kim Rese, Jussuf T. Kaifi, Uta Reichelt, Susanne Petri, Helge Kleinhans, Emre F. Yekebas & Jakob R. Izbicki. (2007) Aggressive Surgery Improves Long-term Survival in Neuroendocrine Pancreatic Tumors. Annals of Surgery 245:2, pages 273-281.
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