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Original Article

Sequence-Specific Dna Breaks Produced by Triplex-Directed Decay of Iodine-125

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Pages 817-823 | Received 25 Aug 1995, Accepted 08 Mar 1996, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Volker Dahmen, Ekkehard Pomplun & Ralf Kriehuber. (2016) Iodine-125-labeled DNA-Triplex-forming oligonucleotides reveal increased cyto- and genotoxic effectiveness compared to Phosphorus-32. International Journal of Radiation Biology 92:11, pages 679-685.
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Roger F. Martin & Ludwig E. Feinendegen. (2016) The quest to exploit the Auger effect in cancer radiotherapy – a reflective review. International Journal of Radiation Biology 92:11, pages 617-632.
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Pavel Lobachevsky, George R. Clark, Patrycja D. Pytel, Brenda Leung, Colin Skene, Laura Andrau, Jonathan M. White, Tom Karagiannis, Carleen Cullinane, Boon Q. Lee, Andrew Stuchbery, Tibor Kibedi, Rodney J. Hicks & Roger F. Martin. (2016) Strand breakage by decay of DNA-bound 124I provides a basis for combined PET imaging and Auger endoradiotherapy. International Journal of Radiation Biology 92:11, pages 686-697.
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Volker Dahmen & Ralf Kriehuber. (2012) Cytotoxic effects and specific gene expression alterations induced by I-125-labeled triplex-forming oligonucleotides. International Journal of Radiation Biology 88:12, pages 972-979.
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Kamal Datta, Ronald D Neumann & Thomas A Winters. (2005) Characterization of a complex 125I-induced DNA double-strand break: Implications for repair . International Journal of Radiation Biology 81:1, pages 13-21.
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Amin I. Kassis. (2004) The Amazing World of Auger Electrons. International Journal of Radiation Biology 80:11-12, pages 789-803.
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Olga A. Sedelnikova, Irina V. Panyutin, Ronald D. Neumann, William M. Bonner & Igor G. Panyutin. (2004) Assessment of DNA damage produced by 125I‐triplex‐forming oligonucleotides in cells. International Journal of Radiation Biology 80:11-12, pages 927-931.
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E. K. Gaidamakova, R. D. Neumann & I. G. Panyutin. (2004) Antisense radiotherapy: targeting full‐size mdr1 mRNA with 125I‐labelled oligonucleotides. International Journal of Radiation Biology 80:11-12, pages 889-893.
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L. E. Feinendegen & R. D. Neumann. (2004) Dosimetry and risk from low‐ versus high‐LET radiation of Auger events and the role of nuclide carriers. International Journal of Radiation Biology 80:11-12, pages 813-822.
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Articles from other publishers (24)

Volker Dahmen, Sabine Schmitz & Ralf Kriehuber. (2017) Induction of the chromosomal translocation t(14;18) by targeting the BCL-2 locus with specific binding I-125-labeled triplex-forming oligonucleotides. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 823, pages 58-64.
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Marlies Gijs, An Aerts, Nathalie Impens, Sarah Baatout & André Luxen. (2016) Aptamers as radiopharmaceuticals for nuclear imaging and therapy. Nuclear Medicine and Biology 43:4, pages 253-271.
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Nadia Falzone, Bart Cornelissen & Katherine A. Vallis. 2012. Radiation Damage in Biomolecular Systems. Radiation Damage in Biomolecular Systems 461 478 .
Elzbieta Pastwa, Richard I. Somiari, Mariusz Malinowski, Stella B. Somiari & Thomas A. Winters. (2009) In vitro non-homologous DNA end joining assays—The 20th anniversary. The International Journal of Biochemistry & Cell Biology 41:6, pages 1254-1260.
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H. Nikjoo, P. Girard, D. E. Charlton, K. G. Hofer & C. A Laughton. (2006) Auger electrons—a nanoprobe for structural, molecular and cellular processes. Radiation Protection Dosimetry 122:1-4, pages 72-79.
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Kamal Datta, Pawel Jaruga, Miral Dizdaroglu, Ronald D. Neumann & Thomas A. Winters. (2006) Molecular Analysis of Base Damage Clustering Associated with a Site-Specific Radiation-Induced DNA Double-Strand Break. Radiation Research 166:5, pages 767-781.
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. 2006. RADIOIONIDATION REACTIONS FOR RADIO PHARMACEUTICALS. RADIOIONIDATION REACTIONS FOR RADIO PHARMACEUTICALS 29 72 .
Kamal Datta, Ronald D. Neumann & Thomas A. Winters. (2005) Characterization of complex apurinic/apyrimidinic-site clustering associated with an authentic site-specific radiation-induced DNA double-strand break. Proceedings of the National Academy of Sciences 102:30, pages 10569-10574.
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I. G. PANYUTIN, O. A. SEDELNIKOVA, V. N. KARAMYCHEV & R. D. NEUMANN. (2003) Antigene Radiotherapy. Annals of the New York Academy of Sciences 1002:1, pages 134-140.
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Lisa Bodei, Amin I. Kassis, S. James Adelstein & Giuliano Mariani. (2003) Radionuclide Therapy with Iodine-125 and Other Auger–Electron-Emitting Radionuclides: Experimental Models and Clinical Applications. Cancer Biotherapy and Radiopharmaceuticals 18:6, pages 861-877.
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Hooshang Nikjoo & Shuzo Uehara. 2003. Charged Particle and Photon Interactions with Matter. Charged Particle and Photon Interactions with Matter.
Elzbieta Pastwa, Ronald D. Neumann, Katherina Mezhevaya & Thomas A. Winters. (2003) Repair of Radiation-Induced DNA Double-Strand Breaks is Dependent upon Radiation Quality and the Structural Complexity of Double-Strand Breaks. Radiation Research 159:2, pages 251-261.
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Igor G. Panyutin, Thomas A. Winters, Ludwig E. Feinendegen & Ronald D. Neumann. 2003. Molecular Nuclear Medicine. Molecular Nuclear Medicine 697 712 .
Andrea Odersky, Irina V. Panyutin, Igor G. Panyutin, Christian Schunck, Elke Feldmann, Wolfgang Goedecke, Ronald D. Neumann, Günter Obe & Petra Pfeiffer. (2002) Repair of Sequence-specific 125I-induced Double-strand Breaks by Nonhomologous DNA End Joining in Mammalian Cell-free Extracts. Journal of Biological Chemistry 277:14, pages 11756-11764.
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O.A. SedelnikovaV.N. KaramychevI.G. PanyutinR.D. Neumann. (2002) Sequence-Specific Gene Cleavage in Intact Mammalian Cells by 125 I-Labeled Triplex-Forming Oligonucleotides Conjugated with Nuclear Localization Signal Peptide . Antisense and Nucleic Acid Drug Development 12:1, pages 43-49.
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Irina V. Panyutin, Andrew N. Luu, Igor G. Panyutin & Ronald D. Neumann. (2001) Strand Breaks in Whole Plasmid DNA Produced by the Decay of 125 I in a Triplex-Forming Oligonucleotide . Radiation Research 156:2, pages 158-166.
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Olga A Sedelnikova, Andrew N Luu, Valeri N Karamychev, Igor G Panyutin & Ronald D Neumann. (2001) Development of DNA-based radiopharmaceuticals carrying Auger-electron emitters for antigene radiotherapy. International Journal of Radiation Oncology*Biology*Physics 49:2, pages 391-396.
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OLGA A. SEDELNIKOVA, IGOR G. PANYUTIN, ANDREW N. LUU, MICHAEL W. REED, THOMAS LICHT, MICHAEL M. GOTTESMAN & RONALD D. NEUMANN. (2000) Targeting the Human mdr 1 Gene by 125I-Labeled Triplex-Forming Oligonucleotides . Antisense and Nucleic Acid Drug Development 10:6, pages 443-452.
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A. T. M. Shamsul Hoque, Olga A. Sedelnikova, Andrew N. Luu, William D. Swaim, Igor G. Panyutin & Bruce J. Baum. (2000) Use of Polyethylenimine-Adenovirus Complexes to Examine Triplex Formation in Intact Cells. Antisense and Nucleic Acid Drug Development 10:4, pages 229-241.
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Vladislav A Malkov, Igor G Panyutin, Ronald D Neumann, Victor B Zhurkin & R.Daniel Camerini-Otero. (2000) Radioprobing of a RecA-three-stranded DNA complex with iodine 125: evidence for recognition of homology in the major groove of the target duplex 1 1Edited by P. E. Wright. Journal of Molecular Biology 299:3, pages 629-640.
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Anupam Bishayee, Dandamudi V. Rao, Lionel G. Bouchet, Wesley E. Bolch & Roger W. Howell. (2000) Protection by DMSO against Cell Death Caused by Intracellularly Localized Iodine-125, Iodine-131 and Polonium-210. Radiation Research 153:4, pages 416-427.
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K. Mezhevaya, T. A. Winters & R. D. Neumann. (1999) Gene targeted DNA double-strand break induction by 125l-labeled triplex-forming oligonucleotides is highly mutagenic following repair in human cells. Nucleic Acids Research 27:21, pages 4282-4290.
Crossref
Valentina Zarytova & Asya Levina. 1999. Triple Helix Forming Oligonucleotides. Triple Helix Forming Oligonucleotides 87 97 .
I. G. Panyutin & R. D. Neumann. (1997) Radioprobing of DNA: distribution of DNA breaks produced by decay of 125I incorporated into a triplex-forming oligonucleotide correlates with geometry of the triplex. Nucleic Acids Research 25:4, pages 883-887.
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