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Original Article

Concomitant boost radiotherapy and multidrug chemotherapy in the neoadjuvant treatment of locally advanced rectal cancer: Results of a phase II study

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Pages 1151-1157 | Received 10 Dec 2010, Accepted 16 Apr 2011, Published online: 18 Aug 2011

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Roberta Carbonara, Alessia Surgo, Maria Paola Ciliberti, Fabiana Gregucci, Ilaria Bonaparte, Luca Nicosia, Elisa Meldolesi, Morena Caliandro, Valentina Ferraro, Riccardo Inchingolo, Riccardo Memeo, Elena Ludovico, Roberto Calbi, Mariadea Lavalle, Maria Antonietta Gambacorta, Filippo Alongi & Alba Fiorentino. (2022) Impact of preoperative chemoradiation with higher dose intensity modulated radiotherapy on pathological complete response for locally advanced rectal cancer: a systematic review. Expert Review of Anticancer Therapy 22:11, pages 1249-1259.
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M. Ingle, I. White, J. Chick, H. Stankiewicz, A. Mitchell, H. Barnes, T. Herbert, S. Nill, U. Oelfke, R. Huddart, B. Ng-Cheng-Hin, S. Hafeez, S. Lalondrelle, A. Dunlop & S. Bhide. (2023) Understanding the Benefit of Magnetic Resonance-guided Adaptive Radiotherapy in Rectal Cancer Patients: a Single-centre Study. Clinical Oncology 35:2, pages e135-e142.
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M.P.W. Intven, S.R. de Mol van Otterloo, S. Mook, P.A.H. Doornaert, E.N. de Groot-van Breugel, G.G. Sikkes, M.E. Willemsen-Bosman, H.M. van Zijp & R.H.N. Tijssen. (2021) Online adaptive MR-guided radiotherapy for rectal cancer; feasibility of the workflow on a 1.5T MR-linac: clinical implementation and initial experience. Radiotherapy and Oncology 154, pages 172-178.
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N. Hearn, D. Atwell, K. Cahill, J. Elks, D. Vignarajah, J. Lagopoulos & M. Min. (2021) Neoadjuvant Radiotherapy Dose Escalation in Locally Advanced Rectal Cancer: a Systematic Review and Meta-analysis of Modern Treatment Approaches and Outcomes. Clinical Oncology 33:1, pages e1-e14.
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F. Roeder, E. Meldolesi, S. Gerum, V. Valentini & C. Rödel. (2020) Recent advances in (chemo-)radiation therapy for rectal cancer: a comprehensive review. Radiation Oncology 15:1.
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Vincenzo Valentini, Maria Antonietta Gambacorta, Francesco Cellini, Cynthia Aristei, Claudio Coco, Brunella Barbaro, Sergio Alfieri, Domenico D'Ugo, Roberto Persiani, Francesco Deodato, Antonio Crucitti, Marco Lupattelli, Giovanna Mantello, Federico Navarria, Claudio Belluco, Angela Buonadonna, Caterina Boso, Sara Lonardi, Luciana Caravatta, Maria Cristina Barba, Fabio Maria Vecchio, Ernesto Maranzano, Domenico Genovesi, Giovanni Battista Doglietto, Alessio Giuseppe Morganti, Giuseppe La Torre, Salvatore Pucciarelli & Antonino De Paoli. (2019) The INTERACT Trial: Long-term results of a randomised trial on preoperative capecitabine-based radiochemotherapy intensified by concomitant boost or oxaliplatin, for cT2 (distal)–cT3 rectal cancer. Radiotherapy and Oncology 134, pages 110-118.
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Sven de Mey, Heng Jiang, Hui Wang, Benedikt Engels, Thierry Gevaert, Inès Dufait, Olivier Feron, Joeri Aerts, Valeri Verovski & Mark De Ridder. (2018) Potential of memory T cells in bridging preoperative chemoradiation and immunotherapy in rectal cancer. Radiotherapy and Oncology 127:3, pages 361-369.
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Omar Abdel-Rahman, Aalok Kumar, Hagen F. Kennecke, Caroline H. Speers & Winson Y. Cheung. (2018) Impact of Duration of Neoadjuvant Radiation on Rectal Cancer Survival: A Real World Multi-center Retrospective Cohort Study. Clinical Colorectal Cancer 17:1, pages e21-e28.
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Mark T.W. Teo, Lucy McParland, Ane L. Appelt & David Sebag-Montefiore. (2018) Phase 2 Neoadjuvant Treatment Intensification Trials in Rectal Cancer: A Systematic Review. International Journal of Radiation Oncology*Biology*Physics 100:1, pages 146-158.
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Vincenzo Picardi, Gabriella Macchia, Alessandra Guido, Lucia Giaccherini, Francesco Deodato, Andrea Farioli, Savino Cilla, Gaetano Compagnone, Andrea Ardizzoni, Dajana Cuicchi, Maria Antonietta Gambacorta, Francesco Cellini, Giovanni Frezza, Gilberto Poggioli, Vincenzo Valentini, Lorenzo Fuccio & Alessio Giuseppe Morganti. (2017) Preoperative Chemoradiation With VMAT-SIB in Rectal Cancer: A Phase II Study. Clinical Colorectal Cancer 16:1, pages 16-22.
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Naohito Beppu, Hidenori Yoshie, Fumihiko Kimura, Tsukasa Aihara, Hiroshi Doi, Norihiko Kamikonya, Nagahide Matsubara, Naohiro Tomita, Hidenori Yanagi & Naoki Yamanaka. (2015) Clinicopathological outcomes of preoperative chemoradiotherapy using S-1 plus Irinotecan for T4 lower rectal cancer. Surgery Today 46:7, pages 852-859.
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Ji Zhu, Fangqi Liu, Weilie Gu, Peng Lian, Weiqi Sheng, Junyan Xu, Gang Cai, Debing Shi, Sanjun Cai & Zhen Zhang. (2014) Concomitant boost IMRT-based neoadjuvant chemoradiotherapy for clinical stage II/III rectal adenocarcinoma: results of a phase II study. Radiation Oncology 9:1.
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Mattia F. Osti, Linda Agolli, Stefano Bracci, Luigi Masoni, Maurizio Valeriani, Teresa Falco, Vitaliana De Sanctis & Riccardo Maurizi Enrici. (2014) Neoadjuvant chemoradiation with concomitant boost radiotherapy associated to capecitabine in rectal cancer patients. International Journal of Colorectal Disease 29:7, pages 835-842.
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Ben-hua Xu, Pan Chi, Jin-hua Guo, Guo-xian Guan, Tian-lan Tang, Ying-hong Yang, Ming-qiu Chen, Jian-yuan Song & Chang-yin Feng. (2018) Pilot Study of Intense Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: Retrospective Review of a Phase II Study. Tumori Journal 100:2, pages 149-157.
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Ji Zhu, Peng Lian, Fangqi Liu, Ye Xu, Junyan Xu, Zuqing Guan, Liping Liang, Minghe Wang, Sanjun Cai & Zhen Zhang. (2013) Phase II trial of first-line chemoradiotherapy with intensity-modulated radiation therapy followed by chemotherapy for synchronous unresectable distant metastases rectal adenocarcinoma. Radiation Oncology 8:1.
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C. Tiselius, U. Gunnarsson, K. Smedh, B. Glimelius & L. Påhlman. (2013) Patients with rectal cancer receiving adjuvant chemotherapy have an increased survival: a population-based longitudinal study. Annals of Oncology 24:1, pages 160-165.
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