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Original Articles Radiophysics/Radiobiology

LET-painting increases tumour control probability in hypoxic tumours

, , , , , , , , & show all
Pages 25-32 | Received 04 Jun 2013, Accepted 30 Jul 2013, Published online: 10 Sep 2013

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Eirik Malinen & Ludvig Paul Muren. (2014) Image guided therapy – Do we get the picture?. Acta Oncologica 53:1, pages 3-5.
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Crossref
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Crossref
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Crossref
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Crossref
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Katrien Konings, Charlot Vandevoorde, Bjorn Baselet, Sarah Baatout & Marjan Moreels. (2020) Combination Therapy With Charged Particles and Molecular Targeting: A Promising Avenue to Overcome Radioresistance. Frontiers in Oncology 10.
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Tapesh Bhattacharyya, Masashi Koto, Hiroaki Ikawa, Kazuhiko Hayashi, Yasuhito Hagiwara, Hirokazu Makishima, Goro Kasuya, Naoyoshi Yamamoto, Tadashi Kamada & Hiroshi Tsuji. (2019) First prospective feasibility study of carbon-ion radiotherapy using compact superconducting rotating gantry. The British Journal of Radiology 92:1103, pages 20190370.
Crossref
Eleanor A Blakely, Bruce Faddegon, Christopher Tinkle, Charles Bloch, Michael Dominello, Robert J Griffin, Michael C Joiner & Jay Burmeister. (2019) Three discipline collaborative radiation therapy (3DCRT) special debate: The United States needs at least one carbon ion facility. Journal of Applied Clinical Medical Physics 20:11, pages 6-13.
Crossref
Atsushi Ito & Ryoichi Hirayama. (2019) 8.2.4 Oxygen Effect in the High LET Region8.2.4 高LET領域における酸素効果. RADIOISOTOPES 68:10, pages 709-714.
Crossref
Daniel Sánchez‐Parcerisa, Miguel López‐Aguirre, Ana Dolcet Llerena & José Manuel Udías. (2019) MultiRBE: Treatment planning for protons with selective radiobiological effectiveness. Medical Physics 46:9, pages 4276-4284.
Crossref
Aihong Mao, Hongyun Guo, Yang Liu, Fang Wang, Jinzhou Tang, Shiqi Liao, Yongdong Zhang, Chao Sun, Xiaojun Xia & Hong Zhang. (2019) Exogenous melatonin modulates carbon ion radiation-induced immune dysfunction in mice. Toxicology 417, pages 35-41.
Crossref
Christin Glowa, Peter Peschke, Stephan Brons, Jürgen Debus & Christian P. Karger. (2019) Intrinsic and extrinsic tumor characteristics are of minor relevance for the efficacy of split-dose carbon ion irradiation in three experimental prostate tumors. Radiotherapy and Oncology 133, pages 120-124.
Crossref
Ramin Abolfath, Yusuf Helo, Lawrence Bronk, Alejandro Carabe, David Grosshans & Radhe Mohan. (2019) Renormalization of radiobiological response functions by energy loss fluctuations and complexities in chromosome aberration induction: deactivation theory for proton therapy from cells to tumor control. The European Physical Journal D 73:3.
Crossref
Harald Paganetti, Eleanor Blakely, Alejandro Carabe-Fernandez, David J. Carlson, Indra J. Das, Lei Dong, David Grosshans, Kathryn D. Held, Radhe Mohan, Vitali Moiseenko, Andrzej Niemierko, Robert D. Stewart & Henning Willers. (2019) Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy. Medical Physics 46:3, pages e53-e78.
Crossref
O Sokol, M Krämer, S Hild, M Durante & E Scifoni. (2019) Kill painting of hypoxic tumors with multiple ion beams. Physics in Medicine & Biology 64:4, pages 045008.
Crossref
Lucas N Burigo, José Ramos-Méndez, Mark Bangert, Reinhard W Schulte & Bruce Faddegon. (2019) Simultaneous optimization of RBE-weighted dose and nanometric ionization distributions in treatment planning with carbon ions. Physics in Medicine & Biology 64:1, pages 015015.
Crossref
CK Ying, David Bolst, Anatoly Rosenfeld & Susanna Guatelli. (2019) Characterization of the mixed radiation field produced by carbon and oxygen ion beams of therapeutic energy: A Monte Carlo simulation study. Journal of Medical Physics 44:4, pages 263.
Crossref
Jan Schuemann, Niels Bassler & Taku Inaniwa. (2018) Computational models and tools. Medical Physics 45:11.
Crossref
Piero Fossati, Naruhiro Matsufuji, Tadashi Kamada & Christian P. Karger. (2018) Radiobiological issues in prospective carbon ion therapy trials. Medical Physics 45:11.
Crossref
Masahiro Onishi, Noriyuki Okonogi, Takahiro Oike, Yuya Yoshimoto, Hiro Sato, Yoshiyuki Suzuki, Tadashi Kamada & Takashi Nakano. (2018) High linear energy transfer carbon-ion irradiation increases the release of the immune mediator high mobility group box 1 from human cancer cells. Journal of Radiation Research 59:5, pages 541-546.
Crossref
Alexander Helm, Daniel K. Ebner, Walter Tinganelli, Palma Simoniello, Alessandra Bisio, Valentina Marchesano, Marco Durante, Shigeru Yamada & Takashi Shimokawa. (2018) Combining Heavy-Ion Therapy with Immunotherapy: An Update on Recent Developments. International Journal of Particle Therapy 5:1, pages 84-93.
Crossref
Fada Guan, Changran Geng, Duo Ma, Lawrence Bronk, Matthew Kerr, Yuting Li, Drake Gates, Benjamin Kroger, Narayan Sahoo, Uwe Titt, David Grosshans & Radhe Mohan. (2018) RBE Model-Based Biological Dose Optimization for Proton Radiobiology Studies. International Journal of Particle Therapy 5:1, pages 160-171.
Crossref
X. W. Mao, M. Boerma, D. Rodriguez, M. Campbell-Beachler, T. Jones, S. Stanbouly, V. Sridharan, A. Wroe & G. A. Nelson. (2018) Acute Effect of Low-Dose Space Radiation on Mouse Retina and Retinal Endothelial Cells. Radiation Research 190:1, pages 45-52.
Crossref
Harald Paganetti & Drosoula Giantsoudi. (2018) Relative Biological Effectiveness Uncertainties and Implications for Beam Arrangements and Dose Constraints in Proton Therapy. Seminars in Radiation Oncology 28:3, pages 256-263.
Crossref
Changran Geng, Drake Gates, Lawrence Bronk, Duo Ma & Fada Guan. (2018) Physical parameter optimization scheme for radiobiological studies of charged particle therapy. Physica Medica 51, pages 13-21.
Crossref
Daphne Haas-Kogan, Daniel Indelicato, Harald Paganetti, Natia Esiashvili, Anita Mahajan, Torunn Yock, Stella Flampouri, Shannon MacDonald, Maryam Fouladi, Kry Stephen, John Kalapurakal, Stephanie Terezakis, Hanne Kooy, David Grosshans, Mike Makrigiorgos, Kavita Mishra, Tina Young Poussaint, Kenneth Cohen, Thomas Fitzgerald, Vinai Gondi, Arthur Liu, Jeff Michalski, Dragan Mirkovic, Radhe Mohan, Stephanie Perkins, Kenneth Wong, Bhadrasain Vikram, Jeff Buchsbaum & Larry Kun. (2018) National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury. International Journal of Radiation Oncology*Biology*Physics 101:1, pages 152-168.
Crossref
O. Mohamad, S. Yamada & M. Durante. (2018) Clinical Indications for Carbon Ion Radiotherapy. Clinical Oncology 30:5, pages 317-329.
Crossref
Jan Unkelbach & Harald Paganetti. (2018) Robust Proton Treatment Planning: Physical and Biological Optimization. Seminars in Radiation Oncology 28:2, pages 88-96.
Crossref
L Strigari, F Torriani, L Manganaro, T Inaniwa, F Dalmasso, R Cirio & A Attili. (2018) Tumour control in ion beam radiotherapy with different ions in the presence of hypoxia: an oxygen enhancement ratio model based on the microdosimetric kinetic model. Physics in Medicine & Biology 63:6, pages 065012.
Crossref
Osama Mohamad, Hirokazu Makishima & Tadashi Kamada. (2018) Evolution of Carbon Ion Radiotherapy at the National Institute of Radiological Sciences in Japan. Cancers 10:3, pages 66.
Crossref
Armin Lühr, Cläre von Neubeck, Mechthild Krause & Esther G.C. Troost. (2018) Relative biological effectiveness in proton beam therapy – Current knowledge and future challenges. Clinical and Translational Radiation Oncology 9, pages 35-41.
Crossref
Zheng Wang, Wei-Wei Wang, Kambiz Shahnazi & Guo-Liang Jiang. 2018. Target Volume Delineation and Treatment Planning for Particle Therapy. Target Volume Delineation and Treatment Planning for Particle Therapy 221 234 .
Wenhua Cao, Azin Khabazian, Pablo P Yepes, Gino Lim, Falk Poenisch, David R Grosshans & Radhe Mohan. (2017) Linear energy transfer incorporated intensity modulated proton therapy optimization. Physics in Medicine & Biology 63:1, pages 015013.
Crossref
Christian P Karger & Peter Peschke. (2017) RBE and related modeling in carbon-ion therapy. Physics in Medicine & Biology 63:1, pages 01TR02.
Crossref
Constantin Dreher, Daniel Habermehl, Oliver Jäkel & Stephanie E. Combs. (2017) Effective radiotherapeutic treatment intensification in patients with pancreatic cancer: higher doses alone, higher RBE or both?. Radiation Oncology 12:1.
Crossref
Vincent Grégoire & Jesper Eriksen. (2017) Impact of hypoxia in head and neck cancer radiotherapy. Clinical and Translational Imaging 5:6, pages 497-505.
Crossref
O Sokol, E Scifoni, W Tinganelli, W Kraft-Weyrather, J Wiedemann, A Maier, D Boscolo, T Friedrich, S Brons, M Durante & M Krämer. (2017) Oxygen beams for therapy: advanced biological treatment planning and experimental verification. Physics in Medicine & Biology 62:19, pages 7798-7813.
Crossref
K. Noda, T. Furukawa, T. Fujimoto, Y. Hara, T. Inaniwa, Y. Iwata, K. Katagiri, N. Kanematsu, K. Mizushima, S. Mori, N. Saotome, Y. Saraya, S. Sato, T. Shirai, M. Takada, Y. Takei, R. Tansyo & S. Yonai. (2017) Recent progress and future plans of heavy-ion cancer radiotherapy with HIMAC. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 406, pages 374-378.
Crossref
Marco Durante, Roberto Orecchia & Jay S. Loeffler. (2017) Charged-particle therapy in cancer: clinical uses and future perspectives. Nature Reviews Clinical Oncology 14:8, pages 483-495.
Crossref
Taku Inaniwa, Nobuyuki Kanematsu, Koji Noda & Tadashi Kamada. (2017) Treatment planning of intensity modulated composite particle therapy with dose and linear energy transfer optimization. Physics in Medicine and Biology 62:12, pages 5180-5197.
Crossref
Akram Mohammadi, Eiji Yoshida, Hideaki Tashima, Fumihiko Nishikido, Taku Inaniwa, Atsushi Kitagawa & Taiga Yamaya. (2017) Production of an 15 O beam using a stable oxygen ion beam for in-beam PET imaging. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 849, pages 76-82.
Crossref
Asghar Mesbahi & Maryam Oladghaffari. (2017) An Overview on the Clinical Application of Radiobiological Modeling in Radiation Therapy of Cancer. International Journal of Radiology & Radiation Therapy 2:1.
Crossref
Sara Tegami, Stephen D. Bello, Shuang Luan, Andrea Mairani, Katia Parodi & Michael H. Holzscheiter. (2017) LET Monitoring Using Liquid Ionization Chambers. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 06:02, pages 197-207.
Crossref
Shinichiro Mori. 2017. Image-Based Computer-Assisted Radiation Therapy. Image-Based Computer-Assisted Radiation Therapy 131 182 .
C Bopp, R Hirayama, T Inaniwa, A Kitagawa, N Matsufuji & K Noda. (2016) Adaptation of the microdosimetric kinetic model to hypoxia. Physics in Medicine and Biology 61:21, pages 7586-7599.
Crossref
Liheng Tian, Qiang Li, Xinguo Liu, Zhongying Dai, Tingyan Fu, Pengbo He, Yuanlin Yan, Yuanyuan Ma & Qiyan Huang. (2016) Theoretical substantiation of biological efficacy enhancement for β‐delayed particle decay 9 C beam: A Monte Carlo study in combination with analysis with the local effect model approach . Medical Physics 43:3, pages 1200-1211.
Crossref
Kathryn D. Held, Hidemasa Kawamura, Takuya Kaminuma, Athena Evalour S. Paz, Yukari Yoshida, Qi Liu, Henning Willers & Akihisa Takahashi. (2016) Effects of Charged Particles on Human Tumor Cells. Frontiers in Oncology 6.
Crossref
Oliver Jäkel. 2016. Particle Radiotherapy. Particle Radiotherapy 127 137 .
Francesco Tommasino, Emanuele Scifoni & Marco Durante. (2015) New Ions for Therapy. International Journal of Particle Therapy 2:3, pages 428-438.
Crossref
Walter Tinganelli, Marco Durante, Ryoichi Hirayama, Michael Krämer, Andreas Maier, Wilma Kraft-Weyrather, Yoshiya Furusawa, Thomas Friedrich & Emanuele Scifoni. (2015) Kill-painting of hypoxic tumours in charged particle therapy. Scientific Reports 5:1.
Crossref
R. Alonzi. (2015) Functional Radiotherapy Targeting using Focused Dose Escalation. Clinical Oncology 27:10, pages 601-617.
Crossref
Emanuele Scifoni. (2015) Radiation biophysical aspects of charged particles: From the nanoscale to therapy. Modern Physics Letters A 30:17, pages 1540019.
Crossref
Marcus Fager, Iuliana Toma-Dasu, Maura Kirk, Derek Dolney, Eric S. Diffenderfer, Neha Vapiwala & Alejandro Carabe. (2015) Linear Energy Transfer Painting With Proton Therapy: A Means of Reducing Radiation Doses With Equivalent Clinical Effectiveness. International Journal of Radiation Oncology*Biology*Physics 91:5, pages 1057-1064.
Crossref
Daniel Habermehl, Katarina Ilicic, Sarah Dehne, Stefan Rieken, Lena Orschiedt, Stephan Brons, Thomas Haberer, Klaus-Josef Weber, Jürgen Debus & Stephanie E. Combs. (2014) The Relative Biological Effectiveness for Carbon and Oxygen Ion Beams Using the Raster-Scanning Technique in Hepatocellular Carcinoma Cell Lines. PLoS ONE 9:12, pages e113591.
Crossref
Michael Krämer, Emanuele Scifoni, Frederike Schmitz, Olga Sokol & Marco Durante. (2014) Overview of recent advances in treatment planning for ion beam radiotherapy. The European Physical Journal D 68:10.
Crossref
L. Antonovic, E. Lindblom, A. Dasu, N. Bassler, Y. Furusawa & I. Toma-Dasu. (2014) Clinical oxygen enhancement ratio of tumors in carbon ion radiotherapy: the influence of local oxygenation changes. Journal of Radiation Research 55:5, pages 902-911.
Crossref
M Durante. (2014) New challenges in high-energy particle radiobiology. The British Journal of Radiology 87:1035, pages 20130626.
Crossref
O. Jäkel. 2014. Comprehensive Biomedical Physics. Comprehensive Biomedical Physics 487 504 .

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