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Acta Oncologica Volume 55, 2016 - Issue 2
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ORIGINAL ARTICLE: Lung Cancer

A novel oral insulin-like growth factor-1 receptor pathway modulator and its implications for patients with non-small cell lung carcinoma: A phase I clinical trial

Simon EkmanDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, SwedenCorrespondence[email protected]
,
Johan HarmenbergAxelar AB, Karolinska Institute Science Park, Solna, Sweden
,
Jan-Erik FrödinDepartment of Oncology, Karolinska University Hospital, Stockholm, Sweden
,
Stefan BergströmDepartment of Oncology, Hospital of Gävle, Gävle, Sweden
,
Cecilia WassbergSection of Radiology, Department of Radiology, Oncology and Radiation Sciences, Uppsala University, Uppsala, Sweden
,
Staffan EksborgChildhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
,
Olle LarssonCellular and Molecular Tumor Pathology, Department of Oncology and Pathology, Cancer Centre Karolinska, Karolinska University Hospital, Stockholm, Sweden
,
Magnus AxelsonDepartment of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden
,
Markus JerlingAxelar AB, Karolinska Institute Science Park, Solna, Sweden
,
Lars AbrahmsenAxelar AB, Karolinska Institute Science Park, Solna, Sweden
,
Åsa HedlundDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
,
Carina AlvforsUppsala Clinical Research Center, Uppsala, Sweden
,
Birgitta StåhlAxelar AB, Karolinska Institute Science Park, Solna, Sweden
&
Michael BergqvistDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
 show all
Pages 140-148 | Received 01 Jan 2015, Accepted 29 Apr 2015, Published online: 10 Jul 2015

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Haim Werner, Rive Sarfstein & Ilan Bruchim. (2019) Investigational IGF1R inhibitors in early stage clinical trials for cancer therapy. Expert Opinion on Investigational Drugs 28:12, pages 1101-1112.
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Articles from other publishers (11)

Panpan Wang, Victor CY. Mak & Lydia WT. Cheung. (2023) Drugging IGF-1R in cancer: New insights and emerging opportunities. Genes & Diseases 10:1, pages 199-211.
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Syuan-Ling Lin, Chih-Yang Lin, Wei Lee, Chiao-Fang Teng, Woei-Cherng Shyu & Long-Bin Jeng. (2022) Mini Review: Molecular Interpretation of the IGF/IGF-1R Axis in Cancer Treatment and Stem Cells-Based Therapy in Regenerative Medicine. International Journal of Molecular Sciences 23:19, pages 11781.
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Xiongye Xu, Yanli Qiu, Simin Chen, Shuaishuai Wang, Ruifu Yang, Baomo Liu, Yufei Li, Jiating Deng, Yan Su, Ziying Lin, Jincui Gu, Shaoli Li, Lixia Huang & Yanbin Zhou. (2022) Different Roles of the Insulin-like Growth Factor (IGF) Axis in Non-small Cell Lung Cancer. Current Pharmaceutical Design 28:25, pages 2052-2064.
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Mohammed A. Mansour, Valentina S. Caputo & Eiman Aleem. (2021) Highlights on selected growth factors and their receptors as promising anticancer drug targets. The International Journal of Biochemistry & Cell Biology 140, pages 106087.
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Fenfang Liao, Yongheng Chen, Qingqing Wu, Jiaqi Wen, Xiangjie Chen, Weizhang Wang, Dan Xu & Manyu Liu. (2021) Selective elimination of CML stem/progenitor cells by picropodophyllin in vitro and in vivo is associated with p53 activation. Biochemical and Biophysical Research Communications 579, pages 1-7.
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Kaleb B. Tsegay, Christiana M. Adeyemi, Edward P. Gniffke, D. Noah Sather, John K. Walker & Stephen E. P. Smith. (2021) A Repurposed Drug Screen Identifies Compounds That Inhibit the Binding of the COVID-19 Spike Protein to ACE2. Frontiers in Pharmacology 12.
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Anna Ianza, Marianna Sirico, Ottavia Bernocchi & Daniele Generali. (2021) Role of the IGF-1 Axis in Overcoming Resistance in Breast Cancer. Frontiers in Cell and Developmental Biology 9.
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Anhao Tian, Bo Kang, Baizhou Li, Biying Qiu, Wenhong Jiang, Fangjie Shao, Qingqing Gao, Rui Liu, Chengwei Cai, Rui Jing, Wei Wang, Pengxiang Chen, Qinghui Liang, Lili Bao, Jianghong Man, Yan Wang, Yu Shi, Jin Li, Minmin Yang, Lisha Wang, Jianmin Zhang, Simon Hippenmeyer, Junming Zhu, Xiuwu Bian, Ying‐Jie Wang & Chong Liu. (2020) Oncogenic State and Cell Identity Combinatorially Dictate the Susceptibility of Cells within Glioma Development Hierarchy to IGF1R Targeting. Advanced Science 7:21, pages 2001724.
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Christabel Wilson, Mhairi Nimick, Hayley Nehoff & John C. Ashton. (2017) ALK and IGF-1R as independent targets in crizotinib resistant lung cancer. Scientific Reports 7:1.
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Robert Aiken, Magnus Axelson, Johan Harmenberg, Maria Klockare, Olle Larsson & Cecilia Wassberg. (2017) Phase I clinical trial of AXL1717 for treatment of relapsed malignant astrocytomas: analysis of dose and response. Oncotarget 8:46, pages 81501-81510.
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Anastassios Philippou, Panagiotis F. Christopoulos & Dr. Michael Koutsilieris. (2017) Clinical studies in humans targeting the various components of the IGF system show lack of efficacy in the treatment of cancer. Mutation Research/Reviews in Mutation Research 772, pages 105-122.
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