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Connective Tissue Research Volume 54, 2013 - Issue 1
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Research Article

Effect of Ulinastatin on the Expression of iNOS, MMP-2, and MMP-3 in Degenerated Nucleus Pulposus Cells of Rabbits

Guo HuaDepartment of Spine Surgery, Red Cross Hospital Affiliated of Xi’an Jiaotong University, Xi’an, PR China
,
Zhang HaipingDepartment of Spine Surgery, Red Cross Hospital Affiliated of Xi’an Jiaotong University, Xi’an, PR China
,
He BaorongDepartment of Spine Surgery, Red Cross Hospital Affiliated of Xi’an Jiaotong University, Xi’an, PR China
&
Hao DingjunDepartment of Spine Surgery, Red Cross Hospital Affiliated of Xi’an Jiaotong University, Xi’an, PR ChinaCorrespondence[email protected]
Pages 29-33 | Received 14 Jan 2012, Accepted 25 Jul 2012, Published online: 04 Sep 2012

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Mei-Xiang Zhan, Li Tang, Yun-Fei Lu, Huang-Hui Wu, Zhi-Bin Guo, Zhong-Mou Shi, Chen-Long Yang, Yi-Qing Zou, Fei Yang & Guo-Zhong Chen. (2021) Ulinastatin Exhibits Antinociception in Rat Models of Acute Somatic and Visceral Pain Through Inhibiting the Local and Central Inflammation. Journal of Pain Research 14, pages 1201-1214.
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Xi Luo, Le Huan, Feng Lin, Fanqi Kong, Xiaofei Sun, Fudong Li, Jian Zhu, Jingchuan Sun, Ximing Xu, Kaiqiang Sun, Liwei Duan & Jiangang Shi. (2021) Ulinastatin Ameliorates IL-1β-Induced Cell Dysfunction in Human Nucleus Pulposus Cells via Nrf2/NF-κB Pathway. Oxidative Medicine and Cellular Longevity 2021, pages 1-21.
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Yan Zhang, Yi-Shu Zhang, Xiao-Juan Li, Chao-Rong Huang, Hui-Jin Yu, Xiao-Xia Yang & Bin-Xiong Wang. (2019) Overexpression of miR-150 Inhibits the NF-κB Signal Pathway in Intervertebral Disc Degeneration through Targeting <b><i>P2X7</i></b>. Cells Tissues Organs 207:3-4, pages 165-176.
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Jian Chen, Jun Xuan, Yun-Tao Gu, Ke-Si Shi, Jun-Jun Xie, Jiao-Xiang Chen, Zeng-Ming Zheng, Yu Chen, Xi-Bang Chen, Yao-Sen Wu, Xiao-Lei Zhang & Xiang-Yang Wang. (2017) Celastrol reduces IL-1? induced matrix catabolism, oxidative stress and inflammation in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration in vivo. Biomedicine & Pharmacotherapy 91, pages 208-219.
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Zhen Tao, Feng‑Qing Hu, Chuan‑Fen Li, Tao Zhang, Bing‑Zhen Cao & Lian‑Qi Cui. (2016) Effect of ulinastatin, a human urinary protease inhibitor, on heatstroke‑induced apoptosis and inflammatory responses in rats. Experimental and Therapeutic Medicine.
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Jiang-Ying Ru, Hai-Dong Xu, Dai Shi, Jun-Bo Pan, Xiao-Jin Pan & Yan-Fen Wang. (2016) Blockade of NF-κB and MAPK pathways by ulinastatin attenuates wear particle-stimulated osteoclast differentiation in vitro and in vivo. Bioscience Reports 36:5.
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Xu-wei Luo, Kang Liu, Zhu Chen, Ming Zhao, Xiao-wei Han, Yi-guang Bai & Gang Feng. (2016) Adenovirus-mediated GDF-5 promotes the extracellular matrix expression in degenerative nucleus pulposus cells生长分化因子-5(GDF-5)促进人退行性变髓核细胞外基质表达情况的研究. Journal of Zhejiang University-SCIENCE B 17:1, pages 30-42.
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Cheng Wang, Wen-Jun Wang, Yi-Guo Yan, Yong-Xiao Xiang, Jian Zhang, Zhi-Han Tang & Zhi-Sheng Jiang. (2015) MicroRNAs: New players in intervertebral disc degeneration. Clinica Chimica Acta 450, pages 333-341.
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Wen-Jun Wang, Xiao-Hua Yu, Cheng Wang, Wei Yang, Wen-Si He, Shu-Jun Zhang, Yi-Guo Yan & Jian Zhang. (2015) MMPs and ADAMTSs in intervertebral disc degeneration. Clinica Chimica Acta 448, pages 238-246.
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Ming Feng, Yaqing Shu, Yu Yang, Xueping Zheng, Rui Li, Yuge Wang, Yongqiang Dai, Wei Qiu, Zhengqi Lu & Xueqiang Hu. (2014) Ulinastatin attenuates experimental autoimmune encephalomyelitis by enhancing anti-inflammatory responses. Neurochemistry International 64, pages 64-72.
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