606
Views
60
CrossRef citations to date
0
Altmetric
Research Article

Comparison of the anti-tumor effects of denosumab and zoledronic acid on the neoplastic stromal cells of giant cell tumor of bone

, , &
Pages 439-449 | Received 27 Mar 2013, Accepted 20 Sep 2013, Published online: 23 Sep 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Mingmin Shi, Lei Chen, Yangxin Wang, Wei Wang, Yujie Zhang & Shigui Yan. (2019) Effect of bisphosphonates on local recurrence of giant cell tumor of bone: a meta-analysis. Cancer Management and Research 11, pages 669-680.
Read now
Carol P. Y. Lau, Kwok Chuen Wong, Lin Huang, Gang Li, Stephen K.W. Tsui & Shekhar Madhukar Kumta. (2015) A mouse model of luciferase-transfected stromal cells of giant cell tumor of bone. Connective Tissue Research 56:6, pages 493-503.
Read now
Vincent Y Ng, Darin J Davidson, Edward Y Kim, Seth M Pollack, Ernest U Conrad III & Robin L Jones. (2014) The multidisciplinary management of giant cell tumor of bone. Expert Review of Anticancer Therapy 14:7, pages 783-790.
Read now

Articles from other publishers (57)

Dhivyaa Anandan, Amit Kumar, Manasseh N Jeyakkani, Dan Barnabas Inja & Amit Kumar Jaiswal. (2023) Investigation of Giant Cell Tumor of Bone and Tissue Engineering Approaches for the Treatment of Giant Cell Tumor of Bone. ACS Applied Bio Materials 6:10, pages 3946-3958.
Crossref
Xiaoqi Tan, Yue Zhang, Daiqing Wei, Yunkang Yang & Feifan Xiang. (2023) Denosumab for giant cell tumors of bone from 2010 to 2022: a bibliometric analysis. Clinical and Experimental Medicine 23:7, pages 3053-3075.
Crossref
Shinji Tsukamoto, Suraj Hindiskere, Kanya Honoki, Andreas F. Mavrogenis, Yasuhito Tanaka, Pramod S. Chinder, Davide Maria Donati & Costantino Errani. (2022) Outcome of re-operation for local recurrence following pre-operative denosumab administration and curettage for giant cell tumour of bone with difficult joint preservation. International Orthopaedics 47:1, pages 265-273.
Crossref
Marwa Mohsen, Hasnaa Osama, Mina Nicola, Haitham Saeed & Mohamed E. A. Abdelrahim. (2022) Effect of bisphosphonates on bone giant cell tumor recurrence: a meta-analysis. Beni-Suef University Journal of Basic and Applied Sciences 11:1.
Crossref
Lizz van der Heijden, Astrid Lipplaa, Kirsten van Langevelde, Judith V.M.G. Bovée, Michiel A.J. van de Sande & Hans Gelderblom. (2022) Updated concepts in treatment of giant cell tumor of bone. Current Opinion in Oncology 34:4, pages 371-378.
Crossref
M. MAHDAL, J. JINDRA, I. STANICZKOVÁ ZAMBO, L. PAZOUREK, L. NACHTNEBL & T. TOMÁŠ. (2022) Treatment of Giant Cell Tumor of Bone in the Distal Radius and Ulna. Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca 89:3, pages 188-192.
Crossref
Ruiwen Xu & Peter F. M. Choong. (2022) Metastatic giant cell tumour of bone: a narrative review of management options and approaches. ANZ Journal of Surgery 92:4, pages 691-696.
Crossref
Sakib Arfee, AnzarTariq Malik, Ashish Nehru, Umar Ali, Akib Arfee & AdnanAadil Arfee. (2022) Comparison of local and intravenous zoledronic acid on histopathology and recurrence rate after extended curettage in giant cell tumors of proximal tibia: A prospective study. Journal of Pharmacy And Bioallied Sciences 14:5, pages 289.
Crossref
Jun Mei, Xiaoxu Song, Xiaoming Guan, Dou Wu, Junjie Wang & Qiang Liu. (2021) Postoperative bisphosphonate do not significantly alter the fusion rate after lumbar spinal fusion: a meta-analysis. Journal of Orthopaedic Surgery and Research 16:1.
Crossref
Hiu-Woo Lau, Kwok-Chuen Wong, Wang-Kei Chiu & Shekhar-Madhukar Kumta. (2021) Local Recurrence After Minimally Invasive Curettage For Primary Giant Cell Tumor of Bone With Perioperative Bisphosphonate Is Comparable to Open Curettage: Retrospective Comparison With 9-Year Follow-Up. Arthroscopy, Sports Medicine, and Rehabilitation 3:6, pages e1729-e1736.
Crossref
Eréndira Estrada‐Villaseñor, Margarita Valdés‐Flores, Abelardo Meneses‐García, Phaedra Silva‐Bermudez, Raul Pichardo‐Bahena, Pedro Ostoa‐Saloma, Gabriela Mercado‐Celis, Ernesto D. Delgado‐Cedillo, Anell Olivos‐Meza & Carlos Landa‐Solís. (2021) A novel model to culture cells from giant cell tumor of bone using three‐dimensional (3D) polycaprolactone scaffold. Engineering in Life Sciences 21:8-9, pages 539-543.
Crossref
Joaquim Soares do Brito, André Spranger, Paulo Almeida, José Portela & Irene Barrientos-Ruiz. (2021) Giant cell tumour of bone around the knee: a systematic review of the functional and oncological outcomes. EFORT Open Reviews 6:8, pages 641-650.
Crossref
Arvind Kumar, Siddhartha Sinha, Yawar Haider, Javed Jameel & Sandeep Kumar. (2021) Role of Zoledronic Acid Supplementation in Reducing Post-Surgical Recurrence of Giant Cell Tumor of Bone: A Meta-Analysis of Comparative Studies. Cureus.
Crossref
Shinji Tsukamoto, Andreas F. Mavrogenis, Akira Kido & Costantino Errani. (2021) Current Concepts in the Treatment of Giant Cell Tumors of Bone. Cancers 13:15, pages 3647.
Crossref
Himanshu Kanwat, Roshan Banjara, Venkatesan Sampath Kumar, Abdul Majeed, Shivanand Gamnagatti & Shah Alam Khan. (2021) Comparison of Denosumab and Zoledronic acid as neoadjuvant therapy in patients with giant cell tumor of bone. Journal of Orthopaedic Surgery 29:2, pages 230949902110075.
Crossref
Dominic Puthoor. (2021) Denosumab in giant cell tumor of bone – science wins over evidence. Journal of Orthopaedic Association of South Indian States 18:1, pages 7.
Crossref
David Louis Perrin, Julia D. Visgauss, David A. Wilson, Anthony M. Griffin, Albiruni R. Abdul Razak, Peter C. Ferguson & Jay S. Wunder. (2021) The role of Denosumab in joint preservation for patients with giant cell tumour of bone. The Bone & Joint Journal 103-B:1, pages 184-191.
Crossref
Nasir Ud Din, Masood Umer & Yong-Koo Park. (2020) Histomorphometric Analysis of Pre- and Post-Denosumab–Treated Giant Cell Tumor of Bone. International Journal of Surgical Pathology 28:8, pages 859-867.
Crossref
Motoki Tanikawa, Hiroshi Yamada, Tomohiro Sakata & Mitsuhito Mase. (2020) Dosing interval adjustment of denosumab for the treatment of giant cell tumor of the sphenoid bone: A case report. Surgical Neurology International 11, pages 370.
Crossref
Daniel T. Miles, Ryan T. Voskuil, Wood Dale, Joel L. Mayerson & Thomas J. Scharschmidt. (2020) Integration of denosumab therapy in the management of giant cell tumors of bone. Journal of Orthopaedics 22, pages 38-47.
Crossref
Hengyuan Li, Junjie Gao, Youshui Gao, Nong Lin, Minghao Zheng & Zhaoming Ye. (2020) Denosumab in Giant Cell Tumor of Bone: Current Status and Pitfalls. Frontiers in Oncology 10.
Crossref
Shinji Tsukamoto, Andreas F. Mavrogenis, Piergiuseppe Tanzi, Giulio Leone, Giovanni Ciani, Alberto Righi, Manabu Akahane, Kanya Honoki, Yasuhito Tanaka, Davide Maria Donati & Costantino Errani. (2020) Denosumab for Bone Giant Cell Tumor of the Distal Radius. Orthopedics 43:5, pages 284-291.
Crossref
Francesca Punzo, Chiara Tortora, Maura Argenziano, Daniela Di Pinto, Elvira Pota, Martina Di Martino, Alessandra Di Paola & Francesca Rossi. (2020) Can Denosumab be used in combination with Doxorubicin in Osteosarcoma?. Oncotarget 11:28, pages 2763-2773.
Crossref
Lizz van der Heijden, Sander Dijkstra, Michiel van de Sande & Hans Gelderblom. (2020) Current concepts in the treatment of giant cell tumour of bone. Current Opinion in Oncology 32:4, pages 332-338.
Crossref
Vivek Ajit Singh & Ajay Puri. (2020) The current standing on the use of denosumab in giant cell tumour of the bone. Journal of Orthopaedic Surgery 28:3, pages 230949902097975.
Crossref
Carol P. Y. Lau, Cathy S. H. Fung, Kwok Chuen Wong, Yu‐Hsuan Wang, Lin Huang, Stephen K. W. Tsui, Oscar K. Lee & Shekhar M. Kumta. (2019) Simvastatin Possesses Antitumor and Differentiation‐Promoting Properties That Affect Stromal Cells in Giant Cell Tumor of Bone. Journal of Orthopaedic Research 38:2, pages 297-310.
Crossref
Peter M. Anderson. 2020. Current Advances in Osteosarcoma. Current Advances in Osteosarcoma 45 53 .
Guannan Wang, Sujing JiangZhouqi Li & Ying Dong. (2019) Denosumab and Sunitinib in the treatment of giant-cell tumor of bone with pulmonary and bone metastases in an adolescent. Medicine 98:46, pages e17778.
Crossref
Rishi Ram Poudel, Vivek Verma & Akshay Tiwari. (2019) Multicentric Giant Cell Tumor (GCT) of bone treated with denosumab alone: A report of two cases. Journal of Clinical Orthopaedics and Trauma 10:6, pages 1050-1053.
Crossref
Astrid Lipplaa, Judith R. Kroep, Lizz van der Heijden, Paul C. Jutte, Pancras C.W. Hogendoorn, Sander Dijkstra & Hans Gelderblom. (2019) Adjuvant Zoledronic Acid in High-Risk Giant Cell Tumor of Bone: A Multicenter Randomized Phase II Trial. The Oncologist 24:7, pages 889-e421.
Crossref
Astrid Lipplaa, Sander Dijkstra & Hans Gelderblom. (2019) Challenges of denosumab in giant cell tumor of bone, and other giant cell-rich tumors of bone. Current Opinion in Oncology 31:4, pages 329-335.
Crossref
Bin Liu, Xiangyang Liu, Yixin Chen, GuoPing Wang, Guohua Wang, Xiongjie Shen, Hongzhe Liu & Xiaoyun Liao. (2019) Clinical effect observation of intravenous application of zoledronic acid in patients with cervical spondylosis and osteoporosis after anterior cervical discectomy and fusion: A randomized controlled study. Journal of Orthopaedic Surgery 27:2, pages 230949901984702.
Crossref
Shinji Tsukamoto, Andreas F. Mavrogenis, Giulio Leone, Alberto Righi, Manabu Akahane, Piergiuseppe Tanzi, Akira Kido, Kanya Honoki, Yasuhito Tanaka, Davide Maria Donati & Costantino Errani. (2018) Denosumab does not decrease the risk of lung metastases from bone giant cell tumour. International Orthopaedics 43:2, pages 483-489.
Crossref
Isao Shibuya, Masamichi Takami, Arei Miyamoto, Akiko Karakawa, Akira Dezawa, Shigeru Nakamura & Ryutaro Kamijo. (2017) In Vitro Study of the Effects of Denosumab on Giant Cell Tumor of Bone: Comparison with Zoledronic Acid. Pathology & Oncology Research 25:1, pages 409-419.
Crossref
Byeong-Joo Noh & Yong-Koo Park. (2018) Giant cell tumor of bone: updated molecular pathogenesis and tumor biology. Human Pathology 81, pages 1-8.
Crossref
Manish G. Agarwal, Manit K. Gundavda, Rajat Gupta & Rajeev Reddy. (2018) Does Denosumab Change the Giant Cell Tumor Treatment Strategy? Lessons Learned From Early Experience. Clinical Orthopaedics & Related Research 476:9, pages 1773-1782.
Crossref
Guido Scoccianti, Francesca Totti, Maurizio Scorianz, Giacomo Baldi, Giuliana Roselli, Giovanni Beltrami, Alessandro Franchi, Rodolfo Capanna & Domenico Andrea Campanacci. (2018) Preoperative Denosumab With Curettage and Cryotherapy in Giant Cell Tumor of Bone: Is There an Increased Risk of Local Recurrence?. Clinical Orthopaedics & Related Research 476:9, pages 1783-1790.
Crossref
Boris Itkin, Samanta Straminsky, Gabriela De Ronato, Daniel Lewi, Adolfo Marantz & Ariel Bardach. (2018) Prognosis of metastatic giant cell tumor of bone in the pre-denosumab era. A systematic review and a meta-analysis. Japanese Journal of Clinical Oncology 48:7, pages 640-652.
Crossref
Victor Lousan do Nascimento Poubel, Diogo Lenzi Capella, Adair Roberto Soares Santos, Márcio Correa, Letícia Ruhland & Elena Riet Correa Rivero. (2018) Evaluation of Mandibular Bone After Dental Extraction in Rats Treated With Antiresorptive Drugs. Journal of Oral and Maxillofacial Surgery 76:3, pages 474-482.
Crossref
Zile Singh Kundu, Rajeev Sen, Ankur Dhiman, Pankaj Sharma, Ramchander Siwach & Parveen Rana. (2018) Effect of Intravenous Zoledronic Acid on Histopathology and Recurrence after Extended Curettage in Giant Cell Tumors of Bone: A Comparative Prospective Study. Indian Journal of Orthopaedics 52:1, pages 45-50.
Crossref
L. Jeys, G. Morris, S. Evans, J. Stevenson, M. Parry & J. Gregory. (2017) Surgical Innovation in Sarcoma Surgery. Clinical Oncology 29:8, pages 489-499.
Crossref
Olga D. Savvidou, Ioanna K. Bolia, George D. Chloros, John Papanastasiou, Panagiotis Koutsouradis & Panayiotis J. Papagelopoulos. (2017) Denosumab: Current Use in the Treatment of Primary Bone Tumors. Orthopedics 40:4, pages 204-210.
Crossref
Lizz van der Heijden, P.D. Sander Dijkstra, Jean-Yves Blay & Hans Gelderblom. (2017) Giant cell tumour of bone in the denosumab era. European Journal of Cancer 77, pages 75-83.
Crossref
Noritaka Yonezawa, Hideki Murakami, Satoshi Kato, Akihiko Takeuchi & Hiroyuki Tsuchiya. (2017) Giant cell tumor of the thoracic spine completely removed by total spondylectomy after neoadjuvant denosumab therapy. European Spine Journal 26:S1, pages 236-242.
Crossref
Patrick Thornley, Anthony Habib, Anthony Bozzo, Nathan Evaniew & Michelle Ghert. (2017) The Role of Denosumab in the Modern Treatment of Giant Cell Tumor of Bone. JBJS Reviews 5:4.
Crossref
Shunji Nishimura, Kazuhiko Hashimoto, Akihiro Tan, Yukinobu Yagyu & Masao Akagi. (2017) Successful treatment with denosumab in a patient with sacral giant cell tumor of bone refractory to combination therapy with arterial embolization and zoledronic acid: A case report. Molecular and Clinical Oncology.
Crossref
Mehmet Ali Deveci, Semra Paydaş, Gülfiliz Gönlüşen, Cenk Özkan, Ömer Sunkar Biçer & Mustafa Tekin. (2017) Clinical and pathological results of denosumab treatment for giant cell tumors of bone: Prospective study of 14 cases. Acta Orthopaedica et Traumatologica Turcica 51:1, pages 1-6.
Crossref
Czar Louie Gaston, Robert J. Grimer, Michael Parry, Silvia Stacchiotti, Angelo Paolo Dei Tos, Hans Gelderblom, Stefano Ferrari, Giacomo G. Baldi, Robin L. Jones, Sant Chawla, Paolo Casali, Axel LeCesne, Jean-Yves Blay, Sander P. D. Dijkstra, David M. Thomas & Piotr Rutkowski. (2016) Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone. Clinical Sarcoma Research 6:1.
Crossref
Raphaële Charest-Morin, Stefano Boriani, Charles G. Fisher, Shreyaskumar R. Patel, Norio Kawahara, Ehud Mendel, Chetan Bettegowda & Laurence D. Rhines. (2016) Benign Tumors of the Spine. Spine 41:20, pages S178-S185.
Crossref
Leqin Xu, Jian Luo, Rongrong Jin, Zhiying Yue, Peng Sun, Zhengfeng Yang, Xinghai Yang, Wei Wan, Jishen Zhang, Shichang Li, Mingyao Liu & Jianru Xiao. (2016) Bortezomib Inhibits Giant Cell Tumor of Bone through Induction of Cell Apoptosis and Inhibition of Osteoclast Recruitment, Giant Cell Formation, and Bone Resorption. Molecular Cancer Therapeutics 15:5, pages 854-865.
Crossref
Frank Traub, Janith Singh, Brendan C. Dickson, Stephanie Leung, Rakesh Mohankumar, Martin E. Blackstein, Albiruni R. Razak, Anthony M. Griffin, Peter C. Ferguson & Jay S. Wunder. (2016) Efficacy of denosumab in joint preservation for patients with giant cell tumour of the bone. European Journal of Cancer 59, pages 1-12.
Crossref
Ilaria Girolami, Irene Mancini, Antonella Simoni, Giacomo Giulio Baldi, Lisa Simi, Domenico Campanacci, Giovanni Beltrami, Guido Scoccianti, Antonio D'Arienzo, Rodolfo Capanna & Alessandro Franchi. (2016) Denosumab treated giant cell tumour of bone: a morphological, immunohistochemical and molecular analysis of a series. Journal of Clinical Pathology 69:3, pages 240-247.
Crossref
Kenta Mukaihara, Yoshiyuki Suehara, Shinji Kohsaka, Keisuke Akaike, Yu Tanabe, Daisuke Kubota, Midori Ishii, Tsutomu Fujimura, Saiko Kazuno, Taketo Okubo, Tatsuya Takagi, Takashi Yao, Kazuo Kaneko & Tsuyoshi Saito. (2016) Protein Expression Profiling of Giant Cell Tumors of Bone Treated with Denosumab. PLOS ONE 11:2, pages e0148401.
Crossref
Saranatra Waikakul, Apichat Asavamongkolkul & Rapin Phimolsarnti. (2015) Use of warm Ringer’s lactate solution in the management of locally advanced giant cell tumor of bone. International Journal of Clinical Oncology 21:1, pages 177-185.
Crossref
Thomas Brodowicz, Margit Hemetsberger & Reinhard Windhager. (2015) Denosumab for the treatment of giant cell tumor of the bone. Future Oncology 11:13, pages 1881-1894.
Crossref
Nicola Stadler, Thomas Fingernagel, Stefan G. Hofstaetter & Klemens Trieb. (2015) A Recurrent Giant Cell Tumor of Bone Treated with Denosumab. Clinics and Practice 5:1, pages 697.
Crossref
Tobias A. Mattei, Edwin Ramos, Azeem A. Rehman, Andrew Shaw, Shreyasumar R. Patel & Ehud Mendel. (2014) Sustained long-term complete regression of a giant cell tumor of the spine after treatment with denosumab. The Spine Journal 14:7, pages e15-e21.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.