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Research Article

Acid-sensing ion channels in healthy and degenerated human intervertebral disc

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Pages 197-204 | Received 23 Apr 2013, Accepted 11 Jan 2014, Published online: 21 Feb 2014

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Yingjun Guo, Yang Meng, Hao Liu, Beiyu Wang, Chen Ding, Xin Rong, Yi Yang & Ying Hong. (2019) Acid-sensing ion channels mediate the degeneration of intervertebral disc via various pathways—A systematic review. Channels 13:1, pages 367-373.
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Rui Ran, Yi Wu & Hai-hong Zhang. (2023) Acid-sensing Ion Channels: Implications for Intervertebral Disc Degeneration. Current Pharmaceutical Biotechnology 24:11, pages 1343-1350.
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Clément Verkest, Miguel Salinas, Sylvie Diochot, Emmanuel Deval, Eric Lingueglia & Anne Baron. (2022) Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects. Toxins 14:10, pages 709.
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Maite Esquijarosa Hechavarria & Seidu A. Richard. (2022) Edifying the Focal Factors Influencing Mesenchymal Stem Cells by the Microenvironment of Intervertebral Disc Degeneration in Low Back Pain. Pain Research and Management 2022, pages 1-12.
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Ziyu Wang, Letian Han, Haoyu Chen, Shengquan Zhang, Sumei Zhang, Hua Zhang, Yuhao Li, Hui Tao & Jie Li. (2022) Sa12b Improves Biological Activity of Human Degenerative Nucleus Pulposus Mesenchymal Stem Cells in a Severe Acid Environment by Inhibiting Acid-Sensitive Ion Channels. Frontiers in Bioengineering and Biotechnology 10.
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Andy Sivils, Felix Yang, John Q. Wang & Xiang-Ping Chu. (2022) Acid-Sensing Ion Channel 2: Function and Modulation. Membranes 12:2, pages 113.
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Yanbin Zhang, Yiqiang Hu, Wentian Wang, Zijun Guo, Fan Yang, Xianyi Cai & Liming Xiong. (2021) Current Progress in the Endogenous Repair of Intervertebral Disk Degeneration Based on Progenitor Cells. Frontiers in Bioengineering and Biotechnology 8.
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Kangcheng Zhao, Ran An, Qian Xiang, Gaocai Li, Kun Wang, Yu Song, Zhiwei Liao, Shuai Li, Wenbin Hua, Xiaobo Feng, Xinghuo Wu, Yukun Zhang, Abhirup Das & Cao Yang. (2020) Acid‐sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration. Cell Proliferation 54:1.
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Niloofar FarhangLara SilvermanRobby D. Bowles. (2020) Improving Cell Therapy Survival and Anabolism in Harsh Musculoskeletal Disease Environments. Tissue Engineering Part B: Reviews 26:4, pages 348-366.
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Jill P.G. Urban & Jeremy C.T. Fairbank. (2020) Current perspectives on the role of biomechanical loading and genetics in development of disc degeneration and low back pain; a narrative review. Journal of Biomechanics 102, pages 109573.
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Feng Cai, Xin Hong, Xiang Tang, Nai-Cheng Liu, Feng Wang, Lei Zhu, Xin-Hui Xie, Zhi-Yang Xie & Xiao-Tao Wu. (2019) ASIC1a activation induces calcium-dependent apoptosis of BMSCs under conditions that mimic the acidic microenvironment of the degenerated intervertebral disc. Bioscience Reports 39:11.
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Gianluca Vadalà, Luca Ambrosio, Fabrizio Russo, Rocco Papalia & Vincenzo Denaro. (2019) Interaction between Mesenchymal Stem Cells and Intervertebral Disc Microenvironment: From Cell Therapy to Tissue Engineering. Stem Cells International 2019, pages 1-15.
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Dong Wang, Hang Zhu, Wei Cheng, Shiming Lin, Rongxue Shao & Hao Pan. (2019) Effects of hypoxia and ASIC3 on nucleus pulposus cells: From cell behavior to molecular mechanism. Biomedicine & Pharmacotherapy 117, pages 109061.
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Ching-Yu Lee, Tsung-Jen Huang, Meng-Huang Wu, Yen-Yao Li & Kuan-Der Lee. (2019) High Expression of Acid-Sensing Ion Channel 2 (ASIC2) in Bone Cells in Osteoporotic Vertebral Fractures. BioMed Research International 2019, pages 1-10.
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Adela Banciu, Andrei-Alexandru Calota & Diana Florentina Becheru. (2019) In vitro Electromechanical Device for Enhancing Bone Recovery under the Influence of Mechanical Stimuli. In vitro Electromechanical Device for Enhancing Bone Recovery under the Influence of Mechanical Stimuli.
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Raj M. Amin, Nicholas S. Andrade & Brian J. Neuman. (2017) Lumbar Disc Herniation. Current Reviews in Musculoskeletal Medicine 10:4, pages 507-516.
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Jianjun LiuHui TaoHanbang WangFulong DongRenjie ZhangJie LiPeng GePeiwen SongHuaqing ZhangPeng XuXiaoying LiuCailiang Shen. (2017) Biological Behavior of Human Nucleus Pulposus Mesenchymal Stem Cells in Response to Changes in the Acidic Environment During Intervertebral Disc Degeneration. Stem Cells and Development 26:12, pages 901-911.
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Emilio González Martínez, José García-Cosamalón, Iván Cosamalón-Gan, Marta Esteban Blanco, Olivia García-Suarez & José A. Vega. (2017) Biología y mecanobiología del disco intervertebral. Neurocirugía 28:3, pages 135-140.
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Emilio González Martínez, José García-Cosamalón, Iván Cosamalón-Gan, Marta Esteban Blanco, Olivia García-Suarez & José A. Vega. (2017) Biology and mechanobiology of the intervertebral disc. Neurocirugía (English Edition) 28:3, pages 135-140.
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Hamish T. J. Gilbert, Nathan Hodson, Pauline Baird, Stephen M. Richardson & Judith A. Hoyland. (2016) Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target. Scientific Reports 6:1.
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Feng-Lai Yuan, Ming-Hui Xu, Xia Li, He Xinlong, Wei Fang & Jian Dong. (2016) The Roles of Acidosis in Osteoclast Biology. Frontiers in Physiology 7.
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Ji-Nan WeiFeng CaiFeng WangXiao-Tao WuLei LiuXin HongWen-Hao Tang. (2016) Transplantation of CXCR4 Overexpressed Mesenchymal Stem Cells Augments Regeneration in Degenerated Intervertebral Discs. DNA and Cell Biology 35:5, pages 241-248.
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Ren-Peng Zhou, Xiao-Shan Wu, Zhi-Sen Wang, Ya-Ya Xie, Jin-Fang Ge & Fei-Hu Chen. (2016) Novel Insights into Acid-Sensing Ion Channels: Implications for Degenerative Diseases. Aging and disease 7:4, pages 491.
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Feng WangRui ShiFeng CaiYun-Tao WangXiao-Tao Wu. (2015) Stem Cell Approaches to Intervertebral Disc Regeneration: Obstacles from the Disc Microenvironment. Stem Cells and Development 24:21, pages 2479-2495.
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Anne Baron & Eric Lingueglia. (2015) Pharmacology of acid-sensing ion channels – Physiological and therapeutical perspectives. Neuropharmacology 94, pages 19-35.
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E. Viña, V. Parisi, F. Abbate, R. Cabo, M. C. Guerrera, R. Laurà, L. M. Quirós, J. C. Pérez-Varela, T. Cobo, A. Germanà, J. A. Vega & O. García-Suárez. (2014) Acid-sensing ion channel 2 (ASIC2) is selectively localized in the cilia of the non-sensory olfactory epithelium of adult zebrafish. Histochemistry and Cell Biology 143:1, pages 59-68.
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Xue Sun, Jun Jin, Ji-Gang Zhang, Lin Qi, Frank Karl Braun, Xing-Ding Zhang & Feng Xu. (2014) Expression of acid-sensing ion channels in nucleus pulposus cells of the human intervertebral disk is regulated by non-steroid anti-inflammatory drugs. Acta Biochimica et Biophysica Sinica 46:9, pages 774-781.
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