Advanced search
Publication Cover
Connective Tissue Research Volume 56, 2015 - Issue 3
Submit an article Journal homepage
400
Views
29
CrossRef citations to date
0
Altmetric
Original Articles

Inhibitory effects of eugenol on RANKL-induced osteoclast formation via attenuation of NF-κB and MAPK pathways

Vishwa DeepakDepartment of Physiology, University of Pretoria, Pretoria, South Africa,
,
Abe KasongaDepartment of Physiology, University of Pretoria, Pretoria, South Africa,
,
Marlena C. KrugerInstitute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand, and ;Department of Human Nutrition and Associate of the Institute for Food, Nutrition and Well-being, University of Pretoria, Pretoria, South Africa
&
Magdalena CoetzeeDepartment of Physiology, University of Pretoria, Pretoria, South Africa, Correspondence[email protected]
Pages 195-203 | Received 31 Jul 2014, Accepted 11 Nov 2014, Published online: 11 Dec 2014

Citations (29)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Carolina Estefania De Anda-Cuéllar, Socorro Ruíz-Rodríguez, Marine Ortiz-Magdaleno, Diana María Escobar-García & Amaury Pozos-Guillén. (2022) Effect of 4-Allyl-1-hydroxy-2-methoxybenzene (eugenol) in the expression of genes involved in cellular cycle and apoptotic process in dental pulp fibroblasts. Acta Odontologica Scandinavica 80:5, pages 321-327.
Read now

Articles from other publishers (28)

Noor Fathima Anjum, Dhivya Shanmugarajan, B. R. Prashantha Kumar, Syed Faizan, Priya Durai, Ruby Mariam Raju, Saleem Javid & Madhusudan N. Purohit. (2023) Novel Derivatives of Eugenol as a New Class of PPARγ Agonists in Treating Inflammation: Design, Synthesis, SAR Analysis and In Vitro Anti-Inflammatory Activity. Molecules 28:9, pages 3899.
Crossref
Antonella Di Sotto, Federico De Paolis, Marco Gullì, Annabella Vitalone & Silvia Di Giacomo. 2023. Terpenes. Terpenes 1 55 .
Yi Kuan Du, Yue Xiao, Shao Min Zhong, Yi Xing Huang, Qian Wen Chen, Yu Qi Zhou, Jin Yan Guo & Chun Yang. (2021) Study on the Mechanism of Acori Graminei Rhizoma in the Treatment of Alzheimer’s Disease Based on Network Pharmacology and Molecular Docking. BioMed Research International 2021, pages 1-12.
Crossref
Edyta Makuch, Anna Nowak, Andrzej Günther, Robert Pełech, Łukasz Kucharski, Wiktoria Duchnik & Adam Klimowicz. (2021) The Effect of Cream and Gel Vehicles on the Percutaneous Absorption and Skin Retention of a New Eugenol Derivative With Antioxidant Activity. Frontiers in Pharmacology 12.
Crossref
Ga-Ram Kim, Eun-Nam Kim, Kyoung Jin Park, Ki Hyun Kim & Gil-Saeng Jeong. (2021) Inhibitory Effect of LGS and ODE Isolated from the Twigs of Syringa oblata subsp. dilatata on RANKL-Induced Osteoclastogenesis in Macrophage Cells. Molecules 26:6, pages 1779.
Crossref
Irene Simfia, Jessica Schiavi & Laoise M. McNamara. (2020) Alterations in osteocyte mediated osteoclastogenesis during estrogen deficiency and under ROCK-II inhibition: An in vitro study using a novel postmenopausal multicellular niche model. Experimental Cell Research 392:1, pages 112005.
Crossref
Mengdie Li, Fang Li, Tao Wang, Liang Zhao & Yijie Shi. (2019) Fabrication of carboxymethylcellulose hydrogel containing β-cyclodextrin–eugenol inclusion complexes for promoting diabetic wound healing. Journal of Biomaterials Applications 34:6, pages 851-863.
Crossref
Amina Chniguir, Coralie Pintard, Dan Liu, Pham My-Chan Dang, Jamel El-Benna & Rafik Bachoual. (2019) Eugenol prevents fMLF-induced superoxide anion production in human neutrophils by inhibiting ERK1/2 signaling pathway and p47phox phosphorylation. Scientific Reports 9:1.
Crossref
Eun‐Nam Kim, Yu Gyeong Kim, Jeong‐Hyung Lee, Byung Sun Min & Gil‐Saeng Jeong. (2019) 6,7,4 ′ ‐Trihydroxyflavone inhibits osteoclast formation and bone resorption in vitro and in vivo . Phytotherapy Research 33:11, pages 2948-2959.
Crossref
Siyuan Shao, Fangsheng Fu, Ziyi Wang, Fangming Song, Chen Li, Zuo‐xing Wu, Jiaxing Ding, Kai Li, Yu Xiao, Yiji Su, Xixi Lin, Guixin Yuan, Jinmin Zhao, Qian Liu & Jiake Xu. (2018) Diosmetin inhibits osteoclast formation and differentiation and prevents LPS‐induced osteolysis in mice. Journal of Cellular Physiology 234:8, pages 12701-12713.
Crossref
Jae Shin, Denis Che, Byoung Cho, Hyun Kang, Jisu Kim & Seon Jang. (2019) Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells. Experimental and Therapeutic Medicine.
Crossref
Zhilei Cui, Zhen Liu, Junxiang Zeng, Lei Chen, Qiong Wu, Jiahang Mo, Guorui Zhang, Lin Song, Weiguo Xu, Shulin Zhang & Xuejun Guo. (2019) Eugenol inhibits non‐small cell lung cancer by repressing expression of NF‐κB‐regulated TRIM59. Phytotherapy Research 33:5, pages 1562-1569.
Crossref
Abe Kasonga, Marlena C. Kruger & Magdalena Coetzee. (2019) Activation of PPARs Modulates Signalling Pathways and Expression of Regulatory Genes in Osteoclasts Derived from Human CD14+ Monocytes. International Journal of Molecular Sciences 20:7, pages 1798.
Crossref
Abe E. Kasonga, Marlena C. Kruger & Magdalena Coetzee. (2019) Free fatty acid receptor 4-β-arrestin 2 pathway mediates the effects of different classes of unsaturated fatty acids in osteoclasts and osteoblasts. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864:3, pages 281-289.
Crossref
Manoj K. Pandey, Subash C. Gupta, Deepkamal Karelia, Patrick J. Gilhooley, Mehdi Shakibaei & Bharat B. Aggarwal. (2018) Dietary nutraceuticals as backbone for bone health. Biotechnology Advances 36:6, pages 1633-1648.
Crossref
Joice Nascimento Barboza, Carlos da Silva Maia Bezerra Filho, Renan Oliveira Silva, Jand Venes R. Medeiros & Damião Pergentino de Sousa. (2018) An Overview on the Anti-inflammatory Potential and Antioxidant Profile of Eugenol. Oxidative Medicine and Cellular Longevity 2018, pages 1-9.
Crossref
Syed S. Islam, Ibtehaj Al-Sharif, Ahlam Sultan, Amer Al-Mazrou, Adnane Remmal & Abdelilah Aboussekhra. (2018) Eugenol potentiates cisplatin anti-cancer activity through inhibition of ALDH-positive breast cancer stem cells and the NF-κB signaling pathway. Molecular Carcinogenesis 57:3, pages 333-346.
Crossref
Yu Zhou, Yunlong Gao, Chao Xu, Hui Shen, Qing Tian & Hong-Wen Deng. (2018) A novel approach for correction of crosstalk effects in pathway analysis and its application in osteoporosis research. Scientific Reports 8:1.
Crossref
Shaakirah Moosa, Abe E. Kasonga, Vishwa Deepak, Sumari Marais, Innocentia B. Magoshi, Megan J. Bester, Marlena C. Kruger & Magdalena Coetzee. (2018) Rooibos tea extracts inhibit osteoclast formation and activity through the attenuation of NF-κB activity in RAW264.7 murine macrophages. Food & Function 9:6, pages 3301-3312.
Crossref
Hatem M. Abuohashish, Dina A. Khairy, Maha M. Abdelsalam, Ahmed Alsayyah, Mohammed M. Ahmed & Salim S. Al-Rejaie. (2018) In-vivo assessment of the osteo-protective effects of eugenol in alveolar bone tissues. Biomedicine & Pharmacotherapy 97, pages 1303-1310.
Crossref
Shu-Ying Liu, Chih-Hao Huang, Jia-Ching Shieh & Tai-Lin Lee. (2017) Cinnamomum osmophloeum Kanehira ethanol extracts prevents human liver-derived HepG2 cell death from oxidation stress by induction of ghrelin gene expression. Journal of Biosciences 42:3, pages 439-448.
Crossref
Vishwa Deepak, Binglin Wang, Dwayne Koot, Abe Kasonga, Xiao Xing Stander, Magdalena Coetzee & Andre Stander. (2017) In silico design and bioevaluation of selective benzotriazepine BRD4 inhibitors with potent antiosteoclastogenic activity. Chemical Biology & Drug Design 90:1, pages 97-111.
Crossref
Bernadette van Heerden, Abe Kasonga, Marlena Kruger & Magdalena Coetzee. (2017) Palmitoleic Acid Inhibits RANKL-Induced Osteoclastogenesis and Bone Resorption by Suppressing NF-κB and MAPK Signalling Pathways. Nutrients 9:5, pages 441.
Crossref
Mpho Rantlha, Travers Sagar, Marlena C. Kruger, Magdalena Coetzee & Vishwa Deepak. (2016) Ellagic acid inhibits RANKL-induced osteoclast differentiation by suppressing the p38 MAP kinase pathway. Archives of Pharmacal Research 40:1, pages 79-87.
Crossref
Vishwa Deepak, Marlena C Kruger & Magdalena Coetzee. (2016) Geraniol attenuates osteoclast differentiation by suppressingNF-kB activity and expression of osteoclastogenic genes. Medicinal Chemistry Research 26:1, pages 19-26.
Crossref
S. Fujisawa & Y. Murakami. 2016. Drug Discovery from Mother Nature. Drug Discovery from Mother Nature 45 66 .
Vishwa Deepak, Marlena C. Kruger, Annie Joubert & Magdalena Coetzee. (2015) Piperine alleviates osteoclast formation through the p38/c-Fos/NFATc1 signaling axis. BioFactors 41:6, pages 403-413.
Crossref
Amcois Visagie, Abe Kasonga, Vishwa Deepak, Shaakirah Moosa, Sumari Marais, Marlena Kruger & Magdalena Coetzee. (2015) Commercial Honeybush (Cyclopia spp.) Tea Extract Inhibits Osteoclast Formation and Bone Resorption in RAW264.7 Murine Macrophages—An in vitro Study. International Journal of Environmental Research and Public Health 12:11, pages 13779-13793.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.