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Connective Tissue Research Volume 25, 1990 - Issue 1
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Original Article

Mechanism of Crosslinking of Proteins by Glutaraldehyde IV: In Vitro and In Vivo Stability of a Crosslinked Collagen Matrix

David T. Cheung Laboratory of Connective Tissue Biochemistry, Orthopaedic Hospital, University of Southern California School of Medicine, 2400 S. Flower St., Los Angeles, California, 90007, USA
,
Deborah Tong Laboratory of Connective Tissue Biochemistry, Orthopaedic Hospital, University of Southern California School of Medicine, 2400 S. Flower St., Los Angeles, California, 90007, USA
,
Natasha Perelman Laboratory of Connective Tissue Biochemistry, Orthopaedic Hospital, University of Southern California School of Medicine, 2400 S. Flower St., Los Angeles, California, 90007, USA
,
Delia Ertl Laboratory of Connective Tissue Biochemistry, Orthopaedic Hospital, University of Southern California School of Medicine, 2400 S. Flower St., Los Angeles, California, 90007, USA
&
Marcel E. Nimni Laboratory of Connective Tissue Biochemistry, Orthopaedic Hospital, University of Southern California School of Medicine, 2400 S. Flower St., Los Angeles, California, 90007, USA
Pages 27-34 | Received 21 Nov 1988, Accepted 26 Jan 1990, Published online: 07 Jul 2009

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Lirui Shen, Zhenhua Tian, Wentao Liu & Guoying Li. (2015) Influence on the physicochemical properties of fish collagen gels using self-assembly and simultaneous cross-linking with the N-hydroxysuccinimide adipic acid derivative. Connective Tissue Research 56:3, pages 244-252.
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Zhenhua Tian, Conghu Li, Lian Duan & Guoying Li. (2014) Physicochemical properties of collagen solutions cross-linked by glutaraldehyde. Connective Tissue Research 55:3, pages 239-247.
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Ruo G. Huang, Joseph B. Schwartz & Clyde M. Ofner. (1999) Microencapsulation of Chlorpheniramine Maleate–Resin Particles with Crosslinked Chitosan for Sustained Release. Pharmaceutical Development and Technology 4:1, pages 107-115.
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Articles from other publishers (28)

Xiaoyi Lan, Adetola Adesida & Yaman Boluk. (2022) Rheological and viscoelastic properties of collagens and their role in bioprinting by micro-extrusion. Biomedical Materials 17:6, pages 062005.
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Victor Perez-Puyana, Pablo Cuartero, Mercedes Jiménez-Rosado, Inmaculada Martínez & Alberto Romero. (2022) Physical crosslinking of pea protein-based bioplastics: Effect of heat and UV treatments. Food Packaging and Shelf Life 32, pages 100836.
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Kailei Ding, Cheng Zheng, Xueyu Huang, Shumang Zhang, Meiling Li, Yang Lei & Yunbing Wang. (2022) A PEGylation method of fabricating bioprosthetic heart valves based on glutaraldehyde and 2-amino-4-pentenoic acid co-crosslinking with improved antithrombogenicity and cytocompatibility. Acta Biomaterialia 144, pages 279-291.
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Pragati Agnihotri, Anil Kumar Shakya, Arjun K. Mishra & J. Venkatesh Pratap. (2021) Crystal structure and characterization of nucleoside diphosphate kinase from Vibrio cholerae. Biochimie 190, pages 57-69.
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Mengyu Gao, Yujia Wang, Yuting He, Yi Li, Qiong Wu, Guang Yang, Yanyan Zhou, Diwei Wu, Ji Bao & Hong Bu. (2019) Comparative evaluation of decellularized porcine liver matrices crosslinked with different chemical and natural crosslinking agents. Xenotransplantation 26:1, pages e12470.
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Tatjana Maravic, Lorenzo Breschi, Allegra Comba, Sandra Ribeiro Cunha, Valeria Angeloni, Cesare Nucci, Josimeri Hebling, David Pashley, Franklin Tay & Annalisa Mazzoni. (2018) Experimental use of an acrolein-based primer as collagen cross-linker for dentine bonding. Journal of Dentistry 68, pages 85-90.
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Will Zhang & Michael S. Sacks. (2017) Modeling the response of exogenously crosslinked tissue to cyclic loading: The effects of permanent set. Journal of the Mechanical Behavior of Biomedical Materials 75, pages 336-350.
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Kang Li, Hongye Yang, Huiyi Yan, Yuhong Sun, Xiaohui Chen, Jingmei Guo, Jiaxi Yue & Cui Huang. (2017) Quercetin as a simple but versatile primer in dentin bonding. RSC Advances 7:58, pages 36392-36402.
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F. Li, L. Zhang, M.D. Weir, L. Cheng, K. Zhang & H.H.K. Xu. 2017. Material-Tissue Interfacial Phenomena. Material-Tissue Interfacial Phenomena 147 180 .
Michael S. Sacks, Will Zhang & Silvia Wognum. (2016) A novel fibre-ensemble level constitutive model for exogenous cross-linked collagenous tissues. Interface Focus 6:1, pages 20150090.
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Xiaoya Wang, Wanyin Zhai, Chengtie Wu, Bing Ma, Jiamin Zhang, Hongfeng Zhang, Ziyan Zhu & Jiang Chang. (2015) Procyanidins-crosslinked aortic elastin scaffolds with distinctive anti-calcification and biological properties. Acta Biomaterialia 16, pages 81-93.
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Ana K. Bedran-Russo, Guido F. Pauli, Shao-Nong Chen, James McAlpine, Carina S. Castellan, Rasika S. Phansalkar, Thaiane R. Aguiar, Cristina M.P. Vidal, José G. Napotilano, Joo-Won Nam & Ariene A. Leme. (2014) Dentin biomodification: strategies, renewable resources and clinical applications. Dental Materials 30:1, pages 62-76.
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Noriko Hiraishi, Ryohei Sono, Islam Sofiqul, Cynthia Yiu, Hiroyuki Nakamura, Masayuki Otsuki, Tsutomu Takatsuka & Junji Tagami. (2013) In vitro evaluation of plant-derived agents to preserve dentin collagen. Dental Materials 29:10, pages 1048-1054.
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Joshua Leong, Amy Munnelly, Brianna Liberio, Leonard Cochrane & Naren Vyavahare. (2011) Neomycin and carbodiimide crosslinking as an alternative to glutaraldehyde for enhanced durability of bioprosthetic heart valves. Journal of Biomaterials Applications 27:8, pages 948-960.
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N Manuja, R Nagpal & IK Pandit. (2012) Dental Adhesion. Journal of Clinical Pediatric Dentistry 36:3, pages 223-234.
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Johannes Haag, Silvia Baiguera, Philipp Jungebluth, Daniel Barale, Costantino Del Gaudio, Francesca Castiglione, Alessandra Bianco, Camilla E. Comin, Domenico Ribatti & Paolo Macchiarini. (2012) Biomechanical and angiogenic properties of tissue-engineered rat trachea using genipin cross-linked decellularized tissue. Biomaterials 33:3, pages 780-789.
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Christian D Klink, Marcel Binnebösel, Hamid P Alizai, Andreas Lambertz, Klaus T vonTrotha, Elmar Junker, Catherine Disselhorst-Klug, Ulf P Neumann & Uwe Klinge. (2011) Tension of knotted surgical sutures shows tissue specific rapid loss in a rodent model. BMC Surgery 11:1.
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Vincent M. Friebe, Brandon Mikulis, Sourav Kole, Christy S. Ruffing, Michael S. Sacks & Naren R. Vyavahare. (2011) Neomycin enhances extracellular matrix stability of glutaraldehyde crosslinked bioprosthetic heart valves. Journal of Biomedical Materials Research Part B: Applied Biomaterials 99B:2, pages 217-229.
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Wan-yin Zhai, Chun-ping Jia, Hui Zhao & Yuan-sen Xu. (2011) Procyanidins inhibit tumor angiogenesis by crosslinking extracellular matrix. Chinese Journal of Cancer Research 23:2, pages 99-106.
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David H. Pashley, Franklin R. Tay, Lorenzo Breschi, Leo Tjäderhane, Ricardo M. Carvalho, Marcela Carrilho & Arzu Tezvergil-Mutluay. (2011) State of the art etch-and-rinse adhesives. Dental Materials 27:1, pages 1-16.
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G.V. Macedo, M. Yamauchi & A.K. Bedran-Russo. (2009) Effects of Chemical Cross-linkers on Caries-affected Dentin Bonding. Journal of Dental Research 88:12, pages 1096-1100.
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Amit D. Bhrany, Casey J. Lien, Benjamin L. Beckstead, Neal D. Futran, Nimish H. Muni, Cecilia M. Giachelli & Buddy D. Ratner. (2008) Crosslinking of an oesophagus acellular matrix tissue scaffold. Journal of Tissue Engineering and Regenerative Medicine 2:6, pages 365-372.
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Roger Morris, Helen Cox, Enrico Mombelli & Peter J. Quinn. 2004. Membrane Dynamics and Domains. Membrane Dynamics and Domains 35 118 .
Bo Han, Jason Jaurequi, Bao Wei Tang & Marcel E. Nimni. (2003) Proanthocyanidin: A natural crosslinking reagent for stabilizing collagen matrices. Journal of Biomedical Materials Research Part A 65A:1, pages 118-124.
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Joshua Lovekamp & Narendra Vyavahare. (2001) Periodate-mediated glycosaminoglycan stabilization in bioprosthetic heart valves. Journal of Biomedical Materials Research 56:4, pages 478-486.
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David W. Courtman, Benjamin F. Errett & Gregory J. Wilson. (2001) The role of crosslinking in modification of the immune response elicited against xenogenic vascular acellular matrices. Journal of Biomedical Materials Research 55:4, pages 576-586.
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W. A. Naimark, C. A. Pereira, K. Tsang & J. M. Lee. (1995) HMDC crosslinking of bovine pericardial tissue: a potential role of the solvent environment in the design of bioprosthetic materials. Journal of Materials Science: Materials in Medicine 6:4, pages 235-241.
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A. Delmas, A. Brack & Y. Trudelle. (2002) Studies of the influence of different cross-linking reagents on the immune response against a B-epitope. Bioconjugate Chemistry 3:1, pages 80-84.
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