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Original Article

Preparatory studies of composite mesenchymal stem cell islets for application in intraportal islet transplantation

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Pages 8-17 | Received 02 Jul 2010, Accepted 09 Sep 2010, Published online: 04 Nov 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Hajime Imamura, Tomohiko Adachi, Tatsuya Kin, Shinichiro Ono, Yusuke Sakai, Toshiyuki Adachi, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, A.M. James Shapiro & Susumu Eguchi. (2018) An engineered cell sheet composed of human islets and human fibroblast, bone marrow–derived mesenchymal stem cells, or adipose–derived mesenchymal stem cells: An in vitro comparison study . Islets 10:3.
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Sonia Rawal, S. Janette Williams, Karthik Ramachandran & Lisa Stehno-Bittel. (2017) Integration of mesenchymal stem cells into islet cell spheroids improves long-term viability, but not islet function. Islets 9:5, pages 87-98.
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Bianca Marmontel de Souza, Ana Paula Bouças, Fernanda dos Santos de Oliveira, Karina Pires Reis, Patrícia Ziegelmann, Andrea Carla Bauer & Daisy Crispim. (2017) Effect of co-culture of mesenchymal stem/stromal cells with pancreatic islets on viability and function outcomes: a systematic review and meta-analysis. Islets 9:2, pages 30-42.
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Per-Ola Carlsson. (2011) Influence of microenvironment on engraftment of transplanted β-cells. Upsala Journal of Medical Sciences 116:1, pages 1-7.
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Articles from other publishers (32)

Anna M. Gooch, Sabiha S. Chowdhury, Ping M. Zhang, Zhuma M. Hu & Christof Westenfelder. (2023) Significant expansion of the donor pool achieved by utilizing islets of variable quality in the production of allogeneic “Neo-Islets”, 3-D organoids of Mesenchymal Stromal and islet cells, a novel immune-isolating biotherapy for Type I Diabetes. PLOS ONE 18:8, pages e0290460.
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Hilary E. Murray, Ali Zafar, Khalid M. Qureshi, Michelle B. Paget, Clifford J. Bailey & Richard Downing. (2021) The potential role of multifunctional human amniotic epithelial cells in pancreatic islet transplantation. Journal of Tissue Engineering and Regenerative Medicine.
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Zepeng Qu, Qi Lou, David K. C. Cooper, Zuhui Pu, Ying Lu, Jiao Chen, Yong Ni, Yongqiang Zhan, Jun Chen, Zhenjie Li, Naiyang Zhan, Yi Zeng, Ziwei Tu, Huayi Cao, Yifan Dai, Zhiming Cai & Lisha Mou. (2021) Potential roles of mesenchymal stromal cells in islet allo‐ and xenotransplantation for type 1 diabetes mellitus. Xenotransplantation 28:3.
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Mehdi Razavi, Tanchen Ren, Fengyang Zheng, Arsenii Telichko, Jing Wang, Jeremy J. Dahl, Utkan Demirci & Avnesh S. Thakor. (2020) Facilitating islet transplantation using a three-step approach with mesenchymal stem cells, encapsulation, and pulsed focused ultrasound. Stem Cell Research & Therapy 11:1.
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Xiaohang Li, Hongxin Lang, Baifeng Li, Chengshuo Zhang, Ning Sun, Jianzhen Lin & Jialin Zhang. (2020) Change in Viability and Function of Pancreatic Islets after Coculture with Mesenchymal Stromal Cells: A Systemic Review and Meta-Analysis. Journal of Diabetes Research 2020, pages 1-12.
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Olle Korsgren & Hanne Scholz. 2020. Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas. Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas 821 831 .
Nobuki Ishida, Kohei Ishiyama, Yoshihiro Saeki, Yuka Tanaka & Hideki Ohdan. (2019) Cotransplantation of preactivated mesenchymal stem cells improves intraportal engraftment of islets by inhibiting liver natural killer cells in mice. American Journal of Transplantation 19:10, pages 2732-2745.
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Shiva Pathak, Tung Thanh Pham, Jee-Heon Jeong & Youngro Byun. (2019) Immunoisolation of pancreatic islets via thin-layer surface modification. Journal of Controlled Release 305, pages 176-193.
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Chloe L Rackham & Peter M Jones. (2018) Potential of mesenchymal stromal cells for improving islet transplantation outcomes. Current Opinion in Pharmacology 43, pages 34-39.
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Sirong He, Chengshi Wang, Xiaojiong Du, Younan Chen, Jiuming Zhao, Bole Tian, Huimin Lu, Yi Zhang, Jingping Liu, Guang Yang, Lan Li, Hongxia Li, Jingqiu Cheng & Yanrong Lu. (2018) MSCs promote the development and improve the function of neonatal porcine islet grafts. The FASEB Journal 32:6, pages 3242-3253.
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Chloe L. Rackham, Paramjeet K. Dhadda, Sian J.S. Simpson, Mahdieh Godazgar, Aileen J.F. King & Peter M. Jones. (2018) Composite Mesenchymal Stromal Cell Islets: Implications for Transplantation via the Clinically Preferred Intraportal Route. Transplantation Direct 4:4, pages e354.
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Christof Westenfelder, Anna Gooch, Zhuma Hu, Jon Ahlstrom & Ping Zhang. (2017) Durable Control of Autoimmune Diabetes in Mice Achieved by Intraperitoneal Transplantation of “Neo-Islets,” Three-Dimensional Aggregates of Allogeneic Islet and “Mesenchymal Stem Cells”. Stem Cells Translational Medicine 6:7, pages 1631-1643.
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Elisa Cantarelli, Antonio Citro, Silvia Pellegrini, Alessia Mercalli, Raffaella Melzi, Erica Dugnani, Tatiana Jofra, Georgia Fousteri, Anna Mondino & Lorenzo Piemonti. (2017) Transplant Site Influences the Immune Response After Islet Transplantation. Transplantation 101:5, pages 1046-1055.
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Tuğba Bal, Caner Nazli, Alparslan Okcu, Gökhan Duruksu, Erdal Karaöz & Seda Kizilel. (2017) Mesenchymal stem cells and ligand incorporation in biomimetic poly(ethylene glycol) hydrogels significantly improve insulin secretion from pancreatic islets. Journal of Tissue Engineering and Regenerative Medicine 11:3, pages 694-703.
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W. Staels, S. De Groef, Y. Heremans, V. Coppens, N. Van Gassen, G. Leuckx, M. Van de Casteele, I. Van Riet, A. Luttun, H. Heimberg & N. De Leu. (2016) Accessory cells for β-cell transplantation. Diabetes, Obesity and Metabolism 18:2, pages 115-124.
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Moa Fransson, Johan Brännström, Ida Duprez, Magnus Essand, Katarina Le Blanc, Olle Korsgren & Peetra U. Magnusson. (2015) Mesenchymal stromal cells support endothelial cell interactions in an intramuscular islet transplantation model. Regenerative Medicine Research 3:1.
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Moufida Ben Nasr, Andrea Vergani, James Avruch, Liye Liu, Eirini Kefaloyianni, Francesca D’Addio, Sara Tezza, Domenico Corradi, Roberto Bassi, Alessandro Valderrama-Vasquez, Vera Usuelli, James Kim, Jamil Azzi, Basset El Essawy, James Markmann, Reza Abdi & Paolo Fiorina. (2015) Co-transplantation of autologous MSCs delays islet allograft rejection and generates a local immunoprivileged site. Acta Diabetologica 52:5, pages 917-927.
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Nicoletta Fotino, Carmen Fotino & Antonello Pileggi. (2015) Re-engineering islet cell transplantation. Pharmacological Research 98, pages 76-85.
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Jung-Youn ShinJee-Heon JeongJin HanSuk Ho BhangGun-Jae JeongMuhammad R. HaqueTaslim A. Al-HilalMyungkyung NohYoungro ByunByung-Soo Kim. (2015) Transplantation of Heterospheroids of Islet Cells and Mesenchymal Stem Cells for Effective Angiogenesis and Antiapoptosis. Tissue Engineering Part A 21:5-6, pages 1024-1035.
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Ian T. HoffeckerHiroo Iwata. (2014) Manipulation of Cell Sorting Within Mesenchymal Stromal Cell–Islet Cell Multicellular Spheroids. Tissue Engineering Part A 20:11-12, pages 1643-1653.
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Chloe L. Rackham, Paramjeet K. Dhadda, Aurélie M. Le Lay, Aileen J. F. King & Peter M. Jones. (2014) Preculturing Islets with Adipose-Derived Mesenchymal Stromal Cells is an Effective Strategy for Improving Transplantation Efficiency at the Clinically Preferred Intraportal Site. Cell Medicine 7:1, pages 37-47.
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Arianna Scuteri, Elisabetta Donzelli, Virginia Rodriguez-Menendez, Maddalena Ravasi, Marianna Monfrini, Barbara Bonandrini, Marina Figliuzzi, Andrea Remuzzi & Giovanni Tredici. (2014) A Double Mechanism for the Mesenchymal Stem Cells' Positive Effect on Pancreatic Islets. PLoS ONE 9:1, pages e84309.
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Vaibhav Mundra, Hao Wu & Ram I. Mahato. (2013) Genetically Modified Human Bone Marrow Derived Mesenchymal Stem Cells for Improving the Outcome of Human Islet Transplantation. PLoS ONE 8:10, pages e77591.
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Eleftherios SachlosThomas BollenbachAmber E Kerstetter-FogleCharles C King. (2013) Research Highlights: Highlights from the latest articles in regenerative medicine. Regenerative Medicine 8:1, pages 17-21.
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Aileen King & Chloe Rackham. 2013. Stem Cells and Cancer Stem Cells, Volume 10. Stem Cells and Cancer Stem Cells, Volume 10 271 282 .
Luca Inverardi, Giacomo Lanzoni, Juan Dominguez-Bendala & Camillo Ricordi. 2013. Mesenchymal Stromal Cells. Mesenchymal Stromal Cells 571 597 .
Tasneem Bhaiji, Zheng-Liang Zhi & John C. Pickup. (2012) Improving cellular function and immune protection via layer-by-layer nanocoating of pancreatic islet β-cell spheroids cocultured with mesenchymal stem cells. Journal of Biomedical Materials Research Part A 100A:6, pages 1628-1636.
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Telford Y. Yeung, Karen L. Seeberger, Tatsuya Kin, Adetola Adesida, Nadr Jomha, A. M. James Shapiro & Gregory S. Korbutt. (2012) Human Mesenchymal Stem Cells Protect Human Islets from Pro-Inflammatory Cytokines. PLoS ONE 7:5, pages e38189.
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Emily Sims & Carmella Evans-Molina. (2012) Stem Cells as a Tool to Improve Outcomes of Islet Transplantation. Journal of Transplantation 2012, pages 1-11.
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Joey Lau, Guangxiang Zang & Per-Ola Carlsson. (2011) Pancreatic islet transplantation to the liver: how can vascularization problems be resolved?. Diabetes Management 1:2, pages 219-227.
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Daniel Espes, Olof Eriksson, Joey Lau & Per-Ola Carlsson. (2011) Striated Muscle as Implantation Site for Transplanted Pancreatic Islets. Journal of Transplantation 2011, pages 1-6.
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Cyrus Jahansouz, Cameron Jahansouz, Sean C. Kumer & Kenneth L. Brayman. (2011) Evolution of -Cell Replacement Therapy in Diabetes Mellitus: Islet Cell Transplantation. Journal of Transplantation 2011, pages 1-21.
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