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Upsala Journal of Medical Sciences Volume 117, 2012 - Issue 1

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Original Article

Apparent clearance of valproic acid in elderly epileptic patients: estimation of the confounding effect of albumin concentration

Natalia LamponUnidad Monitorización Fármacos, Laboratorio Central, Hospital Clínico Universitario, Instituto de Investigación Sanitaria (IDIS), 15706 Santiago de Compostela, Spain

J. Carlos TutorUnidad Monitorización Fármacos, Laboratorio Central, Hospital Clínico Universitario, Instituto de Investigación Sanitaria (IDIS), 15706 Santiago de Compostela, SpainCorrespondence[email protected]

Pages 41-46 | Received 28 Sep 2011, Accepted 08 Nov 2011, Published online: 29 Dec 2011

Cite this article
https://doi.org/10.3109/03009734.2011.640412

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Bruno Charlier, Albino Coglianese, Federica De Rosa, Ugo de Grazia, Francesca Felicia Operto, Giangennaro Coppola, Amelia Filippelli, Fabrizio Dal Piaz & Viviana Izzo. (2021) The Effect of Plasma Protein Binding on the Therapeutic Monitoring of Antiseizure Medications. Pharmaceutics 13:8, pages 1208.
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Simon J. C. Davies. 2020. Seminars in Clinical Psychopharmacology. Seminars in Clinical Psychopharmacology 543 576 .

Poh Choo How & Glen Xiong. 2019. Inpatient Geriatric Psychiatry. Inpatient Geriatric Psychiatry 47 61 .

Maxime Doré, Adriana E. San Juan, Anne Julie Frenette & David Williamson. (2017) Clinical Importance of Monitoring Unbound Valproic Acid Concentration in Patients with Hypoalbuminemia. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 37:8, pages 900-907.
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Richard R. Riker, David J. Gagnon, Colman Hatton, Teresa May, David B. Seder, Katie Stokem & Gilles L. Fraser. (2017) Valproate Protein Binding Is Highly Variable in ICU Patients and Not Predicted by Total Serum Concentrations: A Case Series and Literature Review. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 37:4, pages 500-508.
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Amy VandenBerg, Jessica Broadway, Callie Lalich, Rachel Kennedy & Kristen Williams. (2017) Valproate serum concentrations in patients with hypoalbuminemia and medical complications. Mental Health Clinician 7:1, pages 13-15.
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Dimitrios Chatzistefanidis, Leandros Lazaros, Katerina Giaka, Iliada Nakou, Meropi Tzoufi, Ioannis Georgiou, Athanassios Kyritsis & Sofia Markoula. (2016) UGT1A6 - and UGT2B7 -related valproic acid pharmacogenomics according to age groups and total drug concentration levels . Pharmacogenomics 17:8, pages 827-835.
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Sebastian Klein, Silvia Maggioni, Joachim Bucher, Daniel Mueller, Jens Niklas, Valery Shevchenko, Klaus Mauch, Elmar Heinzle & Fozia Noor. (2016) In Silico Modeling for the Prediction of Dose and Pathway-Related Adverse Effects in Humans From In Vitro Repeated-Dose Studies . Toxicological Sciences 149:1, pages 55-66.
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Jatinder Kaur Mukker, Ravi Shankar Prasad Singh & Hartmut Derendorf. 2016. Developing Drug Products in an Aging Society. Developing Drug Products in an Aging Society 139 151 .

Carmelo Lafuente-Lafuente, Élodie Baudry, Elena Paillaud & François Piette. (2013) Pharmacologie clinique et vieillissement. La Presse Médicale 42:2, pages 171-180.
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Apparent clearance of valproic acid in elderly epileptic patients: estimation of the confounding effect of albumin concentration

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Apparent clearance of valproic acid in elderly epileptic patients: estimation of the confounding effect of albumin concentration

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