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Upsala Journal of Medical Sciences Volume 82, 1977 - Issue 1
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Original Article

Clinical Trial in Patients with Diabetes Mellitus of an Insulin-like Compound Obtained from Plant Source

V. S. Baldwa Department of Medicine, S.M.S. Medical College Hospital, Jaipur, India
,
C. M. Bhandari Department of Medicine, S.M.S. Medical College Hospital, Jaipur, India
,
A. Pangaria Department of Medicine, S.M.S. Medical College Hospital, Jaipur, India
&
R. K. Goyal Department of Medicine, S.M.S. Medical College Hospital, Jaipur, India
Pages 39-41 | Received 20 Sep 1976, Published online: 18 Jan 2010

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Sing P. Tan, Tuyen C. Kha, Sophie E. Parks & Paul D. Roach. (2016) Bitter melon (Momordica charantia L.) bioactive composition and health benefits: A review. Food Reviews International 32:2, pages 181-202.
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Articles from other publishers (63)

Tonny Asafo-Agyei, Yaw Appau, Kofi Bobi Barimah & Alex Asase. (2023) Medicinal plants used for management of diabetes and hypertension in Ghana. Heliyon 9:12, pages e22977.
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Aminu Mohammed. (2023) Hypoglycemic Potential of African Medicinal Plants in Diabetic and Non-Diabetic Human Subjects: A Review. Clinical Complementary Medicine and Pharmacology 3:2, pages 100081.
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Gograj Singh Jat, Tusar Kanti Behera & Umesh K. Reddy. 2023. Vegetables for Nutrition and Entrepreneurship. Vegetables for Nutrition and Entrepreneurship 141 177 .
Temitayo O. Ajayi, Alfred F Attah & Goodness A. Tokede. (2022) Ethnomedicinal Survey of Medicinal Plants Used in the Management of Diabetes in Ibadan North East and South East, Oyo State, Nigeria. African Journal of Pharmaceutical Sciences 2:2, pages 47-70.
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Ruksar Salim Damji, Shamiha Chowdhury & Zaib-Un-Nisa Munawar Hussain. 2022. Research Anthology on Recent Advancements in Ethnopharmacology and Nutraceuticals. Research Anthology on Recent Advancements in Ethnopharmacology and Nutraceuticals 872 901 .
Alli Murugesan, Shailesh Kumar R. Yadav & Aparna Dixit. (2022) Anti-hyperglycemic activity of HPLC-fractionated Momordica charantia seed extract enriched in a novel napin-like protein in experimental diabetic rats and its validation with recombinant napin-like protein. Current Research in Biotechnology 4, pages 179-189.
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Younis Ahmad Hajam, Raksha Rani, Preeti Sharma, Imran Ali Khan & Rajesh Kumar. 2022. Plant Secondary Metabolites. Plant Secondary Metabolites 241 280 .
Minu Bharathi R HPriya R Iyer. (2021) A REVIEW ON GLYCEMIC CONTROL BY THE SEEDS OF SYZYGIUM CUMINI AND FRUIT OF MOMORDICA CHARANTIA. INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, pages 43-48.
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Sharmin Afroz, Shadreen Fairuz, Jahanara Alam Joty, Md. Nazim Uddin & Md Atiar Rahman. (2021) Virtual screening of functional foods and dissecting their roles in modulating gene functions to support post COVID‐19 complications. Journal of Food Biochemistry 45:12.
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Ameeduzzafar Zafar, Nabil K. Alruwaili, Dibya Sundar Panda, Syed Sarim Imam, Khalid Saad Alharbi, Muhammad Afzal, Khaled Shalaby, Imran Kazmi & Sultan Alshehri. (2021) Potential of Natural Bioactive Compounds in Management of Diabetes: Review of Preclinical and Clinical Evidence. Current Pharmacology Reports 7:3, pages 107-122.
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Ruksar Salim Damji, Shamiha Chowdhury & Zaib-Un-Nisa Munawar Hussain. 2021. Treating Endocrine and Metabolic Disorders With Herbal Medicines. Treating Endocrine and Metabolic Disorders With Herbal Medicines 1 31 .
Rizwan Ahmad, Lina Hussain AlLehaibi, Hind Nasser AlSuwaidan, Ali Fuad Alghiryafi, Lyla Shafiq Almubarak, Khawlah Nezar AlKhalifah, Hawra Jassim AlMubarak & Majed Ali Alkhathami. (2021) Evaluation of clinical trials for natural products used in diabetes. Medicine 100:16, pages e25641.
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Emanuel L. Peter, Andrew G. Mtewa, Prakash B. Nagendrappa, Anita Kaligirwa & Crispin Duncan Sesaazi. (2020) Systematic review and meta-analysis protocol for efficacy and safety of Momordica charantia L. on animal models of type 2 diabetes mellitus. Systematic Reviews 9:1.
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Ina Vandebroek & David PickingIna Vandebroek & David Picking. 2020. Popular Medicinal Plants in Portland and Kingston, Jamaica. Popular Medicinal Plants in Portland and Kingston, Jamaica 149 158 .
Shahid AkbarShahid Akbar. 2020. Handbook of 200 Medicinal Plants. Handbook of 200 Medicinal Plants 1195 1219 .
Yi-Shuai Wang, Xiang-Qing Zeng, Xu-Zhong Yang, Wei Liu, Peng-Fei Li, Fu-Jun Wang & Jian Zhao. (2019) Real-Time Quantitative PCR Analysis of the Expression Pattern of the Hypoglycemic Polypeptide-P Gene in Momordica charantia. Genes 10:12, pages 1044.
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Chintha Lankatillake, Tien Huynh & Daniel A. Dias. (2019) Understanding glycaemic control and current approaches for screening antidiabetic natural products from evidence-based medicinal plants. Plant Methods 15:1.
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Fan, Kim, Choi, Tang & Moon. (2019) The Role of Momordica charantia in Resisting Obesity. International Journal of Environmental Research and Public Health 16:18, pages 3251.
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Michael Buenor Adinortey, Rosemary Agbeko, Daniel Boison, William Ekloh, Lydia Enyonam Kuatsienu, Emmanuel Ekow Biney, Obed O. Affum, Jeffery Kwarteng & Alexander Kwadwo Nyarko. (2019) Phytomedicines Used for Diabetes Mellitus in Ghana: A Systematic Search and Review of Preclinical and Clinical Evidence. Evidence-Based Complementary and Alternative Medicine 2019, pages 1-23.
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Emanuel L. Peter, Félicien Mushagalusa Kasali, Serawit Deyno, Andrew Mtewa, Prakash B. Nagendrappa, Casim Umba Tolo, Patrick Engeu Ogwang & Duncan Sesaazi. (2019) Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. Journal of Ethnopharmacology 231, pages 311-324.
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Solomon Habtemariam. 2019. Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases. Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases 177 249 .
Emanuel L. Peter, Serawit Deyno, Andrew Mtewa, Félicien Mushagalusa Kasali, Prakash B. Nagendrappa, Duncan Sesaazi, Casim Umba Tolo & Patrick Engeu Ogwang. (2018) Safety and efficacy of Momordica charantia Linnaeus in pre-diabetes and type 2 diabetes mellitus patients: a systematic review and meta-analysis protocol. Systematic Reviews 7:1.
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Gehan F. Abdel Raoof & Khaled Y. Mohamed. 2018. 323 374 .
Ajda Ota & Nataša P. Ulrih. (2017) An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes. Frontiers in Pharmacology 8.
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Maliheh Najari Beidokhti & Anna K. Jäger. (2017) Review of antidiabetic fruits, vegetables, beverages, oils and spices commonly consumed in the diet. Journal of Ethnopharmacology 201, pages 26-41.
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C H Boone, J R Stout, J A Gordon, M J Redd, D D Church, L P Oliveira, D H Fukuda & J R Hoffman. (2017) Acute effects of a beverage containing bitter melon extract (CARELA) on postprandial glycemia among prediabetic adults. Nutrition & Diabetes 7:1, pages e241-e241.
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Sundar Poovitha & Madasamy Parani. (2016) In vitro and in vivo α-amylase and α-glucosidase inhibiting activities of the protein extracts from two varieties of bitter gourd (Momordica charantia L.). BMC Complementary and Alternative Medicine 16:S1.
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Shaheed Ur Rehman, Min Sun Choi, Kevin Choe & Hye Hyun Yoo. (2014) Interactions between herbs and antidiabetics: an overview of the mechanisms, evidence, importance, and management. Archives of Pharmacal Research 38:7, pages 1281-1298.
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Eric Yarnell. (2015) Herbs for Diabetes: Update—Part 2. Alternative and Complementary Therapies 21:1, pages 32-38.
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Olubukola Ajala & Patrick English. 2015. Glucose Intake and Utilization in Pre-Diabetes and Diabetes. Glucose Intake and Utilization in Pre-Diabetes and Diabetes 85 94 .
Jimmy Efird, Yuk Choi, Stephen Davies, Sanjay Mehra, Ethan Anderson & Lalage Katunga. (2014) Potential for Improved Glycemic Control with Dietary Momordica charantia in Patients with Insulin Resistance and Pre-Diabetes. International Journal of Environmental Research and Public Health 11:2, pages 2328-2345.
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Siew Mooi Ching, Zainul Amiruddin Zakaria, Fuziah Paimin & Mehrdad Jalalian. (2013) Complementary alternative medicine use among patients with type 2 diabetes mellitus in the primary care setting: a cross-sectional study in Malaysia. BMC Complementary and Alternative Medicine 13:1.
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Han Han, Renée Corbin, Christina Godfrey, Lawrence Leung, Junfeng Chen, Myeong Soo Lee, Tianshong Zhang & Ling Feng. (2013) The safety and effectiveness of bitter melon (momordica charantia) as an alternative to traditional hypoglycemic agents for the control of fasting blood sugar in patients with type 2 diabetes mellitus: a systematic review protocol. JBI Database of Systematic Reviews and Implementation Reports 11:12, pages 17-32.
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Ahmad Ghorbani. (2013) Best herbs for managing diabetes: a review of clinical studies. Brazilian Journal of Pharmaceutical Sciences 49:3, pages 413-422.
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Baby Joseph & D Jini. (2013) Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pacific Journal of Tropical Disease 3:2, pages 93-102.
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Weena Jiratchariyakul & Gail B. Mahady. (2013) Overview of Botanical Status in EU, USA, and Thailand. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-13.
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J. Gunn, C.-T. Che & N. Farnsworth. 2013. Bioactive Food as Dietary Interventions for Diabetes. Bioactive Food as Dietary Interventions for Diabetes 381 394 .
Dilip Ghosh, Shantanu Das, Debasis Bagchi & R SmartaDennis Chang, Srinivas Nammi & Suzanne Grant. 2012. Innovation in Healthy and Functional Foods. Innovation in Healthy and Functional Foods 455 474 .
Cheow Peng Ooi, Zaitun Yassin & Tengku-Aizan Hamid. (2012) Momordica charantia for type 2 diabetes mellitus. Cochrane Database of Systematic Reviews.
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Mitsumasa Mankura, Yasuko Noda & Akitane Mori. (2012) Hypoglycemic activity of <I>Momordica charantia</I> (bitter melon). Okayama Igakkai Zasshi (Journal of Okayama Medical Association) 124:1, pages 15-26.
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Andreas Blum, Christine Loerz, Hans-Joerg Martin, Claudia A. Staab-Weijnitz & Edmund Maser. (2012) Momordica charantia extract, a herbal remedy for type 2 diabetes, contains a specific 11β-hydroxysteroid dehydrogenase type 1 inhibitor. The Journal of Steroid Biochemistry and Molecular Biology 128:1-2, pages 51-55.
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T. K. LimT. K. Lim. 2012. Edible Medicinal And Non-Medicinal Plants. Edible Medicinal And Non-Medicinal Plants 331 368 .
Rakesh Agarwal, Yogi Amrit Raj & Dinesh Kumar. (2010) Hypoglycemic potential of Momordica charantia Linn in Streptozotocin induced diabetic Albino mice. Environment Conservation Journal 11:3, pages 1-5.
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Si-Xiu Liu, Zhong-Ping Fu, Rui-Min Mu, Zhi-Bi Hu, Fu-Jun Wang & Xiang-Rong Wang. (2009) Expression and characterization of Momordica Chanrantia anti-hyperglycaemic peptide in Escherichia coli. Molecular Biology Reports 37:4, pages 1781-1786.
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Tusar K. Behera, Snigdha Behera, L. K. Bharathi, K. Joseph John, Philipp W. Simon & Jack E. Staub. 2010. Horticultural Reviews, Volume 37. Horticultural Reviews, Volume 37 101 141 .
Andrew Heyman, Lena Edwards, James B. Lavalle & Sahar Swidan. (2010) Cardiometabolic disease in men: an integrative medicine approach to managing hormonal risk factors. Journal of Men's Health 7:1, pages 92-101.
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Cheow Peng Ooi, Zaitun Yassin & Tengku-Aizan Hamid. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
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Lawrence Leung, Richard Birtwhistle, Jyoti Kotecha, Susan Hannah & Sharon Cuthbertson. (2009) Anti-diabetic and hypoglycaemic effects of Momordica charantia (bitter melon): a mini review. British Journal of Nutrition 102:12, pages 1703.
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Antonio Miguel Limcaco Dans, Maria Vanessa C. Villarruz, Cecilia A. Jimeno, Mark Anthony U. Javelosa, Joel Chua, Rhida Bautista & Gwyneth Giselle B. Velez. (2007) The effect of Momordica charantia capsule preparation on glycemic control in Type 2 Diabetes Mellitus needs further studies. Journal of Clinical Epidemiology 60:6, pages 554-559.
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Y. Srivastava, H. Venkatakrishna‐Bhatt, Y. Verma, K. Venkaiah & B. H. Raval. (2006) Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation . Phytotherapy Research 7:4, pages 285-289.
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J. Welihinda, E.H. Karunanayake, M.H.H. Sheriff & K.S.A. Jayasinghe. (1986) Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. Journal of Ethnopharmacology 17:3, pages 277-282.
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