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Scandinavian Journal of Rheumatology Volume 41, 2012 - Issue 1
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Research Article

The C677T polymorphism in the MTHFR gene is associated with the toxicity of methotrexate in a Spanish rheumatoid arthritis population

R CálizVirgen de las Nieves University Hospital, Granada, Spain
,
J del AmoProgenika Biopharma SA, Derio, Vizcaya, SpainCorrespondence[email protected]
,
A BalsaLa Paz University Hospital, Madrid, Spain
,
F BlancoJuan Canalejo Hospital, Coruña, Spain
,
L SilvaPuerta de Hierro University Hospital, Madrid, Spain
,
R SanmartiHospital Clinic, Barcelona, Spain
,
FG MartínezReina Sofía, University Hospital, Córdoba, Spain
,
MD ColladoVirgen de las Nieves University Hospital, Granada, Spain
,
M del Carmen RamirezVirgen de las Nieves University Hospital, Granada, Spain
,
D TejedorProgenika Biopharma SA, Derio, Vizcaya, Spain
,
M ArtiedaProgenika Biopharma SA, Derio, Vizcaya, Spain
,
D Pascual-SalcedoLa Paz University Hospital, Madrid, Spain
,
N OreiroJuan Canalejo Hospital, Coruña, Spain
,
JL AndreuPuerta de Hierro University Hospital, Madrid, Spain
,
E GraellHospital Clinic, Barcelona, Spain
,
L SimonProgenika Biopharma SA, Derio, Vizcaya, Spain
,
A MartínezProgenika Biopharma SA, Derio, Vizcaya, Spain
&
J MuleroPuerta de Hierro University Hospital, Madrid, Spain
 show all
Pages 10-14 | Accepted 22 Aug 2011, Published online: 01 Nov 2011

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Ola Atef Sharaki, Amira Hasan Elgerby, Eman Saad Nassar & Sara Salah Eldin Khalil. (2018) Impact of methylenetetrahydrofolate reductase (MTHFR) A1298C gene polymorphism on the outcome of methotrexate treatment in a sample of Egyptian rheumatoid arthritis patients. Alexandria Journal of Medicine 54:4, pages 633-638.
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T Dimitroulas, A Sandoo, J Hodson, J Smith, KM Douglas & GD Kitas. (2016) Associations between asymmetric dimethylarginine, homocysteine, and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism (rs1801133) in rheumatoid arthritis. Scandinavian Journal of Rheumatology 45:4, pages 267-273.
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M Fodil, VH Teixeira, V Chaudru, P Hilliquin, S Bombardieri, A Balsa, R Westhovens, P Barrera, H Alves, P Migliorin, T Bardin, F Cornelis, A Boudjema & E Petit-Teixeira. (2015) Relationship between SNPs and expression level for candidate genes in rheumatoid arthritis. Scandinavian Journal of Rheumatology 44:1, pages 2-7.
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Atinuke Aluko & Prabha Ranganathan. 2022. Pharmacogenomics in Drug Discovery and Development. Pharmacogenomics in Drug Discovery and Development 527 567 .
G. V. Volynets & A. I. Khavkin. (2021) Inflammatory bowel disease and drug-induced liver damage. Experimental and Clinical Gastroenterology:10, pages 138-146.
Crossref
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Luisa F. Restrepo, Rodrigo Giraldo, John Londoño, Carlos Pinzón, Ani Cortes, Giovanny Ballesteros & Ana María Santos. (2016) Farmacogenética del metotrexato en artritis reumatoide. Revisión sistemática. Revista Colombiana de Reumatología 23:2, pages 102-114.
Crossref
S Jabeen, L Holmboe, G I G Alnæs, A M Andersen, K S Hall & V N Kristensen. (2015) Impact of genetic variants of RFC1, DHFR and MTHFR in osteosarcoma patients treated with high-dose methotrexate. The Pharmacogenomics Journal 15:5, pages 385-390.
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Patricia Moya, Hèctor Corominas, Juliana Salazar & Montserrat Baiget. (2015) Consensus on the Use of Methotrexate Beyond the Clinical Recommendation: Adjusted Dose and Pharmacogenetics. Reumatología Clínica (English Edition) 11:4, pages 261-262.
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Crossref
Vasco C. Romão, Aurea Lima, Miguel Bernardes, Helena Canhão & João Eurico Fonseca. (2014) Three decades of low-dose methotrexate in rheumatoid arthritis: Can we predict toxicity?. Immunologic Research 60:2-3, pages 289-310.
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Gwan Gyu Song, Sang-Cheol Bae & Young Ho Lee. (2014) Association of the MTHFR C677T and A1298C polymorphisms with methotrexate toxicity in rheumatoid arthritis: a meta-analysis. Clinical Rheumatology 33:12, pages 1715-1724.
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Ling Ling Zhang, Sen Yang, Wei Wei & Xue Jun Zhang. (2014) Genetic polymorphisms affect efficacy and adverse drug reactions of DMARDs in rheumatoid arthritis. Pharmacogenetics and Genomics 24:11, pages 531-538.
Crossref
Elena Nikiphorou, Andra Negoescu, John D. Fitzpatrick, Calum T. Goudie, Andrew Badcock, Andrew J. K. Östör & Anshuman P. Malaviya. (2014) Indispensable or intolerable? Methotrexate in patients with rheumatoid and psoriatic arthritis: a retrospective review of discontinuation rates from a large UK cohort. Clinical Rheumatology 33:5, pages 609-614.
Crossref
Tabitha N. Kung, Jessica Dennis, YiQing Ma, Gang Xie, Vivian Bykerk, Janet Pope, Carter Thorne, Edward Keystone, Katherine A. Siminovitch & France Gagnon. (2014) RFC1 80G>A Is a Genetic Determinant of Methotrexate Efficacy in Rheumatoid Arthritis: A Human Genome Epidemiologic Review and Meta-Analysis of Observational Studies . Arthritis & Rheumatology 66:5, pages 1111-1120.
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Hong Zhu, Fei-Yan Deng, Xing-Bo Mo, Ying-Hua Qiu & Shu-Feng Lei. (2014) Pharmacogenetics and pharmacogenomics for rheumatoid arthritis responsiveness to methotrexate treatment: the 2013 update. Pharmacogenomics 15:4, pages 551-566.
Crossref
Rajalingham Sakthiswary, Grace Yin Lai Chan, Ee Tzun Koh, Khai Pang Leong & Bernard Yu Hor Thong. (2014) Methotrexate-Associated Nonalcoholic Fatty Liver Disease with Transaminitis in Rheumatoid Arthritis. The Scientific World Journal 2014, pages 1-5.
Crossref
Jisna R Paul, Deepali Sen & Prabha Ranganathan. 2014. Handbook of Pharmacogenomics and Stratified Medicine. Handbook of Pharmacogenomics and Stratified Medicine 653 681 .
Deepali Sen, Jisna R. Paul & Prabha Ranganathan. 2014. Pharmacogenomics in Drug Discovery and Development. Pharmacogenomics in Drug Discovery and Development 625 660 .
Maša Umićević Mirkov & Marieke JH Coenen. (2013) Pharmacogenetics of disease-modifying antirheumatic drugs in rheumatoid arthritis: towards personalized medicine. Pharmacogenomics 14:4, pages 425-444.
Crossref
Fardina Malik & Prabha Ranganathan. (2013) Methotrexate pharmacogenetics in rheumatoid arthritis: a status report. Pharmacogenomics 14:3, pages 305-314.
Crossref
Cristina Lucía Dávila-Fajardo, Jesse J Swen, José Cabeza Barrera & Henk-Jan Guchelaar. (2013) Genetic risk factors for drug-induced liver injury in rheumatoid arthritis patients using low-dose methotrexate. Pharmacogenomics 14:1, pages 63-73.
Crossref
José Cristian Plaza-PlazaMargarita AguileraMarisa Cañadas-GarreClarice ChemelloAlfonso González-UtrillaMaría José Faus DaderMiguel Angel Calleja. (2012) Pharmacogenetic Polymorphisms Contributing to Toxicity Induced by Methotrexate in the Southern Spanish Population with Rheumatoid Arthritis. OMICS: A Journal of Integrative Biology 16:11, pages 589-595.
Crossref
Lin Yang, Xin Hu & Luhang Xu. (2012) Impact of methylenetetrahydrofolate reductase (MTHFR) polymorphisms on methotrexate-induced toxicities in acute lymphoblastic leukemia: a meta-analysis. Tumor Biology 33:5, pages 1445-1454.
Crossref
Prabha Ranganathan. (2012) Research Highlights. Pharmacogenomics 13:4, pages 377-380.
Crossref

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