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Research Article

Citrullinated vimentin stimulates proliferation, pro-inflammatory cytokine secretion, and PADI4 and RANKL expression of fibroblast-like synoviocytes in rheumatoid arthritis

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Pages 354-358 | Accepted 23 Feb 2012, Published online: 05 Jul 2012

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Read on this site (3)

Danial Hashemi Karoii & Hossein Azizi. (2022) A review of protein-protein interaction and signaling pathway of Vimentin in cell regulation, morphology and cell differentiation in normal cells. Journal of Receptors and Signal Transduction 42:5, pages 512-520.
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Ramamoorthi Ganesan & Mahaboobkhan Rasool. (2017) Fibroblast-like synoviocytes-dependent effector molecules as a critical mediator for rheumatoid arthritis: Current status and future directions. International Reviews of Immunology 36:1, pages 20-30.
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A Lo Gullo, G Mandraffino, MA Sardo, A D’Ascola, F Mamone, S Loddo, A Alibrandi, E Imbalzano, R Mandraffino, E Mormina, C Saitta, R Lo Gullo, A David & A Saitta. (2014) Circulating progenitor cells in rheumatoid arthritis: association with inflammation and oxidative stress. Scandinavian Journal of Rheumatology 43:3, pages 184-193.
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Articles from other publishers (31)

Beatriz Frade-Sosa & Raimon Sanmartí. (2023) Neutrophils, neutrophil extracellular traps, and rheumatoid arthritis: An updated review for clinicians. Reumatología Clínica (English Edition) 19:9, pages 515-526.
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Beatriz Frade-Sosa & Raimon Sanmartí. (2023) Neutrófilos, trampas extracelulares de neutrófilos y artritis reumatoide: una revisión actualizada para clínicos. Reumatología Clínica 19:9, pages 515-526.
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Ken Yoshida, Haruyasu Ito, Daisaburo Kurosaka, Ryo Ikeda, Kentaro Noda, Mitsuru Saito & Daitaro Kurosaka. (2023) Autocitrullination confers monocyte chemotactic properties to peptidylarginine deiminase 4. Scientific Reports 13:1.
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Satoru Shindo, Roodelyne Pierrelus, Atsushi Ikeda, Shin Nakamura, Alireza Heidari, Maria Rita Pastore, Elizabeth Leon, Sunniva Ruiz, Harsh Chheda, Rhea Khatiwala, Tomoki Kumagai, George Tolson, Islam Elderbashy, Kazuhisa Ouhara, Xiaozhe Han, Maria Hernandez, Saynur Vardar-Sengul, Hideki Shiba & Toshihisa Kawai. (2023) Extracellular Release of Citrullinated Vimentin Directly Acts on Osteoclasts to Promote Bone Resorption in a Mouse Model of Periodontitis. Cells 12:8, pages 1109.
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Changjun Lv, Minghui Sun, Yilei Guo, Wenxin Xia, Simiao Qiao, Yu Tao, Yulai Fang, Qin Zhang, Yanrong Zhu, Yusufu Yalikun, Yufeng Xia, Zhifeng Wei & Yue Dai. (2023) Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/PAD4 pathway. Acta Pharmaceutica Sinica B 13:4, pages 1600-1615.
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Kristína Macáková, Júlia Illésová, Vanda Mlynáriková, Alexandra Lesayová, Barbora Konečná, Barbora Vlková, Peter Celec & Emöke Šteňová. (2022) The dynamics of extracellular DNA associates with treatment response in patients with rheumatoid arthritis. Scientific Reports 12:1.
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Yan Wang, Chunyan Liu, Nanyang Zhang, Xianqin Song, Yu Song, Duo Cai, Kehua Fang & Xiaotian Chang. (2022) Anti-PADI4 antibody suppresses breast cancer by repressing the citrullinated fibronectin in the tumor microenvironment. Biomedicine & Pharmacotherapy 153, pages 113289.
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P. Monika, M.N. Chandraprabha, K.N. Chidambara Murthy, Annapoorni Rangarajan, P. Veena Waiker & M. Sathish. (2022) Human primary chronic wound derived fibroblasts demonstrate differential pattern in expression of fibroblast specific markers, cell cycle arrest and reduced proliferation. Experimental and Molecular Pathology 127, pages 104803.
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Oskar Ciesielski, Marta Biesiekierska, Baptiste Panthu, Mirosław Soszyński, Luciano Pirola & Aneta Balcerczyk. (2022) Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives. Cellular and Molecular Life Sciences 79:2.
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Rhea Raj, Sneha Thomas & Vasavi Gorantla. (2023) Accelerated atherosclerosis in rheumatoid arthritis: a systematic review. F1000Research 11, pages 466.
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Rhea Raj, Sneha Thomas & Vasavi Gorantla. (2022) Accelerated atherosclerosis in rheumatoid arthritis: a systematic review. F1000Research 11, pages 466.
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Iris Paola Guzmán-Guzmán, Claudia Isabel Ramírez-Vélez, Ramcés Falfán-Valencia, José Eduardo Navarro-Zarza, Ilse Adriana Gutiérrez-Pérez, Oscar Zaragoza-García, Mónica Ramírez, Natividad Castro-Alarcón & Isela Parra-Rojas. (2021) PADI2 Polymorphisms Are Significantly Associated With Rheumatoid Arthritis, Autoantibodies Serologic Status and Joint Damage in Women from Southern Mexico. Frontiers in Immunology 12.
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Wenpeng Song, Jing Ye, Nanfang Pan, Chunyu Tan & Martin Herrmann. (2021) Neutrophil Extracellular Traps Tied to Rheumatoid Arthritis: Points to Ponder. Frontiers in Immunology 11.
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Jing Wang, Ning Tie, Hongbin Li & Xixiong Kang. (2020) Inhibitory Effect of Tetramerized Single-Chain Variable Fragment of Anti-Cyclic Citrullinated Peptide Antibodies on the Proliferation, Activation, and Secretion of Cytokines of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis In Vitro Co-Culture System. Inflammation 43:6, pages 2245-2255.
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DingJi Zhu, JinJun Zhao, AiJu Lou, Qin Huang, QingQing OuYang, JunQing Zhu, MeiDa Fan, YingQiong He, Hao Ren & Min Yang. (2019) Transforming growth factor β1 promotes fibroblast-like synoviocytes migration and invasion via TGF-β1/Smad signaling in rheumatoid arthritis. Molecular and Cellular Biochemistry 459:1-2, pages 141-150.
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Hans Ulrich Scherer, Tom W. J. Huizinga, Gerhard Krönke, Georg Schett & Rene E. M. Toes. (2018) The B cell response to citrullinated antigens in the development of rheumatoid arthritis. Nature Reviews Rheumatology 14:3, pages 157-169.
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Pengfei Xue, Liming Chen, Xiongsong Lu, Jinlong Zhang, Guofeng Bao, Guanhua Xu, Yuyu Sun, Xiaofeng Guo, Jiawei Jiang, Haiyan Gu & Zhiming Cui. (2017) Vimentin Promotes Astrocyte Activation After Chronic Constriction Injury. Journal of Molecular Neuroscience 63:1, pages 91-99.
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Ru Yang, Yingzi Zhang, Lin Wang, Ji Hu, Jian Wen, Leixi Xue, Mei Tang, Zhichun Liu & Jinxiang Fu. (2016) Increased autophagy in fibroblast-like synoviocytes leads to immune enhancement potential in rheumatoid arthritis. Oncotarget 8:9, pages 15420-15430.
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Qiu-Fang Gao, Xiu-Hong Zhang, Feng-Lai Yuan, Ming-Dong Zhao & Xia Li. (2016) Recombinant human endostatin inhibits TNF-alpha-induced receptor activator of NF-κB ligand expression in fibroblast-like synoviocytes in mice with adjuvant arthritis. Cell Biology International 40:12, pages 1340-1348.
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Wei He, Peter Zhou, Zhigang Chang, Baoling Liu, Xuefeng Liu, Yanming Wang, Yongqing Li & Hasan B. Alam. (2016) Inhibition of peptidylarginine deiminase attenuates inflammation and improves survival in a rat model of hemorrhagic shock. Journal of Surgical Research 200:2, pages 610-618.
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Justyna Fert-Bober, John T. Giles, Ronald J. Holewinski, Jonathan A. Kirk, Helge Uhrigshardt, Erin L. Crowgey, Felipe Andrade, Clifton O. BinghamIIIIII, Jin Kyun Park, Marc K. Halushka, David A. Kass, Joan M. Bathon & Jennifer E. Van Eyk. (2015) Citrullination of myofilament proteins in heart failure. Cardiovascular Research 108:2, pages 232-242.
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Dres Damgaard, Ladislav Senolt, Michael Friberg Nielsen, Ger J Pruijn & Claus H Nielsen. (2014) Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen. Arthritis Research & Therapy 16:6.
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Ahrom Ham, May Rabadi, Mihwa Kim, Kevin M. Brown, Zhe Ma, Vivette D'Agati & H. Thomas Lee. (2014) Peptidyl arginine deiminase-4 activation exacerbates kidney ischemia-reperfusion injury. American Journal of Physiology-Renal Physiology 307:9, pages F1052-F1062.
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Ken Yoshida, Olexandr Korchynskyi, Paul P. Tak, Takeo Isozaki, Jeffrey H. Ruth, Phillip L. Campbell, Dominique L. Baeten, Danielle M. Gerlag, M. Asif Amin & Alisa E. Koch. (2014) Citrullination of Epithelial Neutrophil-Activating Peptide 78/CXCL5 Results in Conversion From a Non-Monocyte-Recruiting Chemokine to a Monocyte-Recruiting Chemokine. Arthritis & Rheumatology 66:10, pages 2716-2727.
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Daniel J. Slade, Sachi Horibata, Scott A. Coonrod & Paul R. Thompson. (2014) A novel role for protein arginine deiminase 4 in pluripotency: The emerging role of citrullinated histone H1 in cellular programming. BioEssays 36:8, pages 736-740.
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Deng-Ho Yang, Chuan-Chou Tu, Shou-Cheng Wang, Cheng-Chung Wei & Ya-Wen Cheng. (2013) Circulating anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis and chronic obstructive pulmonary disease. Rheumatology International 34:7, pages 971-977.
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Zhen Yang, Anapatricia Garcia, Songli Xu, Doris R. Powell, Paula M. Vertino, Shivendra Singh & Adam I. Marcus. (2013) Withania somnifera Root Extract Inhibits Mammary Cancer Metastasis and Epithelial to Mesenchymal Transition. PLoS ONE 8:9, pages e75069.
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Olga Sanchez-Pernaute, Maria Filkova, Antonio Gabucio, Martin Klein, Hanna Maciejewska-Rodrigues, Caroline Ospelt, Fabia Brentano, Beat A Michel, Renate E Gay, Gabriel Herrero-Beaumont, Steffen Gay, Michel Neidhart & Astrid Juengel. (2013) Citrullination enhances the pro-inflammatory response to fibrin in rheumatoid arthritis synovial fibroblasts. Annals of the Rheumatic Diseases 72:8, pages 1400-1406.
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Michelle T Leech & Eric F Morand. (2013) Fibroblasts and synovial immunity. Current Opinion in Pharmacology 13:4, pages 565-569.
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Ritika KhandpurCarmelo Carmona-RiveraAnuradha Vivekanandan-GiriAlison GizinskiSrilakshmi YalavarthiJason S. KnightSean FridaySam LiRajiv M. PatelVenkataraman SubramanianPaul ThompsonPojen ChenDavid A. FoxSubramaniam PennathurMariana J. Kaplan. (2013) NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis. Science Translational Medicine 5:178.
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Lieying Fan, Qiang Wang, Rongqing Liu, Ming Zong, Dongyi He, Hui Zhang, Yuanyuan Ding & Jianwei Ma. (2012) Citrullinated fibronectin inhibits apoptosis and promotes the secretion of pro-inflammatory cytokines in fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Research & Therapy 14:6, pages R266.
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