947
Views
45
CrossRef citations to date
0
Altmetric
Review

Inflammation (or synovitis)-driven osteoarthritis: an opportunity for personalizing prognosis and treatment?

, , , , , , , , & show all
Pages 87-98 | Accepted 05 Jun 2015, Published online: 20 Oct 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Anne Christine Bay-Jensen, Amalie Engstroem, Neha Sharma & Morten Asser Karsdal. (2020) Blood and urinary collagen markers in osteoarthritis: markers of tissue turnover and disease activity. Expert Review of Molecular Diagnostics 20:1, pages 57-68.
Read now
Win Min Oo, Shirley Pei-Chun Yu, Matthew Sean Daniel & David John Hunter. (2018) Disease-modifying drugs in osteoarthritis: current understanding and future therapeutics. Expert Opinion on Emerging Drugs 23:4, pages 331-347.
Read now

Articles from other publishers (43)

V. I. Mazurov, A. M. Lila, L. I. Alekseeva, Ch. T. Baymukhamedov, B. G. Isaeva, D. A. Iskra, M. Yu. Karimov, H. T. Mirakhmedova, A. M. Mkrtumyan, D. A. Nabieva, A. V. Naumov, O. N. Tkacheva, E. A. Trofimov & M. N. Khokhlova. (2023) Multimorbidity in osteoarthritis and pleiotropic effects of slow-acting symptomatic drugs. Resolution of the multidisciplinary International Expert Council. Modern Rheumatology Journal 17:5, pages 123-131.
Crossref
Griffin Copp, Kevin P. Robb & Sowmya Viswanathan. (2023) Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success. Cellular & Molecular Immunology 20:6, pages 626-650.
Crossref
Xunshan Ren, Huangming Zhuang, Fuze Jiang, Yuelong Zhang & Panghu Zhou. (2023) Ceria Nanoparticles Alleviated Osteoarthritis through Attenuating Senescence and Senescence-Associated Secretory Phenotype in Synoviocytes. International Journal of Molecular Sciences 24:5, pages 5056.
Crossref
Sofija Semenistaja, Sandra Skuja, Anda Kadisa & Valerija Groma. (2023) Healthy and Osteoarthritis-Affected Joints Facing the Cellular Crosstalk. International Journal of Molecular Sciences 24:4, pages 4120.
Crossref
Zhizheng Fang, Xiangyu Li, Shujun Lei, Shibin Feng, Chenyu Zhou, Xiaohui Tong & Rongchun Han. (2023) Protective effects of Pudilan Tablets against osteoarthritis in mice induced by monosodium iodoacetate. Scientific Reports 13:1.
Crossref
Dongyun WangYajie QiZhubing WangAnyun GuoYingxin XuYang Zhang. (2023) Recent Advances in Animal Models, Diagnosis, and Treatment of Temporomandibular Joint Osteoarthritis. Tissue Engineering Part B: Reviews 29:1, pages 62-77.
Crossref
Sevdalina Nikolova Lambova. (2023) Knee Osteoarthritis—How Close Are We to Disease-Modifying Treatment: Emphasis on Metabolic Type Knee Osteoarthritis. Life 13:1, pages 140.
Crossref
Vladimirs Naumovs, Valērija Groma & Jānis Mednieks. (2022) From Low-Grade Inflammation in Osteoarthritis to Neuropsychiatric Sequelae: A Narrative Review. International Journal of Molecular Sciences 23:24, pages 16031.
Crossref
Chunmei Tan, Lanqing Li, Juanjuan Han, Kang Xu & Xianqiong Liu. (2022) A new strategy for osteoarthritis therapy: Inhibition of glycolysis. Frontiers in Pharmacology 13.
Crossref
Cemal Orhan, Mehmet Tuzcu, Ali Said Durmus, Nurhan Sahin, Ibrahim Hanifi Ozercan, Patrick Brice Defo Deeh, Abhijeet Morde, Prakash Bhanuse, Manutosh Acharya, Muralidhara Padigaru & Kazim Sahin. (2022) Protective effect of a novel polyherbal formulation on experimentally induced osteoarthritis in a rat model. Biomedicine & Pharmacotherapy 151, pages 113052.
Crossref
Francesca Motta, Elisa Barone, Antonio Sica & Carlo Selmi. (2022) Inflammaging and Osteoarthritis. Clinical Reviews in Allergy & Immunology 64:2, pages 222-238.
Crossref
Reza Talaie, Pooya Torkian, Alexander Clayton, Stephanie Wallace, Hoiwan Cheung, Majid Chalian & Jafar Golzarian. (2022) Emerging Targets for the Treatment of Osteoarthritis: New Investigational Methods to Identify Neo-Vessels as Possible Targets for Embolization. Diagnostics 12:6, pages 1403.
Crossref
J.P.M. Vrouwe, J.J.M. Meulenberg, N.B. Klarenbeek, A. Navas-Cañete, M. Reijnierse, G. Ruiterkamp, L. Bevaart, R.J. Lamers, M. Kloppenburg, R.G.H.H. Nelissen, T.W.J. Huizinga, J. Burggraaf & I.M.C. Kamerling. (2022) Administration of an adeno-associated viral vector expressing interferon-β in patients with inflammatory hand arthritis, results of a phase I/II study. Osteoarthritis and Cartilage 30:1, pages 52-60.
Crossref
Ying He, Wei Wang, Xiaoxiao Xu, Beining Yang, Xijie Yu, Yanru Wu & Jiawei Wang. (2022) Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m6A modification. Bone 154, pages 116182.
Crossref
Marko Ostojic, Ante Zevrnja, Katarina Vukojevic & Violeta Soljic. (2021) Immunofluorescence Analysis of NF-kB and iNOS Expression in Different Cell Populations during Early and Advanced Knee Osteoarthritis. International Journal of Molecular Sciences 22:12, pages 6461.
Crossref
Himadri Shekhar Roy, Rupali Singh & Deepa Ghosh. (2021) Recent advances in nanotherapeutic strategies that target nitric oxide pathway for preventing cartilage degeneration. Nitric Oxide 109-110, pages 1-11.
Crossref
Anne-Christine Bay-Jensen, Asger Bihlet, Inger Byrjalsen, Jeppe Ragnar Andersen, Bente Juhl Riis, Claus Christiansen, Martin Michaelis, Hans Guehring, Christoph Ladel & Morten A. Karsdal. (2021) Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis. Scientific Reports 11:1.
Crossref
Elena Rezuş, Alexandra Burlui, Anca Cardoneanu, Luana Andreea Macovei, Bogdan Ionel Tamba & Ciprian Rezuş. (2021) From Pathogenesis to Therapy in Knee Osteoarthritis: Bench-to-Bedside. International Journal of Molecular Sciences 22:5, pages 2697.
Crossref
Chunhui Yuan, Zongyou Pan, Kun Zhao, Jun Li, Zixuan Sheng, Xudong Yao, Hua Liu, Xiaolei Zhang, Yang Yang, Dongsheng Yu, Yu Zhang, Yuzi Xu, Zhi-Yong Zhang, Tianlong Huang, Wanlu Liu & Hongwei Ouyang. (2020) Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas. Bone Research 8:1.
Crossref
Valerija Groma, Mihails Tarasovs, Sandra Skuja, Sofija Semenistaja, Zaiga Nora-Krukle, Simons Svirskis & Modra Murovska. (2020) Inflammatory Cytokine-Producing Cells and Inflammation Markers in the Synovium of Osteoarthritis Patients Evidenced in Human Herpesvirus 7 Infection. International Journal of Molecular Sciences 21:17, pages 6004.
Crossref
Xingzhao Wen, Hongyi Li, Hao Sun, Anyu Zeng, Ruifu Lin, Jing Zhao & Zhiqi Zhang. (2020) MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway. Life Sciences 253, pages 117718.
Crossref
Xiaotian Du, Yishan Chen, Qin Zhang, Junxin Lin, Yeke Yu, Zongyou Pan, Heng Sun, Chunhui Yuan, Dongsheng Yu, Haoyu Wu, Xiaoan Zhang, Jun Dai, Shouan Zhu, Yiting Zhou & Hongwei Ouyang. (2020) Ezh2 Ameliorates Osteoarthritis by Activating TNFSF13B . Journal of Bone and Mineral Research 35:5, pages 956-965.
Crossref
Cleydlenne Costa Vasconcelos, Alberto Jorge Oliveira Lopes, Emerson Lucas Frazão Sousa, Darleno Sousa Camelo, Fernando César Vilhena Moreira Lima, Cláudia Quintino da Rocha, Gyl Eanes Barros Silva, João Batista Santos Garcia & Maria do Socorro de Sousa Cartágenes. (2019) Effects of Extract of Arrabidaea chica Verlot on an Experimental Model of Osteoarthritis. International Journal of Molecular Sciences 20:19, pages 4717.
Crossref
Christopher J. Burke, Hamza Alizai, Luis S Beltran & Ravinder R. Regatte. (2019) MRI of synovitis and joint fluid. Journal of Magnetic Resonance Imaging 49:6, pages 1512-1527.
Crossref
M.A. Karsdal, K.M. Verburg, C.R. West, A.C. Bay-Jensen, D.S. Keller & R.H.G.P. Arends. (2019) Serological biomarker profiles of rapidly progressive osteoarthritis in tanezumab-treated patients. Osteoarthritis and Cartilage 27:3, pages 484-492.
Crossref
Ali Mobasheri, Simo Saarakkala, Mikko Finnilä, Morten A. Karsdal, Anne-Christine Bay-Jensen & Willem Evert van Spil. (2019) Recent advances in understanding the phenotypes of osteoarthritis. F1000Research 8, pages 2091.
Crossref
Ali Mobasheri, Willem Evert van Spil, Emma Budd, Ilona Uzieliene, Eiva Bernotiene, Anne-Christine Bay-Jensen, Jonathan Larkin, Marc C. Levesque, Oreste Gualillo & Yves Henrotin. (2019) Molecular taxonomy of osteoarthritis for patient stratification, disease management and drug development: biochemical markers associated with emerging clinical phenotypes and molecular endotypes. Current Opinion in Rheumatology 31:1, pages 80-89.
Crossref
A. Berlinberg, E.L. Ashbeck, F.W. Roemer, A. Guermazi, D.J. Hunter, J. Westra, J. Trost & C.K. Kwoh. (2019) Diagnostic performance of knee physical exam and participant-reported symptoms for MRI-detected effusion-synovitis among participants with early or late stage knee osteoarthritis: data from the Osteoarthritis Initiative. Osteoarthritis and Cartilage 27:1, pages 80-89.
Crossref
Ali Mobasheri. 2020. Cell Biology and Translational Medicine, Volume 8. Cell Biology and Translational Medicine, Volume 8 17 31 .
Rong-Hui Deng, Bo Qiu & Pang-Hu Zhou. (2018) Chitosan/hyaluronic acid/plasmid-DNA nanoparticles encoding interleukin-1 receptor antagonist attenuate inflammation in synoviocytes induced by interleukin-1 beta. Journal of Materials Science: Materials in Medicine 29:10.
Crossref
C. Ratzlaff, E.L. Ashbeck, A. Guermazi, F.W. Roemer, J. Duryea & C.K. Kwoh. (2018) A quantitative metric for knee osteoarthritis: reference values of joint space loss. Osteoarthritis and Cartilage 26:9, pages 1215-1224.
Crossref
Hans-Georg Schaible. (2018) Osteoarthritis pain. Recent advances and controversies. Current Opinion in Supportive & Palliative Care 12:2, pages 148-153.
Crossref
Y.Y. Leung, B. Haaland, J.L. Huebner, S.B.S. Wong, M. Tjai, C. Wang, B. Chowbay, J. Thumboo, B. Chakraborty, M.H. Tan & V.B. Kraus. (2018) Colchicine lack of effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): a randomized controlled trial. Osteoarthritis and Cartilage 26:5, pages 631-640.
Crossref
Ernest R. Vina, Di Ran, Erin L. Ashbeck, Charles Ratzlaff & C. Kent Kwoh. (2018) Race, sex, and risk factors in radiographic worsening of knee osteoarthritis. Seminars in Arthritis and Rheumatism 47:4, pages 464-471.
Crossref
Anne-Christine Bay-Jensen, Christian S. Thudium, Oreste Gualillo & Ali Mobasheri. (2018) Biochemical marker discovery, testing and evaluation for facilitating OA drug discovery and development. Drug Discovery Today 23:2, pages 349-358.
Crossref
Alexander Mathiessen & Philip G. Conaghan. (2017) Synovitis in osteoarthritis: current understanding with therapeutic implications. Arthritis Research & Therapy 19:1.
Crossref
Annett Eitner, Gunther O. Hofmann & Hans-Georg Schaible. (2017) Mechanisms of Osteoarthritic Pain. Studies in Humans and Experimental Models. Frontiers in Molecular Neuroscience 10.
Crossref
Ali Mobasheri, Anne-Christine Bay-Jensen, Oreste Gualillo, Jonanthan Larkin, Marc C. Levesque & Yves Henrotin. (2017) Soluble biochemical markers of osteoarthritis: Are we close to using them in clinical practice?. Best Practice & Research Clinical Rheumatology 31:5, pages 705-720.
Crossref
David A. Walsh & Joanne Stocks. (2017) New Therapeutic Targets for Osteoarthritis Pain. SLAS Discovery 22:8, pages 931-949.
Crossref
Y.Y. Leung, J.L. Huebner, B. Haaland, S.B.S. Wong & V.B. Kraus. (2017) Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain. Osteoarthritis and Cartilage 25:9, pages 1420-1427.
Crossref
Ali Mobasheri, Margaret P. Rayman, Oreste Gualillo, Jérémie Sellam, Peter van der Kraan & Ursula Fearon. (2017) The role of metabolism in the pathogenesis of osteoarthritis. Nature Reviews Rheumatology 13:5, pages 302-311.
Crossref
Cui-Cui Liu, Yanmin Zhang, Bing-Ling Dai, Yu-Jiao Ma, Qian Zhang, Yi Wang & Hao Yang. (2017) Chlorogenic acid prevents inflammatory responses in IL-1β-stimulated human SW-1353 chondrocytes, a model for osteoarthritis. Molecular Medicine Reports 16:2, pages 1369-1375.
Crossref
Chio Yokose, Meng Chen, Adey Berhanu, Michael H. Pillinger & Svetlana Krasnokutsky. (2016) Gout and Osteoarthritis: Associations, Pathophysiology, and Therapeutic Implications. Current Rheumatology Reports 18:10.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.