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Original Article

The Leukocyte Protein L1 in Plasma and Synovial Fluid from Patients with Rheumatoid Arthritis and Osteoarthritis

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Pages 74-82 | Received 03 Apr 1990, Published online: 12 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Geir Hetland, Magne Kristoffer Fagerhol, Veselka Petrova Dimova-Svetoslavova, Mohammad Reza Mirlashari, Nhan Trung Nguyen, Andreas Lind, Svein Olav Kolset, Arne Vasli Lund Søraas & Lise Sofie Haug Nissen-Meyer. (2022) Inflammatory markers calprotectin, NETs, syndecan-1 and neopterin in COVID-19 convalescent blood donors. Scandinavian Journal of Clinical and Laboratory Investigation 82:6, pages 481-485.
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Ulla Bregendahl Nielsen, Laerke Valsøe Bruhn, Torkell Ellingsen, Kristian Stengaard-Pedersen & Nete Hornung. (2018) Calprotectin in patients with chronic rheumatoid arthritis correlates with disease activity and responsiveness to methotrexate. Scandinavian Journal of Clinical and Laboratory Investigation 78:1-2, pages 62-67.
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Judith Austermann, Stefanie Zenker & Johannes Roth. (2017) S100-alarmins: potential therapeutic targets for arthritis. Expert Opinion on Therapeutic Targets 21:7, pages 738-750.
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HH Nordal, JG Brun, M Hordvik, M Eidsheim, R Jonsson & A-K Halse. (2016) Calprotectin (S100A8/A9) and S100A12 are associated with measures of disease activity in a longitudinal study of patients with rheumatoid arthritis treated with infliximab. Scandinavian Journal of Rheumatology 45:4, pages 274-281.
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C. Homann, E. Christensen, P. Schlichting, E. K. Philipsen, N. A. Graudal & P. Garred. (2003) Ascites Fluid and Plasma Calprotectin Concentrations in Liver Disease. Scandinavian Journal of Gastroenterology 38:4, pages 415-420.
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John A. Olson, Marianne Forrester, Paul A. Clohessy, Barbara E. Golden, Richard Herriot & John V. Forrester. (1996) Calprotectin is raised in endogenous posterior uveitis. Ocular Immunology and Inflammation 4:2, pages 91-98.
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J. G. Brun, M. Cuida, H. Jacobsen, R. Kloster, A. C. Johannesen, H. M. Høyeraal & R. Jonsson. (1994) Sjögren's Syndrome in Inflammatory Rheumatic Diseases: Analysis of the Leukocyte Protein Calprotectin in Plasma and Saliva. Scandinavian Journal of Rheumatology 23:3, pages 114-118.
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Articles from other publishers (71)

Mari Kärki, Laura Tanner, Satu Lahtinen, Tero Soukka & Harri Niinikoski. (2023) Plasma calprotectin is extremely high in patients with lysinuric protein intolerance. JIMD Reports 64:4, pages 293-299.
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Samantha Louise Smith, Sheree Alexander, Nisha Nair, Sebastien Viatte, Stephen Eyre, Kimme L Hyrich, Ann W Morgan, Anthony G Wilson, John D Isaacs, Darren Plant & Anne Barton. (2023) Pre-treatment calprotectin (MRP8/14) provides no added value to testing CRP alone in terms of predicting response to TNF inhibitors in rheumatoid arthritis in a post hoc analysis. Annals of the Rheumatic Diseases 82:5, pages 611-620.
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Gülden Sincan, Emel Ayvaz, Fuat Erdem & Ahmet Kiziltunç. (2023) The importance of serum calprotectin level in patients with lymphoma. Iraqi Journal of Hematology 12:1, pages 98.
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José Inciarte-Mundo, Beatriz Frade-Sosa & Raimon Sanmartí. (2022) From bench to bedside: Calprotectin (S100A8/S100A9) as a biomarker in rheumatoid arthritis. Frontiers in Immunology 13.
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Nik Syazana Izyan Saffery, Krishnamurithy Genasan, Chee Ken Chan, Khairul Anwar Ayob, Seow Hui Teo, Mohamed Zubair Mohamed Al-Fayyadh, Iekhsan Othman, Syafiq Asnawi Zainal Abidin, Murali Malliga Raman, Hanumantha Rao Balaji Raghavendran & Tunku Kamarul. (2022) Typical response of CD14++CD16– monocyte to knee synovial derived mediators as a key target to overcome the onset and progression of osteoarthritis. Frontiers in Medicine 9.
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Isaac T. Cheng, Huan Meng, Martin Li, Edmund K. Li, Priscilla C. Wong, Jack Lee, Bryan P. Yan, Alex P. W. Lee, Ho So & Lai-Shan Tam. (2022) Serum Calprotectin Level Is Independently Associated With Carotid Plaque Presence in Patients With Psoriatic Arthritis. Frontiers in Medicine 9.
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Mona H. Abd Elsamea, Safaa A. Mahran, Asmaa N. Badr, Dalia T. Kamal & Tayseer M. Khidre. (2022) Evaluation of serum calprotectin level as a biomarker of disease activity in rheumatoid arthritis and osteoarthritis patients. The Egyptian Rheumatologist 44:3, pages 185-190.
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Gholam Hossein Alishiri, Ramezan Ali Ataee, Mahsa Ramezanpour, Danial Chaleshi & Ehsan Rahmanian. (2022) Correlation between Serum Levels of Calprotectin with Disease Activity in Rheumatoid Arthritis Patients. Journal of Advances in Medical and Biomedical Research 30:140, pages 263-268.
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Satoru Yui. (2022) Unintended Observations Leading to Macrophage Growth and Neutrophil Factor Research観察によって導かれたマクロファージ増殖及び好中球因子の研究. YAKUGAKU ZASSHI 142:3, pages 229-239.
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Irene Di Ceglie, Peter L. E. M. van Lent, Edwin J. W. Geven, Marije I. Koenders, Arjen B. Blom, Thomas Vogl, Johannes Roth & Martijn H. J. van den Bosch. (2021) S100A8/A9 is not essential for the development of inflammation and joint pathology in interleukin-1 receptor antagonist knockout mice. Arthritis Research & Therapy 23:1.
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Emma Altobelli, Paolo Matteo Angeletti, Reimondo Petrocelli, Giuseppe Lapergola, Giovanni Farello, Giovanni Cannataro & Luciana Breda. (2021) Serum Calprotectin a Potential Biomarker in Juvenile Idiopathic Arthritis: A Meta-Analysis. Journal of Clinical Medicine 10:21, pages 4861.
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Mauro Giuffrè, Luigi Vetrugno, Stefano Di Bella, Rita Moretti, Debora Berretti & Lory Saveria Crocè. (2021) Calprotectin and SARS-CoV-2: A Brief-Report of the Current Literature. Healthcare 9:8, pages 956.
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Ahmed R. Radwan, Ahmed Allam & Abdullah Radwan. (2021) The relationship of serum calprotectin with disease activity, functional status, ultrasonographic findings and radiological damage in rheumatoid arthritis patients. The Egyptian Rheumatologist 43:2, pages 147-151.
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Ourania S. Kotsiou, Dimitrios Papagiannis, Rodanthi Papadopoulou & Konstantinos I. Gourgoulianis. (2021) Calprotectin in Lung Diseases. International Journal of Molecular Sciences 22:4, pages 1706.
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Hui Shi, Yu Zuo, Srilakshmi Yalavarthi, Kelsey Gockman, Melanie Zuo, Jacqueline A Madison, Christopher Blair, Wrenn Woodward, Sean P Lezak, Njira L Lugogo, Robert J Woods, Christian Lood, Jason S Knight & Yogendra Kanthi. (2021) Neutrophil calprotectin identifies severe pulmonary disease in COVID-19. Journal of Leukocyte Biology 109:1, pages 67-72.
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Matthias Jarlborg, Delphine S. Courvoisier, Céline Lamacchia, Laura Martinez Prat, Michael Mahler, Chelsea Bentow, Axel Finckh, Cem Gabay & Michael J. Nissen. (2020) Serum calprotectin: a promising biomarker in rheumatoid arthritis and axial spondyloarthritis. Arthritis Research & Therapy 22:1.
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Magne Kristoffer Fagerhol, Egil Johnson, Jon‐Magnus Tangen, Ivana Hollan, Mohammad Reza Mirlashari, Lise Sofie Haug Nissen‐Meyer & Geir Hetland. (2020) NETs analysed by novel calprotectin‐based assays in blood donors and patients with multiple myeloma or rheumatoid arthritis: A pilot study. Scandinavian Journal of Immunology 91:5.
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Qin Wang, Weiqian Chen & Jin Lin. (2019) The role of calprotectin in rheumatoid arthritis. Journal of Translational Internal Medicine 7:4, pages 126-131.
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N. Jung, J.-L. Bueb, F. Tolle & S. Bréchard. (2019) Regulation of neutrophil pro-inflammatory functions sheds new light on the pathogenesis of rheumatoid arthritis. Biochemical Pharmacology 165, pages 170-180.
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Jana Hurnakova, Hana Hulejova, Jakub Zavada, Martin Komarc, Lucie Andres Cerezo, Herman Mann, Jiri Vencovsky, Karel Pavelka & Ladislav Senolt. (2018) Serum calprotectin may reflect inflammatory activity in patients with active rheumatoid arthritis despite normal to low C-reactive protein. Clinical Rheumatology 37:8, pages 2055-2062.
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Maria Karolina Jonsson, Nina Paulshus Sundlisæter, Hilde Haugedal Nordal, Hilde Berner Hammer, Anna-Birgitte Aga, Inge Christoffer Olsen, Karl Albert Brokstad, Désirée van der Heijde, Tore K Kvien, Bjørg-Tilde Svanes Fevang, Siri Lillegraven & Espen A Haavardsholm. (2017) Calprotectin as a marker of inflammation in patients with early rheumatoid arthritis. Annals of the Rheumatic Diseases 76:12, pages 2031-2037.
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Niklas Jonsson, Tom Nilsen, Patrik Gille-Johnson, Max Bell, Claes-Roland Martling, Anders Larsson & Johan Mårtensson. (2017) Calprotectin as an early biomarker of bacterial infections in critically ill patients: an exploratory cohort assessment. Critical Care and Resuscitation 19:3, pages 205-213.e2.
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Jana Hurnakova, Hana Hulejova, Jakub Zavada, Petra Hanova, Martin Komarc, Herman Mann, Martin Klein, Olga Sleglova, Marta Olejarova, Sarka Forejtova, Olga Ruzickova, Jiri Vencovsky, Karel Pavelka & Ladislav Senolt. (2017) Relationship between serum calprotectin (S100A8/9) and clinical, laboratory and ultrasound parameters of disease activity in rheumatoid arthritis: A large cohort study. PLOS ONE 12:8, pages e0183420.
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Tomohisa Kato, Hideaki Kouzaki, Koji Matsumoto, Junichi Hosoi & Takeshi Shimizu. (2017) The effect of calprotectin on TSLP and IL-25 production from airway epithelial cells. Allergology International 66:2, pages 281-289.
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Magdalena Kopeć-Mędrek, Małgorzata Widuchowska & Eugeniusz J. Kucharz. (2016) Calprotectin in rheumatic diseases: a review. Rheumatology 54:6, pages 306-309.
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Mads Abildtrup, Gabrielle H. Kingsley & David L. Scott. (2015) Calprotectin as a Biomarker for Rheumatoid Arthritis: A Systematic Review. The Journal of Rheumatology 42:5, pages 760-770.
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Ivy Y Choi, Danielle M Gerlag, Marieke J Herenius, Rogier M Thurlings, Carla A Wijbrandts, Dirk Foell, Thomas Vogl, Johannes Roth, Paul P Tak & Dirk Holzinger. (2015) MRP8/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases 74:3, pages 499-505.
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Peter Kruzliak, Jan Novák, Miroslav Novák & George J. Fodor. (2014) Role of calprotectin in cardiometabolic diseases. Cytokine & Growth Factor Reviews 25:1, pages 67-75.
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Taina Sipponen. (2013) Diagnostics and Prognostics of Inflammatory Bowel Disease with Fecal Neutrophil-Derived Biomarkers Calprotectin and Lactoferrin. Digestive Diseases 31:3-4, pages 336-344.
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