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Review Article

Unique structure and regulation of the nematode detoxification gene regulator, SKN-1: implications to understanding and controlling drug resistance

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Pages 209-223 | Received 20 Jan 2012, Accepted 10 Apr 2012, Published online: 04 Jun 2012

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Chi K. Leung, Koichi Hasegawa, Ying Wang, Andrew Deonarine, Lanlan Tang, Johji Miwa & Keith P. Choe. (2014) Direct Interaction between the WD40 Repeat Protein WDR-23 and SKN-1/Nrf Inhibits Binding to Target DNA. Molecular and Cellular Biology 34:16, pages 3156-3167.
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Chi K. Leung, Ying Wang, Andrew Deonarine, Lanlan Tang, Stephanie Prasse & Keith P. Choe. (2013) A Negative-Feedback Loop between the Detoxification/Antioxidant Response Factor SKN-1 and Its Repressor WDR-23 Matches Organism Needs with Environmental Conditions. Molecular and Cellular Biology 33:17, pages 3524-3537.
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Pauline Fontaine & Keith Choe. (2018) The transcription factor SKN-1 and detoxification gene ugt-22 alter albendazole efficacy in Caenorhabditis elegans. International Journal for Parasitology: Drugs and Drug Resistance 8:2, pages 312-319.
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Tetsunari Fukushige, Harold E Smith, Johji Miwa, Michael W Krause & John A Hanover. (2017) A Genetic Analysis of the Caenorhabditis elegans Detoxification Response . Genetics 206:2, pages 939-952.
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Cheng-Wei Wu, Ying Wang & Keith P Choe. (2017) F-Box Protein XREP-4 Is a New Regulator of the Oxidative Stress Response in Caenorhabditis elegans . Genetics 206:2, pages 859-871.
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Cheng-Wei Wu, Andrew Deonarine, Aaron Przybysz, Kevin Strange & Keith P. Choe. (2016) The Skp1 Homologs SKR-1/2 Are Required for the Caenorhabditis elegans SKN-1 Antioxidant/Detoxification Response Independently of p38 MAPK. PLOS Genetics 12:10, pages e1006361.
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Kishore K Joshi, Tarmie L Matlack & Christopher Rongo. (2016) Dopamine signaling promotes the xenobiotic stress response and protein homeostasis. The EMBO Journal 35:17, pages 1885-1901.
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Ranko Gacesa, Walter C. Dunlap, David J. Barlow, Roman A. Laskowski & Paul F. Long. (2016) Rising levels of atmospheric oxygen and evolution of Nrf2. Scientific Reports 6:1.
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Takahiro Ogawa, Yukihiro Kodera, Dai Hirata, T. Keith Blackwell & Masaki Mizunuma. (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Scientific Reports 6:1.
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Timothy A. Crombie, Lanlan Tang, Keith P. Choe & David Julian. (2016) Inhibition of the oxidative stress response by heat stress in Caenorhabditis elegans . Journal of Experimental Biology.
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Daniel Panitz, Harsha Swamy & Keith Nehrke. (2015) A C. elegans model of electronic cigarette use: Physiological effects of e-liquids in nematodes. BMC Pharmacology and Toxicology 16:1.
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Mrigank Srivastava & Shailja Misra-Bhattacharya. (2015) Overcoming drug resistance for macro parasites. Future Microbiology 10:11, pages 1783-1789.
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Satyamaheshwar Peddibhotla, Pauline Fontaine, Chi K. Leung, Patrick Maloney, Paul M. Hershberger, Ying Wang, Michelle S. Bousquet, Hendrik Luesch, Arianna Mangravita-Novo, Anthony B. Pinkerton, Layton H. Smith, Siobhan Malany & Keith Choe. (2015) Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes. ACS Chemical Biology 10:8, pages 1871-1879.
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Svitlana Kurinna & Sabine Werner. (2015) NRF2 and microRNAs: new but awaited relations. Biochemical Society Transactions 43:4, pages 595-601.
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Lanlan Tang & Keith P. Choe. (2015) Characterization of skn-1/wdr-23 phenotypes in Caenorhabditis elegans; pleiotrophy, aging, glutathione, and interactions with other longevity pathways. Mechanisms of Ageing and Development 149, pages 88-98.
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Jyoti R. Misra, Geanette Lam & Carl S. Thummel. (2013) Constitutive activation of the Nrf2/Keap1 pathway in insecticide-resistant strains of Drosophila. Insect Biochemistry and Molecular Biology 43:12, pages 1116-1124.
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Rui Wang, Daniel E. Mason, Keith P. Choe, Alfred S. Lewin, Eric C. Peters & Hendrik Luesch. (2013) In Vitro and in Vivo Characterization of a Tunable Dual-Reactivity Probe of the Nrf2-ARE Pathway . ACS Chemical Biology 8:8, pages 1764-1774.
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Chi K. Leung, Ying Wang, Siobhan Malany, Andrew Deonarine, Kevin Nguyen, Stefan Vasile & Keith P. Choe. (2013) An Ultra High-Throughput, Whole-Animal Screen for Small Molecule Modulators of a Specific Genetic Pathway in Caenorhabditis elegans. PLoS ONE 8:4, pages e62166.
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