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Ayaka Kojima, Masayuki Nadai, Norie Murayama, Hiroshi Yamazaki & Miki Katoh. (2022) Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2. Xenobiotica 52:7, pages 669-675.
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Xiangge Tian, Meirong Zhou, Jing Ning, Xiaopeng Deng, Lei Feng, Huilian Huang, Dahong Yao & Xiaochi Ma. (2021) The development of novel cytochrome P450 2J2 (CYP2J2) inhibitor and the underlying interaction between inhibitor and CYP2J2. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 737-748.
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Articles from other publishers (67)
Yousef M. Al-saraireh, Fatemah O. F. O. Alshammari, Omar H. Abu-azzam, Sa’ed M. Al-dalain, Yahya M. Al-sarayra, Mansour Haddad, Hafiz Makeen, Aiman Al-Qtaitat, Mohammad Almermesh & Sameeh A. Al-sarayreh. (2023) Targeting Cytochrome P450 Enzymes in Ovarian Cancers: New Approaches to Tumor-Selective Intervention. Biomedicines 11:11, pages 2898.
Crossref
Crossref
Han Ki Lee, Subin Bae, Jongsung Lee, Hyo Sun Cha, Myeong Jin Nam, Jongbok Lee, Kyungmoon Park, Yung-Hun Yang, Kyu Yun Jang, Kwang-Hyeon Liu & See-Hyoung Park. (2023) Bilobetin induces apoptosis in human hepatocellular carcinoma cells via ROS level elevation and inhibition of CYP2J2. Arabian Journal of Chemistry 16:9, pages 105094.
Crossref
Crossref
Jingwei Zhang, Zhixia Qiu, Yongjie Zhang, Guangji Wang & Haiping Hao. (2023) Intracellular spatiotemporal metabolism in connection to target engagement. Advanced Drug Delivery Reviews 200, pages 115024.
Crossref
Crossref
Yanfang Zhang, Jian Lu, Shengbo Huang, Yuanjin Zhang, Jie Liu, Yuan Xu, Bingyi Yao & Xin Wang. (2023) CYP2J deficiency leads to cardiac injury and presents dual regulatory effects on cardiac function in rats. Toxicology and Applied Pharmacology 473, pages 116610.
Crossref
Crossref
Cándido Ortiz-Placín, Alba Castillejo-Rufo, Matías Estarás & Antonio González. (2023) Membrane Lipid Derivatives: Roles of Arachidonic Acid and Its Metabolites in Pancreatic Physiology and Pathophysiology. Molecules 28:11, pages 4316.
Crossref
Crossref
Jinrui Liu, Wenfei Xie, Jinyu Mei, Fangkai Du, Xuecai Tan & Shaogang Liu. (2023) Real-time tracking of endogenous CYP2J2 by red-emitting aggregation-induced emission probe with large Stokes shift. Dyes and Pigments 213, pages 111189.
Crossref
Crossref
Yue Li, Cuiping You, Zhenchuan Liu, Feng He, Fuchun Zhao, Xiaojie Song, Zhongxiang Xie, Shuai Wei, Yongfang Yang, Hongyan Wei, Fengyuan Che & Jixu Yu. (2023) CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage. Journal of Stroke and Cerebrovascular Diseases 32:3, pages 106974.
Crossref
Crossref
Audrey Barranger, Christophe Klopp, Barbara Le Bot, Gaëlle Saramito, Lise Dupont, Stéphanie Llopis, Claudia Wiegand & Françoise Binet. (2023) Insights into the molecular mechanisms of pesticide tolerance in the Aporrectodea caliginosa earthworm. Environmental Pollution 319, pages 120945.
Crossref
Crossref
Yanfang Zhang, Liangcai Gao, Bingyi Yao, Shengbo Huang, Yuanjin Zhang, Jie Liu, Zongjun Liu & Xin Wang. (2022) Role of epoxyeicosatrienoic acids in cardiovascular diseases and cardiotoxicity of drugs. Life Sciences 310, pages 121122.
Crossref
Crossref
Yasuhiro Uno, Norie Murayama, Moe Ijiri, Hiroaki Kawaguchi, Osamu Yamato, Mitsuya Shiraishi, Atsushi Asano, Hiroki Teraoka, Hazuki Mizukawa, Shouta M.M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka & Hiroshi Yamazaki. (2022)
Cytochrome
P450 2J
Genes Are Expressed in Dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes
. Drug Metabolism and Disposition 50:11, pages 1434-1441.
Crossref
Crossref
Hamisha Salim & Alan M. Jones. (2022) Angiotensin II receptor blockers (ARBs) and manufacturing contamination: A retrospective National Register Study into suspected associated adverse drug reactions. British Journal of Clinical Pharmacology 88:11, pages 4812-4827.
Crossref
Crossref
Daniel S. Graciaa, Maia Kipiani, Matthew J. Magee, Lali Mikiashvili, Ketevan Barbakadze, Nino Bablishvili, Sara C. Auld, Wael A. Alghamdi, Mohammad H. Alshaer, Charles A. Peloquin, Zaza Avaliani, Henry M. Blumberg & Russell R. Kempker. (2022) Linezolid Exposure Is Associated with Cytopenias in Patients Treated for Multidrug-Resistant Tuberculosis. Antimicrobial Agents and Chemotherapy 66:9.
Crossref
Crossref
Heui Min Lim, Jongsung Lee, Seon Hak Yu, Myeong Jin Nam, Hyo Sun Cha, Kyungmoon Park, Yung-Hun Yang, Kyu Yun Jang & See-Hyoung Park. (2022) Acetylshikonin, A Novel CYP2J2 Inhibitor, Induces Apoptosis in RCC Cells via FOXO3 Activation and ROS Elevation. Oxidative Medicine and Cellular Longevity 2022, pages 1-20.
Crossref
Crossref
Jan Manousek, Petr Kala, Petr Lokaj, Tomas Ondrus, Katerina Helanova, Marie Miklikova, Vojtech Brazdil, Marie Tomandlova, Jiri Parenica, Monika Pavkova Goldbergova & Jiri Hlasensky. (2021) Oxidative Stress in Takotsubo Syndrome—Is It Essential for an Acute Attack? Indirect Evidences Support Multisite Impact Including the Calcium Overload—Energy Failure Hypothesis. Frontiers in Cardiovascular Medicine 8.
Crossref
Crossref
Jacqueline Wen Hui Leow, Ravi Kumar Verma, Amos Boon Hao Lim, Hao Fan & Eric Chun Yong Chan. (2021) Atypical kinetics of cytochrome P450 2J2: Epoxidation of arachidonic acid and reversible inhibition by xenobiotic inhibitors. European Journal of Pharmaceutical Sciences 164, pages 105889.
Crossref
Crossref
Daniela Fanni, Federica Pinna, Clara Gerosa, Pasquale Paribello, Bernardo Carpiniello, Gavino Faa & Mirko Manchia. (2021)
Anatomical distribution and expression of
CYP
in humans: Neuropharmacological implications
. Drug Development Research 82:5, pages 628-667.
Crossref
Crossref
Bei Wang, Lujin Wu, Jing Chen, Lingli Dong, Chen Chen, Zheng Wen, Jiong Hu, Ingrid Fleming & Dao Wen Wang. (2021) Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets. Signal Transduction and Targeted Therapy 6:1.
Crossref
Crossref
Kevin M. Johnson, Dian Su & Donglu Zhang. 2021. Cytochrome P450. Cytochrome P450
27
54
.
Jian Lu, Ang Chen, Xinrun Ma, Xuyang Shang, Yuanjin Zhang, Yuanqing Guo, Mingyao Liu & Xin Wang. (2020) Generation and Characterization of Cytochrome P450 2J3/10 CRISPR/Cas9 Knockout Rat Model. Drug Metabolism and Disposition 48:11, pages 1129-1136.
Crossref
Crossref
Aditi Das, Austin T. Weigle, William R. Arnold, Justin S. Kim, Lauren N. Carnevale & Hannah C. Huff. (2020) CYP2J2 Molecular Recognition: A New Axis for Therapeutic Design. Pharmacology & Therapeutics 215, pages 107601.
Crossref
Crossref
Ying Luo & Jun-Yan Liu. (2020) Pleiotropic Functions of Cytochrome P450 Monooxygenase-Derived Eicosanoids in Cancer. Frontiers in Pharmacology 11.
Crossref
Crossref
Rasa Liutkeviciene, Alvita Vilkeviciute, Roman Botov, Olga Botova, Dovile Buteikiene & Loresa Kriauciuniene. (2020) Associations between CYP2J2 (-76G>T) rs890293 polymorphism and age-related macular degeneration. Biomedical Papers 164:3, pages 267-272.
Crossref
Crossref
Marco Sisignano, Dieter Steinhilber, Michael J. Parnham & Gerd Geisslinger. (2020) Exploring CYP2J2: lipid mediators, inhibitors and therapeutic implications. Drug Discovery Today 25:9, pages 1744-1753.
Crossref
Crossref
Eric A. Evangelista, Christi W. Cho, Theresa Aliwarga & Rheem A. Totah. (2020) Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors. Frontiers in Pharmacology 11.
Crossref
Crossref
Xin Yang, Shun DengXuegao WeiJing YangQiannan ZhaoCheng YinTianhua DuZhaojiang GuoJixing XiaZezhong YangWen XieShaoli WangQingjun WuFengshan YangXuguo ZhouRalf NauenChris Bass & Youjun Zhang. (2020)
MAPK-directed activation of the whitefly transcription factor
CREB
leads to P450-mediated imidacloprid resistance
. Proceedings of the National Academy of Sciences 117:19, pages 10246-10253.
Crossref
Crossref
Stephan M.G. Schäfer, Maksim Sendetski, Carlo Angioni, Rolf Nüsing, Gerd Geisslinger, Klaus Scholich & Marco Sisignano. (2020) The omega-3 lipid 17,18-EEQ sensitizes TRPV1 and TRPA1 in sensory neurons through the prostacyclin receptor (IP). Neuropharmacology 166, pages 107952.
Crossref
Crossref
Yasuhiro Uno & Hiroshi Yamazaki. (2020) mRNA levels of drug-metabolizing enzymes in 11 brain regions of cynomolgus macaques. Drug Metabolism and Pharmacokinetics 35:2, pages 248-252.
Crossref
Crossref
Jian Lu, Xuyang Shang, Weiguo Zhong, Yuan Xu, Rong Shi & Xin Wang. (2020) New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases. Acta Pharmaceutica Sinica B 10:1, pages 91-104.
Crossref
Crossref
Yıldız Hayran, Nuran Allı, Pınar İncel Uysal & Tuba Çandar. (2020) Association of CYP2J2 polymorphism with susceptibility to psoriasis in Turkish population: a case–control study. Anais Brasileiros de Dermatologia 95:1, pages 25-31.
Crossref
Crossref
Kraisiri Khidkhan, Hazuki Mizukawa, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kei Nomiyama, Nozomu Yokoyama, Osamu Ichii, Wageh Sobhy Darwish, Mitsuyoshi Takiguchi, Shinsuke Tanabe & Mayumi Ishizuka. (2019) Tissue distribution and characterization of feline cytochrome P450 genes related to polychlorinated biphenyl exposure. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 226, pages 108613.
Crossref
Crossref
Tabea Osthues & Marco Sisignano. (2019) Oxidized Lipids in Persistent Pain States. Frontiers in Pharmacology 10.
Crossref
Crossref
Sophie Gravel, Benoit Panzini, Francois Belanger, Jacques Turgeon & Veronique Michaud. (2019) A Pilot Study towards the Impact of Type 2 Diabetes on the Expression and Activities of Drug Metabolizing Enzymes and Transporters in Human Duodenum. International Journal of Molecular Sciences 20:13, pages 3257.
Crossref
Crossref
Alaattin Sen & Holger Stark. (2019) Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis. World Journal of Gastroenterology 25:23, pages 2846-2862.
Crossref
Crossref
Noriaki Ikemura, Satoshi Yamaori, Chinatsu Kobayashi, Shinobu Kamijo, Norie Murayama, Hiroshi Yamazaki & Shigeru Ohmori. (2019) Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by azelnidipine and manidipine. Chemico-Biological Interactions 306, pages 1-9.
Crossref
Crossref
Loaa A. Tag Eldeen, Marow El Sheikh & Salwa Faisal. (2018) The expression of cytochrome P4502J2 gene and 14, 15 epoxyeicosatrienoic acid level influence the amount of insulin secreted from human mesenchymal stem cell-derived insulin-producing cells. Bulletin of the National Research Centre 42:1.
Crossref
Crossref
Shu Yang, Jinping Hu, Yan Li & Zhigang Zhao. (2018)
CYP2J2 is the major enzyme in human liver microsomes responsible for hydroxylation of SYL-927, a novel and selective sphingosine 1-phosphate receptor 1 (S1P
1
) agonist
. Biopharmaceutics & Drug Disposition 39:9, pages 431-436.
Crossref
Crossref
Mayelín Domínguez-González, Meritxell Puigpinós, Mariona Jové, Alba Naudi, Manuel Portero-Otín, Reinald Pamplona & Isidro Ferrer. (2018) Regional vulnerability to lipoxidative damage and inflammation in normal human brain aging. Experimental Gerontology 111, pages 218-228.
Crossref
Crossref
Meetal Solanki, Amy Pointon, Barry Jones & Karl Herbert. (2018) Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity. Drug Metabolism and Disposition 46:8, pages 1053-1065.
Crossref
Crossref
Pierre Lafite, François André, Joan Graves, Darryl Zeldin, Patrick Dansette & Daniel Mansuy. (2018) Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2. International Journal of Molecular Sciences 19:7, pages 2066.
Crossref
Crossref
Hsia-lien Lin, Haoming Zhang & Paul F. Hollenberg. (2018)
Formation of Both Heme and Apoprotein Adducts Contributes to the Mechanism-Based Inactivation of Human CYP2J2 by 17
α
-Ethynylestradiol
. Drug Metabolism and Disposition 46:6, pages 813-822.
Crossref
Crossref
Mei-juan Xu, Li-feng Jiang, Ting Wu, Ji-hong Chu, Yi-dan Wei, Ji-ye Aa, Guang-ji Wang, Hai-ping Hao, Wen-zheng Ju & Ping Li. (2018) Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2. Chemico-Biological Interactions 289, pages 15-22.
Crossref
Crossref
Dabin Jeong, Hyoung-Goo Park, Young-Ran Lim, Yejin Lee, Vitchan Kim, Myung-A. Cho & Donghak Kim. (2018) Terfenadine metabolism of human cytochrome P450 2J2 containing genetic variations (G312R, P351L and P115L). Drug Metabolism and Pharmacokinetics 33:1, pages 61-66.
Crossref
Crossref
Jian Lu, Daozhi Liu, Xiaojing Zhou, Ang Chen, Zhenran Jiang, Xiyun Ye, Mingyao Liu & Xin Wang. (2018) Plant natural product plumbagin presents potent inhibitory effect on human cytochrome P450 2J2 enzyme. Phytomedicine 39, pages 137-145.
Crossref
Crossref
K.K. Wolf & M.F. Paine. 2018. Comprehensive Toxicology. Comprehensive Toxicology
74
98
.
X. Ding, L. Li, L.S. Van Winkle & Q.-Y. Zhang. 2018. Comprehensive Toxicology. Comprehensive Toxicology
171
193
.
E.A. Lock & D.J. Antoine. 2018. Comprehensive Toxicology. Comprehensive Toxicology
30
55
.
Jian Chen, Dong-Fei Wang, Guo-Dong Fu, Jie Ding, Lei-Yang Chen, Jia-Lan Lv, Juan Fang, Xiang Yin & Xiao-Gang Guo. (2017)
Meta-analysis of the association of the
CYP2J2
G-50T polymorphism with coronary artery disease
. Oncotarget 8:35, pages 59618-59627.
Crossref
Crossref
Aneesh Karkhanis, Yanjun Hong & Eric Chun Yong Chan. (2017) Inhibition and inactivation of human CYP2J2: Implications in cardiac pathophysiology and opportunities in cancer therapy. Biochemical Pharmacology 135, pages 12-21.
Crossref
Crossref
Mingzhou Liu, Quanfei Zhu, Jinhua Wu, Xuming Yu, Mingbai Hu, Xianfei Xie, Zheqiong Yang, Jing Yang, Yu-Qi Feng & Jiang Yue. (2017) Glutamate affects the production of epoxyeicosanoids within the brain: The up-regulation of brain CYP2J through the MAPK-CREB signaling pathway. Toxicology 381, pages 31-38.
Crossref
Crossref
Shuang Geng, Yutong Wang, Yongmei Sun, Jinfeng Li, Honglei Yin, Zhilei Zeng, Xiaopeng Yang, Yuzhen Zhang & Yunliang Wang. (2017) Gene- gene interaction between CYP2J2 and PPAR -? gene on late-onset Alzheimer?s disease in the eastern Chinese Han population. Behavioural Brain Research 322, pages 362-367.
Crossref
Crossref
G. Proietti, K. K. Abelak, D. Bishop-Bailey, A. Macchiarulo & I. Nobeli. (2016) Computational modelling of the binding of arachidonic acid to the human monooxygenase CYP2J2. Journal of Molecular Modeling 22:11.
Crossref
Crossref
Fang Xie, Xinxin Ding & Qing-Yu Zhang. (2016) An update on the role of intestinal cytochrome P450 enzymes in drug disposition. Acta Pharmaceutica Sinica B 6:5, pages 374-383.
Crossref
Crossref
R. S. Foti & D. K. Dalvie. (2016) Cytochrome P450 and Non-Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics. Drug Metabolism and Disposition 44:8, pages 1229-1245.
Crossref
Crossref
Shufeng Zhou. 2016. Cytochrome P450 2D6. Cytochrome P450 2D6
1
100
.
Alan Polnariev. 2016. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions
143
151
.
Furong Zhang, Xuming Yu, Chunyan He, Xiufang Ouyang, Jinhua Wu, Jie Li, Junjie Zhang, Xuejiao Duan, Yu Wan & Jiang Yue. (2015) Effects of sexually dimorphic growth hormone secretory patterns on arachidonic acid metabolizing enzymes in rodent heart. Toxicology and Applied Pharmacology 289:3, pages 495-506.
Crossref
Crossref
Huacheng Yan, Yanying Kong, Baoxia He, Mukun Huang, Jian Li, Jiaqiang Zheng, Lei Liang, Jianjun Bi, Shujin Zhao & Lei Shi. (2015) CYP2J2 rs890293 polymorphism is associated with susceptibility to Alzheimer?s disease in the Chinese Han population. Neuroscience Letters 593, pages 56-60.
Crossref
Crossref
Hemantkumar Chavan, Feng Li, Robert Tessman, Kristen Mickey, Kenneth Dorko, Timothy Schmitt, Sean Kumer, Sumedha Gunewardena, Nilesh Gaikwad & Partha Krishnamurthy. (2015) Functional Coupling of ATP-binding Cassette Transporter Abcb6 to Cytochrome P450 Expression and Activity in Liver. Journal of Biological Chemistry 290:12, pages 7871-7886.
Crossref
Crossref
Aiyuan Guo, Wu Zhu, Chong Zhang, Shu Wen, Xiaoping Chen, Mingliang Chen, Jianglin Zhang, Juan Su, Wangqing Chen, Yue Zhao, Siyu Yan, Yijing He, Zhaoqian Liu, Honghao Zhou, Xiang Chen & Jie Li. (2014) Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients. Archives of Dermatological Research 307:2, pages 183-190.
Crossref
Crossref
Alan Polnariev. 2015. A worldwide yearly survey of new data in adverse drug reactions. A worldwide yearly survey of new data in adverse drug reactions
185
194
.
Chen Chen & Dao Wen Wang. 2015. Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer. Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer
193
221
.
Laura L. Maurer & Martin A. Philbert. 2015. Occupational Neurology. Occupational Neurology
61
70
.
F. Peter Guengerich. 2015. Cytochrome P450. Cytochrome P450
523
785
.
Rüdiger Kaspera, Brian J. Kirby, Tariku Sahele, Ann C. Collier, Evan D. Kharasch, Jashvant D. Unadkat & Rheem A. Totah. (2014) Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo. Biochemical Pharmacology 91:1, pages 109-118.
Crossref
Crossref
Ahmad Al Ali, David Touboul, Jean-Pierre Le Caër, Isabelle Schmitz-Afonso, Jean-Pierre Flinois, Catherine Marchetti, Isabelle De Waziers, Alain Brunelle, Olivier Laprévote & Philippe Beaune. (2014) Optimization and validation of a label-free MRM method for the quantification of cytochrome P450 isoforms in biological samples. Analytical and Bioanalytical Chemistry 406:20, pages 4861-4874.
Crossref
Crossref
Elisabeth M. Hersman & Namandjé N. Bumpus. (2014) A Targeted Proteomics Approach for Profiling Murine Cytochrome P450 Expression. Journal of Pharmacology and Experimental Therapeutics 349:2, pages 221-228.
Crossref
Crossref
Hyoung-Goo Park, Young-Ran Lim, Songhee Han & Donghak Kim. (2014) Expression and Characterization of Truncated Recombinant Human Cytochrome P450 2J2. Toxicological Research 30:1, pages 33-38.
Crossref
Crossref