1,445
Views
55
CrossRef citations to date
0
Altmetric
Review Article

Extrahepatic metabolism at the body's internal–external interfaces

, , , , , , , , , , , & show all
Pages 291-324 | Received 22 Aug 2013, Accepted 11 Feb 2014, Published online: 25 Mar 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Omozojie P. Aigbogun, Chukwunonso K. Nwabufo, Madeline N. Owens, Kevin J. H. Allen, Jeremy S. Lee, Christopher P. Phenix & Ed S. Krol. (2022) An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds. Xenobiotica 52:8, pages 916-927.
Read now
Risto O. Juvonen, Elmeri M. Jokinen, Juhani Huuskonen, Olli Kärkkäinen, Hannu Raunio & Olli T. Pentikäinen. (2021) Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13. Xenobiotica 51:11, pages 1207-1216.
Read now
Zachary Enlo-Scott, Erica Bäckström, Ian Mudway & Ben Forbes. (2021) Drug metabolism in the lungs: opportunities for optimising inhaled medicines. Expert Opinion on Drug Metabolism & Toxicology 17:5, pages 611-625.
Read now
Olga Antonova, Blaga Rukova, Boris Mladenov, Simeon Rangelov, Zora Hammoudeh, Desislava Nesheva, Rada Staneva, Viktoria Spasova, Evgeni Grigorov, Savina Hadjidekova, Chavdar Slavov & Draga Toncheva. (2020) Expression profiling of muscle invasive and non-invasive bladder tumors for biomarkers identification related to drug resistance, sensitivity and tumor progression. Biotechnology & Biotechnological Equipment 34:1, pages 506-514.
Read now
Yildiz Yilmaz, Gareth Williams, Nenad Manevski, Markus Walles, Stephan Krähenbühl & Gian Camenisch. (2019) Functional assessment of rat pulmonary flavin-containing monooxygenase activity. Xenobiotica 49:5, pages 503-512.
Read now
Sabine Plöttner, Lilian Annika Bastian, Heiko Udo Käfferlein & Thomas Brüning. (2016) Effects of benzo[a]pyrene, aromatic amines, and a combination of both on CYP1A1 activities in RT-4 human bladder papilloma cells. Journal of Toxicology and Environmental Health, Part A 79:22-23, pages 1106-1117.
Read now
Liudmila Korkina. (2016) Metabolic and redox barriers in the skin exposed to drugs and xenobiotics. Expert Opinion on Drug Metabolism & Toxicology 12:4, pages 377-388.
Read now

Articles from other publishers (48)

Julie Nilles, Johanna Weiss, Max Sauter, Walter E. Haefeli, Stephanie Ruez & Dirk Theile. (2023) Comprehensive in vitro analysis evaluating the variable drug–drug interaction risk of rifampicin compared to rifabutin. Archives of Toxicology 97:8, pages 2219-2230.
Crossref
Piyush Pradeep Mehta & Vividha Dhapte-Pawar. 2023. Pulmonary Drug Delivery Systems: Material and Technological Advances. Pulmonary Drug Delivery Systems: Material and Technological Advances 399 437 .
Arduino A. Mangoni & Elzbieta A. Jarmuzewska. 2023. Optimizing Pharmacotherapy in Older Patients. Optimizing Pharmacotherapy in Older Patients 3 14 .
Qiaoying Chen, Shujun Yi, Qingqing Ye, Yumin Zhu, Wenjue Zhong & Lingyan Zhu. (2022) Insights into the Dermal Absorption, Deposition, and Elimination of Poly- and Perfluoroalkyl Substances in Rats: The Importance of Skin Exposure. Environmental Science & Technology 56:23, pages 16975-16984.
Crossref
Jacklyn Kelty, Nataliia Kovalchuk, Eric Uwimana, Lei Yin, Xinxin Ding & Laura Van Winkle. (2022) In vitro airway models from mice, rhesus macaques, and humans maintain species differences in xenobiotic metabolism and cellular responses to naphthalene. American Journal of Physiology-Lung Cellular and Molecular Physiology 323:3, pages L308-L328.
Crossref
Julia Buchmueller, Florian Kaltner, Christoph Gottschalk, Maria Maares, Albert Braeuning & Stefanie Hessel-Pras. (2022) Structure-Dependent Toxicokinetics of Selected Pyrrolizidine Alkaloids In Vitro. International Journal of Molecular Sciences 23:16, pages 9214.
Crossref
A’edah Abu-Bakar, Boon Hooi Tan, Hasseri Halim, Salfarina Ramli, Yan Pan & Chin Eng Ong. (2022) Cytochromes P450: Role in Carcinogenesis and Relevance to Cancers. Current Drug Metabolism 23:5, pages 355-373.
Crossref
Muhammad Mohiuddin Alamgir, Qamar Jamal & Talat Mirza. (2022) Gene-gene and gene-environment interaction: an important predictor of oral cancer among smokeless tobacco users in Karachi. Journal of the Pakistan Medical Association 72:3, pages 477-482.
Crossref
Margaret O. James. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 563 584 .
Ji-Eun Seo, Kelly Davis, Pritpal Malhi, Xiaobo He, Matthew Bryant, John Talpos, Susan Burks, Nan Mei & Xiaoqing Guo. (2021) Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta). Toxicology 462, pages 152936.
Crossref
Arduino A. Mangoni & Elzbieta A. Jarmuzewska. (2021) Incorporating pharmacokinetic data into personalised prescribing for older people: challenges and opportunities. European Geriatric Medicine 12:3, pages 435-442.
Crossref
Marie Shinohara, Hiroshi Arakawa, Yuuichi Oda, Nobuaki Shiraki, Shinji Sugiura, Takumi Nishiuchi, Taku Satoh, Keita Iino, Sylvia Leo, Yusuke Kato, Karin Araya, Takumi Kawanishi, Tomoki Nakatsuji, Manami Mitsuta, Kosuke Inamura, Tomomi Goto, Kenta Shinha, Wataru Nihei, Kikuo Komori, Masaki Nishikawa, Shoen Kume, Yukio Kato, Toshiyuki Kanamori, Yasuyuki Sakai & Hiroshi Kimura. (2021) Coculture with hiPS-derived intestinal cells enhanced human hepatocyte functions in a pneumatic-pressure-driven two-organ microphysiological system. Scientific Reports 11:1.
Crossref
Tomasz M. Karpiński, Artur Adamczak & Marcin Ożarowski. (2021) Radioprotective Effects of Plants from the Lamiaceae Family. Anti-Cancer Agents in Medicinal Chemistry 22:1, pages 4-19.
Crossref
Ingrid Kratzer, Joakim Ek & Helen Stolp. (2020) The molecular anatomy and functions of the choroid plexus in healthy and diseased brain. Biochimica et Biophysica Acta (BBA) - Biomembranes 1862:11, pages 183430.
Crossref
Muna Ibrahim, Erin M. MacFarlane, Geronimo Matteo, Myriam P. Hoyeck, Kayleigh R. C. Rick, Salar Farokhi, Catherine M. Copley, Shannon O’Dwyer & Jennifer E. Bruin. (2019) Functional cytochrome P450 1A enzymes are induced in mouse and human islets following pollutant exposure. Diabetologia 63:1, pages 162-178.
Crossref
Kelli Gerth, Sunitha Kodidela, Madeline Mahon, Sanjana Haque, Neha Verma & Santosh Kumar. (2019) Circulating Extracellular Vesicles Containing Xenobiotic Metabolizing CYP Enzymes and Their Potential Roles in Extrahepatic Cells Via Cell–Cell Interactions. International Journal of Molecular Sciences 20:24, pages 6178.
Crossref
F. Oesch, E. Fabian & Robert Landsiedel. (2019) Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models. Archives of Toxicology 93:12, pages 3419-3489.
Crossref
Anja Fritz, Diana Busch, Joanna Lapczuk, Marek Ostrowski, Marek Drozdzik & Stefan Oswald. (2018) Expression of clinically relevant drug‐metabolizing enzymes along the human intestine and their correlation to drug transporters and nuclear receptors: An intra‐subject analysis. Basic & Clinical Pharmacology & Toxicology 124:3, pages 245-255.
Crossref
Eric Fabian, Caroline Gomes, Barbara Birk, Tabitha Williford, Tzutzuy Ramirez Hernandez, Christian Haase, Rene Zbranek, Bennard van Ravenzwaay & Robert Landsiedel. (2018) In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds. Archives of Toxicology 93:2, pages 401-416.
Crossref
Ondřej Zapletal, Jiřina Procházková, Vít Dubec, Jiřina Hofmanová, Alois Kozubík & Jan Vondráček. (2019) Butyrate interacts with benzo[a]pyrene to alter expression and activities of xenobiotic metabolizing enzymes involved in metabolism of carcinogens within colon epithelial cell models. Toxicology 412, pages 1-11.
Crossref
Rabindra Tirouvanziam. 2019. The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine. The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine 123 135 .
Piyush Bajaj, Swapan K. Chowdhury, Robert Yucha, Edward J. Kelly & Guangqing Xiao. (2018) Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics. Drug Metabolism and Disposition 46:11, pages 1692-1702.
Crossref
. 2018. Toxicology and Risk Assessment. Toxicology and Risk Assessment 221 387 .
Frances C. Shaffo, Ana Cristina Grodzki, Allison D. Fryer & Pamela J. Lein. (2018) Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma. American Journal of Physiology-Lung Cellular and Molecular Physiology 315:4, pages L485-L501.
Crossref
Kyeong-Nam Yu, Soo-Yeon Kang, Stephen Hong & Moo-Yeal Lee. (2018) High-throughput metabolism-induced toxicity assays demonstrated on a 384-pillar plate. Archives of Toxicology 92:8, pages 2501-2516.
Crossref
F. Oesch, E. Fabian & Robert Landsiedel. (2018) Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models. Archives of Toxicology 92:8, pages 2411-2456.
Crossref
Liudmila Korkina, Vladimir Kostyuk, Alla Potapovich, Wolfgang Mayer, Nigma Talib & Chiara De Luca. (2018) Secondary Plant Metabolites for Sun Protective Cosmetics: From Pre-Selection to Product Formulation. Cosmetics 5:2, pages 32.
Crossref
Simon C. Baker, Volker M. Arlt, Radek Indra, Madeleine Joel, Marie Stiborová, Ian Eardley, Niaz Ahmad, Wolfgang Otto, Maximilian Burger, Peter Rubenwolf, David H. Phillips & Jennifer Southgate. (2018) Differentiation‐associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic‐metabolizing activity of “luminal” muscle‐invasive bladder cancers. Molecular Carcinogenesis 57:5, pages 606-618.
Crossref
Ingrid Kratzer, Nathalie Strazielle, Elodie Saudrais, Kati Mönkkönen, Céline Malleval, Sandrine Blondel & Jean-François Ghersi-Egea. (2018) Glutathione Conjugation at the Blood–CSF Barrier Efficiently Prevents Exposure of the Developing Brain Fluid Environment to Blood-Borne Reactive Electrophilic Substances. The Journal of Neuroscience 38:14, pages 3466-3479.
Crossref
Frank Toner, Graham Allan, Stephen S. Dimond, John M. WaechterJrJr & Dieter Beyer. (2018) In vitro percutaneous absorption and metabolism of Bisphenol A (BPA) through fresh human skin. Toxicology in Vitro 47, pages 147-155.
Crossref
K.K. Wolf & M.F. Paine. 2018. Comprehensive Toxicology. Comprehensive Toxicology 74 98 .
David E. Lefebvre, Nikia Ross, Andrea L. Kocmarek, Simon Cowell, Shelley Dai, Cunye Qiao, Ivan Curran, Terry Koerner, Genevieve S. Bondy & Jason H. Fine. (2017) In vitro immunomodulation of splenocytes from DO11.10 mice by the food colouring agent amaranth. Food and Chemical Toxicology 110, pages 395-401.
Crossref
Ond?ej Zapletal, Zuzana Tylichov?Ji?? Ne?a, Ji?? Kohoutek, Miroslav Machala, Alena Milcov?Michaela Pokorn?Jan Topinka, Mary Pat Moyer, Ji?ina Hofmanov?Alois Kozub?k & Jan Vondr??ek. (2016) Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models. Archives of Toxicology 91:5, pages 2135-2150.
Crossref
Michael Fasullo, Julian Freedland, Nicholas St. John, Cinzia Cera, Patricia Egner, Matthew Hartog & Xinxin Ding. (2017) An in vitro system for measuring genotoxicity mediated by human CYP3A4 in Saccharomyces cerevisiae . Environmental and Molecular Mutagenesis 58:4, pages 217-227.
Crossref
B. Blömeke. 2017. Das Toxikologiebuch. Das Toxikologiebuch 329 344 .
Jia-Ching Wu, Ching-Shu Lai, Mei-Ling Tsai, Chi-Tang Ho, Ying-Jan Wang & Min-Hsiung Pan. (2017) Chemopreventive effect of natural dietary compounds on xenobiotic-induced toxicity. Journal of Food and Drug Analysis 25:1, pages 176-186.
Crossref
Vibeke Hougaard Sunesen. 2016. Metabolite Safety in Drug Development. Metabolite Safety in Drug Development 177 211 .
Kenji Matsui. (2016) A portion of plant airborne communication is endorsed by uptake and metabolism of volatile organic compounds. Current Opinion in Plant Biology 32, pages 24-30.
Crossref
Tom T. G. Nieskens, Janny G. P. Peters, Marieke J. Schreurs, Niels Smits, Rob Woestenenk, Katja Jansen, Thom K. van der Made, Melanie Röring, Constanze Hilgendorf, Martijn J Wilmer & Rosalinde Masereeuw. (2016) A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity. The AAPS Journal 18:2, pages 465-475.
Crossref
Matthew A. Ladda & Kerry B. Goralski. (2016) The Effects of CKD on Cytochrome P450–Mediated Drug Metabolism. Advances in Chronic Kidney Disease 23:2, pages 67-75.
Crossref
Martijn J. Wilmer, Chee Ping Ng, Henriëtte L. Lanz, Paul Vulto, Laura Suter-Dick & Rosalinde Masereeuw. (2016) Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening. Trends in Biotechnology 34:2, pages 156-170.
Crossref
Andrea Mattarei, Michele Azzolini, Mario Zoratti, Lucia Biasutto & Cristina Paradisi. (2015) N-Monosubstituted Methoxy-oligo(ethylene glycol) Carbamate Ester Prodrugs of Resveratrol. Molecules 20:9, pages 16085-16102.
Crossref
Robert S. Foti, Rachel F. Tyndale, Kristine L. P. Garcia, Douglas H. Sweet, Swati Nagar, Satish Sharan & Dan A. Rock. (2015) “Target-Site” Drug Metabolism and Transport. Drug Metabolism and Disposition 43:8, pages 1156-1168.
Crossref
Guillaume Margaillan, Michèle Rouleau, John K. Fallon, Patrick Caron, Lyne Villeneuve, Véronique Turcotte, Philip C. Smith, Melanie S. Joy & Chantal Guillemette. (2015) Quantitative Profiling of Human Renal UDP-glucuronosyltransferases and Glucuronidation Activity: A Comparison of Normal and Tumoral Kidney Tissues. Drug Metabolism and Disposition 43:4, pages 611-619.
Crossref
Nenad Manevski, Piet Swart, Kamal Kumar Balavenkatraman, Barbara Bertschi, Gian Camenisch, Olivier Kretz, Hilmar Schiller, Markus Walles, Barbara Ling, Reto Wettstein, Dirk J. Schaefer, Peter Itin, Joanna Ashton-Chess, Francois Pognan, Armin Wolf & Karine Litherland. (2015) Phase II Metabolism in Human Skin: Skin Explants Show Full Coverage for Glucuronidation, Sulfation, N -Acetylation, Catechol Methylation, and Glutathione Conjugation . Drug Metabolism and Disposition 43:1, pages 126-139.
Crossref
Mohamed Abou-Elwafa Abdallah, Gopal Pawar & Stuart Harrad. (2015) Evaluation of in vitro vs. in vivo methods for assessment of dermal absorption of organic flame retardants: A review. Environment International 74, pages 13-22.
Crossref
Nenad Manevski, Kamal Kumar Balavenkatraman, Barbara Bertschi, Piet Swart, Markus Walles, Gian Camenisch, Hilmar Schiller, Olivier Kretz, Barbara Ling, Reto Wettstein, Dirk J. Schaefer, Francois Pognan, Armin Wolf & Karine Litherland. (2014) Aldehyde Oxidase Activity in Fresh Human Skin. Drug Metabolism and Disposition 42:12, pages 2049-2057.
Crossref
F. Oesch, E. Fabian, K. Guth & R. Landsiedel. (2014) Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models. Archives of Toxicology 88:12, pages 2135-2190.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.