6,612
Views
42
CrossRef citations to date
0
Altmetric
Review Article

Ocular cytochrome P450s and transporters: roles in disease and endobiotic and xenobiotic disposition

, , &
Pages 247-260 | Received 21 Jan 2014, Accepted 27 Apr 2014, Published online: 26 May 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Rui Wang, Yuan Gao, Anchang Liu & Guangxi Zhai. (2021) A review of nanocarrier-mediated drug delivery systems for posterior segment eye disease: challenges analysis and recent advances. Journal of Drug Targeting 29:7, pages 687-702.
Read now
Jennifer L. Dumouchel, Upendra A. Argikar, Christopher M. Adams, Ganesh Prasanna, Takeru Ehara, Sean Kim, Chris Breen & Muneto Mogi. (2021) Understanding metabolism related differences in ocular efficacy of MGV354. Xenobiotica 51:1, pages 5-14.
Read now
Libei Zhao, Manqiang Peng, Wenxiang Lin, Qian Tan, Muhammad Ahmad Khan & Ding Lin. (2020) Efficacy of Sub-Tenon Micro-Perfusion of Cyclophosphamide in Rabbits with Severe Ocular Inflammation. Drug Design, Development and Therapy 14, pages 3407-3416.
Read now
S. Cyrus Khojasteh, Ivonne M. C. M. Rietjens, Deepak Dalvie & Grover Miller. (2017) Biotransformation and bioactivation reactions – 2016 literature highlights. Drug Metabolism Reviews 49:3, pages 285-317.
Read now
Upendra A. Argikar, Jennifer L. Dumouchel, Christine E. Dunne & Andrea J. Bushee. (2017) Ocular non-P450 oxidative, reductive, hydrolytic, and conjugative drug metabolizing enzymes. Drug Metabolism Reviews 49:3, pages 372-394.
Read now
Francesca Toselli, Peter R. Dodd & Elizabeth M. J. Gillam. (2016) Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs. Drug Metabolism Reviews 48:3, pages 379-404.
Read now

Articles from other publishers (36)

Eriko Kunikane, Yusuke Orii, Akiko Inoue & Masaru Inatani. (2023) Patient Factors Influencing Intraocular Penetration of Brimonidine-Related Eye Drops in Adults: A Post Hoc Pooled Analysis. Ophthalmology and Therapy 12:6, pages 3083-3098.
Crossref
Irina A. Pikuleva. (2023) Challenges and Opportunities in P450 Research on the Eye. Drug Metabolism and Disposition 51:10, pages 1295-1307.
Crossref
Anam Hammid, John K. Fallon, Kati-Sisko Vellonen, Toni Lassila, Mika Reinisalo, Arto Urtti, Francisco Gonzalez, Ari Tolonen, Philip C. Smith & Paavo Honkakoski. (2023) Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues. European Journal of Pharmaceutical Sciences, pages 106603.
Crossref
Murat Akkurt Arslan, Françoise Brignole-Baudouin, Solenne Chardonnet, Cédric Pionneau, Frédéric Blond, Christophe Baudouin & Karima Kessal. (2023) Profiling tear film enzymes reveals major metabolic pathways involved in the homeostasis of the ocular surface. Scientific Reports 13:1.
Crossref
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski & Seppo Auriola. (2023) Mass spectrometry in ocular drug research. Mass Spectrometry Reviews.
Crossref
Viliana Gugleva & Velichka Andonova. (2023) Recent Progress of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Ocular Drug Delivery Platforms. Pharmaceuticals 16:3, pages 474.
Crossref
Felipe M. González-Fernández, Andrea Delledonne, Sara Nicoli, Paolo Gasco, Cristina Padula, Patrizia Santi, Cristina Sissa & Silvia Pescina. (2023) Nanostructured Lipid Carriers for Enhanced Transscleral Delivery of Dexamethasone Acetate: Development, Ex Vivo Characterization and Multiphoton Microscopy Studies. Pharmaceutics 15:2, pages 407.
Crossref
Divyesh H. Shastri, Ana Catarina Silva & Hugo Almeida. (2023) Ocular Delivery of Therapeutic Proteins: A Review. Pharmaceutics 15:1, pages 205.
Crossref
Jin-Lian Jiang, Jiang-Fu Qian, De-Hui Xiao, Xia Liu, Fang Zhu, Jie Wang, Zhou-Xiong Xing, De-Lin Xu, Yuan Xue & Yi-Huai He. (2022) Relationship of familial cytochrome P450 4V2 gene mutation with liver cirrhosis: A case report and review of the literature. World Journal of Clinical Cases 10:28, pages 10346-10357.
Crossref
Dora Molina-Ortiz, Carmen Torres-Zárate & Rebeca Santes-Palacios. (2022) Human Orphan Cytochromes P450: An Update. Current Drug Metabolism 23:12, pages 942-963.
Crossref
Dimitrios Karamichos, Paulina Escandon, Brenda Vasini, Sarah E. Nicholas, Lyly Van, Deanna H. Dang, Rebecca L. Cunningham & Kamran M. Riaz. (2022) Anterior pituitary, sex hormones, and keratoconus: Beyond traditional targets. Progress in Retinal and Eye Research 88, pages 101016.
Crossref
Eva M. del Amo, Anam Hammid, Melanie Tausch, Elisa Toropainen, Amir Sadeghi, Annika Valtari, Jooseppi Puranen, Mika Reinisalo, Marika Ruponen, Arto Urtti, Achim Sauer & Paavo Honkakoski. (2022) Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations. International Journal of Pharmaceutics 613, pages 121361.
Crossref
Mariama Salihu, Gaber El-Saber Batiha, Keneth Iceland Kasozi, George D. Zouganelis, Souty M.Z. Sharkawi, Eman Ibrahim Ahmed, Ibe Michael Usman, Halima Nalugo, Juma J. Ochieng, Ibrahim Ssengendo, Olatayo Segun Okeniran, Theophilus Pius, Kyobe Ronald Kimanje, Eric Simidi Kegoye, Ritah Kenganzi & Fred Ssempijja. (2022) Crinum jagus (J. Thomps. Dandy): Antioxidant and protective properties as a medicinal plant on toluene-induced oxidative stress damages in liver and kidney of rats. Toxicology Reports 9, pages 699-712.
Crossref
Akshita Chauhan & Tabassum Khan. (2021) Prodrugs - Current development and applications in ocular drug delivery. Journal of Drug Delivery Science and Technology 66, pages 102836.
Crossref
Tayler F.L. Wishart, Mary Flokis, Daisy Y. Shu, Shannon J. Das & Frank J. Lovicu. (2021) Hallmarks of lens aging and cataractogenesis. Experimental Eye Research 210, pages 108709.
Crossref
Ankit Balhara, Abdul Basit, Upendra A. Argikar, Jennifer L. Dumouchel, Saranjit Singh & Bhagwat Prasad. (2021) Comparative Proteomics Analysis of the Postmitochondrial Supernatant Fraction of Human Lens-Free Whole Eye and Liver. Drug Metabolism and Disposition 49:7, pages 592-600.
Crossref
Bruce A. Berkowitz, Robert H. Podolsky, Karen Lins Childers, Aicha Saadane, Timothy S. Kern, Robin Roberts, Hailey Olds, Joydip Joy, Collin Richards, Tilman Rosales, Michael Schneider, Brennan Schilling, Arthur Orchanian, Emma Graffice, Kenan Sinan, Haohua Qian & Lamis Harp. (2021) Sildenafil-evoked photoreceptor oxidative stress in vivo is unrelated to impaired visual performance in mice. PLOS ONE 16:3, pages e0245161.
Crossref
Dylan E. Parsons, Soo Hyeon Lee, Young Joo Sun, Gabriel Velez, Alexander G. Bassuk, Mark Smith & Vinit B. Mahajan. (2021) Peptidomimetics Therapeutics for Retinal Disease. Biomolecules 11:3, pages 339.
Crossref
Imran Ahmed. 2021. Ophthalmic Product Development. Ophthalmic Product Development 93 119 .
Sascha C.T. Nicklisch & Amro Hamdoun. (2020) Disruption of small molecule transporter systems by Transporter‐Interfering Chemicals (TICs). FEBS Letters 594:23, pages 4158-4185.
Crossref
SYM Lim, M Alshagga, CE Ong, JY Chieng & Y Pan. (2020) Cytochrome P450 4B1 (CYP4B1) as a target in cancer treatment. Human & Experimental Toxicology 39:6, pages 785-796.
Crossref
Alexandre Matet, Francine Behar-Cohen, Nathalie Cassoux, Xavier Declèves & Salvatore Cisternino. 2020. Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy. Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy 303 335 .
Laure-Alix Clerbaux, Alicia Paini, Annie Lumen, Hanan Osman-Ponchet, Andrew P. Worth & Olivier Fardel. (2019) Membrane transporter data to support kinetically-informed chemical risk assessment using non-animal methods: Scientific and regulatory perspectives. Environment International 126, pages 659-671.
Crossref
M. Reid Groseclose & Stephen Castellino. (2019) An Investigation into Retigabine (Ezogabine) Associated Dyspigmentation in Rat Eyes by MALDI Imaging Mass Spectrometry. Chemical Research in Toxicology 32:2, pages 294-303.
Crossref
Anelise Russo, Patrícia M. Biselli-Chicote, Rosa S. Kawasaki-Oyama, Márcia M. U. Castanhole-Nunes, José V. Maniglia, Dalísio de Santi Neto, Érika C. Pavarino & Eny M. Goloni-Bertollo. (2018) Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma. Journal of Oncology 2018, pages 1-13.
Crossref
Jennifer L. Dumouchel, Nagendra Chemuturi, Mark N. Milton, Gian Camenisch, James Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh R. Iyer & Upendra A. Argikar. (2018) Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route. Drug Metabolism and Disposition 46:11, pages 1670-1683.
Crossref
Emma M. Heikkinen, Eva M. del Amo, Veli-Pekka Ranta, Arto Urtti, Kati-Sisko Vellonen & Marika Ruponen. (2018) Esterase activity in porcine and albino rabbit ocular tissues. European Journal of Pharmaceutical Sciences 123, pages 106-110.
Crossref
Bruce A. Berkowitz, Robert H. Podolsky, Benjamin Farrell, Hojun Lee, Christopher Trepanier, Ali M. Berri, Kristin Dernay, Emma Graffice, Fatema Shafie-Khorassani, Timothy S. Kern & Robin Roberts. (2018) D- cis -Diltiazem Can Produce Oxidative Stress in Healthy Depolarized Rods In Vivo . Investigative Opthalmology & Visual Science 59:7, pages 2999.
Crossref
Juan C. Altamirano-VallejoJose Navarro-PartidaAlejandro Gonzalez-De la RosaJane H. HsiaoJose S. Olguín-GutierrezAna C. Gonzalez-VillegasBrian C. KellerLourdes Bouzo-LopezArturo Santos. (2018) Characterization and Pharmacokinetics of Triamcinolone Acetonide-Loaded Liposomes Topical Formulations for Vitreoretinal Drug Delivery. Journal of Ocular Pharmacology and Therapeutics 34:5, pages 416-425.
Crossref
Maria A. Grimaudo, Silvia Pescina, Cristina Padula, Patrizia Santi, Angel Concheiro, Carmen Alvarez-Lorenzo & Sara Nicoli. (2018) Poloxamer 407/TPGS Mixed Micelles as Promising Carriers for Cyclosporine Ocular Delivery. Molecular Pharmaceutics 15:2, pages 571-584.
Crossref
Francisco J. Otero-Espinar, Anxo Fernández-Ferreiro, Miguel González-Barcia, José Blanco-Méndez & Asteria Luzardo. 2018. Drug Targeting and Stimuli Sensitive Drug Delivery Systems. Drug Targeting and Stimuli Sensitive Drug Delivery Systems 211 270 .
Upendra A. Argikar, Jennifer L. Dumouchel, Valerie M. Kramlinger, Amanda L. Cirello, Mithat Gunduz, Christine E. Dunne & Bindi Sohal. (2017) Do We Need to Study Metabolism and Distribution in the Eye: Why, When, and Are We There Yet?. Journal of Pharmaceutical Sciences 106:9, pages 2276-2281.
Crossref
J. Lee & R. M. Pelis. (2016) Drug Transport by the Blood-Aqueous Humor Barrier of the Eye. Drug Metabolism and Disposition 44:10, pages 1675-1681.
Crossref
Venkata Kashyap YellepeddiSrinath Palakurthi. (2016) Recent Advances in Topical Ocular Drug Delivery. Journal of Ocular Pharmacology and Therapeutics 32:2, pages 67-82.
Crossref
Masaaki KurataIkuyo AtsumiYoshinori YamagiwaHideyuki Sakaki. (2016) Ocular instillation toxicity study: current status and points to consider on study design and evaluation. Fundamental Toxicological Sciences 3:5, pages 217-232.
Crossref
Kazem Khoshaman, Reza Yousefi, Ali Mohammad Tamaddon, Luciano Saso & Ali Akbar Moosavi-Movahedi. (2015) The impact of Hydrogen peroxide on structure, stability and functional properties of Human R12C mutant αA-crystallin: The imperative insights into pathomechanism of the associated congenital cataract incidence. Free Radical Biology and Medicine 89, pages 819-830.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.