Advanced search
Publication Cover
Drug Metabolism Reviews Volume 3, 1975 - Issue 1
Submit an article Journal homepage
58
Views
155
CrossRef citations to date
0
Altmetric
Research Article

Interaction of Methylenedioxyphenyl (1,3-Benzodioxole) Compounds with Enzymes and Their Effects on Mammals

Ernest Hodgson Department of Entomology, North Carolina State University Raleigh, North Carolina, 27607
&
Richard M. Philpot National Institute for Environmental Health Sciences, Research Triangle Park, North Carolina, 27709
Pages 231-301 | Published online: 22 Sep 2008

Citations (155)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (25)

Ai-Hong Yang, Lei Zhang, De-Xian Zhi, Wen-Li Liu, Xue Gao & Xin He. (2018) Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole. Xenobiotica 48:11, pages 1164-1172.
Read now
Michael Murray. (2012) Toxicological Actions of Plant-Derived and Anthropogenic Methylenedioxyphenyl-Substituted Chemicals in Mammals and Insects. Journal of Toxicology and Environmental Health, Part B 15:6, pages 365-395.
Read now
PeterP. Fu, Qingsu Xia, Lei Guo, Hongtao Yu & Po-Chuen Chan. (2008) Toxicity of Kava Kava. Journal of Environmental Science and Health, Part C 26:1, pages 89-112.
Read now
William W. Johnson. (2008) Cytochrome P450 Inactivation by Pharmaceuticals and Phytochemicals: Therapeutic Relevance. Drug Metabolism Reviews 40:1, pages 101-147.
Read now
Shiji Liu, Suqing Shi, Guangyu Hou & Jun Nie. (2007) Benzodioxole derivative as coinitiator for dental resin. Acta Odontologica Scandinavica 65:6, pages 313-318.
Read now
David L. Straus & Janice E. Chambers. (2006) Effects of Piperonyl Butoxide on the Metabolism of DEF S,S,S-Tributyl Phosphorotrithioate) in Fingerling Channel Catfish. Toxicology Mechanisms and Methods 16:4, pages 235-239.
Read now
M. Nakajima, M. Suzuki, R. Yamaji, H. Takashina, N. Shimada, H. Yamazaki & T. Yokoi. (1999) Isoform selective inhibition and inactivation of human cytochrome P450s by methylenedioxyphenyl compounds. Xenobiotica 29:12, pages 1191-1202.
Read now
R. R. Dalvi & P. S. Dalvi. (1991) Differences in the Effects of Piperine and Piperonyl Butoxide on Hepatic Drug-Metabolizing Enzyme System in Rats. Drug and Chemical Toxicology 14:1-2, pages 219-229.
Read now
J. Petridou-fischer & A. Dahl. (1988) Inhibition of nasal and liver cytochrome P-450 mono-oxygenases by dioxolanes. Xenobiotica 18:1, pages 1-9.
Read now
E. Becker, B. Messner And & J. Berndt. (1987) Two Mechanisms of Cc14-Induced Fatty Liver: Lipid Peroxidation Or Covalent Binding Studied in Cultured Rat Hepatocytes. Free Radical Research Communications 3:1-5, pages 299-308.
Read now
L. R. Kao & C. F. Wilkinson. (1987) Inhibition of cytochrome P-450c-mediated benzo[a]pyrene hydroxylase and ethoxyresorufin O-deethylase by dihydrosafrole. Xenobiotica 17:7, pages 793-805.
Read now
F. Peter Guengerich, Daniel C. Liebler & Donald L. Reed. (1985) Enzymatic activation of chemicals to toxic metabolites. CRC Critical Reviews in Toxicology 14:3, pages 259-307.
Read now
C. B. Marcus, M. Murray & C. F. Wilkinson. (1985) Spectral and inhibitory interactions of methylenedioxyphenyl and related compounds with purified isozymes of cytochrome P-450. Xenobiotica 15:4, pages 351-362.
Read now
Marcel Delaforge, Costas Ioannides & Dennis V. Parke. (1985) Ligand-complex formation between cytochromes P-450 and P-448 and methylenedioxyphenyl compounds. Xenobiotica 15:4, pages 333-342.
Read now
M. Murray, Krystyna Hetnarski & C. F. Wilkinson. (1985) Selective inhibitory interactions of alkoxymethylenedioxybenzenes towards mono-oxygenase activity in rat-hepatic microsomes. Xenobiotica 15:5, pages 369-379.
Read now
M. Murray, C. F. Wilkinso & C. E. Dube. (1985) Induction of rat-hepatic microsomal cytochrome P-450 and aryl hydrocarbon hydroxylase by 1,3-benzodioxole derivatives. Xenobiotica 15:5, pages 361-368.
Read now
C. F. Wilkinson & M. Murray. (1984) Considerations of Toxicologic Interactions in Developing New Chemicals. Drug Metabolism Reviews 15:5-6, pages 897-917.
Read now
Ernest Hodgson. (1984) Development of Safer Insecticides. Drug Metabolism Reviews 15:5-6, pages 881-895.
Read now
J. W. Hubbard, K. K. Midha & J. K. Cooper. (1982) Identification of phenolic acids in human urine by ion monitoring. Xenobiotica 12:1, pages 63-71.
Read now
Bernard Testa & Peter Jenner. (1981) Inhibitors of Cytochrome P-450s and Their Mechanism of Action. Drug Metabolism Reviews 12:1, pages 1-117.
Read now
Ernest Hodgson, ArunP. Kulkarni, DavidL. Fabacher & KarenM. Robacker. (1980) Induction of hepatic drug metabolizing enzymes in mammals by pesticides: A review. Journal of Environmental Science and Health, Part B 15:6, pages 723-754.
Read now
Ernest Hodgson. (1979) Comparative Aspects of the Distribution of Cytochrome P-450 Dependent Mono-Oxygenase Systems: An Overview. Drug Metabolism Reviews 10:1, pages 15-33.
Read now
J. R. Gumbrecht & M. R. Franklin. (1979) The Formation of Cytochrome P-450-Metabolic Intermediate Complexes from Amines, in the Isolated Perfused Rat Liver. Xenobiotica 9:9, pages 547-554.
Read now
M. J. Melancon & J. J. Lech. (1979) Structural requirements for the inhibition of phthalate ester hydrolysis in rainbow trout by methylenedioxyphenyl compounds. Xenobiotica 9:5, pages 317-322.
Read now
Sami Ahmad & Andrew J. Forgash. (1976) Nonoxidative Enzymes in the Metabolism of Insecticides. Drug Metabolism Reviews 5:1, pages 141-164.
Read now

Articles from other publishers (130)

Nutan V. Sadgir, Sunil L. Dhonnar & Bapu S. Jagdale. (2023) Synthesis, molecular structure, FMO, spectroscopic, antimicrobial and in-silico investigation of (E)-1-(benzo[d][1,3]dioxol-5-yl)-3-(4-aryl)prop-2-en-1-one derivative: Experimental and computational study. Results in Chemistry 5, pages 100887.
Crossref
Zongyang Lv, Kristin E. Cano, Lijia Jia, Marcin Drag, Tony T. Huang & Shaun K. Olsen. (2022) Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development. Frontiers in Chemistry 9.
Crossref
Thomas G. Osimitz & Wiebke Droege. (2022) Perspectives on interpretation of Rivera-González et al., (2021). Chemosphere 288, pages 132599.
Crossref
M. Saeed Mirzaei, Maxim V. Ivanov, Avat Arman Taherpour & Saber Mirzaei. (2021) Mechanism-Based Inactivation of Cytochrome P450 Enzymes: Computational Insights. Chemical Research in Toxicology 34:4, pages 959-987.
Crossref
Chieh‐Hung Tien, Alina Trofimova, Aleksandra Holownia, Branden S. Kwak, Reed T. Larson & Andrei K. Yudin. (2020) Carboxyboronate as a Versatile In Situ CO Surrogate in Palladium‐Catalyzed Carbonylative Transformations. Angewandte Chemie International Edition 60:8, pages 4342-4349.
Crossref
Chieh‐Hung Tien, Alina Trofimova, Aleksandra Holownia, Branden S. Kwak, Reed T. Larson & Andrei K. Yudin. (2020) Carboxyboronate as a Versatile In Situ CO Surrogate in Palladium‐Catalyzed Carbonylative Transformations. Angewandte Chemie 133:8, pages 4388-4395.
Crossref
Reem A.K. Al-Harbi, Marwa A.M.Sh. El-Sharief & Samir Y. Abbas. (2019) Synthesis and anticancer activity of bis-benzo[d][1,3]dioxol-5-yl thiourea derivatives with molecular docking study. Bioorganic Chemistry 90, pages 103088.
Crossref
Xin He, Zi-jun Wu, Li-li Wang, Xue Gao, Yue Hai, Wen-li Liu, Le-mei Du, Lei Zhang, Ai-hong Yang & Nan-nan Huang. (2019) An important mechanism of herb-induced hepatotoxicity: To produce RMs based on active functional groups-containing ingredients from phytomedicine by binding CYP450s. Chinese Herbal Medicines 11:3, pages 239-257.
Crossref
Jing Wang, Jinliang Yang, Muhammad Atif, Roberta Bongiovanni, Gang Li, Zhongmin Xue & Xiaoping Yang. (2018) One-component photoinitiator based on benzophenone and sesamol. Polymers for Advanced Technologies 29:8, pages 2264-2272.
Crossref
Sergey V. Makarenko, Kirill D. Sadykov & Ruslan I. Baichurin. (2018) Alkyl 3-bromo-3-nitroacrylates – convenient building blocks for the construction of benzo-fused six-membered N,N-, N,O- and five-membered O,O-heterocycles. Chemistry of Heterocyclic Compounds 54:5, pages 502-507.
Crossref
E. Hodgson & S.A. Meyer. 2018. Comprehensive Toxicology. Comprehensive Toxicology 538 574 .
Gareth K. Jennings, Caroline M. Ritchie, Lisa S. Shock, Charles E. Lyons & John C. Hackett. (2016) N -Heterocyclic Carbene Capture by Cytochrome P450 3A4 . Molecular Pharmacology 90:1, pages 42-51.
Crossref
Ahmed Kamal, Moku Balakrishna, Velatooru Loka Reddy, Syed Riyaz, Chandrakant Bagul, Bethu Murali Satyanarayana & Janapala Venkateswar Rao. (2015) Synthesis and Biological Evaluation of Benzo[ d ][1,3]Dioxol-5-yl Chalcones as Antiproliferating Agents . Chemical Biology & Drug Design 86:5, pages 1267-1284.
Crossref
Jinliang Yang, Suqing Shi & Jun Nie. (2015) Reasons for the yellowness of photocured samples by the benzophenone/1,3-benzodioxole photoinitiating system. New Journal of Chemistry 39:7, pages 5453-5458.
Crossref
Maria Almira Correia & Paul. F. Hollenberg. 2015. Cytochrome P450. Cytochrome P450 177 259 .
Nevin Üner, Petek Piner & Özge Temiz. (2014) Piperonyl Butoxide Increases Oxidative Toxicity of Fenthion in the Brain of Oreochromis niloticus . Journal of Biochemical and Molecular Toxicology 28:2, pages 84-90.
Crossref
Despina Philippou, Valerio Borzatta, Elisa Capparella, Leni Moroni, Linda Field & Graham Moores. (2013) The interactions between piperonyl butoxide and E4, a resistance-associated esterase from the peach-potato aphid, Myzus persicae Sulzer (Hemiptera: Aphididae) . Pest Management Science 69:4, pages 499-506.
Crossref
Jinliang Yang, Suqing Shi, Fei Xu & Jun Nie. (2013) Synthesis and photopolymerization kinetics of benzophenone sesamol one-component photoinitiator. Photochemical & Photobiological Sciences 12:2, pages 323-329.
Crossref
Jinliang Yang, Fei Xu, Suqing Shi & Jun Nie. (2012) Influence of structure of benzodioxole derivatives on photoinitiation efficiency of benzophenone. Photochemical & Photobiological Sciences 11:8, pages 1377-1382.
Crossref
Alexander V. LyubimovBill Gurley, Kim E. Fifer & Zöe Gardner. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 79 .
Corie A. Ellison, Alice L. Crane & James R. Olson. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics 685 702 .
Ernest Hodgson. 2012. Pesticide Biotransformation and Disposition. Pesticide Biotransformation and Disposition 149 178 .
Carrie R. Fleming & Richard T. Di Giulio. (2011) The role of CYP1A inhibition in the embryotoxic interactions between hypoxia and polycyclic aromatic hydrocarbons (PAHs) and PAH mixtures in zebrafish (Danio rerio). Ecotoxicology 20:6, pages 1300-1314.
Crossref
Davide Ravelli, Angelo Albini & Maurizio Fagnoni. (2010) Smooth Photocatalytic Preparation of 2‐Substituted 1,3‐Benzodioxoles. Chemistry – A European Journal 17:2, pages 572-579.
Crossref
Suqing Shi, Pu Xiao, Kemin Wang, Yongkuan Gong & Jun Nie. (2010) Influence of chemical structures of benzodioxole-based coinitiators on the properties of the unfilled dental resin. Acta Biomaterialia 6:8, pages 3067-3071.
Crossref
Thomas G. Osimitz. 2010. Hayes' Handbook of Pesticide Toxicology. Hayes' Handbook of Pesticide Toxicology 2127 2151 .
Ernest Hodgson. 2010. Hayes' Handbook of Pesticide Toxicology. Hayes' Handbook of Pesticide Toxicology 941 959 .
E. Hodgson & S.A. Meyer. 2010. Comprehensive Toxicology. Comprehensive Toxicology 475 500 .
Wenfu Mao, Arthur R. Zangerl, May R. Berenbaum & Mary A. Schuler. (2008) Metabolism of myristicin by Depressaria pastinacella CYP6AB3v2 and inhibition by its metabolite. Insect Biochemistry and Molecular Biology 38:6, pages 645-651.
Crossref
Suqing Shi & Jun Nie. (2007) A natural component as coinitiator for unfilled dental resin composites. Journal of Biomedical Materials Research Part B: Applied Biomaterials 82B:1, pages 44-50.
Crossref
Su Qing Shi, Hong Gao & Jun Nie. (2007) A natural component as initiator for photopolymerization of 1,6-hexanedioldiacrylate. Chinese Chemical Letters 18:6, pages 750-753.
Crossref
Suqing Shi, Hong Gao, Gangqiang Wu & Jun Nie. (2007) Cyclic acetal as coinitiator for bimolecular photoinitiating systems. Polymer 48:10, pages 2860-2865.
Crossref
Daniel Mansuy. (2007) A brief history of the contribution of metalloporphyrin models to cytochrome P450 chemistry and oxidation catalysis. Comptes Rendus Chimie 10:4-5, pages 392-413.
Crossref
Maria Almira Correia & Paul R. Ortiz de Montellano. 2005. Cytochrome P450. Cytochrome P450 247 322 .
Deena M. Wassenberg & Richard T. Di Giulio. (2004) Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in Fundulus heteroclitus . Environmental Health Perspectives 112:17, pages 1658-1664.
Crossref
Dallas L Clouatre. (2004) Kava kava: examining new reports of toxicity. Toxicology Letters 150:1, pages 85-96.
Crossref
James M. Mathews, Amy S. Etheridge & Sherry R. Black. (2002) Inhibition of Human Cytochrome P450 Activities by Kava Extract and Kavalactones. Drug Metabolism and Disposition 30:11, pages 1153-1157.
Crossref
James L. Ferrero, Samuel B. Thomas, Kennan C. Marsh, A. David Rodrigues, John T. Uchic & Alex M. Buko. (2002) Implication of P450-Metabolite Complex Formation in the Nonlinear Pharmacokinetics and Metabolic Fate of (±)-(1′ R *,3 R *)-3-Phenyl-1-[(1′,2′,3′,4′-tetrahydro-5′,6′-methylene-dioxy-1′-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200) in Dogs . Drug Metabolism and Disposition 30:10, pages 1094-1101.
Crossref
Martin J. Ronis, J. Craig Rowlands, Reza Hakkak & Thomas M. Badger. (2001) Inducibility of Hepatic CYP1A Enzymes by 3-Methylcholanthrene and Isosafrole Differs in Male Rats Fed Diets Containing Casein, Soy Protein Isolate or Whey from Conception to Adulthood. The Journal of Nutrition 131:4, pages 1180-1188.
Crossref
Ernest Hodgson & E. Levi Patricia. 2001. Handbook of Pesticide Toxicology. Handbook of Pesticide Toxicology 531 562 .
Ernest Hodgson. 2001. Handbook of Pesticide Toxicology. Handbook of Pesticide Toxicology 507 513 .
Surrinder Koul, Jawahir L. Koul, Subhash C. Taneja, Kanaya L. Dhar, Deshvir S. Jamwal, Kuldeep Singh, Rashmeet K. Reen & Jaswant Singh. (2000) Structure–activity relationship of piperine and its synthetic analogues for their inhibitory potentials of rat hepatic microsomal constitutive and inducible cytochrome P450 activities. Bioorganic & Medicinal Chemistry 8:1, pages 251-268.
Crossref
P.J Dierickx. (1999) CYP1/2 Activation and Glutathione-dependent Cytotoxicity of Four Pesticides in Hep G2 and Fa32 Cells. Toxicology in Vitro 13:4-5, pages 779-783.
Crossref
Ernest Hodgson. (2016) Induction and inhibition of pesticide-metabolizing enzymes: roles in synergism of pesticides and pesticide action. Toxicology and Industrial Health 15:1-2, pages 6-11.
Crossref
Michel SchalkFrancisco Cabello-HurtadoMarie-Agnès Pierrel, Rossitza Atanassova, Patrick Saindrenan & Danièle Werck-Reichhart. (1998) Piperonylic Acid, a Selective, Mechanism-Based Inactivator of the trans -Cinnamate 4-Hydroxylase: A New Tool to Control the Flux of Metabolites in the Phenylpropanoid Pathway1 . Plant Physiology 118:1, pages 209-218.
Crossref
Toshiyuki Watanabe, Sunao Manabe, Yoshihiko Ohashi, Hideaki Okamiya, Hiroshi Onodera & Kunitoshi Mitsumori. (1998) Comparison of the Induction Profile of Hepatic Drug-metabolizing Enzymes Between Piperonyl Butoxide and Phenobarbital in Rats.. Journal of Toxicologic Pathology 11:1, pages 1-10.
Crossref
Z.Sylvia Zhao, S Khan & Peter J O'Brien. (1997) The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants. Chemico-Biological Interactions 108:1-2, pages 107-118.
Crossref
Doug-Young Ryu, Patricia E Levi & Ernest Hodgson. (1997) Regulation of hepatic CYP1A isozymes by piperonyl butoxide and acenaphthylene in the mouse. Chemico-Biological Interactions 105:1, pages 53-63.
Crossref
Bjørn Einar Grøsvik, Håvard E. Larsen & Anders Goksøyr. (1997) Effects of piperonyl butoxide and β-naphthoflavone on cytochrome P4501A expression and activity in Atlantic salmon ( Salmo salar L.) . Environmental Toxicology and Chemistry 16:3, pages 415-423.
Crossref
Raquel Manteiga, Douglas L. Park & Syed S. Ali. 1997. Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology 1 30 .
Peter H. Roos & Axel Mahnke. (1996) Metabolite complex formation of orphenadrine with cytochrome P450. Biochemical Pharmacology 52:1, pages 73-84.
Crossref
E Hodgson & P E Levi. (1996) Pesticides: an important but underused model for the environmental health sciences.. Environmental Health Perspectives 104:suppl 1, pages 97-106.
Crossref
E. Hodgson, R.L. Rose, D.-Y. Ryu, G. Falls, B.L. Blake & P.E. Levi. (1995) Pesticide-metabolizing enzymes. Toxicology Letters 82-83, pages 73-81.
Crossref
Ernest Hodgson, Doug-young Ryu, Nancy Adams & Patricia E. Levi. (1995) Biphasic responses in synergistic interactions. Toxicology 105:2-3, pages 211-216.
Crossref
Doug-Young Ryu, Patricia E Levi & Ernest Hodgson. (1995) Regulation of cytochrome P-450 isozymes CYP1A1, CYP1A2 and CYP2B10 by three benzodioxole compounds. Chemico-Biological Interactions 96:3, pages 235-247.
Crossref
David F.V. Lewis, Costas Ioannides & Dennis V. Parke. (1995) Computer graphics analysis of the interaction of alkoxy methylenedioxybenzenes with cytochromes P4501. Toxicology Letters 76:1, pages 39-45.
Crossref
Ernest Hodgson, Randy L. Rose, Nancy H. Adams, Nora J. Deamer, Mary Beth Genter, Krishnappa Venkatesh & Patricia E. Levi. 1995. Molecular Aspects of Oxidative Drug Metabolizing Enzymes. Molecular Aspects of Oxidative Drug Metabolizing Enzymes 461 478 .
Paul R. Ortiz de Montellano & Maria Almira Correia. 1995. Cytochrome P450. Cytochrome P450 305 364 .
William S. Baldwin & Gerald A. Leblanc. (2009) Identification of multiple steroid hydroxylases in Daphnia magna and their modulation by xenobiotics . Environmental Toxicology and Chemistry 13:7, pages 1013-1021.
Crossref
Dick T.H.M. Sijm, Geert Schaap & Antoon Opperhuizen. (1993) The effect of the biotransformation inhibitor piperonylbutoxide on the bioconcentration of 2,8-dichlorodibenzo-p-dioxin and pentachlorobenzene in goldfish. Aquatic Toxicology 27:3-4, pages 345-359.
Crossref
Kelly W. Beers, Derek W. Nicoll, Dianne K. Anestis, Patrick I. Brown & Gary O. Rankin. (1993) Effect of microsomal enzyme modulators on N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS)-induced nephrotoxicity in the Fischer 344 rat. Toxicology 84:1-3, pages 141-155.
Crossref
Peter H. Roos, Beata Golub-Ciosk, Petra Kallweit, Detlef Kauczinski & Walter G. Hanstein. (1993) Formation of ligand and metabolite complexes as a means for selective quantitation of cytochrome P450 isozymes. Biochemical Pharmacology 45:11, pages 2239-2250.
Crossref
Nancy H. Adams, Patricia E. Levi & Ernest Hodgson. (1993) Regulation of cytochrome P-450 isozymes by methylenedioxyphenyl compounds. Chemico-Biological Interactions 86:3, pages 255-274.
Crossref
Rina Varsano, Haim D. Rabinowitch & Baruch Rubin. (1992) Mode of action of piperonyl butoxide as herbicide synergist of atrazine and terbutryn in maize. Pesticide Biochemistry and Physiology 44:3, pages 174-182.
Crossref
D.L. Neldon-Ortiz & M.A. Qureshi. (1992) The effects of direct and microsomal activated aflatoxin B1 on chicken peritoneal macrophages in vitro. Veterinary Immunology and Immunopathology 31:1-2, pages 61-76.
Crossref
Yoshito Kumagai, Karen A Wickham, Debra A. Schmitz & Arthur K. Cho. (1991) Metabolism of methylenedioxyphenyl compounds by Rabbit liver preparations. Biochemical Pharmacology 42:5, pages 1061-1067.
Crossref
Thomas D. Steele, William K. Brewster, Michael P. Johnson, David E. Nichols & George K.W. Yim. (1991) Assessment of the role of ?-methylapinine in the neurotoxicity of MDMA. Pharmacology Biochemistry and Behavior 38:2, pages 345-351.
Crossref
Craig B. Marcus, Neil M. Wilson, Colin R. Jefcoate, Christopher F. Wilkinson & Curtis J. Omiecinski. (1990) Selective induction of cytochrome P450 isozymes in rat liver by 4-n-alkyl-methylenedioxybenzenes. Archives of Biochemistry and Biophysics 277:1, pages 8-16.
Crossref
Mohammed A. Q. Khan. 1990. Controlled Release, Biochemical Effects of Pesticides, Inhibition of Plant Pathogenic Fungi. Controlled Release, Biochemical Effects of Pesticides, Inhibition of Plant Pathogenic Fungi 109 171 .
Jonathan J. Neal. (1989) Methylenedioxyphenyl-containing alkaloids and autosynergism. Phytochemistry 28:2, pages 451-453.
Crossref
J. J. Neal & May Berenbaum. (1989) Decreased sensitivity of mixed-function oxidases frompapilio polyxenes to inhibitors in host plants. Journal of Chemical Ecology 15:1, pages 439-446.
Crossref
J. J. Neal. (1989) Myristicin, safrole, and fagaramide as phytosynergists of xanthotoxin. Journal of Chemical Ecology 15:1, pages 309-315.
Crossref
David A. Erickson, Mark S. Goodrich & John J. Lech. (1988) The effect of piperonyl butoxide on hepatic cytochrome P-450-dependent monooxygenase activities in rainbow trout (Salmo gairdneri). Toxicology and Applied Pharmacology 94:1, pages 1-10.
Crossref
YIN-TAK WOO, DAVID Y. LAI, JOSEPH C. ARCOS & MARY F. ARGUS. 1988. Natural, Metal, Fiber, and Macromolecular Carcinogens. Natural, Metal, Fiber, and Macromolecular Carcinogens 3 616 .
A. R. Dahl. 1988. Inhalation Toxicology. Inhalation Toxicology 41 65 .
Alan R. Dahl. 1988. Molecular Neurobiology of the Olfactory System. Molecular Neurobiology of the Olfactory System 51 70 .
Craig B. Marcus, Michael Murray, Krystyna Hetnarski & Christopher F. Wilkinson. (1987) Methylenedioxyphenyl complexes with microsomal cytochrome P-450: In vivo complex formation in rat liver and in midgut tissues of the Southern armyworm (Spodoptera eridania). Pesticide Biochemistry and Physiology 28:1, pages 140-147.
Crossref
Craig B. Marcus, Michael Murray, Cheng Wang & Christopher F. Wilkinson. (1986) Methylenedioxyphenyl compounds as inducers of cytochrome P-450 and monooxygenase activity in the southern armyworm (Spodoptera eridania) and the rat. Pesticide Biochemistry and Physiology 26:3, pages 310-322.
Crossref
J.F. Brady, E.W. Di Stefano & A.K. Cho. (1986) Spectral and inhibitory interactions of (±)−3, 4-methylenedioxyamphetamine (MDA) and (±)−3, 4-methylenedioxymethampetamine (MDMA) with rat hepatic microsomes. Life Sciences 39:16, pages 1457-1464.
Crossref
C.R. Wolf. (1986) Cytochrome P-450s: polymorphic multigene families involved in carcinogen activation. Trends in Genetics 2, pages 209-214.
Crossref
Paul R. Ortiz de Montellano & Norbert O. Reich. 1986. Cytochrome P-450. Cytochrome P-450 273 314 .
Heather N. Yeowell, Patricia Linko, Ernest Hodgson & Joyce A. Goldstein. (1985) Induction of specific cytochrome P-450 isozymes by methylenedioxyphenyl compounds and antagonism by 3-methylcholanthrene. Archives of Biochemistry and Biophysics 243:2, pages 408-419.
Crossref
Michael Murray, Christopher F. Wilkinson & K. Hetnarski. (1985) Cytochrome P-450 and monooxygenase activity in hepatic microsomes from N-phenylimidazole-treated rats. Toxicology Letters 25:2, pages 191-198.
Crossref
Alan R. Dahl & Damian A. Brezinski. (1985) Inhibition of rabbit nasal and hepatic cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase by methylenedioxyphenyl compounds. Biochemical Pharmacology 34:5, pages 631-636.
Crossref
Jon C. Cook & Ernest Hodgson. (1985) The induction of cytochrome P-450 by isosafrole and related methylenedioxyphenyl compounds. Chemico-Biological Interactions 54, pages 299-315.
Crossref
ERNEST HODGSON. 1985. Pharmacology. Pharmacology 225 321 .
Michael Murray, Craig B. Marcus & Christopher F. Wilkinson. (2006) Quantitative Structure‐Activity Relationships in the Displacement of the Dihydrosafrole Metabolite‐Cytochrome P‐450 Complex. Quantitative Structure-Activity Relationships 4:1, pages 18-22.
Crossref
Scot D. Pencil, William J. BrattinJr.Jr., Eric A. GlendeJr.Jr. & Richard O. Recknagel. (1984) Carbon tetrachloride-dependent inhibition of lipid secretion by isolated hepatocytes characterization and requirement for bioactivation. Biochemical Pharmacology 33:15, pages 2419-2423.
Crossref
M.W. Anders, Joan M. Sunram & Christopher F. Wilkinson. (1984) Mechanism of the metabolism of 1,3-benzodioxoles to carbon monoxide. Biochemical Pharmacology 33:4, pages 577-580.
Crossref
Paul R. Ortiz de Montellano. 1984. 201 211 .
René Feyereisen, Kevin C. Langry & Paul R. Ortiz de Montellano. (1984) Self-catalyzed destruction of insect cytochrome. Insect Biochemistry 14:1, pages 19-26.
Crossref
Jon C. Cook & Ernest Hodgson. (1983) Induction of cytochrome P-450 by methylenedioxyphenyl compounds: Importance of the methylene carbon. Toxicology and Applied Pharmacology 68:1, pages 131-139.
Crossref
Michael Murray, Christopher F. Wilkinson & Christopher E. Dub?. (1983) Effects of dihydrosafrole on cytochromes P-450 and drug oxidation in hepatic microsomes from control and induced rats. Toxicology and Applied Pharmacology 68:1, pages 66-76.
Crossref
C.F. Wilkinson, M. Murray, C. Marcus & C. Dub?. 1983. Mode of Action, Metabolism and Toxicology. Mode of Action, Metabolism and Toxicology 463 468 .
Ernest Hodgson. (1983) The significance of cytochrome P-450 in insects. Insect Biochemistry 13:3, pages 237-246.
Crossref
Ernest Hodgson & Arun P. Kulkarni. 1983. Pest Resistance to Pesticides. Pest Resistance to Pesticides 207 228 .
Richard T. Mayer, C.W. Fisher, J. Cocke, A.C. Bridges & J.K. Olson. (1982) Studies on a fluorescent insect growth regulator metabolite complex with house-fly microsomal cytochrome P-450. Pesticide Biochemistry and Physiology 17:1, pages 24-34.
Crossref
Charles W. Fisher & Richard T. Mayer. (1982) Characterization of house fly microsomal mixed function oxidases: Inhibition by juvenile hormone I and piperonyl butoxide. Toxicology 24:1, pages 15-31.
Crossref
Jarle Klungsøyr & Ronald R. Scheline. (2009) Metabolism in Rats of Several Carboxylic Acid Derivatives Containing the 3,4‐Methylenedioxyphenyl Group. Acta Pharmacologica et Toxicologica 49:4, pages 305-312.
Crossref
Paul R.Ortiz De Montellano & James M. Mathews. (1981) Inactivation of hepatic cytochrome p-450 by a 1,2,3-benzothiadiazole insecticide synergist. Biochemical Pharmacology 30:10, pages 1138-1141.
Crossref
Kuo-Mei Chang, C.F. Wilkinson & Krystyna Hetnarski. (1981) Spectral and inhibitory interactions of methylenedioxyphenyl compounds with southern armyworm (Spodoptera eridania) midgut microsomes. Pesticide Biochemistry and Physiology 15:1, pages 32-42.
Crossref
C. Ioannides, M. Delaforge & D.V. Parke. (1981) Safrole: Its metabolism, carcinogenicity and interactions with cytochrome P-450. Food and Cosmetics Toxicology 19, pages 657-666.
Crossref
D.E. Ryan, P.E. Thomas & W. Levin. (1980) Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms.. Journal of Biological Chemistry 255:16, pages 7941-7955.
Crossref
T.R Fennell, B.C. Sweatman & J.W. Bridges. (1980) The induction of hepatic cytochrome P-450 in C57 BL/10 and DBA/2 mice by isosafrole and piperonyl butoxide. A comparative study with other inducing agents. Chemico-Biological Interactions 31:2, pages 189-201.
Crossref
Yu Loh-Sheng, Christopher F. Wilkinson & Marion W. Anders. (1980) Generation of carbon monoxide during the microsomal metabolism of methylenedioxyphenyl compounds. Biochemical Pharmacology 29:8, pages 1113-1122.
Crossref
M.A.Q. Khan. (1980) Induction of drug-metabolizing enzymes by insecticides and other xenobiotics. Pharmacology & Therapeutics 11:1, pages 43-107.
Crossref
A.R. Dahl & E. Hodgson. (1979) The interaction of aliphatic analogs of methylene-dioxyphenyl compounds with cytochromes P-450 and P-420. Chemico-Biological Interactions 27:2-3, pages 163-175.
Crossref
Clifford R. Elcombe & John J. Lech. (1979) Induction and characterization of hemoprotein(s) P-450 and monooxygenation in rainbow trout (Salmo gairdneri). Toxicology and Applied Pharmacology 49:3, pages 437-450.
Crossref
Robert Snyder & Herbert Remmer. (1979) Classes of hepatic microsomal mixed function oxidase inducers. Pharmacology & Therapeutics 7:2, pages 203-244.
Crossref
Maurice Dickins, Clifford R. Elcombe, Stephen J. Moloney, Karl J. Netter & James W. Bridges. (1979) Further studies on the dissociation of the isosafrole metabolite-cytochrome p-450 complex. Biochemical Pharmacology 28:2, pages 231-238.
Crossref
Volker Ullrich. 1979. Blood Vessels. Blood Vessels 67 104 .
Arun P. Kulkarni & Ernest Hodgson. (1978) Cumene hydroperoxide-generated spectral interactions of piperonyl butoxide and other synergists with microsomes from mammals and insects. Pesticide Biochemistry and Physiology 9:1, pages 75-83.
Crossref
David F. Callen, C.Roland Wolf & Richard M. Philpot. (1978) Cumene hydroperoxide and yeast cytochrome P-450: Spectral interactions and effect on the genetic activity of promutagens. Biochemical and Biophysical Research Communications 83:1, pages 14-20.
Crossref
Alan R. Dahl & Ernest Hodgson. (1978) Complexes of trivalent oxygenated phosphorus compounds with cytochrome P-450 and cytochrome P-420: The origin of double Soret spectra. Chemico-Biological Interactions 21:2-3, pages 137-154.
Crossref
A.R. Dahl & Ernest Hodgson. (1978) The affinity of cytochrome P-450 for ethyl isocyanide: An explanation of double Soret spectra. Chemico-Biological Interactions 20:2, pages 171-180.
Crossref
Gerald M. Marquardt, Victor DiStefano & Lydia L. Ling. 1978. The Psychopharmacology of Hallucinogens. The Psychopharmacology of Hallucinogens 84 104 .
Richard T. Mayer, John W. Jermyn, M.Danny Burke & Russell A. Prough. (1977) Methoxyresorufin as a substrate for the fluorometric assay of insect microsomal O-dealkylases. Pesticide Biochemistry and Physiology 7:4, pages 349-354.
Crossref
Ernest Hodgson & Mont R. Juchau. (1977) Ligand binding to human placental cytochrome P-450: Interaction of steroids and heme-binding ligands. Journal of Steroid Biochemistry 8:6, pages 669-675.
Crossref
D.L. Gil & C.F. Wilkinson. (1977) Structure-activity relationships of 1,2,3-benzothiadiazole insecticide synergists as inhibitors of microsomal oxidation. Pesticide Biochemistry and Physiology 7:2, pages 183-193.
Crossref
Michael R. Franklin. 1977. Microsomes and Drug Oxidations. Microsomes and Drug Oxidations 284 291 .
Michael R. Franklin. (1977) Inhibition of mixed-function oxidations by substrates forming reduced cytochrome P-450 metabolic-intermediate complexes. Pharmacology & Therapeutics. Part A: Chemotherapy, Toxicology and Metabolic Inhibitors 2:1, pages 227-245.
Crossref
Richard T. Mayer & Russell A. Prough. (1976) Characterization of a metabolite-cytochrome P-450 complex derived from the aerobic metabolism of an insect juvenile hormone analog by rat microsomal fractions. Toxicology and Applied Pharmacology 38:2, pages 439-454.
Crossref
Richard T. Mayer & M.Danny Burke. (1976) Albumin and cytochrome P450 binding characteristics of juvenile hormone and its analogs. Pesticide Biochemistry and Physiology 6:4, pages 377-385.
Crossref
D.L. Gil & C.F. Wilkinson. (1976) Structure-activity relationships of 1,2,3-benzothiadiazoles as synergists for carbaryl against the house fly (Musca domestica). Pesticide Biochemistry and Physiology 6:4, pages 338-349.
Crossref
Michael R. Franklin. (1976) A new class of inhibitory cytochrome P-450 complexes formed during metabolism: A comparison with amphetamine and SKF 525-A type complexes. Chemico-Biological Interactions 14:3-4, pages 337-346.
Crossref
M R Franklin. (1976) Methylenedioxyphenyl insecticide synergists as potential human health hazards.. Environmental Health Perspectives 14, pages 29-37.
Crossref
A.P. Kulkarni & Ernest Hodgson. (1976) Spectral interactions of insecticide synergists with microsomal cytochrome P-450 from insecticide-resistant and susceptible house flies. Pesticide Biochemistry and Physiology 6:2, pages 183-191.
Crossref
ERNEST HODGSON. 1976. 73 97 .
Ernest Hodgson & Laurence G. Tate. 1976. Insecticide Biochemistry and Physiology. Insecticide Biochemistry and Physiology 115 148 .
C. F. Wilkinson. 1976. Insecticide Biochemistry and Physiology. Insecticide Biochemistry and Physiology 605 647 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.