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Research Article

Spironolactone: Disposition, Metabolism, Pharmacodynamics, and Bioavailability

Pages 151-188 | Published online: 22 Sep 2008

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Jonatan Barrera-Chimal, Peter Kolkhof, Ixchel Lima-Posada, Joachim Alexandre, Patrick Rossignol & Frederic Jaisser. (2021) Differentiation between emerging non-steroidal and established steroidal mineralocorticoid receptor antagonists: head-to-head comparisons of pharmacological and clinical characteristics. Expert Opinion on Investigational Drugs 30:11, pages 1141-1157.
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M. Hildebrand, W. Krause, G. Kühne & G.-A. Hoyer. (1987) Pharmacokinetics and metabolism of mespirenone, a new aldosterone antagonist, in rat and cynomolgus monkey. Xenobiotica 17:5, pages 623-634.
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D. R. Boreham, C. W. Vose, R. F. Palmer, T. F. Slater & K. Cheeseman. (1981) The metabolism of canrenone in vitro by rat liver preparations. Xenobiotica 11:4, pages 231-240.
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Ulrich Kintscher, George L. Bakris & Peter Kolkhof. (2022) Novel non‐steroidal mineralocorticoid receptor antagonists in cardiorenal disease. British Journal of Pharmacology 179:13, pages 3220-3234.
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Tsuyoshi HOMMA, Michio FUJISAWA, Kiyoshi ARAI, Marie ISHII, Toshio SADA & Masahiro IKEDA. (2012) Spironolactone, but not Eplerenone, Impairs Glucose Tolerance in a Rat Model of Metabolic Syndrome. Journal of Veterinary Medical Science 74:8, pages 1015-1022.
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