14
Views
54
CrossRef citations to date
0
Altmetric
Research Article

Possible Mechanisms in Hepatocarcinogensis by the Peroxisome Proliferator Di(2-Ethylhexyl)Phthalate

, , &
Pages 65-102 | Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

MORENO PAOLINI, LAURA POZZETTI, ANDREA SAPONE, ALESSANDRO CAMERINO & GIORGIO CANTELLI-FORTI. (1998) Testosterone hydroxylase as multibiomarker of effect in evaluating vinclozolin cocarcinogenesis. Biomarkers 3:3, pages 191-203.
Read now
Daniel Enrique Lerda. (1996) Genotoxicity tests on the compounds of polyethylene glycol terephthalate (PET): dimethylterephthalate (DMT) and terephtalic acid (TPA). International Journal of Environmental Health Research 6:2, pages 125-130.
Read now
WilliamT. Stott, JamesS. Bus, JamesE. Gibson & PerryJ. Gehring. (1990) Role of mechanistic data in the interpretation of oncogenicity data and risk assessment. Environmental Carcinogenesis Reviews 8:2, pages 287-298.
Read now

Articles from other publishers (50)

Petko I. Petkov, Terry W. Schultz, E. Maria Donner, Masamitsu Honma, Takeshi Morita, Shuichi Hamada, Akihiro Wakata, Masayuki Mishima, Jiro Maniwa, Milen Todorov, Elena Kaloyanova, Stefan Kotov & Ovanes G. Mekenyan. (2016) Integrated approach to testing and assessment for predicting rodent genotoxic carcinogenicity. Journal of Applied Toxicology 36:12, pages 1536-1550.
Crossref
Pınar Erkekoglu, Naciye D. Zeybek, Belma K. Giray, Walid Rachidi, Murat Kızılgün, Isabelle Hininger-Favier, Alain Favier, Esin Asan & Filiz Hincal. (2014) The effects of di(2-ethylhexyl)phthalate on rat liver in relation to selenium status. International Journal of Experimental Pathology 95:1, pages 64-77.
Crossref
Elio Arias. (2012) Effects of the peroxisome proliferator di(2-ethylhexyl)phthalate on cell turnover and peroxisome proliferation in primary chick embryo hepatocytes. Environmental Toxicology and Chemistry 31:12, pages 2856-2860.
Crossref
Peter M. Lorz, Friedrich K. Towae, Walter Enke, Rudolf Jäckh, Naresh Bhargava & Wolfgang Hillesheim. 2003. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
Li‐Chuan Chen, Vickie Tatum, Howard P. Glauert & Ching K. Chow. (2001) Peroxisome proliferator perfluorodecanoic acid alters glutathione and related enzymes. Journal of Biochemical and Molecular Toxicology 15:2, pages 107-113.
Crossref
Beatriz Silva Lima & Jan Willem Van der Laan. (2000) Mechanisms of Nongenotoxic Carcinogenesis and Assessment of the Human Hazard. Regulatory Toxicology and Pharmacology 32:2, pages 135-143.
Crossref
Ivan RusynMichelle L. RoseHeidi K. BojesRonald G. Thurman. (2000) Novel Role of Oxidants in the Molecular Mechanism of Action of Peroxisome Proliferators. Antioxidants & Redox Signaling 2:3, pages 607-621.
Crossref
Peter M. Lorz, Friedrich K. Towae, Walter Enke, Rudolf Jäckh & Naresh Bhargava. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
Irina G. Shabalina, Theoharis Panaretakis, Anders Bergstrand & Joseph W. Depierre. (1999) Effects of the rodent peroxisome proliferator and hepatocarcinogen, perfluorooctanoic acid, on apoptosis in human hepatoma HepG2 cells. Carcinogenesis 20:12, pages 2237-2246.
Crossref
Moreno Paolini, Jessica Barillari, Silvia Trespidi, Luca Valgimigli, Gian Franco Pedulli & Giorgio Cantelli-Forti. (1999) Captan impairs CYP-catalyzed drug metabolism in the mouse. Chemico-Biological Interactions 123:2, pages 149-170.
Crossref
Laura Pozzetti, Moreno Paolini, Jessica Barillari & Giorgio Cantelli-Forti. (1999) Induction and suppression of murine CYP-mediated biotransformation by dithianon: organ- and sex-related differences. Cancer Letters 141:1-2, pages 47-56.
Crossref
M.A Faouzi, T Dine, B Gressier, K Kambia, M Luyckx, D Pagniez, C Brunet, M Cazin, A Belabed & J.C Cazin. (1999) Exposure of hemodialysis patients to di-2-ethylhexyl phthalate. International Journal of Pharmaceutics 180:1, pages 113-121.
Crossref
M Paolini, L Pozzetti, P Perocco, M Mazzullo & G Cantelli-Forti. (1999) Molecular non-genetic biomarkers of effect related to methyl thiophanate cocarcinogenesis: organ- and sex-specific cytochrome P450 induction in the rat. Cancer Letters 135:2, pages 203-213.
Crossref
F. J. Gonzalez, J. M. Peters & R. C. Cattley. (1998) Mechanism of Action of the Nongenotoxic Peroxisome Proliferators: Role of the Peroxisome Proliferator-Activated Receptor  . JNCI Journal of the National Cancer Institute 90:22, pages 1702-1709.
Crossref
Lai K Leung & Howard P Glauert. (1998) Effect of the peroxisome proliferator ciprofibrate on hepatic cyclooxygenase and phospholipase A2 in rats. Toxicology 126:1, pages 65-73.
Crossref
John P. Vanden Heuvel. (1996) Perfluorodecanoic acid as a useful pharmacologic tool for the study of peroxisome proliferation. General Pharmacology: The Vascular System 27:7, pages 1123-1129.
Crossref
Farber Emmanuel. (1996) Alcohol and Other Chemicals in the Development of Hepatocellular Carcinoma. Clinics in Laboratory Medicine 16:2, pages 377-394.
Crossref
Lai K. Leung & Howard P. Glauert. (1996) Reduction of the concentrations of prostaglandins E2 and F2α, and thromboxane B2 in cultured rat hepatocytes treated with the peroxisome proliferator ciprofibrate. Toxicology Letters 85:3, pages 143-149.
Crossref
David J. Waxman. 1996. Physiological Functions of Cytochrome P450 in Relation to Structure and Regulation. Physiological Functions of Cytochrome P450 in Relation to Structure and Regulation 341 374 .
C. Van den Branden, D. De Craemer, M. Pauwels & J. Vamecq. (1995) Peroxisomes in mice fed a diet supplemented with low doses of fish oil. Lipids 30:8, pages 701-705.
Crossref
Ginger L. Gist & Je Anne R. Burg. (2016) Trichloroethylene — a Review of the Literature From a Health Effects Perspective. Toxicology and Industrial Health 11:3, pages 253-307.
Crossref
D. De Craemer. (1995) Secondary alterations of human hepatocellular peroxisomes. Journal of Inherited Metabolic Disease 18:S1, pages 181-213.
Crossref
D. De Craemer. 1995. Diagnosis of human peroxisomal disorders. Diagnosis of human peroxisomal disorders 181 213 .
Ryohei Hasegawa, Toshinori Yoshida, Yasumoto Mizoguchi, Mitsuru Futakuchi, Dae Joong Kim, Lin Cui & Nobuyuki Ito. (1994) Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital. Cancer Letters 83:1-2, pages 89-95.
Crossref
D De Craemer, J Vamecq, F Roels, L Vallée, M Pauwels & C Van den Branden. (1994) Peroxisomes in liver, heart, and kidney of mice fed a commercial fish oil preparation: original data and review on peroxisomal changes induced by high-fat diets.. Journal of Lipid Research 35:7, pages 1241-1250.
Crossref
J. Ashby, A. Brady, C.R. Elcombe, B.M. Elliott, J. Ishmael, J. Odum, J.D. Tugwood, S. Kettle & I.F.H. Purchase. (2017) Mechanistically-based Human Hazard Assessment of Peroxisome Proliferator-induced Hepatocarcinogenesis. Human & Experimental Toxicology 13:2_suppl, pages S1-S117.
Crossref
Rolf K. Berge & Erlend Hvattum. (1994) Impact of cytochrome P450 system on lipoprotein metabolism. Effect of abnormal fatty acids (3-thia fatty acids). Pharmacology & Therapeutics 61:3, pages 345-383.
Crossref
J A Styles. (1993) Measurement of ploidy and cell proliferation in the rodent liver.. Environmental Health Perspectives 101:suppl 5, pages 67-71.
Crossref
Robert K. Ockner, Raja M. Kaikaus & Nathan M. Bass. (1993) Fatty-acid metabolism and the pathogenesis of hepatocellular carcinoma: Review and hypothesis. Hepatology 18:3, pages 669-676.
Crossref
Tim Borges, Richard E. Peterson, Henry C. Pitot, Larry W. Robertson & Howard P. Glauert. (1993) Effect of the peroxisome proliferator perfluorodecanoic acid on the promotion of two-stage hepatocarcinogenesis in rats. Cancer Letters 72:1-2, pages 111-120.
Crossref
H.A.A.M. Dirven, P.H.H. van den Broek, M.C.E. Peeters, J.G.P. Peters, W.C. Mennes, B.J. Blaauboer, J. Noordhoek & F.J. Jongeneelen. (1993) Effects of the peroxisome proliferator mono(2-ethylhexyl)phthalate in primary hepatocyte cultures derived from rat, guinea pig, rabbit and monkey. Biochemical Pharmacology 45:12, pages 2425-2434.
Crossref
R.J. Bull, M. Templin, J.L. Larson & D.K. Stevens. (1993) The role of dichloroacetate in the hepatocarcinogenicity of trichloroethylene. Toxicology Letters 68:1-2, pages 203-211.
Crossref
Y. Boie, M. Adam, T.H. Rushmore & B.P. Kennedy. (1993) Enantioselective activation of the peroxisome proliferator-activated receptor.. Journal of Biological Chemistry 268:8, pages 5530-5534.
Crossref
William T. Stott. 1993. Handbook of Hazardous Materials. Handbook of Hazardous Materials 545 561 .
H. A. A. M. Dirven, P. H. H. van den Broek & F. J. Jongeneelen. (1993) Determination of four metabolites of the plasticizer di (2-ethylhexyl) phthalate in human urine samples. International Archives of Occupational and Environmental Health 64:8, pages 555-560.
Crossref
H. A. A. M. Dirven, P. H. H. van den Broek, A. M. M. Arends, H. H. Nordkamp, A. J. G. M. de Lepper, P. Th. Henderson & F. J. Jongeneelen. (1993) Metabolites of the plasticizer di (2-ethylhexyl) phthalate in urine samples of workers in polyvinylchloride processing industries. International Archives of Occupational and Environmental Health 64:8, pages 549-554.
Crossref
Neil H. James, Catherine A. Molloy, Anthony R. Soames, Nicola J. French & Ruth A. Roberts. (1992) An in vitro model of rodent nongenotoxic hepatocarcinogenesis. Experimental Cell Research 203:2, pages 407-419.
Crossref
Scott J. Grossman, John G. DeLuca, Robert J. Zamboni, Kevin P. Keenan, Darryl H. Patrick, Eugene G. Herold, Matthew J. van Zwieten & Anthony G. Zacchei. (1992) Enantioselective induction of peroxisomal proliferation in CD-1 mice by leukotriene antagonists. Toxicology and Applied Pharmacology 116:2, pages 217-224.
Crossref
H.A.A.M. Dirven, P.H.H. Van Den Broek, J.G.P. Peters, J. Noordhoek & F.J. Jongeneelen. (1992) Microsomal lauric acid hydroxylase activities after treatment of rats with three classical cytochrome P450 inducers and peroxisome proliferating compounds. Biochemical Pharmacology 43:12, pages 2621-2629.
Crossref
John P. Vanden Heuvel, Benedict I. Kuslikis & Richard E. Peterson. (1992) Covalent binding of perfluorinated fatty acids to proteins in the plasma, liver and testes of rats. Chemico-Biological Interactions 82:3, pages 317-328.
Crossref
Howard P. Glauert, Suseela Srinivasan, Vickie L. Tatum, Li-Chuan Chen, Danita M. Saxon, L.Travis Lay, Tim Borges, Michael Baker, Linda H. Chen, Larry W. Robertson & Ching K. Chow. (1992) Effects of the peroxisome proliferators ciprofibrate and perfluorodecanoic acid on hepatic cellular antioxidants and lipid peroxidation in rats. Biochemical Pharmacology 43:6, pages 1353-1359.
Crossref
Dirk de Craemer, Ingrid Kerckaert & Frank Roels. (1991) Hepatocellular peroxisomes in human alcoholic and drug-induced hepatitis: A quantitative study. Hepatology 14:5, pages 811-817.
Crossref
H.A.A.M. Dirven, J.L.G. Theuws, F.J. Jongeneelen & R.P. Bos. (1991) Non-mutagenicity of 4 metabolites of di(2-ethylhexyl)phthalate (DEHP) and 3 structurally related derivatives of di(2-ethylhexyl)adipate (DEHA) in the Salmonella mutagenicity assay. Mutation Research/Genetic Toxicology 260:1, pages 121-130.
Crossref
Dorothy C. Gosting, M. Ellin Doyle, Carol E. Steinhart & Barbara A. Cochrane. 1991. Food Safety 1990. Food Safety 1990 171 259 .
Frans A.G. Reubsaet, Jacques H. Veerkamp, Marloes L.P. Brückwilder, J.M.Frans Trijbels & Leo A.H. Monnens. (1991) Peroxisomal oxidases and catalase in liver and kidney homogenates of normal and di(ethylhexyl)phthalate-fed rats. International Journal of Biochemistry 23:9, pages 961-967.
Crossref
Thomas L. Goldsworthy, Thomas M. Monticello, Kevin T. Morgan, Edilberto Bermudez, Daniel M. Wilson, Rudolf Jäckh & Byron E. Butterworth. (1991) Examination of potential mechanisms of carcinogenicity of 1,4-dioxane in rat nasal epithelial cells and hepatocytes. Archives of Toxicology 65:1, pages 1-9.
Crossref
N. Bichet, D. Cahard, G. Fabre, B. Remandet, D. Gouy & J-P. Cano. (1990) Toxicological studies on a benzofuran derivative. Toxicology and Applied Pharmacology 106:3, pages 509-517.
Crossref
W. Parzefall, J. Schuppler, G. Barthel, B. Meyer-Rogge & R. Schulte-Hermann. (1990) Toxicological studies on a benzofurane derivative. Toxicology and Applied Pharmacology 106:3, pages 482-499.
Crossref
Byron E. Butterworth. (1990) Consideration of both genotoxic and nongenotoxic mechanisms in predicting carcinogenic potential. Mutation Research/Reviews in Genetic Toxicology 239:2, pages 117-132.
Crossref
Byron E. Butterworth. (1989) Nongenotoxic carcinogens in the regulatory environment. Regulatory Toxicology and Pharmacology 9:3, pages 244-256.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.