218
Views
136
CrossRef citations to date
0
Altmetric
Research Article

In Vitro Methods for Assessing Human Hepatic Drug Metabolism: Their use in Drug Development

, , , , , & show all
Pages 453-484 | Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (16)

S. Marini, E. Grasso, V. Longo, P. Puccini, B. Riccardi & P. Giovanni Gervasi. (2003) 4-Biphenylaldehyde and 9-anthraldehyde: two fluorescent substrates for determining P450 enzyme activities in rat and human. Xenobiotica 33:1, pages 1-11.
Read now
Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
Read now
V. Subrahmanyam, A. B. Renwick, D. G. Walters, R. J. Price, A. P. Tonelli & B. G. Lake. (2002) Metabolism of a novel phosphodiesterase-IV inhibitor (V11294) by human hepatic cytochrome P450 forms. Xenobiotica 32:6, pages 521-534.
Read now
A. B. Renwick, G. Lavignette, P. D. Worboys, B. Williams, D. Surry, D. F. V. Lewis, R. J. Price, B. G. Lake & D. C. Evans. (2001) Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes. Xenobiotica 31:12, pages 861-878.
Read now
A. B. Renwick, D. Surry, R. J. Price, B. G. Lake & D. C. Evans. (2000) Metabolism of 7-benzyloxy-4-trifluoromethylcoumarin by human hepatic cytochrome P450 isoforms. Xenobiotica 30:10, pages 955-969.
Read now
SEAN EKINS & STEVEN A. WRIGHTON. (1999) THE ROLE OF CYP2B6 IN HUMAN XENOBIOTIC METABOLISM*. Drug Metabolism Reviews 31:3, pages 719-754.
Read now
D. McKILLOP, D. J. BACK, A. D. McCORMICK, J. A. EVANS & J. TJIA. (1999) Preclinical and in vitro assessment of the potential of D0870, an antifungal agent, for producing clinical drug interactions. Xenobiotica 29:4, pages 395-408.
Read now
A. B. RENWICK, H. MISTRY, S. E. BALL, D. G. WALTERS, J. KAO & B. G. LAKE. (1998) Metabolism of Zaleplon by human hepatic microsomal cytochrome P450 isoforms. Xenobiotica 28:4, pages 337-348.
Read now
A. R. BOOBIS, D. McKILLOP*D. T. ROBINSON, D. A. ADAMS & D. J. McCORMICK. (1998) Interlaboratory comparison of the assessment of P450 activities in human hepatic microsomal samples. Xenobiotica 28:5, pages 493-506.
Read now
Slobodan Rendic & Frederick J. Di Carlo. (1997) Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors. Drug Metabolism Reviews 29:1-2, pages 413-580.
Read now
J. C. GORSKI, D. R. JONES, S. A. WRIGHTON & S. D. HALL. (1997) Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone. Xenobiotica 27:3, pages 243-256.
Read now
B. G. LAKE, S. E. BALL, A. B. RENWICK, J. M. TREDGER, J. KAO, J. A. BEAMAND & R. J. PRICE. (1997) Induction of CYP3A isoforms in cultured precisioncut human liver slices. Xenobiotica 27:11, pages 1165-1173.
Read now
H. Hanioka, M. Hamamura, K. Kakino, H. Ogata, H. Jinno, A. Takahashi, T. Nishimura & M. Ando. (1995) Dog liver microsomal P450 enzyme-mediated toluene biotransformation. Xenobiotica 25:11, pages 1207-1217.
Read now

Articles from other publishers (120)

М. Я. Головенко, В. Б. Ларіонов & І. П. Валіводзь. (2023) СПЕКТРАЛЬНА ХАРАКТЕРИСТИКА ЦИТОХРОМУ P450 ПРИ ВЗАЄМОДІЇ З ПРОПОКСАЗЕПАМОМ ТА ЙОГО МЕТАБОЛІТОМ. Medical and Clinical Chemistry:2, pages 12-19.
Crossref
Siva Nageswara Rao Gajula, Sakina Asgar Vora, Amol G. Dikundwar & Rajesh Sonti. 2023. Dosage Forms - Innovation and Future Perspectives. Dosage Forms - Innovation and Future Perspectives.
Stefano Fontana, Simone Braggio, Mauro Corsi, Rob Riley, Chris Strock, Jenifer Bradley, Caterina Virginio & Paul Walker. 2023. The Handbook of Medicinal Chemistry. The Handbook of Medicinal Chemistry 533 596 .
Soumendra Darbar, Sangita Agarwal, Srimoyee Saha & Aniruddha Adhikari. 2023. Lantibiotics as Alternative Therapeutics. Lantibiotics as Alternative Therapeutics 377 409 .
Yongmei Li, Michelle McCabe, Lalitha Podila, Timothy S. Tracy & Donald Tweedie. 2021. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 665 684 .
Habibur Rahman, S.K. Manirul Haque & Masoom Raza Siddiqui. (2020) A Comprehensive Review on Importance and Quantitation of Atypical Antipsychotic Drugs and their Active Metabolites in Commercial Dosage Forms. Current Pharmaceutical Analysis 16:8, pages 989-1019.
Crossref
Ha Young Yoon, Min Hyoung Ahn, Jeong Yee, Nari Lee, Ji Min Han & Hye Sun Gwak. (2020) Influence of CYP2C9 and CYP2A6 on plasma concentrations of valproic acid: a meta-analysis. European Journal of Clinical Pharmacology 76:8, pages 1053-1058.
Crossref
Sayada Reemsha Kazmi, Ren Jun, Myeong-Sang Yu, Chanjin Jung & Dokyun Na. (2019) In silico approaches and tools for the prediction of drug metabolism and fate: A review. Computers in Biology and Medicine 106, pages 54-64.
Crossref
Maike Passon. 2019. Bioactive Molecules in Food. Bioactive Molecules in Food 1929 1958 .
James Reuberson, Helen Horsley, Richard J. Franklin, Daniel Ford, Judi Neuss, Daniel Brookings, Qiuya Huang, Bart Vanderhoydonck, Ling-Jie Gao, Mi-Yeon Jang, Piet Herdewijn, Anant Ghawalkar, Farnaz Fallah-Arani, Adnan R. Khan, Jamie Henshall, Mark Jairaj, Sarah Malcolm, Eleanor Ward, Lindsay Shuttleworth, Yuan Lin, Shengqiao Li, Thierry Louat, Mark Waer, Jean Herman, Andrew Payne, Tom Ceska, Carl Doyle, Will Pitt, Mark Calmiano, Martin Augustin, Stefan Steinbacher, Alfred Lammens & Rodger Allen. (2018) Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo . Journal of Medicinal Chemistry 61:15, pages 6705-6723.
Crossref
J.R. Cashman. 2018. Comprehensive Toxicology. Comprehensive Toxicology 87 125 .
F.P. Guengerich. 2018. Comprehensive Toxicology. Comprehensive Toxicology 45 53 .
F.P. Guengerich. 2018. Comprehensive Toxicology. Comprehensive Toxicology 54 86 .
Maike Passon. 2017. Sweeteners. Sweeteners 1 30 .
Qi Yan, David Machalz, Andy Zöllner, Erik J. Sorensen, Gerhard Wolber & Matthias Bureik. (2017) Efficient substrate screening and inhibitor testing of human CYP4Z1 using permeabilized recombinant fission yeast. Biochemical Pharmacology 146, pages 174-187.
Crossref
. 2016. Microbial Biotechnology. Microbial Biotechnology 387 408 .
Arnout Schepers, Cheri Li, Arnav Chhabra, Benjamin Tschudy Seney & Sangeeta Bhatia. (2016) Engineering a perfusable 3D human liver platform from iPS cells. Lab on a Chip 16:14, pages 2644-2653.
Crossref
Yongmei Li, Michelle McCabe, Lalitha Podila, Timothy S. Tracy & Donald J. Tweedie. 2014. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 441 460 .
Rui Liu, Mengnan Qin, Pengzhou Hang, Yan Liu, Zhiren Zhang & Gaofeng Liu. (2012) Effects of Panax notoginseng Saponins on the Activities of CYP1A2, CYP2C9, CYP2D6 and CYP3A4 in Rats In Vivo . Phytotherapy Research 26:8, pages 1113-1118.
Crossref
Jing Zhao, Xiaolin He, Nana Yang, Lizhou Sun & Genxi Li. (2012) Study of Drug Metabolism by Xanthine Oxidase. International Journal of Molecular Sciences 13:4, pages 4873-4879.
Crossref
David E. Moody. 2012. Handbook of Drug Interactions. Handbook of Drug Interactions 25 116 .
M Modarai, J Gertsch, A Suter, M Heinrich & A Kortenkamp. (2007) Cytochrome P450 inhibitory action of Echinacea preparations differs widely and co-varies with alkylamide content. Journal of Pharmacy and Pharmacology 59:4, pages 567-573.
Crossref
N. H. PASSLER, H.-M. CHAN, A. J. STEWART, S. H. DURAN, E. G. WELLES, H.-C. LIN & W. R. RAVIS. (2010) Distribution of voriconazole in seven body fluids of adult horses after repeated oral dosing. Journal of Veterinary Pharmacology and Therapeutics 33:1, pages 35-41.
Crossref
J.R. Cashman & M.S. Motika. 2010. Comprehensive Toxicology. Comprehensive Toxicology 77 110 .
F.P. Guengerich. 2010. Comprehensive Toxicology. Comprehensive Toxicology 31 39 .
Syed Sher SHAH, Kazuaki SASAKI, Yuhei HAYASHI, Seiko MOTOYAMA, Abdou Rania HELMI, Waleed Fathy KHALIL & Minoru SHIMODA. (2009) Inhibitory Effects of Ketoconazole, Cimetidine and Erythromycin on Hepatic CYP3A Activities in Cats. Journal of Veterinary Medical Science 71:9, pages 1151-1159.
Crossref
John Timbrell. 2008. Principles of Biochemical Toxicology, Fourth Edition. Principles of Biochemical Toxicology, Fourth Edition 75 127 .
Vandana Hirani, Anton Yarovoy, Anita Kozeska, Ronald P. Magnusson & Jerome M. Lasker. (2008) Expression of CYP4F2 in human liver and kidney: Assessment using targeted peptide antibodies. Archives of Biochemistry and Biophysics 478:1, pages 59-68.
Crossref
Colleen A. McNaneyDieter M. DrexlerSerhiy Y. HnatyshynTatyana A. ZvyagaJay O. KnipeJames V. BelcastroMark Sanders. (2008) An Automated Liquid Chromatography-Mass Spectrometry Process to Determine Metabolic Stability Half-Life and Intrinsic Clearance of Drug Candidates by Substrate Depletion. ASSAY and Drug Development Technologies 6:1, pages 121-129.
Crossref
C. LAINESSE, D. FRANK, F. BEAUDRY & M. DOUCET. (2007) Comparative oxidative metabolic profiles of clomipramine in cats, rats and dogs: preliminary results from an in vitro study. Journal of Veterinary Pharmacology and Therapeutics 30:5, pages 387-393.
Crossref
Charles W. Locuson, Larry C. Wienkers, Jeffrey P. Jones & Timothy S. Tracy. (2007) CYP2C9 Protein Interactions with Cytochrome b 5 : Effects on the Coupling of Catalysis . Drug Metabolism and Disposition 35:7, pages 1174-1181.
Crossref
Etienne Caron, Nathalie Rioux, Olivier Nicolas, Hugo Lebel‐Talbot & Bettina A. Hamelin. (2006) Quantification of the expression and inducibility of 12 rat cytochrome P450 isoforms by quantitative RT–PCR. Journal of Biochemical and Molecular Toxicology 19:6, pages 368-378.
Crossref
Donna M. Dambach, Barbara A. Andrews & Frederic Moulin. (2016) New Technologies and Screening Strategies for Hepatotoxicity: Use of In Vitro Models. Toxicologic Pathology 33:1, pages 17-26.
Crossref
Xiaoxin Cai, Regina W. Wang, Richard W. Edom, David C. Evans, Magang Shou, A. David Rodrigues, Wensheng Liu, Dennis C. Dean & Thomas A. Baillie. (2004) VALIDATION OF (-)- N -3-BENZYL-PHENOBARBITAL AS A SELECTIVE INHIBITOR OF CYP2C19 IN HUMAN LIVER MICROSOMES . Drug Metabolism and Disposition 32:6, pages 584-586.
Crossref
Robert S. Foti & Michael B. Fisher. (2004) IMPACT OF INCUBATION CONDITIONS ON BUFURALOL HUMAN CLEARANCE PREDICTIONS: ENZYME LABILITY AND NONSPECIFIC BINDING. Drug Metabolism and Disposition 32:3, pages 295-304.
Crossref
David E. Moody. 2004. Handbook of Drug Interactions. Handbook of Drug Interactions 3 88 .
Susan K. Paulson & Timothy J. Maziasz. 2004. Applications of Pharmacokinetic Principles in Drug Development. Applications of Pharmacokinetic Principles in Drug Development 405 425 .
Gabriela Pérez, Beatriz Tabares, Ramiro Jover, Maria-José Gómez-Lechón & José V. Castell. (2003) Semi-automatic quantitative RT-PCR to measure CYP induction by drugs in human hepatocytes. Toxicology in Vitro 17:5-6, pages 643-649.
Crossref
John M. Neal, Kent L. Kunze, René H. Levy, Robert A. O'Reilly & William F. Trager. (2003) K I IV, AN IN VIVO PARAMETER FOR PREDICTING THE MAGNITUDE OF A DRUG INTERACTION ARISING FROM COMPETITIVE ENZYME INHIBITION . Drug Metabolism and Disposition 31:8, pages 1043-1048.
Crossref
Miquel Salva, Josep M. Jansat, Antonio Martinez-Tobed & Jose M. Palacios. (2003) Identification of the Human Liver Enzymes Involved in the Metabolism of the Antimigraine Agent Almotriptan. Drug Metabolism and Disposition 31:4, pages 404-411.
Crossref
M. Teresa Donato & Jos?? V. Castell. (2003) Strategies and Molecular Probes to Investigate the Role of Cytochrome P450 in Drug Metabolism. Clinical Pharmacokinetics 42:2, pages 153-178.
Crossref
Noriko Kose, Minae Isawa, Junko Kizu, Norio Miyazaki, Akira Takanaka & Emi Nakashima. (2003) Application of the PKCYP Test to Predict Caffeine Clearance Mediated by CYP1A2 in a Rat Acute Liver Injury Model. Drug Metabolism and Pharmacokinetics 18:5, pages 296-302.
Crossref
Poh-Sing Ng, Susumu Imaoka, Toyoko Hiroi, Mayuko Osada, Toshio Niwa, Tetsuya Kamataki & Yoshihiko Funae. (2003) Production of Inhibitory Polyclonal Antibodies against Cytochrome P450s. Drug Metabolism and Pharmacokinetics 18:3, pages 163-172.
Crossref
G. Elaut, G. Török, M. Vinken, G. Laus, P. Papeleu, D. Tourwe & V. Rogiers. (2002) Major Phase I Biotransformation Pathways of Trichostatin A in Rat Hepatocytes and in Rat and Human Liver Microsomes. Drug Metabolism and Disposition 30:12, pages 1320-1328.
Crossref
K. Lecointre, V. Furlan & A.‐M. Taburet. (2002) In vitro effects of tacrolimus on human cytochrome P450. Fundamental & Clinical Pharmacology 16:6, pages 455-460.
Crossref
Jean-Fran?ois L?vesque, Mireille Gaudreault, Robert Houle & Nathalie Chauret. (2002) Evaluation of human hepatocyte incubation as a new tool for metabolism study of androstenedione and norandrostenedione in a doping control perspective. Journal of Chromatography B 780:1, pages 145-153.
Crossref
George Lunn. 2001. Kirk-Othmer Encyclopedia of Chemical Technology. Kirk-Othmer Encyclopedia of Chemical Technology.
Feng Gao, Diane L. Johnson, Sean Ekins, John Janiszewski, Kevin G. Kelly, R. Daniel Meyer & Michael West. (2002) Optimizing Higher Throughput Methods to Assess Drug–Drug Interactions for CYP1A2, CYP2C9, CYP2C19, CYP2D6, rCYP2D6, and CYP3A4 In Vitro Using a Single Point IC50. SLAS Discovery 7:4, pages 373-382.
Crossref
Nobumitsu Hanioka, Shogo Ozawa, Hideto Jinno, Toshiko Tanaka-Kagawa, Tetsuji Nishimura, Masanori Ando & Jun-ichi Sawada. (2002) Interaction of Irinotecan (CPT-11) and Its Active Metabolite 7-Ethyl-10-Hydroxycamptothecin (SN-38) with Human Cytochrome P450 Enzymes. Drug Metabolism and Disposition 30:4, pages 391-396.
Crossref
Allen Cato & Lynda SuttonDavid Duch & Robert Ferris. 2002. Clinical Drug Trials And Tribulations, Revised And Expanded. Clinical Drug Trials And Tribulations, Revised And Expanded.
. 2002. Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists. Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists 121 168 .
Catinella Silvia, Pelizzi Nicola, Puccini Paola, Marchetti Silvia, Zanol Margherita, Acerbi Daniela & Ventura Paolo. (2001) Phase I metabolism of ganstigmine. Rat, dog, monkey and human liver microsomal extracts investigated by liquid chromatography electrospray tandem mass spectrometry. Journal of Mass Spectrometry 36:12, pages 1287-1293.
Crossref
W. F. Khalil, T. Saitoh, M. Shimoda & E. Kokue. (2008) In vitro cytochrome P450‐mediated hepatic activities for five substrates in specific pathogen free chickens . Journal of Veterinary Pharmacology and Therapeutics 24:5, pages 343-348.
Crossref
Genevieve Ubeaud, Claus-Ditter Schiller, Fabrice Hurbin, Daniel Jaeck & Philippe Coassolo. (2001) Comparison of the stability of some major cytochrome P450 and conjugation reactions in rat, dog and human hepatocyte monolayers. European Journal of Drug Metabolism and Pharmacokinetics 26:1-2, pages 37-45.
Crossref
Takuo WASHIOHirohiko ARISAWAKazuhiro KOHSAKAHiroshi YASUDA. (2001) Identification of Human Drug-Metabolizing Enzymes Involved in the Metabolism of SNI-2011.. Biological and Pharmaceutical Bulletin 24:11, pages 1263-1266.
Crossref
Larry C Wienkers. (2001) Problems associated with in vitro assessment of drug inhibition of CYP3A4 and other P-450 enzymes and its impact on drug discovery. Journal of Pharmacological and Toxicological Methods 45:1, pages 79-84.
Crossref
D. L. Hiller, A. H. Brockman, L. Goulet, S. Ahmed, R. O. Cole & T. Covey. (2000) Application of a non-indexed dual sprayer pneumatically assisted electrospray source to the high throughput quantitation of target compounds in biological fluids. Rapid Communications in Mass Spectrometry 14:21, pages 2034-2038.
Crossref
Peter J Eddershaw, Alan P Beresford & Martin K Bayliss. (2000) ADME/PK as part of a rational approach to drug discovery. Drug Discovery Today 5:9, pages 409-414.
Crossref
I.A WASFI, N.S BONI, M ELGHAZALI, A.A ABDEL HADI, A.M ALMUHRAMI, I.M BAREZAIG & N.A ALKATHEERI. (2000) The pharmacokinetics, metabolism and urinary detection time of caffeine in camels. Research in Veterinary Science 69:1, pages 69-74.
Crossref
Sean Ekins, Barbara J. Ring, James Grace, Donna J. McRobie-Belle & Steven A. Wrighton. (2000) Present and future in vitro approaches for drug metabolism. Journal of Pharmacological and Toxicological Methods 44:1, pages 313-324.
Crossref
Mitchell A Hamman, Barbara D Haehner-Daniels, Steven A Wrighton, Allan E Rettie & Stephen D Hall. (2000) Stereoselective sulfoxidation of sulindac sulfide by flavin-containing monooxygenases. Biochemical Pharmacology 60:1, pages 7-17.
Crossref
Cristina Rodr?guez-Antona, Ramiro Jover, Maria-Jos? G?mez-Lech?n & Jos? V. Castell. (2000) Quantitative RT-PCR Measurement of Human Cytochrome P-450s: Application to Drug Induction Studies. Archives of Biochemistry and Biophysics 376:1, pages 109-116.
Crossref
C. Prakash, A. Kamel, D. Cui, R. D. Whalen, J. J. Miceli & D. Tweedie. (2001) Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions. British Journal of Clinical Pharmacology 49:S1, pages 35-42.
Crossref
F. Peter Guengerich. (2000) Pharmacogenomics of cytochrome P450 and other enzymes involved in biotransformation of xenobiotics. Drug Development Research 49:1, pages 4-16.
Crossref
Kenworthy, Bloomer, Clarke & Houston. (2001) CYP3A4 drug interactions: correlation of 10 in vitro probe substrates . British Journal of Clinical Pharmacology 48:5, pages 716-727.
Crossref
Jiunn H. Lin. (1999) Role of pharmacokinetics in the discovery and development of indinavir. Advanced Drug Delivery Reviews 39:1-3, pages 33-49.
Crossref
Sandra CoeckeVera RogiersMartin BaylissJosé CastellJohannes DoehmerGérard FabreJeffrey FryArmin Kern & Carl Westmoreland. (2019) The use of Long-term Hepatocyte Cultures for Detecting Induction of Drug Metabolising Enzymes: The Current Status. Alternatives to Laboratory Animals 27:4, pages 579-638.
Crossref
Georges de Sousa, Florence Nicolas, Michel Placidi, Roger Rahmani, Marc Benicourt, Bernard Vannier, Giocondo Lorenzon, Karine Mertens, Sandra Coecke, Andre Callaerts, Vera Rogiers, Shamas Khan, Phil Roberts, Paul Skett, Alain Fautrel, Christophe Chesne & Andre Guillouzo. (1999) A multi-laboratory evaluation of cryopreserved monkey hepatocyte functions for use in pharmaco–toxicology. Chemico-Biological Interactions 121:1, pages 77-97.
Crossref
Krishna R Iyer & Michael W Sinz. (1999) Characterization of Phase I and Phase II hepatic drug metabolism activities in a panel of human liver preparations. Chemico-Biological Interactions 118:2, pages 151-169.
Crossref
Allan Rettie & Michael Fisher. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 131 151 .
John Cashman. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 477 505 .
Sean Ekins, Jukka Maenpää & Steven Wrighton. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 363 399 .
A Rodrigues. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 279 320 .
Sijiu Shen, Michael R. Marchick, Margaret R. Davis, George A. Doss & Lance R. Pohl. (1999) Metabolic Activation of Diclofenac by Human Cytochrome P450 3A4:  Role of 5-Hydroxydiclofenac. Chemical Research in Toxicology 12:2, pages 214-222.
Crossref
Peter J Eddershaw & Maurice Dickins. (1999) Advances in in vitro drug metabolism screening. Pharmaceutical Science & Technology Today 2:1, pages 13-19.
Crossref
Richard M. Philpot, Christine P. Biagini, Geraldine T. Carver, Lila H. Overby, M. Keith Wyatt & Kiyoshi Itagaki. 1999. Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes. Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes 71 79 .
Susan Rotzinger, Jian Fang, Ronald T Coutts & Glen B Baker. (1998) Human CYP2D6 and metabolism of m-chlorophenylpiperazine. Biological Psychiatry 44:11, pages 1185-1191.
Crossref
Brian G. Lake, Anthony B. Renwick, Morag E. Cunninghame, Roger J. Price, Dominic Surry & David C. Evans. (1998) Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver. Toxicology 131:1, pages 9-20.
Crossref
K.M.L. Crommentuyn, J.H.M. Schellens, J.D. van den Berg & J.H. Beijnen. (1998) In-vitro metabolism of anti-cancer drugs, methods and applications: paclitaxel, docetaxel, tamoxifen and ifosfamide. Cancer Treatment Reviews 24:5, pages 345-366.
Crossref
Uwe Christians, Wolfgang Jacobsen & Leslie C. Floren. (1998) Metabolism and Drug Interactions of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors in Transplant Patients. Pharmacology & Therapeutics 80:1, pages 1-34.
Crossref
Yuji Horikiri, Takehiko Suzuki & Masakazu Mizobe. (1998) Stereoselective metabolism of bisoprolol enantiomers in dogs and humans. Life Sciences 63:13, pages 1097-1108.
Crossref
Albert P. Li. (1998) The Scientific Basis of Drug-Drug Interactions: Mechanism and Preclinical Evaluation. Drug Information Journal 32:3, pages 657-664.
Crossref
Xin-Ru Pan-Zhou, Erika Cretton-Scott, Xiao-Jian Zhou, Ming-Xue Yang, Jerome M. Lasker & Jean-Pierre Sommadossi. (1998) Role of Human Liver P450s and Cytochrome b5 in the Reductive Metabolism of 3′-Azido-3′-deoxythymidine (AZT) to 3′-Amino-3′-deoxythymidine. Biochemical Pharmacology 55:6, pages 757-766.
Crossref
Victoria A. Eagling, John F. Tjia & David J. Back. (2002) Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes. British Journal of Clinical Pharmacology 45:2, pages 107-114.
Crossref
M. Zaigler & U. Fuhr. 1998. Forschung ohne Tierversuche 1997. Forschung ohne Tierversuche 1997 54 60 .
Flavia Zucco, Isabella De Angelis & Annalaura Stammati. 1998. Animal Cell Culture Techniques. Animal Cell Culture Techniques 395 422 .
Robert J. Riley & D. Howbrook. (1997) In vitro analysis of the activity of the major human hepatic CYP enzyme (CYP3A4) using [N-methyl-14C]-erythromycin. Journal of Pharmacological and Toxicological Methods 38:4, pages 189-193.
Crossref
T Inaba, N.E Fischer, D.S Riddick, D.J Stewart & T Hidaka. (1997) HIV protease inhibitors, saquinavir, indinavir and ritonavir: inhibition of CYP3A4-mediated metabolism of testosterone and benzoxazinorifamycin, KRM-1648, in human liver microsomes. Toxicology Letters 93:2-3, pages 215-219.
Crossref
Olivia Corcoran, Manfred Spraul, Martin Hofmann, Ismail M Ismail, John C Lindon & Jeremy K Nicholson. (1997) 750 MHz HPLC-NMR spectroscopic identification of rat microsomal metabolites of phenoxypyridines. Journal of Pharmaceutical and Biomedical Analysis 16:3, pages 481-489.
Crossref
Chandrani Gunaratna & Peter T Kissinger. (1997) Application of microdialysis to study the in vitro metabolism of drugs in liver microsomes. Journal of Pharmaceutical and Biomedical Analysis 16:2, pages 239-248.
Crossref
John R. Cashman, Yi-An Bi, Jing Lin, Rima Youil, Melanie Knight, Susan Forrest & Eileen Treacy. (1997) Human Flavin-Containing Monooxygenase Form 3:  cDNA Expression of the Enzymes Containing Amino Acid Substitutions Observed in Individuals with Trimethylaminuria. Chemical Research in Toxicology 10:8, pages 837-841.
Crossref
Jing Lin & John R. Cashman. (1997) Detoxication of Tyramine by the Flavin-Containing Monooxygenase:  Stereoselective Formation of the Trans Oxime . Chemical Research in Toxicology 10:8, pages 842-852.
Crossref
Lila H Overby, Geraldine C Carver & Richard M Philpot. (1997) Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans. Chemico-Biological Interactions 106:1, pages 29-45.
Crossref
Mitchell A. Hamman, Gary A. Thompson & Stephen D. Hall. (1997) Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C. Biochemical Pharmacology 54:1, pages 33-41.
Crossref
Aleksandra Pastrakuljic, Bing K. Tang, Eve A. Roberts & Wemer Kalow. (1997) Distinction of CYP1A1 and CYP1A2 activity by selective inhibition using fluvoxamine and isosafrole. Biochemical Pharmacology 53:4, pages 531-538.
Crossref
A. David Rodrigues & Shekman L. Wong. 1997. 65 101 .
Steven A. Wrighton, Mark VandenBranden & Barbara J. Ring. (1996) The human drug metabolizing cytochromes P450. Journal of Pharmacokinetics and Biopharmaceutics 24:5, pages 461-473.
Crossref
Graham R. Jang, Steven A. Wrighton & Leslie Z. Benet. (1996) Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes. Biochemical Pharmacology 52:5, pages 753-761.
Crossref
Jurgen Schmider, David J. Greenblatt, Lisa L. von Moltke & Richard I. Shader. (1996) Relationship of In Vitro Data on Drug Metabolism to In Vivo Pharmacokinetics and Drug Interactions. Journal of Clinical Psychopharmacology 16:4, pages 267-272.
Crossref
Kristian Linnet & Ove Wiborg. (1996) Steady-state serum concentrations of the neuroleptic perphenazine in relation to CYP2D6 genetic polymorphism. Clinical Pharmacology & Therapeutics 60:1, pages 41-47.
Crossref
J CASHMAN. (1996) Drug discovery and drug metabolism. Drug Discovery Today 1:5, pages 209-216.
Crossref
G S Bailey, D E Williams & J D Hendricks. (1996) Fish models for environmental carcinogenesis: the rainbow trout.. Environmental Health Perspectives 104:suppl 1, pages 5-21.
Crossref
BARBARA J. RING, SHELLY N. BINKLEY, MARK VANDENBRANDEN & STEVEN A. WRIGHTON. (2008) In vitro interaction of the antipsychotic agent olanzapine with human cytochromes P450 CYP2C9, CYP2C19, CYP2D6 and CYP3A . British Journal of Clinical Pharmacology 41:3, pages 181-186.
Crossref
Andrew Parkinson. (2016) An Overview of Current Cytochrome P450 Technology for Assessing the Safety and Efficacy of New Materials. Toxicologic Pathology 24:1, pages 45-57.
Crossref
J. S. Leeder & A. B. Okey. 1996. Drug-Induced Hepatotoxicity. Drug-Induced Hepatotoxicity 119 153 .
Robert J. Fontana & Paul B. Watkins. (1995) GENETIC PREDISPOSITION TO DRUG-INDUCED LIVER DISEASE. Gastroenterology Clinics of North America 24:4, pages 811-838.
Crossref
Uwe Christians & Karl-Friedrich Sewing. (1995) Alternative cyclosporine metabolic pathways and toxicity. Clinical Biochemistry 28:6, pages 547-559.
Crossref
V. Rogiers, B. Blaauboer, P. Maurel, I. Phillips & E. Shephard. (1995) Hepatocyte-based in vitro models and their application in pharmacotoxicology. Toxicology in Vitro 9:5, pages 685-694.
Crossref
Brian Burchell, Catherine H Brierley & David Rance. (1995) Specificity of human UDP-Glucuronosyltransferases and xenobiotic glucuronidation. Life Sciences 57:20, pages 1819-1831.
Crossref
Clifford E. Berkman, Sang B. Park, Steven A. Wrighton & John R. Cashman. (1995) In vitro-in vivo correlations of human (s)-nicotine metabolism. Biochemical Pharmacology 50:4, pages 565-570.
Crossref
G. de Sousa, N. Florence, B. Vallès, P. Coassolo & R. Rahmani. (1995) Relationships betweenin vitro andin vivo biotransformation of drugs in humans and animals: pharmaco-toxicological consequences. Cell Biology and Toxicology 11:3-4, pages 147-153.
Crossref
John R. Cashman, Sang B. Park, Clifford E. Berkman & Lisa E. Cashman. (1995) Role of hepatic flavin-containing monooxygenase 3 in drug and chemical metabolism in adult humans. Chemico-Biological Interactions 96:1, pages 33-46.
Crossref
Steven A. Wrighton, Barbara J. Ring & Mark Vandenbranden. (2016) The Use of In Vitro Metabolism Techniques in the Planning and Interpretation of Drug Safety Studies. Toxicologic Pathology 23:2, pages 199-208.
Crossref
Markku Pasanen, Pertti Pellinen, Frej Stenbäck, Risto O. Juvonen, Hannu Raunio & Olavi Pelkonen. (1995) The role of CYP enzymes in cocaine-induced liver damage. Archives of Toxicology 69:5, pages 287-290.
Crossref
Tanja Kimonen, Risto O. Juvonen, Esko Alhava & Markku Pasanen. (1995) The inhibition of CYP enzymes in mouse and human liver by pilocarpine. British Journal of Pharmacology 114:4, pages 832-836.
Crossref
Charles L. Crespi. 1995. Advances in Drug Research Volume 26. Advances in Drug Research Volume 26 179 235 .
V Spaldin, S Madden, WF Pool, TF Woolf & BK Park. (2012) The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes.. British Journal of Clinical Pharmacology 38:1, pages 15-22.
Crossref
J.Christopher Gorski, David R. Jones, Steven A. Wrighton & Stephen D. Hall. (1994) Characterization of dextromethorphan N-demethylation by human liver microsomes. Biochemical Pharmacology 48:1, pages 173-182.
Crossref
J. Christopher Gorski, Stephen D. Hall, David R. Jones & Mark VandenBranden. (1994) Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily. Biochemical Pharmacology 47:9, pages 1643-1653.
Crossref
M.J. Seaton & E.S. Vesell. (1993) Variables affecting nicotine metabolism. Pharmacology & Therapeutics 60:3, pages 461-500.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.