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Research Article

Role of Human Cytochromes P450 in the Metabolic Activation of Chemical Carcinogens and Toxins

Frank J. Gonzalez National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892
&
Harry V. Gelboin National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892
Pages 165-183 | Published online: 22 Sep 2008

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M. Ozkarsli, H. Sevim & A. Sen. (2008) In vivo effects of Urtica urens (dwarf nettle) on the expression of CYP1A in control and 3-methylcholanthrene-exposed rats. Xenobiotica 38:1, pages 48-61.
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N. Ishiguro, C. Senda, W. Kishimoto, K. Sakai, Y. Funae, T. Igarashi. (2000) Identification of CYP3A4 as the predominant isoform responsible for the metabolism of ambroxol in human liver microsomes. Xenobiotica 30:1, pages 71-80.
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D. F. V. Lewis, M. G. Bird, M. Dickins, B. G. Lake, P. J. Eddershaw, M. H. Tarbit, P. S. Goldfarb. (2000) Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform. Xenobiotica 30:1, pages 1-25.
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K. Inoue, T. Asao & T. Shimada. (2000) Ethnic-related differences in the frequency distribution of genetic polymorphisms in the CYP1A1 and CYP1B1 genes in Japanese and Caucasian populations. Xenobiotica 30:3, pages 285-295.
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M. C. Henderson, C. L. Miranda, J. F. Stevens, M. L. Deinzer & D. R. Buhler. (2000) In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica 30:3, pages 235-251.
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J. J. P. Bogaards, M. Bertrand, P. Jackson, M. J. Oudshoorn, R. J. Weaver, P. J. Van Bladeren & B. Walther. (2000) Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. Xenobiotica 30:12, pages 1131-1152.
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J. Szeliga, R.G. Harvey, C. Cortez & A. Dipple. (1999) DNA Adducts from syn 7-Methylbenz[A]anthracene 3,4-Dihydrodiol 1,2-Epoxide. Polycyclic Aromatic Compounds 13:1, pages 41-53.
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Lars W. Wormhoudt, Jan N. M. Commandeur & Nico P. E. Vermeulen. (1999) Genetic Polymorphisms of Human N-Acetyltransferase, Cytochrome P450, Glutathione-S-Transferase, and Epoxide Hydrolase Enzymes: Relevance to Xenobiotic Metabolism and Toxicity. Critical Reviews in Toxicology 29:1, pages 59-124.
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COSTAS IOANNIDES. (1999) Effect of diet and nutrition on the expression of cytochromes P450. Xenobiotica 29:2, pages 109-154.
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D. F. V. LEWIS, B. G. LAKE, M. DICKINS, P. J. EDDERSHAW, M. H. TARBIT & P. S. GOLDFARB. (1999) Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrome b5 binding site and comparisons with CYP2B1 and CYP2B4. Xenobiotica 29:4, pages 361-393.
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Jukka Hakkola, Olavi Pelkonen, Markku Pasanen & Hannu Raunio. (1998) Xenobiotic-Metabolizing Cytochrome P450 Enzymes in the Human Feto-Placental Unit: Role in Intrauterine Toxicity. Critical Reviews in Toxicology 28:1, pages 35-72.
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Simon D. Spivack, Michael J. Fasco, Vernon E. Walker & Laurence S. Kaminsky. (1997) The Molecular Epidemiology of Lung Cancer. Critical Reviews in Toxicology 27:4, pages 319-365.
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David F. V. Lewis. (1997) Quantitative Structure-Activity Relationships in Substrates, Inducers, and Inhibitors of Cytochrome P4501 (CYP1). Drug Metabolism Reviews 29:3, pages 589-650.
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Slobodan Rendic & Frederick J. Di Carlo. (1997) Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors. Drug Metabolism Reviews 29:1-2, pages 413-580.
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R. GOONERATNE, C. L. MIRANDA, M. C. HENDERSON & D. R. BUHLER*. (1997) β-Naphthoflavone induced CYP1A1 and 1A3 proteins in the liver of rainbow trout (Oncorhynchus mykiss). Xenobiotica 27:2, pages 175-187.
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D. F. V. LEWIS, P. J. EDDERSHAW, P. S. GOLDFARB & M. H. TARBIT. (1997) Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102 : structural studies on specific CYP2D6substrate metabolism. Xenobiotica 27:4, pages 319-340.
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D. F. V. LEWIS*B. G. LAKE. (1997) Molecular modelling of mammalian CYP2B isoforms and their interaction with substrates, inhibitors and redox partners. Xenobiotica 27:5, pages 443-478.
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Pablo Steinberg, Heinz Frank, Franz Oesch & Albrecht Seidel. (1996) The Stereoisomeric Fjord-Region Benzo[c]phenanthrene-3,4-Dihydrodiol 1,2-Oxides Malignantly Transform Rat Liver Epithelial Cells. Polycyclic Aromatic Compounds 10:1-4, pages 275-282.
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Kent E. Pinkerton, Janice L. Peake, Imelda Espiritu, Michael Goldsmith & Hanspeter Witschi. (1996) Quantitative Histology and Cytochrome P-450 Immunocytochemistry of the Lung Parenchyma Following 6 Months of Exposure of Strain A/J Mice to Cigarette Sidestream Smoke. Inhalation Toxicology 8:9, pages 927-945.
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D. F. V. Lewis, P. J. Eddershaw, P. S. Goldfarb & M. H. Tarbit. (1996) Molecular modelling of CYP3A4 from an alignment with CYP102: Identification of key interactions between putative active site residues and CYP3A-specific chemicals. Xenobiotica 26:10, pages 1067-1086.
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D. F. V. Lewis & B. G. Lake. (1996) Molecular modelling of CYP1A subfamily members based on an alignment with CYP102: rationalization of CYP1A substrate specificity in terms of active site amino acid residues. Xenobiotica 26:7, pages 723-753.
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Keun-Hong Kim, Ilsan Choi, Yeon-Weol Lee, Chong-Kwan Cho, Hwa-Seung Yoo, Seung-Bae Lee, Suk Ho Choi, Ki-Rok Kwon & Jun-Hyeog Jang. (2014) Target genes involved in antiproliferative effect of modified ginseng extracts in lung cancer A549 cells. Acta Biochimica et Biophysica Sinica 46:6, pages 441-449.
Crossref
Koei Ikeda, Kenji Shiraishi, Ayami Eguchi, Hironobu Osumi, Kentaro Matsuishi, Emi Matsubara, Kousuke Fujino, Hidekatsu Shibata, Kentaro Yoshimoto, Takeshi Mori, Hisamitsu Omori & Makoto Suzuki. (2013) Association of a Genetic Variant of CYP19A1 with Multicentric Development of Lung Adenocarcinomas. Annals of Surgical Oncology 21:3, pages 939-945.
Crossref
Mohammad Zeeshan Najm, Salman Akhtar, Istaq Ahmad, Shilpi Chattopadhyay, Nasar Mallick, Sarah Siddiqui, Shuaib Zaidi, Waseem Ahmad Siddiqui & Syed Akhtar Husain. (2013) Mutation and protein expression analysis of CYP1A1 gene—a study on female breast cancer cases from India. Tumor Biology 35:3, pages 1965-1971.
Crossref
Shuichi Kuno, Fuminori Sakurai, Kahori Shimizu, Naoya Matsumura, Soonih Kim, Hitoshi Watanabe, Katsuhisa Tashiro, Masashi Tachibana, Tsuyoshi Yokoi & Hiroyuki Mizuguchi. (2014) Development of Mice Exhibiting Hepatic Microsomal Activity of Human CYP3A4 Comparable to That in Human Liver Microsomes by Intravenous Administration of an Adenovirus Vector Expressing Human CYP3A4. Drug Metabolism and Pharmacokinetics 29:4, pages 296-304.
Crossref
Peter P. Fu & Qingsu Xia. 2014. Nutraceutical and Functional Food Regulations in the United States and Around the World. Nutraceutical and Functional Food Regulations in the United States and Around the World 151 168 .
Yunjung Kim, Sara E. Trace, James J. Crowley, Kimberly A. Brownley, Robert M. Hamer, David S. Pisetsky, Patrick F. Sullivan & Cynthia M. Bulik. (2013) Assessment of gene expression in peripheral blood using RNAseq before and after weight restoration in anorexia nervosa. Psychiatry Research 210:1, pages 287-293.
Crossref
Ah-Ng KongJong Lee & Ah-Ng Kong. 2013. Inflammation, Oxidative Stress, and Cancer. Inflammation, Oxidative Stress, and Cancer 3 20 .
Nicola J. Hewitt, Robert J. Edwards, Ellen Fritsche, Carsten Goebel, Pierre Aeby, Julia Scheel, Kerstin Reisinger, Gladys Ouédraogo, Daniel Duche, Joan Eilstein, Alain Latil, Julia Kenny, Claire Moore, Jochen Kuehnl, Joao Barroso, Rolf Fautz & Stefan Pfuhler. (2013) Use of Human In Vitro Skin Models for Accurate and Ethical Risk Assessment: Metabolic Considerations. Toxicological Sciences 133:2, pages 209-217.
Crossref
Elisabeth Eckert, Gabriele Leng, Wolfgang Gries & Thomas Göen. (2013) Excretion of mercapturic acids in human urine after occupational exposure to 2-chloroprene. Archives of Toxicology 87:6, pages 1095-1102.
Crossref
Ching Ho Poon, Tsz Yan Wong, Yanfei Wang, Yuki Tsuchiya, Miki Nakajima, Tsuyoshi Yokoi & Lai K. Leung. (2012) The citrus flavanone naringenin suppresses CYP1B1 transactivation through antagonising xenobiotic-responsive element binding . British Journal of Nutrition 109:9, pages 1598-1605.
Crossref
Tomohide Uno, Yuichiro Obe, Chika Ogura, Tatsushi Goto, Kohei Yamamoto, Masahiko Nakamura, Kengo Kanamaru, Hiroshi Yamagata & Hiromasa Imaishi. (2012) Metabolism of 7‐ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants. Biopharmaceutics & Drug Disposition 34:2, pages 87-97.
Crossref
Yasuhiro Kazuki, Kaoru Kobayashi, Sasitorn Aueviriyavit, Takeshi Oshima, Yoshimi Kuroiwa, Yasuko Tsukazaki, Naoto Senda, Hiroki Kawakami, Sumio Ohtsuki, Satoshi Abe, Masato Takiguchi, Hidetoshi Hoshiya, Naoyo Kajitani, Shoko Takehara, Kinya Kubo, Tetsuya Terasaki, Kan Chiba, Kazuma Tomizuka & Mitsuo Oshimura. (2013) Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans. Human Molecular Genetics 22:3, pages 578-592.
Crossref
Sung-Il Jang, Yeon-Weol Lee, Chong-Kwan Cho, Hwa-Seung Yoo & Jun-Hyeog Jang. (2013) Identification of Target Genes Involved in the Antiproliferative Effect of Enzyme-Modified Ginseng Extract in HepG2 Hepatocarcinoma Cell. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-8.
Crossref
Ripudaman K. Bains. (2013) African variation at Cytochrome P450 genes. Evolution, Medicine, and Public Health 2013:1, pages 118-134.
Crossref
Ewa Augustin, Barbara Borowa-Mazgaj, Agnieszka Kikulska, Milena Kordalewska & Monika Pawłowska. (2012) CYP3A4 overexpression enhances the cytotoxicity of the antitumor triazoloacridinone derivative C-1305 in CHO cells. Acta Pharmacologica Sinica 34:1, pages 146-156.
Crossref
Frank I. Scott & John P. Lynch. 2013. Molecular Pathology of Neoplastic Gastrointestinal Diseases. Molecular Pathology of Neoplastic Gastrointestinal Diseases 3 29 .
Alexander V. LyubimovAndrew Bessire, Kuresh Youdim, Susan Hurst & Caroline A. Lee. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 88 .
Evangelos P. Daskalopoulos, Matti A. Lang, Marios Marselos, Foteini Malliou & Maria Konstandi. (2012) D 2 -Dopaminergic Receptor-Linked Pathways: Critical Regulators of CYP3A, CYP2C, and CYP2D . Molecular Pharmacology 82:4, pages 668-678.
Crossref
Langeswaran Kulanthaivel, Perumal Srinivasan, Vijayaprakash Shanmugam & Balasubramanian Maruthaiveeran Periyasamy. (2012) Therapeutic efficacy of kaempferol against AFB1 induced experimental hepatocarcinogenesis with reference to lipid peroxidation, antioxidants and biotransformation enzymes. Biomedicine & Preventive Nutrition 2:4, pages 252-259.
Crossref
K. Langeswaran, A.J. Jagadeesan, R. Revathy & M.P. Balasubramanian. (2012) Chemotherapeutic efficacy of limonin against Aflatoxin B1 induced primary hepatocarcinogenesis in Wistar albino rats. Biomedicine & Aging Pathology 2:4, pages 206-211.
Crossref
Ching-Chuan Kuo, Huang-Hui Chen & Wenchang Chiang. (2012) Adlay (薏苡 yì yĭ; “soft-shelled job's tears”; the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf) is a Potential Cancer Chemopreventive Agent toward Multistage Carcinogenesis Processes. Journal of Traditional and Complementary Medicine 2:4, pages 267-275.
Crossref
Zaijian Li, Weiyuan Zhang, Xiaocong Lu, Jing Li, Bin He, Hui Jiang, Shasha Wang, Zheng Lu, Chunmei Wang & Jiyue Cao. (2012) Reaction temperature alters chorzoxazone metabolism in carp (Cyprinus carpio) hepatic microsomes. Fish Physiology and Biochemistry 38:5, pages 1225-1231.
Crossref
Eula Bingham & William J. McGowan. 2003. Patty's Toxicology. Patty's Toxicology 1 92 .
Slobodan Rendic & F. Peter Guengerich. (2012) Contributions of Human Enzymes in Carcinogen Metabolism. Chemical Research in Toxicology 25:7, pages 1316-1383.
Crossref
Evangelos P. Daskalopoulos, Foteini Malliou, Georgia Rentesi, Marios Marselos, Matti A. Lang & Maria Konstandi. (2012) Stress is a critical player in CYP3A , CYP2C , and CYP2D regulation: role of adrenergic receptor signaling pathways . American Journal of Physiology-Endocrinology and Metabolism 303:1, pages E40-E54.
Crossref
Hsien-Tsung Yao, Yi-Wei Chang, Naoto Uramaru, Yoko Watanabe, Shigeyuki Kitamura, Yueh-Hsiung Kuo, Chong-Kuei Lii & Teng-Kuang Yeh. (2012) Effects of Bu-Zhong-Yi-Qi-Tang on hepatic drug-metabolizing enzymes and plasma tolbutamide concentration in rats. Journal of Ethnopharmacology 142:1, pages 121-128.
Crossref
S. Hafeez, A. Ahmed, Asif Z. Rashid & Mahmood Akhtar Kayani. (2012) Down-Regulation of CYP1A1 Expression in Breast Cancer. Asian Pacific Journal of Cancer Prevention 13:5, pages 1757-1760.
Crossref
Alexander V. LyubimovBill Gurley, Kim E. Fifer & Zöe Gardner. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 79 .
Hsien-Tsung Yao, Mei-Ning Luo, Lang-Bang Hung, Meng-Tsan Chiang, Jia-Hsuan Lin, Chong-Kuei Lii & Chun-Yin Huang. (2012) Effects of chitosan oligosaccharides on drug-metabolizing enzymes in rat liver and kidneys. Food and Chemical Toxicology 50:5, pages 1171-1177.
Crossref
Linbao Zhang, Lihua Qiu, Huifeng Wu, Xiaoli Liu, Liping You, Dong Pei, Leilei Chen, Qing Wang & Jianmin Zhao. (2012) Expression profiles of seven glutathione S-transferase (GST) genes from Venerupis philippinarum exposed to heavy metals and benzo[a]pyrene. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 155:3, pages 517-527.
Crossref
N. Cardenas-Rodriguez, E. Lara-Padilla, C. Bandala, J. Lopez-Cruz, C. Uscanga-Carmona, P.F. Lucio-Monter & E. Floriano-Sanchez. (2012) CYP2W1, CYP4F11 and CYP8A1 Polymorphisms and Interaction of CYP2W1 Genotypes with Risk Factors in Mexican Women with Breast Cancer. Asian Pacific Journal of Cancer Prevention 13:3, pages 837-846.
Crossref
David Vauzour, Katerina Vafeiadou & Jeremy P. E. Spencer. 2012. Phytonutrients. Phytonutrients 110 145 .
Mitali Chattopadhyay, Ravinder Kodela, Niharika Nath, Cherease R. Street, Carlos A. Velázquez-Martínez, Daniel Boring & Khosrow Kashfi. (2012) Hydrogen sulfide-releasing aspirin modulates xenobiotic metabolizing enzymes in vitro and in vivo. Biochemical Pharmacology 83:6, pages 733-740.
Crossref
Begum Tutuncu, Vural Kuçukatay, Sevki Arslan, Barbaros Sahin, Asli Semiz & Alaattin Sen. (2012) Alteration of drug metabolizing enzymes in sulphite oxidase deficiency. Journal of Clinical Biochemistry and Nutrition 51:1, pages 50-54.
Crossref
Dumrongsak Pekthong, Coraline Desbans, Hélène Martin & Lysiane Richert. (2012) Bupropion Hydroxylation as a Selective Marker of Rat CYP2B1 Catalytic Activity. Drug Metabolism and Disposition 40:1, pages 32-38.
Crossref
John P. Lynch & Anil K. Rustgi. 2012. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 2129 2155 .
Sandra JM Healy, Tom Verfaillie, Richard Jäger, Patrizia Agostinis & Afshin Samali. 2012. Endoplasmic Reticulum Stress in Health and Disease. Endoplasmic Reticulum Stress in Health and Disease 3 22 .
Naglaa Assaf, Neveen A. Salem, Wagdy K.B. Khalil & Hanaa H. Ahmed. (2011) Evaluation of the potential toxicity of dibromoacetonitrile-induced apoptosis and tumor-initiating activity in rat liver. Food and Chemical Toxicology 49:12, pages 3055-3062.
Crossref
Tomohide Uno, Satoru Kaji, Tatsushi Goto, Hiromasa Imaishi, Masahiko Nakamura, Kengo Kanamaru, Hiroshi Yamagata, Yoshio Kaminishi & Takao Itakura. (2011) Metabolism of the herbicides chlorotoluron, diuron, linuron, simazine, and atrazine by CYP1A9 and CYP1C1 from Japanese eel (Anguilla japonica). Pesticide Biochemistry and Physiology 101:2, pages 93-102.
Crossref
Ellen L. Goode, Kristin L. White, Robert A. Vierkant, Catherine M. Phelan, Julie M. Cunningham, Joellen M. Schildkraut, Andrew Berchuck, Melissa C. Larson, Brooke L. Fridley, Janet E. Olson, Penelope M. Webb, Xiaoqing Chen, Jonathan Beesley, Georgia Chenevix‐Trench & Thomas A. Sellers. (2010) Xenobiotic‐Metabolizing gene polymorphisms and ovarian cancer risk. Molecular Carcinogenesis 50:5, pages 397-402.
Crossref
Hsien-Tsung Yao, Jia-Hsuan Lin, Meng-Tsan Chiang, Wenchang Chiang, Mei-Nin Luo & Chong-Kuei Lii. (2011) Suppressive Effect of the Ethanolic Extract of Adlay Bran on Cytochrome P-450 Enzymes in Rat Liver and Lungs. Journal of Agricultural and Food Chemistry 59:8, pages 4306-4314.
Crossref
Ami Oguro, Koichi Sakamoto, Yoshihiko Funae & Susumu Imaoka. (2011) Overexpression of CYP3A4, but not of CYP2D6, Promotes Hypoxic Response and Cell Growth of Hep3B Cells. Drug Metabolism and Pharmacokinetics 26:4, pages 407-415.
Crossref
Andrea Mencarelli, Marco Migliorati, Miriam Barbanti, Sabrina Cipriani, Giuseppe Palladino, Eleonora Distrutti, Barbara Renga & Stefano Fiorucci. (2010) Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells. Biochemical Pharmacology 80:11, pages 1700-1707.
Crossref
Huan Wang & Lai K. Leung. (2010) The carotenoid lycopene differentially regulates phase I and II enzymes in dimethylbenz[a]anthracene-induced MCF-7 cells. Nutrition 26:11-12, pages 1181-1187.
Crossref
Mala Pande, Christopher I. Amos, Cathy Eng & Marsha L. Frazier. (2010) Interactions between cigarette smoking and selected polymorphisms in xenobiotic metabolizing enzymes in risk for colorectal cancer: A case-only analysis. Molecular Carcinogenesis 49:11, pages 974-980.
Crossref
Barbara Bonamassa & Dexi Liu. (2010) Nonviral gene transfer as a tool for studying transcription regulation of xenobiotic metabolizing enzymes. Advanced Drug Delivery Reviews 62:13, pages 1250-1256.
Crossref
Ping Zhan, Jing Wang, Yu Zhang, Li-Xin Qiu, Su-feng Zhao, Qian Qian, Shu-Zhen Wei, Li-Ke Yu & Yong Song. (2010) CYP2E1 Rsa I/Pst I polymorphism is associated with lung cancer risk among Asians. Lung Cancer 69:1, pages 19-25.
Crossref
Hsien-Tsung Yao, Chong-Kuei Lii, Ruey-Hwang Chou, Jia-Hsuan Lin, Hui-Ting Yang & Meng-Tsan Chiang. (2010) Effect of Chitosan on Hepatic Drug-Metabolizing Enzymes and Oxidative Stress in Rats Fed Low- and High-Fat Diets. Journal of Agricultural and Food Chemistry 58:8, pages 5187-5193.
Crossref
Eugene G. Hrycay & Stelvio M. Bandiera. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 70 .
Lushan Yu, Sijie Lu, Naping Zhao, Shaoqing Ni, Tongwei Yao & Su Zeng. (2008) Male-specific induction of CYP3A2 in rats by zolmitriptan. Journal of Pharmacy and Pharmacology 60:12, pages 1601-1607.
Crossref
Lei GuoNan MeiWayne LiaoPo-Chuen ChanPeter P. Fu. (2010) Ginkgo Biloba Extract Induces Gene Expression Changes in Xenobiotics Metabolism and the Myc-Centered Network . OMICS: A Journal of Integrative Biology 14:1, pages 75-90.
Crossref
Lei Guo, Qiang Shi, Stacey Dial, Qingsu Xia, Nan Mei, Quan-zhen Li, Po-Chuen Chan & Peter Fu. (2010) Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies – Changes in drug metabolizing genes and potential mechanisms linked to kava toxicity. Food and Chemical Toxicology 48:2, pages 686-696.
Crossref
Tsuyoshi Okuda, Akihiko Sekizawa, Yuditiya Purwosunu, Masaaki Nagatsuka, Miki Morioka, Masaki Hayashi & Takashi Okai. (2010) Genetics of Endometrial Cancers. Obstetrics and Gynecology International 2010, pages 1-8.
Crossref
Keith Anderson, Jonathan M. Cooper, Stephen J. Haswell, Damian Marshall, Huabing Yin & Xunli Zhang. (2010) Microfluidic-based measurements of cytochrome P450 enzyme activity of primary mammalian hepatocytes. The Analyst 135:6, pages 1282.
Crossref
J. Fujimoto & Y. Iimuro. 2010. Comprehensive Toxicology. Comprehensive Toxicology 437 455 .
H.M. Mehendale. 2010. Comprehensive Toxicology. Comprehensive Toxicology 459 474 .
Vasilis P Androutsopoulos, Aristidis M Tsatsakis & Demetrios A Spandidos. (2009) Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention. BMC Cancer 9:1.
Crossref
W.-H. Jia, Q.-H. Pan, H.-D. Qin, Y.-F. Xu, G.-P. Shen, L. Chen, L.-Z. Chen, Q.-S. Feng, M.-H. Hong, Y.-X. Zeng & Y. Y. Shugart. (2009) A Case-control and a family-based association study revealing an association between CYP2E1 polymorphisms and nasopharyngeal carcinoma risk in Cantonese. Carcinogenesis 30:12, pages 2031-2036.
Crossref
Susanne Rudzok, Eike Schmücking, Carolin Graebsch, Olf Herbarth & Mario Bauer. (2009) The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2. Environmental Toxicology and Pharmacology 28:3, pages 370-378.
Crossref
Sharanjot Saini, Hiroshi Hirata, Shahana Majid & Rajvir Dahiya. (2009) Functional Significance of Cytochrome P 450 1B1 in Endometrial Carcinogenesis . Cancer Research 69:17, pages 7038-7045.
Crossref
Hidekazu Ooe, Junko Kon, Hideki Oshima & Toshihiro Mitaka. (2009) Thyroid Hormone Is Necessary for Expression of Constitutive Androstane Receptor in Rat Hepatocytes. Drug Metabolism and Disposition 37:9, pages 1963-1969.
Crossref
Qin Wang, Xin Sheng, John H. Horner & Martin Newcomb. (2009) Quantitative Production of Compound I from a Cytochrome P450 Enzyme at Low Temperatures. Kinetics, Activation Parameters, and Kinetic Isotope Effects for Oxidation of Benzyl Alcohol. Journal of the American Chemical Society 131:30, pages 10629-10636.
Crossref
Livia Capponi, Andrea Schmitz, Wolfgang Thormann, Regula Theurillat & Meike Mevissen. (2009) In vitro evaluation of differences in phase 1 metabolism of ketamine and other analgesics among humans, horses, and dogs. American Journal of Veterinary Research 70:6, pages 777-786.
Crossref
Amalia Vioque-Fernández, Eduardo Alves de Almeida & Juan López-Barea. (2009) Assessment of Doñana National Park contamination in Procambarus clarkii: Integration of conventional biomarkers and proteomic approaches. Science of The Total Environment 407:5, pages 1784-1797.
Crossref
Munish Kumar, Sudhir K. Agarwal & Sudhir K. Goel. (2008) Lung cancer risk in north Indian population: role of genetic polymorphisms and smoking. Molecular and Cellular Biochemistry 322:1-2, pages 73-79.
Crossref
D.F.V. Lewis, Y. Ito & B.C. Lake. (2009) Molecular Modelling of CYP2F Substrates: Comparison of Naphthalene Metabolism by Human, Rat and Mouse CYP2F Subfamily Enzymes. Drug Metabolism and Drug Interactions 24:2-4.
Crossref
Pramod Vishwanath Prasad, Ramamani Arumugam, Mark Willman, Ren-Shan Ge, Regine Sitruk-Ware & Narender Kumar. (2009) Distribution, metabolism and excretion of a synthetic androgen 7α-methyl-19-nortestosterone, a potential male-contraceptive. Steroids 74:1, pages 121-131.
Crossref
Madhu S. Singh & Michael Michael. 2009. Cancer Epidemiology. Cancer Epidemiology 243 264 .
Xiaocui MaYuyou DuanChristine J. JungJian WuCatherine A. VandeVoortMark A. Zern. (2008) The Differentiation of Hepatocyte-Like Cells from Monkey Embryonic Stem Cells. Cloning and Stem Cells 10:4, pages 485-494.
Crossref
Yuguang Wang, Xuan Ye, Zengchun Ma, Qiande Liang, Beibei Lu, Hongling Tan, Chengrong Xiao, Boli Zhang & Yue Gao. (2008) Induction of cytochrome P450 1A1 expression by ginsenoside Rg1 and Rb1 in HepG2 cells. European Journal of Pharmacology 601:1-3, pages 73-78.
Crossref
Michelle Cotterchio, Beatrice A. Boucher, Michael Manno, Steven Gallinger, Allan B. Okey & Patricia A. Harper. (2008) Red Meat Intake, Doneness, Polymorphisms in Genes that Encode Carcinogen-Metabolizing Enzymes, and Colorectal Cancer Risk. Cancer Epidemiology, Biomarkers & Prevention 17:11, pages 3098-3107.
Crossref
Eun Yi Cho, Chul-Ho Yun, Ho-Zoon Chae, Han-Jung Chae & Taeho Ahn. (2008) Lysophosphatidylserine-induced functional switch of human cytochrome P450 1A2 and 2E1 from monooxygenase to phospholipase D. Biochemical and Biophysical Research Communications 376:3, pages 584-589.
Crossref
Haibiao Gong & Wen Xie. 2008. Nuclear Receptors in Drug Metabolism. Nuclear Receptors in Drug Metabolism 185 210 .
Ekambaram Ganapathy, Rajendran Peramaiyan, Devaraja Rajasekaran, Magesh Venkataraman & Sakthisekaran Dhanapal. (2008) MODULATORY EFFECT OF NARINGENIN ON N -METHYL- N′ -NITRO- N -NITROSOGUANIDINE- AND SATURATED SODIUM CHLORIDE-INDUCED GASTRIC CARCINOGENESIS IN MALE WISTAR RATS . Clinical and Experimental Pharmacology and Physiology 35:10, pages 1190-1196.
Crossref
Nico Scheer, Jillian Ross, Anja Rode, Branko Zevnik, Sandra Niehaves, Nicole Faust & C. Roland Wolf. (2008) A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. Journal of Clinical Investigation 118:9, pages 3228-3239.
Crossref
Eun Yi Cho, Chul-Ho Yun, Ho-Zoon Chae, Han-Jung Chae & Taeho Ahn. (2008) Anionic phospholipid-induced regulation of reactive oxygen species production by human cytochrome P450 2E1. FEBS Letters 582:12, pages 1771-1776.
Crossref
Kyong-Ah Yoon, Jin Hee Kim, Hyea-Jin Gil, Hyukkee Hwang, Bin Hwangbo & Jin Soo Lee. (2008) CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women. Lung Cancer 60:1, pages 40-46.
Crossref
Tomohide Uno, Sota Okamoto, Satoko Masuda, Hiromasa Imaishi, Masahiko Nakamura, Kengo Kanamaru, Hiroshi Yamagata, Mohamed A.H. El-Kady, Yoshio Kaminishi & Takao Itakura. (2008) Bioconversion by functional P450 1A9 and P450 1C1 of Anguilla japonica. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 147:3, pages 278-285.
Crossref
Luigi Quintieri, Pietro Palatini, Alberto Nassi, Paolo Ruzza & Maura Floreani. (2008) Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes. Biochemical Pharmacology 75:6, pages 1426-1437.
Crossref
D. Pekthong, H. Martin, C. Abadie, A. Bonet, B. Heyd, G. Mantion & L. Richert. (2008) Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide. Journal of Ethnopharmacology 115:3, pages 432-440.
Crossref
Nancy Hernández-Martínez, Heriberto Caballero-Ortega, Víctor Dorado-González, Norma Labra-Ruiz, Jesús Javier Espinosa-Aguirre, Josefina Gómez-Garduño & Araceli Vences-Mejía. (2007) Tissue-specific induction of the carcinogen-inducible cytochrome P450 isoforms in the gastrointestinal tract. Environmental Toxicology and Pharmacology 24:3, pages 297-303.
Crossref
Robert D. Bruno & Vincent C.O. Njar. (2007) Targeting cytochrome P450 enzymes: A new approach in anti-cancer drug development. Bioorganic & Medicinal Chemistry 15:15, pages 5047-5060.
Crossref
Helen Steed & Michael B Sawyer. (2007) Pharmacology, pharmacokinetics and pharmacogenomics of paclitaxel. Pharmacogenomics 8:7, pages 803-815.
Crossref
Jason M. GodPatricia TateLyndon L. Larcom. (2007) Anticancer Effects of Four Varieties of Muscadine Grape. Journal of Medicinal Food 10:1, pages 54-59.
Crossref
Osama A. Badary, Mohamed F. Abd-Ellah, Mohamed A. El-Mahdy, Salama A. Salama & Farid M. Hamada. (2007) Anticlastogenic activity of thymoquinone against benzo(a)pyrene in mice. Food and Chemical Toxicology 45:1, pages 88-92.
Crossref
B. Oesch-Bartlomowicz & F. Oesch. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 193 214 .
Hidekazu Ooe, Junko Kon, Shigeki Miyamoto, Yoshiyasu Ozone, Shin-ichi Ninomiya & Toshihiro Mitaka. (2006) Cytochrome P450 Expression of Cultured Rat Small Hepatocytes after Long-Term Cryopreservation. Drug Metabolism and Disposition 34:10, pages 1667-1671.
Crossref
Manoj K. Pandey & Mukul Das. (2006) Assessment of carcinogenic potential of repeated fish fried oil in mice. Molecular Carcinogenesis 45:10, pages 741-751.
Crossref
Taeho Ahn, Chul-Ho Yun & Doo-Byoung Oh. (2006) Tissue-specific effect of ascorbic acid supplementation on the expression of cytochrome P450 2E1 and oxidative stress in streptozotocin-induced diabetic rats. Toxicology Letters 166:1, pages 27-36.
Crossref
Aparajita Dey, Sanjay Yadav, Alok Dhawan, Prahlad K. Seth & Devendra Parmar. (2006) Evidence for cytochrome P450 3A expression and catalytic activity in rat blood lymphocytes. Life Sciences 79:18, pages 1729-1735.
Crossref
Sachiyo Kawashima, Kaoru Kobayashi, Kaori Takama, Tomoaki Higuchi, Tomomi Furihata, Masakiyo Hosokawa & Kan Chiba. (2006) INVOLVEMENT OF HEPATOCYTE NUCLEAR FACTOR 4α IN THE DIFFERENT EXPRESSION LEVEL BETWEEN CYP2C9 AND CYP2C19 IN THE HUMAN LIVER . Drug Metabolism and Disposition 34:6, pages 1012-1018.
Crossref
Nelson L.S. Chan, Huan Wang, Yun Wang, Hau Yi Leung & Lai K. Leung. (2006) Polycyclic aromatic hydrocarbon-induced CYP1B1 activity is suppressed by perillyl alcohol in MCF-7 cells. Toxicology and Applied Pharmacology 213:2, pages 98-104.
Crossref
Manoj K. Pandey, Sanjay Yadav, Devendra Parmar & Mukul Das. (2006) Induction of hepatic cytochrome P450 isozymes, benzo(a)pyrene metabolism and DNA binding following exposure to polycyclic aromatic hydrocarbon residues generated during repeated fish fried oil in rats. Toxicology and Applied Pharmacology 213:2, pages 126-134.
Crossref
Uta Herbst, Judith Iris Fuchs, Wera Teubner & Pablo Steinberg. (2006) Malignant transformation of human colon epithelial cells by benzo[c]phenanthrene dihydrodiolepoxides as well as 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Toxicology and Applied Pharmacology 212:2, pages 136-145.
Crossref
Frank J. GonzalezAi-Ming Yu. (2006) CYTOCHROME P450 AND XENOBIOTIC RECEPTOR HUMANIZED MICE. Annual Review of Pharmacology and Toxicology 46:1, pages 41-64.
Crossref
Sompop Peamkrasatam, Kampon Sriwatanakul, Kazuma Kiyotani, Masaki Fujieda, Hiroshi Yamazaki, Tetsuya Kamataki & Krongtong Yoovathaworn. (2006) In vivo Evaluation of Coumarin and Nicotine as Probe Drugs to Predict the Metabolic Capacity of CYP2A6 Due to Genetic Polymorphism in Thais. Drug Metabolism and Pharmacokinetics 21:6, pages 475-484.
Crossref
Salah Ahmed Sheweita. (2006) Glutathione Alleviates the Influence of N-Nitrosamines on the Activity of Carcinogen-Metabolizing Enzymes in the Liver of Male Mice. Journal of Taibah University Medical Sciences 1:1, pages 72-81.
Crossref
John Lynch & Anil K. Rustgi. 2006. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 477 498 .
M. Denise DearingWilliam J. FoleyStuart McLean. (2005) The Influence of Plant Secondary Metabolites on the Nutritional Ecology of Herbivorous Terrestrial Vertebrates. Annual Review of Ecology, Evolution, and Systematics 36:1, pages 169-189.
Crossref
A.S. Wenzlaff, M.L. Cote, C.H. Bock, S.J. Land, S.K. Santer, D.R. Schwartz & A.G. Schwartz. (2005) CYP1A1 and CYP1B1 polymorphisms and risk of lung cancer among never smokers: a population-based study. Carcinogenesis 26:12, pages 2207-2212.
Crossref
Guohua Qin & Ziqiang Meng. (2005) Effect of sulfur dioxide inhalation on CYP1A1 and CYP1A2 in rat liver and lung. Toxicology Letters 160:1, pages 34-42.
Crossref
Joanna Y. Wilson, Suzy R. Cooke, Michael J. Moore, Daniel Martineau, Igor Mikaelian, Donald A. Metner, W. Lyle Lockhart & John J. Stegeman. (2005) Systemic Effects of Arctic Pollutants in Beluga Whales Indicated by CYP1A1 Expression. Environmental Health Perspectives 113:11, pages 1594-1599.
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Hyun-Jung Kim, Sang Bum Lee, Song-Kyu Park, Hwan Mook Kim, Young In Park & Mi-Sook Dong. (2005) Effects of hydroxyl group numbers on the B-ring of 5,7-dihydroxyflavones on the differential inhibition of human CYP 1A and CYP1B1 enzymes. Archives of Pharmacal Research 28:10, pages 1114-1121.
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