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Drug Metabolism Reviews Volume 27, 1995 - Issue 1-2
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Research Article

Isotope Effect Studies on the Cytochrome P450 Enzymes

Kenneth r. Korzekwa Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892
,
James r. Gillette Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20892
&
William f. Trager Department of Medicinal Chemistry, University of Washington, Seattle, Washington, 98195
Pages 45-59 | Published online: 22 Sep 2008

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STEVEN A. WRIGHTON, ERIN G. SCHUETZ, KENNETH E. THUMMEL, DANNY D. SHEN, KENNETH R. KORZEKWA & PAUL B. WATKINS. (2000) THE HUMAN CYP3A SUBFAMILY: PRACTICAL CONSIDERATIONS*. Drug Metabolism Reviews 32:3-4, pages 339-361.
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Articles from other publishers (18)

Ken Korzekwa. 2021. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 237 256 .
Andrew J. Gow & Henry J. Forman. 2015. Comparative Biology of the Normal Lung. Comparative Biology of the Normal Lung 355 374 .
Ken Korzekwa. 2014. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 149 166 .
Francis K. Yoshimoto, Yishan Zhou, Hwei-Ming Peng, David Stidd, Jennifer A. Yoshimoto, Kamalesh K. Sharma, Susan Matthew & Richard J. Auchus. (2012) Minor Activities and Transition State Properties of the Human Steroid Hydroxylases Cytochromes P450c17 and P450c21, from Reactions Observed with Deuterium-Labeled Substrates. Biochemistry 51:36, pages 7064-7077.
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Stefan Balaz. (2009) Modeling Kinetics of Subcellular Disposition of Chemicals. Chemical Reviews 109:5, pages 1793-1899.
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Tamara S. Dowers & Jeffrey P. Jones. (2006) KINETIC ISOTOPE EFFECTS IMPLICATE A SINGLE OXIDANT FOR CYTOCHROME P450-MEDIATED O -DEALKYLATION, N -OXYGENATION, AND AROMATIC HYDROXYLATION OF 6-METHOXYQUINOLINE . Drug Metabolism and Disposition 34:8, pages 1288-1290.
Crossref
Charles W. Locuson, Hisashi Suzuki, Allan E. Rettie & Jeffrey P. Jones. (2004) Charge and Substituent Effects on Affinity and Metabolism of Benzbromarone-Based CYP2C19 Inhibitors. Journal of Medicinal Chemistry 47:27, pages 6768-6776.
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Sidney D. Nelson & William F. Trager. (2003) THE USE OF DEUTERIUM ISOTOPE EFFECTS TO PROBE THE ACTIVE SITE PROPERTIES, MECHANISM OF CYTOCHROME P450-CATALYZED REACTIONS, AND MECHANISMS OF METABOLICALLY DEPENDENT TOXICITY. Drug Metabolism and Disposition 31:12, pages 1481-1497.
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R. Morris Bullock & Bruce R. Bender. 2002. Encyclopedia of Catalysis. Encyclopedia of Catalysis.
Matthias Wüst & Rodney B. Croteau. (2002) Hydroxylation of Specifically Deuterated Limonene Enantiomers by Cytochrome P450 Limonene-6-Hydroxylase Reveals the Mechanism of Multiple Product Formation. Biochemistry 41:6, pages 1820-1827.
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Supatra Porasuphatana, Pei Tsai, Sovitj Pou & Gerald M Rosen. (2002) Perferryl complex of nitric oxide synthase: role in secondary free radical formation. Biochimica et Biophysica Acta (BBA) - General Subjects 1569:1-3, pages 111-116.
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Matthias Wüst, Dawn B Little, Michel Schalk & Rodney Croteau. (2001) Hydroxylation of Limonene Enantiomers and Analogs by Recombinant (−)-Limonene 3- and 6-Hydroxylases from Mint (Mentha) Species: Evidence for Catalysis within Sterically Constrained Active Sites. Archives of Biochemistry and Biophysics 387:1, pages 125-136.
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LeeAnn Higgins, Kenneth R. Korzekwa, Streedhara Rao, Magong Shou & Jeffrey P. Jones. (2001) An Assessment of the Reaction Energetics for Cytochrome P450-Mediated Reactions. Archives of Biochemistry and Biophysics 385:1, pages 220-230.
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Hyerim Lee, Paul R. Ortiz de Montellano & Ann E. McDermott. (1999) Deuterium Magic Angle Spinning Studies of Substrates Bound to Cytochrome P450. Biochemistry 38:33, pages 10808-10813.
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David Wade. (1999) Deuterium isotope effects on noncovalent interactions between molecules. Chemico-Biological Interactions 117:3, pages 191-217.
Crossref
K. R. Korzekwa, N. Krishnamachary, M. Shou, A. Ogai, R. A. Parise, A. E. Rettie, F. J. Gonzalez & T. S. Tracy. (1998) Evaluation of Atypical Cytochrome P450 Kinetics with Two-Substrate Models:  Evidence That Multiple Substrates Can Simultaneously Bind to Cytochrome P450 Active Sites. Biochemistry 37:12, pages 4137-4147.
Crossref
Stephen R. Dueker, A. Daniel Jones & Andrew J. Clifford. 1998. Mathematical Modeling in Experimental Nutrition. Mathematical Modeling in Experimental Nutrition 363 378 .
Y. Benchekroun, S. Dautraix, M. Desage & J. L. Brazier. (1997) Deuterium isotope effects on caffeine metabolism. European Journal of Drug Metabolism and Pharmacokinetics 22:2, pages 127-133.
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