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Drug Metabolism Reviews Volume 27, 1995 - Issue 1-2
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Research Article

Inhibition of P450 Cytochromes by Reactive Intermediates

Yoichi Osawa Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20892
,
Julio c. Davila Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20892
,
Mikiya Nakatsuka Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20892
,
Carl A. Meyer Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20892
&
John f. Darbyshire Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20892
Pages 61-72 | Published online: 22 Sep 2008

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Jayaprakasam Bolleddula, Kevin DeMent, James P. Driscoll, Philip Worboys, Patrick J. Brassil & David L. Bourdet. (2014) Biotransformation and bioactivation reactions of alicyclic amines in drug molecules. Drug Metabolism Reviews 46:3, pages 379-419.
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Mike Aguiar, Robert Masse & Bernard F. Gibbs. (2005) Regulation of Cytochrome P450 by Posttranslational Modification. Drug Metabolism Reviews 37:2, pages 379-404.
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M. T. Donato, X. Ponsoda, E. O’Connor, J. V. Castell & M. J. Gómez-Lechón. (2001) Role of endogenous nitric oxide in liver-specific functions and survival of cultured rat hepatocytes. Xenobiotica 31:5, pages 249-264.
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Edward T. Morgan. (1997) Regulation of Cytochromes P450 During Inflammation and Infection. Drug Metabolism Reviews 29:4, pages 1129-1188.
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Articles from other publishers (10)

Brigitte GanterRonald D SnyderDonald N HalbertMay D Lee. (2006) Toxicogenomics in drug discovery and development: mechanistic analysis of compound/class-dependent effects using the DrugMatrix ® database . Pharmacogenomics 7:7, pages 1025-1044.
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Monica I. Jushchyshyn, Jan L. Wahlstrom, Paul F. Hollenberg & Larry C. Wienkers. (2006) Mechanism of Inactivation of Human Cytochrome P450 2B6 by Phencyclidine. Drug Metabolism and Disposition 34:9, pages 1523-1529.
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J Fisher, M Lumpkin, J Boyd, D Mahle, J.V Bruckner & H.A El-Masri. (2004) PBPK modeling of the metabolic interactions of carbon tetrachloride and tetrachloroethylene in B6C3F1 mice. Environmental Toxicology and Pharmacology 16:1-2, pages 93-105.
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Kazuo Asagiri, Mikiya Nakatsuka, Hideki Konishi, Soichi Noguchi, Masayo Takata, Toshihiro Habara & Takafumi Kudo. (2003) Involvement of peroxynitrite in LPS-induced apoptosis of trophoblasts. Journal of Obstetrics and Gynaecology Research 29:1, pages 49-55.
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Tong Li-Masters & Edward T Morgan. (2002) Down-regulation of phenobarbital-induced cytochrome P4502B mRNAs and proteins by endotoxin in mice: independence from nitric oxide production by inducible nitric oxide synthase. Biochemical Pharmacology 64:12, pages 1703-1711.
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Luc Ferrari, Ning Peng, James R. Halpert & Edward T. Morgan. (2001) Role of Nitric Oxide in Down-Regulation of CYP2B1 Protein, but Not RNA, in Primary Cultures of Rat Hepatocytes. Molecular Pharmacology 60:1, pages 209-216.
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Yasuhiko Kamada, Mikiya Nakatsuka, Kazuo Asagiri, Soichi Noguchi, Toshihiro Habara, Masayo Takata & Takafumi Kudo. (2000) GnRH agonist-suppressed expression of nitric oxide synthases and generation of peroxynitrite in adenomyosis. Human Reproduction 15:12, pages 2512-2519.
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Elizabeth S. Roberts, Hsia-lien Lin, Jan R. Crowley, Jennifer L. Vuletich, Yoichi Osawa & Paul F. Hollenberg. (1998) Peroxynitrite-Mediated Nitration of Tyrosine and Inactivation of the Catalytic Activity of Cytochrome P450 2B1. Chemical Research in Toxicology 11:9, pages 1067-1074.
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Marion B. Sewer, Thomas B. Barclay & Edward T. Morgan. (1998) Down-Regulation of Cytochrome P450 mRNAs and Proteins in Mice Lacking a Functional NOS2 Gene. Molecular Pharmacology 54:2, pages 273-279.
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Marion B Sewer & Edward T Morgan. (1997) Nitric oxide-independent suppression of P450 2C11 expression by interleukin-1? and endotoxin in primary rat hepatocytes. Biochemical Pharmacology 54:6, pages 729-737.
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