Citations (147)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (10)
Chaitanya K. Jaladanki, Anuj Gahlawat, Gajanan Rathod, Hardeep Sandhu, Kousar Jahan & Prasad V. Bharatam. (2020) Mechanistic studies on the drug metabolism and toxicity originating from cytochromes P450. Drug Metabolism Reviews 52:3, pages 366-394.
Read now
Read now
Mark P Grillo. (2015) Detecting reactive drug metabolites for reducing the potential for drug toxicity. Expert Opinion on Drug Metabolism & Toxicology 11:8, pages 1281-1302.
Read now
Read now
S. Palani, S. Raja, S.
Nirmal Kumar & B.
Senthil Kumar. (2011) Nephroprotective and antioxidant activities of Salacia oblonga on acetaminophen-induced toxicity in rats. Natural Product Research 25:19, pages 1876-1880.
Read now
Read now
Faustin PascalT. Manfo, EdouardA. Nantia, AngèleN. Tchana, ThomasK. Monsees & PaulF. Moundipa. (2011) Evaluation of the effect of Carpolobia alba (Polygalaceae) aqueous extract on male reproductive function in rats. Journal of Applied Animal Research 39:1, pages 80-84.
Read now
Read now
S. Palani, S. Raja, R. Naresh & B. Senthil Kumar. (2010) Evaluation of nephroprotective, diuretic, and antioxidant activities of plectranthus amboinicus on acetaminophen-induced nephrotoxic rats. Toxicology Mechanisms and Methods 20:4, pages 213-221.
Read now
Read now
N. N. Patel, C. M. Crincoli, E. L. Kennedy, D. M. Frederick, R. Tchao & P. J. Harvison. (2008) Effect of gender, dose, and time on 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT)-induced hepatotoxicity in Fischer 344 rats. Xenobiotica 38:4, pages 435-449.
Read now
Read now
Kasturi Sarkar & Parames C. Sil. (2007) Attenuation of Acetaminophen-Induced Hepatotoxicity In Vivo and In Vitro by a 43-kD Protein Isolated from the Herb Cajanus indicus L. Toxicology Mechanisms and Methods 17:6, pages 305-315.
Read now
Read now
Jos G. M. Bessems & Nico P. E. Vermeulen. (2001) Paracetamol (Acetaminophen)-Induced Toxicity: Molecular and Biochemical Mechanisms, Analogues and Protective Approaches. Critical Reviews in Toxicology 31:1, pages 55-138.
Read now
Read now
M. Hojo, K. Hanioka, M. Miyata & Y. Yamazoe. (2000) Hepatotoxicity of acetaminophen and N-acetyl-p-benzoquinone imine and enhancement by fructose. Xenobiotica 30:9, pages 933-941.
Read now
Read now
Steven D. Cohen & Edward A. Khairallah. (1997) Selective Protein Arylation and Acetaminophen-Induced Hepatotoxicity. Drug Metabolism Reviews 29:1-2, pages 59-77.
Read now
Read now
Articles from other publishers (137)
Mitchell R. McGill, Yihong Kaufmann, Francesca V. LoBianco, Mary A. Schleiff, Nukhet Aykin-Burns & Grover P. Miller. (2023) The Role of Cytochrome P450 3A4-Mediated Metabolism in Sorafenib and Lapatinib Hepatotoxicity. Livers 3:2, pages 310-321.
Crossref
Crossref
Amir Rostami, Tourandokht Baluchnejadmojarad & Mehrdad Roghani. (2023) Hepatoprotective Effect of Myricetin following Lipopolysaccharide/DGalactosamine:
Involvement of Autophagy and Sirtuin 1. Current Molecular Pharmacology 16:3, pages 419-433.
Crossref
Crossref
Wasim Akram, Priti Tagde, Sakeel Ahmed, Swamita Arora, Talha Bin Emran, Ahmad O. Babalghith, Sherouk Hussein Sweilam & Jesus Simal-Gandara. (2023) Guaiazulene and related compounds: A review of current perspective on biomedical applications. Life Sciences 316, pages 121389.
Crossref
Crossref
Zunera Chauhdary, Muhammad Ajmal Shah & Mariam S. Al-Ghamdi. 2023. Phytonutrients and Neurological Disorders. Phytonutrients and Neurological Disorders
369
379
.
MARK P. GRILLO. 2022. Drug Metabolism Handbook. Drug Metabolism Handbook
703
743
.
MARK P. GRILLO. 2022. Drug Metabolism Handbook. Drug Metabolism Handbook
677
702
.
Jonathan Ricardo Rosas-Ramírez, José Manuel Orozco-Hernández, Gustavo Axel Elizalde-Velázquez, Demetrio Raldúa, Hariz Islas-Flores & Leobardo Manuel Gómez-Oliván. (2022) Teratogenic effects induced by paracetamol, ciprofloxacin, and their mixture on Danio rerio embryos: Oxidative stress implications. Science of The Total Environment 806, pages 150541.
Crossref
Crossref
R. Scott Obach & Nina Isoherranen. 2022. Atkinson's Principles of Clinical Pharmacology. Atkinson's Principles of Clinical Pharmacology
151
168
.
Mark P. Grillo. 2021. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity
167
205
.
Noah R. Flynn, Michael D. Ward, Mary A. Schleiff, Corentine M. C. Laurin, Rohit Farmer, Stuart J. Conway, Gunnar Boysen, S. Joshua Swamidass & Grover P. Miller. (2021) Bioactivation of Isoxazole-Containing Bromodomain and Extra-Terminal Domain (BET) Inhibitors. Metabolites 11:6, pages 390.
Crossref
Crossref
Asal Ahmadi, Hassan Gandomi, Abdollah Derakhshandeh, Ali Misaghi & Negin Noori. (2021) Phytochemical composition and in vitro safety evaluation of Ziziphora clinopodioides Lam. ethanolic extract: Cytotoxicity, genotoxicity and mutagenicity assessment. Journal of Ethnopharmacology 266, pages 113428.
Crossref
Crossref
Ravindrababu Pingili, A. Krishnamanjari Pawar & Siva Reddy Challa. (2019)
Quercetin reduced the formation of
N
‐acetyl‐
p
‐benzoquinoneimine, a toxic metabolite of paracetamol in rats and isolated rat hepatocytes
. Phytotherapy Research 33:7, pages 1770-1783.
Crossref
Crossref
Sasikala M. Chinnappan, Annie George, Praveen Thaggikuppe, YogendraKumar Choudhary, Vandana K. Choudhary, Yesha Ramani & Rashmi Dewangan. (2019)
Nephroprotective Effect of Herbal Extract
Eurycoma longifolia
on Paracetamol-Induced Nephrotoxicity in Rats
. Evidence-Based Complementary and Alternative Medicine 2019, pages 1-6.
Crossref
Crossref
Ravindra Babu Pingili, A. Krishnamanjari Pawar & Siva R. Challa. (2019) Effect of chrysin on the formation of N-acetyl-p-benzoquinoneimine, a toxic metabolite of paracetamol in rats and isolated rat hepatocytes. Chemico-Biological Interactions 302, pages 123-134.
Crossref
Crossref
Shristy S. Tiwari, Balasaheb B. Chavan, Bhoopendra S. Kushwah, Naga Veera Yerra, Sumit Mukesh, Abhay T. Sangamwar, Jagadeshwar Reddy Thaota & M.V.N. Kumar Talluri. (2019) In vitroand in vivo investigation of metabolic fate of riociguat by HPLC-Q-TOF/MS/MS and in silico evaluation of the metabolites by ADMET predictor™. Journal of Pharmaceutical and Biomedical Analysis 164, pages 326-336.
Crossref
Crossref
Lingli Zheng, Lianhong Yin, Lina Xu, Yan Qi, Hua Li, Youwei Xu, Xu Han, Kexin Liu & Jinyong Peng. (2018) Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Biomedicine & Pharmacotherapy 97, pages 481-488.
Crossref
Crossref
Mijat Božović & Rino Ragno. (2017) Calamintha nepeta (L.) Savi and its Main Essential Oil Constituent Pulegone: Biological Activities and Chemistry. Molecules 22:2, pages 290.
Crossref
Crossref
Olavi Pelkonen & Jorma T. Ahokas. 2017. Toxicology of Herbal Products. Toxicology of Herbal Products
67
80
.
Samuel Ayodele Egieyeh, James Syce, Sarel F. Malan & Alan Christoffels. (2016) Prioritization of anti-malarial hits from nature: chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs. Malaria Journal 15:1.
Crossref
Crossref
Saravanan Shanmugam, Parimelazhagan Thangaraj, Bruno dos Santos Lima, Rahul Chandran, Adriano Antunes de Souza Araújo, Narendra Narain, Mairim Russo Serafini & Lucindo José Quintans Júnior. (2016) Effects of luteolin and quercetin 3-β-d-glucoside identified from Passiflora subpeltata leaves against acetaminophen induced hepatotoxicity in rats. Biomedicine & Pharmacotherapy 83, pages 1278-1285.
Crossref
Crossref
Kab Bae Kim & Ki-Woong Kim. (2016) Reactive Oxygen Species and Cellular Immune Function of Workers Chronically Exposed to High-Level Dusts. Journal of Korean Society of Occupational and Environmental Hygiene 26:3, pages 286-292.
Crossref
Crossref
Richard A. Thompson, Emre M. Isin, Monday O. Ogese, Jerome T. Mettetal & Dominic P. Williams. (2016) Reactive Metabolites: Current and Emerging Risk and Hazard Assessments. Chemical Research in Toxicology 29:4, pages 505-533.
Crossref
Crossref
Marwa E. Sayour, Rania M. Abd El Salam, Mohamed F. Elyamany, Abeer M. El Sayed & Raafat A. El-Awady. (2016) Combination of Paracetamol and the Glutathione Depleting Agent Buthionine Sulfoximine Show Differential Effect on Liver Cancer Cells and Normal Hepatocytes. Pharmacology & Pharmacy 07:11, pages 443-458.
Crossref
Crossref
Afolabi C. Akinmoladun, M. Tolulope Olaleye, Kayode Komolafe, Abayomi O. Adetuyi & Afolabi A. Akindahunsi. (2015)
Effect of homopterocarpin, an isoflavonoid from
Pterocarpus
erinaceus
, on indices of liver injury and oxidative stress in acetaminophen-provoked hepatotoxicity
. Journal of Basic and Clinical Physiology and Pharmacology 26:6, pages 555-562.
Crossref
Crossref
Kuang-Ting Yeh, Wen-Tien Wu, Yi-Maun Subeq, Chi-Chien Niu, Kuang-Wen Liao, Ing-Ho Chen, Jen-Hung Wang & Ru-Ping Lee. (2015) Non-Steroid Anti-Inflammatory Drugs Are Better than Acetaminophen on Fever Control at Acute Stage of Fracture. PLOS ONE 10:10, pages e0137225.
Crossref
Crossref
Arpita Mandal, Arpita Patra, Shreya Mandal, Suchismita Roy, Shreya Das Mahapatra, Tapasi Das Mahapatra, Tanmay Paul, Koushik Das, Keshab Chandra Mondal & Dilip Kumar Nandi. (2014) Therapeutic potential of different commercially available synbiotic on acetaminophen-induced uremic rats. Clinical and Experimental Nephrology 19:2, pages 168-177.
Crossref
Crossref
Jeff B. Helms, Lauren P. Saunders, Jamie Meyer, Charles J. Costa, Eric Plowman, Nick Williford, Matthew Corbitt, Jeremy P. Holden & Craig Gatto. (2015) Kinetic Characterization of Na,K-ATPase Inhibition by the Acetaminophen Metabolite N-Acetylbenzoquinoneimine. Open Journal of Molecular and Integrative Physiology 05:01, pages 1-17.
Crossref
Crossref
Eberhard Scheuch, Karen Methling, Patrick J. Bednarski, Stefan Oswald & Werner Siegmund. (2015) Quantitative LC–MS/MS determination of flupirtine, its N-acetylated and two mercapturic acid derivatives in man. Journal of Pharmaceutical and Biomedical Analysis 102, pages 377-385.
Crossref
Crossref
Manal M. Sayed & Eman A. El-Kordy. (2014) The protective effect of curcumin on paracetamol-induced liver damage in adult male rabbits. The Egyptian Journal of Histology 37:4, pages 629-639.
Crossref
Crossref
Xi-Yuan Zheng, Ying-Fan Yang, Wan Li, Xin Zhao, Yi Sun, Hua Sun, Yue-Hua Wang & Xiao-Ping Pu. (2014) Two xanthones from Swertia punicea with hepatoprotective activities in vitro and in vivo. Journal of Ethnopharmacology 153:3, pages 854-863.
Crossref
Crossref
Richard B. Silverman & Mark W. Holladay. 2014. The Organic Chemistry of Drug Design and Drug Action. The Organic Chemistry of Drug Design and Drug Action
357
422
.
Ji-Hoon ParkKang-Sik SeoSurendar TadiBong-Hyun AhnJung-Uee LeeJun-Young HeoJeongsu HanMyoung-Sub SongSoon-Ha KimYong-Hyeon YimHueng-Sik ChoiMinho ShongGiRyang Kweon. (2013)
An Indole Derivative Protects Against Acetaminophen-Induced Liver Injury by Directly Binding to
N
-Acetyl-
p
-Benzoquinone Imine in Mice
. Antioxidants & Redox Signaling 18:14, pages 1713-1722.
Crossref
Crossref
Ki-Woong Kim, Yong Lim Won, Kyung Sun Ko, Kyung-Hwa Heo & Yong Hyun Chung. (2012) The Effects of Hazardous Chemical Exposure on Cardiovascular Disease in Chemical Products Manufacturing Workers. Toxicological Research 28:4, pages 269-277.
Crossref
Crossref
S. Cyrus Khojasteh, Dylan P. Hartley, Kevin A. Ford, Hirdesh Uppal, Shimako Oishi & Sidney D. Nelson. (2012) Characterization of Rat Liver Proteins Adducted by Reactive Metabolites of Menthofuran. Chemical Research in Toxicology 25:11, pages 2301-2309.
Crossref
Crossref
Alexander V. LyubimovRonald E. White. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
40
.
Husamettin Gul, Bulent Uysal, Erdinc Cakir, Halil Yaman, Enis Macit, Ali Osman Yildirim, Yusuf Emrah Eyi, Umit Kaldirim, Emin Oztas, Emin Ozgur Akgul, Tuncer Cayci, Mehmet Ozler, Turgut Topal, Sukru Oter, Ahmet Korkmaz, Mehmet Toygar & Suzi Demirbag. (2012) The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury. Environmental Toxicology and Pharmacology 34:1, pages 81-86.
Crossref
Crossref
Sang-Won Hong, Hee-Seung Lee, Kyung Hee Jung, Hyunseung Lee & Soon-Sun Hong. (2012) Protective effect of fucoidan against acetaminophen-induced liver injury. Archives of Pharmacal Research 35:6, pages 1099-1105.
Crossref
Crossref
Zariyantey Abdul Hamid, Siti Balkis Budin, Ng Wen Jie, Asmah Hamid, Khairana Husain & Jamaludin Mohamed. (2012) Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats. Journal of Zhejiang University SCIENCE B 13:3, pages 176-185.
Crossref
Crossref
Angelo Theodoratos, Anneke C. Blackburn, Jean Cappello, Padmaja Tummala, Jane E. Dahlstrom & Philip G. Board. (2012) Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate–cysteine ligase. Biochemical Pharmacology 83:3, pages 427-433.
Crossref
Crossref
Shiekh Tanveer Ahmad, Wani Arjumand, Sana Nafees, Amlesh Seth, Nemat Ali, Summya Rashid & Sarwat Sultana. (2012) Hesperidin alleviates acetaminophen induced toxicity in wistar rats by abrogation of oxidative stress, apoptosis and inflammation. Toxicology Letters 208:2, pages 149-161.
Crossref
Crossref
Sanford P. Markey. 2012. Principles of Clinical Pharmacology. Principles of Clinical Pharmacology
153
172
.
R. Nagalekshmi, Aditya Menon, Dhanya K. Chandrasekharan & Cherupally Krishnan Krishnan Nair. (2011) Hepatoprotective activity of Andrographis Paniculata and Swertia Chirayita. Food and Chemical Toxicology 49:12, pages 3367-3373.
Crossref
Crossref
Hayati Kandiş, Melih Engin Erkan, Ümran Yildirim, Harun Güneş, Mesut Erbaş, Hayriye AK Yildirim, Suat Gezer & İsmail Hamdi Kara. (2010)
Comparison of the effects of
N
-acetyl cysteine and erdosteine in rats with renal injury caused by paracetamol intoxication
. Human & Experimental Toxicology 30:9, pages 1350-1358.
Crossref
Crossref
Hideo Takakusa, Michelle D. Wahlin, Chunsheng Zhao, Kelsey L. Hanson, Lee Sun New, Eric Chun Yong Chan & Sidney D. Nelson. (2011) Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib. Drug Metabolism and Disposition 39:6, pages 1022-1030.
Crossref
Crossref
Angeliki P Kourounakis, Eleni A Rekka & Panos N Kourounakis. (1997) Antioxidant Activity of Guaiazulene and Protection Against Paracetamol Hepatotoxicity in Rats. Journal of Pharmacy and Pharmacology 49:9, pages 938-942.
Crossref
Crossref
Anke Van Summeren, Johan Renes, Freek G. Bouwman, Jean-Paul Noben, Joost H. M. van Delft, Jos C. S. Kleinjans & Edwin C. M. Mariman. (2011) Proteomics Investigations of Drug-Induced Hepatotoxicity in HepG2 Cells. Toxicological Sciences 120:1, pages 109-122.
Crossref
Crossref
Yohannes Teffera, Deborah Choquette, Jingzhou Liu, Adria E. Colletti, L. Steven Hollis, Min-Hwa Jasmine Lin & Zhiyang Zhao. (2010) Bioactivation of Isothiazoles: Minimizing the Risk of Potential Toxicity in Drug Discovery. Chemical Research in Toxicology 23:11, pages 1743-1752.
Crossref
Crossref
Jian Yu, Dean G. Brown & Doug Burdette. (2010) In Vitro Metabolism Studies of Nomifensine Monooxygenation Pathways: Metabolite Identification, Reaction Phenotyping, and Bioactivation Mechanism. Drug Metabolism and Disposition 38:10, pages 1767-1778.
Crossref
Crossref
Václav Martínek, Jan Sklenář, Martin Dračínský, Miroslav Šulc, Kateřina Hofbauerová, Karel Bezouška, Eva Frei & Marie Stiborová. (2010) Glycosylation Protects Proteins against Free Radicals Generated from Toxic Xenobiotics. Toxicological Sciences 117:2, pages 359-374.
Crossref
Crossref
Javad Sajedianfard, Mahdi Saeb & Muhammad-Hassan Baigzadeh. (2009) Therapeutic effect of cimetidine on acetaminophen-induced nephrotoxicity in rabbits. Comparative Clinical Pathology 19:4, pages 373-376.
Crossref
Crossref
Hsi-Chu Peng, Yun-Hsin Wang, Chi-Chung Wen, Wei-Hua Wang, Chien-Chung Cheng & Yau-Hung Chen. (2010) Nephrotoxicity assessments of acetaminophen during zebrafish embryogenesis. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 151:4, pages 480-486.
Crossref
Crossref
Mark P. Grillo. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia
1
42
.
Mark P. Grillo. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia
1
26
.
B. Alex Merrick & Maribel E. Bruno. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia
1
33
.
V. V. Shumyantseva, E. V. Suprun, T. V. Bulko, O. V. Dobrynina & A. I. Archakov. (2010) Sensor systems for medical application based on hemoproteins and nanocomposite materials. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 4:1, pages 25-36.
Crossref
Crossref
Zhao-Hui Huang, Teruo Murakami, Atsuko Okochi, Ryoko Yumoyo, Junya Nagai & Mikihisa Takano. (2001) Expression and function of P-glycoprotein in rats with carbon tetrachloride-induced acute hepatic failure. Journal of Pharmacy and Pharmacology 53:6, pages 873-881.
Crossref
Crossref
V.V. Shumyantseva, E.V. Suprun, T.V. Bulko, O.V. Dobrinina & A.I. Archakov. (2010) Sensor systems for medical application based on hemoproteins and nanocomposite materials. Biomeditsinskaya Khimiya 56:1, pages 55-71.
Crossref
Crossref
Hao Yin, Linling Cheng, Michael Holt, Numsen HailJrJr, Robert MacLaren & Cynthia Ju. (2010) Lactoferrin protects against acetaminophen-induced liver injury in mice. Hepatology, pages NA-NA.
Crossref
Crossref
Naoya MATSUNAGA. (2009) Dosing Time Based on Molecular Mechanism of Biological Clock of Hepatic Drug Metabolic Enzyme肝薬物代謝酵素の体内時計の分子機構を基盤にした投薬タイミング. YAKUGAKU ZASSHI 129:11, pages 1357-1365.
Crossref
Crossref
John A. Timbrell & Timothy C. Marrs. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Hao Chen, Michael Zientek, Mehran Jalaie, Yanhua Zhang, Christopher Bigge & Abdul Mutlib. (2009)
Characterization of Cytochrome P450-Mediated Bioactivation of a Compound Containing the Chemical Scaffold, 4,5-Dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a Chemically Reactive
p
-Chlorophenyl Isocyanate Intermediate in Human Liver Microsomes
. Chemical Research in Toxicology 22:9, pages 1603-1612.
Crossref
Crossref
O.O. Odeyemi, M.T. Yakubu, P.J. Masika & A.J. Afolayan. (2009)
Toxicological Evaluation of the Essential Oil from
Mentha longifolia
L. subsp.
capensis
Leaves in Rats
. Journal of Medicinal Food 12:3, pages 669-674.
Crossref
Crossref
Fyaz M. D. Ismail, Michael G. B. Drew, Suppiah Navaratnam & Roger H. Bisby. (2009) A pulse radiolysis study of free radicals formed by one-electron oxidation of the antimalarial drug pyronaridine. Research on Chemical Intermediates 35:4, pages 363-377.
Crossref
Crossref
Mark P. Grillo. 2009. Drug Metabolism Handbook. Drug Metabolism Handbook
655
696
.
Mark P. Grillo. 2009. Drug Metabolism Handbook. Drug Metabolism Handbook
629
653
.
B. Alex Merrick & Frank A. Witzmann. 2009. Molecular, Clinical and Environmental Toxicology. Molecular, Clinical and Environmental Toxicology
367
400
.
Michael P Holt, LinLing Cheng & Cynthia Ju. (2008) Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury. Journal of Leukocyte Biology 84:6, pages 1410-1421.
Crossref
Crossref
John Timbrell. 2008. Principles of Biochemical Toxicology, Fourth Edition. Principles of Biochemical Toxicology, Fourth Edition
193
291
.
Yohannes Teffera, Adria E. Colletti, Jean Christophe Harmange, L. Steven Hollis, Brian K. Albrecht, Alessandro A. Boezio, Jingzhou Liu & Zhiyang Zhao. (2008)
Chemical Reactivity of Methoxy 4-
O
-Aryl Quinolines: Identification of Glutathione Displacement Products in Vitro and in Vivo
. Chemical Research in Toxicology 21:11, pages 2216-2222.
Crossref
Crossref
Francesca Borrelli & Edzard Ernst. (2008) Black cohosh (Cimicifuga racemosa): a systematic review of adverse events. American Journal of Obstetrics and Gynecology 199:5, pages 455-466.
Crossref
Crossref
Hao Chen, Yanhua Zhang, Jeremy Edmunds, Christopher Bigge & Abdul Mutlib. (2008)
Bioactivation of a Dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide) Scaffold to a Putative
p
-Chlorophenyl Isocyanate in Rat Liver Microsomes and
In Vivo
in Rats
. Chemical Research in Toxicology 21:5, pages 1095-1106.
Crossref
Crossref
B. Alex Merrick. 2007. Clinical Proteomics. Clinical Proteomics
403
433
.
S Parikh, J-B Ouedraogo, J A Goldstein, P J Rosenthal & D L Kroetz. (2007) Amodiaquine Metabolism is Impaired by Common Polymorphisms in CYP2C8: Implications for Malaria Treatment in Africa. Clinical Pharmacology & Therapeutics 82:2, pages 197-203.
Crossref
Crossref
Sidney Nelson & Sam Bruschi. 2007. Drug-Induced Liver Disease, Second Edition. Drug-Induced Liver Disease, Second Edition
353
388
.
Nah-Young Shin, Qinfeng Liu, Sheryl L. Stamer & Daniel C. Liebler. (2007) Protein Targets of Reactive Electrophiles in Human Liver Microsomes. Chemical Research in Toxicology 20:6, pages 859-867.
Crossref
Crossref
Maurizio Moretti & Carlo Felice Marchioni. (2007) An overview of erdosteine antioxidant activity in experimental research. Pharmacological Research 55:4, pages 249-254.
Crossref
Crossref
SANFORD P. MARKEY. 2007. Principles of Clinical Pharmacology. Principles of Clinical Pharmacology
143
162
.
Tatsuya Matsura, Tadashi Nishida, Aki Togawa, Shunsuke Horie, Chiaki Kusumoto, Shuzo Ohata, Junya Nakada, Yuichi Ishibe, Kazuo Yamada & Yoshiji Ohta. (2006) Mechanisms of protection by melatonin against acetaminophen-induced liver injury in mice. Journal of Pineal Research 41:3, pages 211-219.
Crossref
Crossref
. (2006) The Design and Fabrication of μCCA-μGI Device for Toxicity Evaluation of Acetaminophen. Journal of Korean Pharmaceutical Sciences 36:4, pages 263-269.
Crossref
Crossref
Bunyamin Isik, Reyhan Bayrak, Ali Akcay & Sadik Sogut. (2006) Erdosteine Against Acetaminophen Induced Renal Toxicity. Molecular and Cellular Biochemistry 287:1-2, pages 185-191.
Crossref
Crossref
Rajesh Bhattacharjee & Parames C. Sil. (2006)
The protein fraction of
Phyllanthus niruri
plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties
. Phytotherapy Research 20:7, pages 595-601.
Crossref
Crossref
Irena MANOV, Helen MOTANIS, Idan FRUMIN & Theodore C. IANCU. (2006) Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects1. Acta Pharmacologica Sinica 27:3, pages 259-272.
Crossref
Crossref
Rosalind E. Jenkins, Neil R. Kitteringham, Christie L. Hunter, Sally Webb, Tony J. Hunt, Robert Elsby, Rod B. Watson, Dominic Williams, Stephen R. Penningtonand & B. Kevin Park. (2006) Relative and absolute quantitative expression profiling of cytochromes P450 using isotope‐coded affinity tags. PROTEOMICS 6:6, pages 1934-1947.
Crossref
Crossref
Tadashi Nishida, Tatsuya Matsura, Junya Nakada, Aki Togawa, Masachika Kai, Isao Sumioka, Yukari Minami, Yoshimi Inagaki, Yuichi Ishibe, Hisao Ito, Yoshiji Ohta & Kazuo Yamada. (2006) Geranylgeranylacetone protects against acetaminophen-induced hepatotoxicity by inducing heat shock protein 70. Toxicology 219:1-3, pages 187-196.
Crossref
Crossref
Bushra Ateeq, M. Abul Farah & Waseem Ahmad. (2006) Evidence of apoptotic effects of 2,4-D and butachlor on walking catfish, Clarias batrachus, by transmission electron microscopy and DNA degradation studies. Life Sciences 78:9, pages 977-986.
Crossref
Crossref
PREMILA ABRAHAM, INDIRANI KANAKASABAPATHY & BONDU JOSEPH DIAN. (2005) Propylthiouracil attenuates acetaminophen-induced renal damage in the rat. Nephrology 10:6, pages 588-593.
Crossref
Crossref
Geng Tao Liu, Yan Li, Huai Ling Wei, Hui Zhang, Ji Yan Xu & Ling Hong Yu. (2005) Mechanism of protective action of bicyclol against CCl4-induced liver injury in mice. Liver International 25:4, pages 872-879.
Crossref
Crossref
Jinping Gan, Timothy W. Harper, Mei-Mann Hsueh, Qinling Qu & W. Griffith Humphreys. (2005) Dansyl Glutathione as a Trapping Agent for the Quantitative Estimation and Identification of Reactive Metabolites. Chemical Research in Toxicology 18:5, pages 896-903.
Crossref
Crossref
Ying Li, Catherine M. Bentzley & Joan B. Tarloff. (2005) Comparison of para-aminophenol cytotoxicity in rat renal epithelial cells and hepatocytes. Toxicology 209:1, pages 69-76.
Crossref
Crossref
George A. Doss, Randall R. Miller, Zhoupeng Zhang, Yohannes Teffera, Ravi P. Nargund, Brenda Palucki, Min K. Park, Yui S. Tang, David C. Evans, Thomas A. Baillie & Ralph A. Stearns. (2005) Metabolic Activation of a 1,3-Disubstituted Piperazine Derivative: Evidence for a Novel Ring Contraction to an Imidazoline. Chemical Research in Toxicology 18:2, pages 271-276.
Crossref
Crossref
Moo-Yeal Lee, Chan Beum Park, Jonathan S. Dordick & Douglas S. Clark. (2005) Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses. Proceedings of the National Academy of Sciences 102:4, pages 983-987.
Crossref
Crossref
Michael McMillian, Alex Y. Nie, J. Brandon Parker, Angelique Leone, Stewart Bryant, Michael Kemmerer, Judy Herlich, Yanhong Liu, Lynn Yieh, Anton Bittner, Xuejun Liu, Jackson Wan & Mark D. Johnson. (2004) A gene expression signature for oxidant stress/reactive metabolites in rat liver. Biochemical Pharmacology 68:11, pages 2249-2261.
Crossref
Crossref
Naoya Matsunaga, Naomi Nakamura, Noriyo Yoneda, Tian Qin, Hideyuki Terazono, Hideto To, Shun Higuchi & Shigehiro Ohdo. (2004) Influence of Feeding Schedule on 24-h Rhythm of Hepatotoxicity Induced by Acetaminophen in Mice. Journal of Pharmacology and Experimental Therapeutics 311:2, pages 594-600.
Crossref
Crossref
Irena Manov, Mark Hirsh & Theodore C. Iancu. (2004) N-Acetylcysteine does not Protect HepG2 Cells against Acetaminophen-Induced Apoptosis. Basic & Clinical Pharmacology & Toxicology 94:5, pages 213-225.
Crossref
Crossref
Richard B. Silverman. 2004. The Organic Chemistry of Drug Design and Drug Action. The Organic Chemistry of Drug Design and Drug Action
405
495
.
Shufeng Zhou. (2003) Separation and detection methods for covalent drug–protein adducts. Journal of Chromatography B 797:1-2, pages 63-90.
Crossref
Crossref
Chengxiu Li, Jie Liu, Joseph E. Saavedra, Larry K. Keefer & Michael P. Waalkes. (2003) The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced nephrotoxicity in mice. Toxicology 189:3, pages 173-180.
Crossref
Crossref
M.V Vertzoni, H.A Archontaki & P Galanopoulou. (2003) Development and optimization of a reversed-phase high-performance liquid chromatographic method for the determination of acetaminophen and its major metabolites in rabbit plasma and urine after a toxic dose. Journal of Pharmaceutical and Biomedical Analysis 32:3, pages 487-493.
Crossref
Crossref
Daniel E. Mason & Daniel C. Liebler. (2003) Quantitative Analysis of Modified Proteins by LC−MS/MS of Peptides Labeled with Phenyl Isocyanate. Journal of Proteome Research 2:3, pages 265-272.
Crossref
Crossref
Massimo Maffei. 2003. Dietary Supplements of Plant Origin. Dietary Supplements of Plant Origin
105
170
.
Im-Sook Song, Young-Mi Lee, Suk-Jae Chung & Chang-Koo Shim. (2003)
Multiple Alterations of Canalicular Membrane Transport Activities in Rats with CCl
4
-induced Hepatic Injury
. Drug Metabolism and Disposition 31:4, pages 482-490.
Crossref
Crossref
J Liu. (2003) The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice. Hepatology 37:2, pages 324-333.
Crossref
Crossref
N. P. E. Vermeulen. 2003. Stereochemical Aspects of Drug Action and Disposition. Stereochemical Aspects of Drug Action and Disposition
229
248
.
Joseph W. DePierre. 2003. Organic Bromine and Iodine Compounds. Organic Bromine and Iodine Compounds
205
251
.
Masanao Isozaki, Kousei Ιto, Yasuhiro Masubuchi & Toshiharu Horie. (2002) Plasma Retinol Binding Protein for Monitoring the Acetaminophen-induced Hepatotoxicity. Drug Metabolism and Pharmacokinetics 17:6, pages 540-545.
Crossref
Crossref
Suck Won Kim, Jon E. Grant, David E. Adson & Rory P. Remmel. (2001) A Preliminary Report on Possible Naltrexone and Nonsteroidal Analgesic Interactions. Journal of Clinical Psychopharmacology 21:6, pages 632-634.
Crossref
Crossref
Sidney D. Nelson. (2001) Molecular mechanisms of adverse drug reactions. Current Therapeutic Research 62:12, pages 885-899.
Crossref
Crossref
Sarah BullIngrid LangezaalRichard Clothier & Sandra Coecke. (2001) A Genetically Engineered Cell-based System for Detecting Metabolism-mediated Toxicity. Alternatives to Laboratory Animals 29:6, pages 703-716.
Crossref
Crossref
Marco Mucciarelli, Wanda Camusso, Cinzia M. Bertea, Simone Bossi & Massimo Maffei. (2001) Effect of (+)-pulegone and other oil components of Mentha×piperita on cucumber respiration. Phytochemistry 57:1, pages 91-98.
Crossref
Crossref
Beau T. Hansen, Juliet A. Jones, Daniel E. Mason & Daniel C. Liebler. (2001) SALSA: A Pattern Recognition Algorithm To Detect Electrophile-Adducted Peptides by Automated Evaluation of CID Spectra in LC−MS−MS Analyses. Analytical Chemistry 73:8, pages 1676-1683.
Crossref
Crossref
João Meireles Ribeiro, António Carloto, Marı́a Jesús Costas & José Carlos Cameselle. (2001) Human placenta hydrolases active on free ADP-ribose: an ADP-sugar pyrophosphatase and a specific ADP-ribose pyrophosphatase. Biochimica et Biophysica Acta (BBA) - General Subjects 1526:1, pages 86-94.
Crossref
Crossref
G.R.N. Jones. (2001) Causes of Alzheimer?s disease: paracetamol (acetaminophen) today? Amphetamines tomorrow?. Medical Hypotheses 56:1, pages 121-123.
Crossref
Crossref
Chandrika Srinivasan, Walter M Williams, Mukunda B Ray & Theresa S Chen. (2001) Prevention of acetaminophen-induced liver toxicity by 2(R,S)-n-propylthiazolidine-4(R)-carboxylic acid in mice. Biochemical Pharmacology 61:2, pages 245-252.
Crossref
Crossref
Colin J. Henderson, C. Roland Wolf, Neil Kitteringham, Helen Powell, Diana Otto & B. Kevin Park. (2000)
Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione
S
-transferase Pi
. Proceedings of the National Academy of Sciences 97:23, pages 12741-12745.
Crossref
Crossref
B.Kevin Park, Neil R. Kitteringham, Helen Powell & Munir Pirmohamed. (2000) Advances in molecular toxicology–towards understanding idiosyncratic drug toxicity. Toxicology 153:1-3, pages 39-60.
Crossref
Crossref
Michael Fountoulakis, Peter Berndt, Urs A. Boelsterli, Flavio Crameri, Michael Winter, Silvio Albertini & Laura Suter. (2000) Two-dimensional database of mouse liver proteins: Changes in hepatic protein levels following treatment with acetaminophen or its nontoxic regioisomer 3-acetamidophenol. Electrophoresis 21:11, pages 2148-2161.
Crossref
Crossref
Raymond Vanholder, Rita De Smet & Gerrit Lesaffer. (1999) p-Cresol: a toxin revealing many neglected but relevant aspects of uraemic toxicity. Nephrology Dialysis Transplantation 14:12, pages 2813-2815.
Crossref
Crossref
Sidhartha D. Ray, M.Arun Kumar & D. Bagchi. (1999) A Novel Proanthocyanidin IH636 Grape Seed Extract Increases in Vivo Bcl-Xl Expression and Prevents Acetaminophen-Induced Programmed and Unprogrammed Cell Death in Mouse Liver. Archives of Biochemistry and Biophysics 369:1, pages 42-58.
Crossref
Crossref
Judy A. Lawson, Michael A. Fisher, Carol A. Simmons, Anwar Farhood & Hartmut Jaeschke. (1999) Inhibition of Fas Receptor (CD95)-Induced Hepatic Caspase Activation and Apoptosis by Acetaminophen in Mice. Toxicology and Applied Pharmacology 156:3, pages 179-186.
Crossref
Crossref
Stephane Mabie, Kay Castagnoli & Neal Castagnoli. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism
49
79
.
Philip Smith. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism
1
47
.
M. A. Rusu, N. Bucur, C. Puic??M. T??maş. (1999) Effects ofCorylus avellana in acetaminophen and CCl4 induced toxicosis. Phytotherapy Research 13:2, pages 120-123.
Crossref
Crossref
Jo�o Meireles Ribeiro, Mar�a Jes�s Costas & Jos� Carlos Cameselle. (1999) ADP-ribose pyrophosphatase-I partially purified from livers of rats overdosed with acetaminophen reveals enzyme inhibition in vivo reverted in vitro by dithiothreitol. Journal of Biochemical and Molecular Toxicology 13:3-4, pages 171-177.
Crossref
Crossref
Robert P. Tonge, Edward J. Kelly, Sam A. Bruschi, Tom Kalhorn, David L. Eaton, Daniel W. Nebert & Sidney D. Nelson. (1998) Role of CYP1A2 in the Hepatotoxicity of Acetaminophen: Investigations UsingCyp1a2Null Mice. Toxicology and Applied Pharmacology 153:1, pages 102-108.
Crossref
Crossref
Michael B. Fisher, Stella J. Thompson, Vera Ribeiro, Maria C. Lechner & Allan E. Rettie. (1998) P450-Catalyzed In-Chain Desaturation of Valproic Acid: Isoform Selectivity and Mechanism of Formation of Δ3-Valproic Acid Generated by Baculovirus- Expressed CYP3A1. Archives of Biochemistry and Biophysics 356:1, pages 63-70.
Crossref
Crossref
Yongchang Qiu, Leslie Z. Benet & Alma L. Burlingame. (1998) Identification of the Hepatic Protein Targets of Reactive Metabolites of Acetaminophen in Vivoin Mice Using Two-dimensional Gel Electrophoresis and Mass Spectrometry. Journal of Biological Chemistry 273:28, pages 17940-17953.
Crossref
Crossref
Weiqiao Chen, Luke L. Koenigs, Stella J. Thompson, Raimund M. Peter, Allan E. Rettie, William F. Trager & Sidney D. Nelson. (1998) Oxidation of Acetaminophen to Its Toxic Quinone Imine and Nontoxic Catechol Metabolites by Baculovirus-Expressed and Purified Human Cytochromes P450 2E1 and 2A6. Chemical Research in Toxicology 11:4, pages 295-301.
Crossref
Crossref
Katherine C. Watt, Charles G. Plopper, Alison J. Weir, Brian Tarkington & Alan R. Buckpitt. (1998) Cytochrome P450 2E1 in Rat Tracheobronchial Airways: Response to Ozone Exposure. Toxicology and Applied Pharmacology 149:2, pages 195-202.
Crossref
Crossref
Anne-Marie Mølck, Morten Poulsen, Søren Tindgard Lauridsen & Preben Olsen. (1998) Lack of histological cerebellar changes in Wistar rats given pulegone for 28 days. Comparison of immersion and perfusion tissue fixation. Toxicology Letters 95:2, pages 117-122.
Crossref
Crossref
Aniya Yoko, Yokomakura Takahiro, Yonamine Masato, Nagamine Tatsumi & Nakanishi Hisaharu. (1998) Protective Effect of the Mold Monascus Anka Against Acetaminophen-Induced Liver Toxicity in Rats. Japanese Journal of Pharmacology 78:1, pages 79-82.
Crossref
Crossref
Anna B Hill, Phillip R Jefferies, Gary B Quistad & John E Casida. (1997) Dialkylquinoneimine metabolites of chloroacetanilide herbicides induce sister chromatid exchanges in cultured human lymphocytes. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 395:2-3, pages 159-171.
Crossref
Crossref
Sharon L. Walmsley, Louise M. Winn, Maureen L. Harrison, Jack P. Uetrecht & Peter G. Wells. (1997) Oxidative stress and thiol depletion in plasma and peripheral blood lymphocytes from HIV-infected patients. AIDS 11:14, pages 1689-1697.
Crossref
Crossref
João Meireles Ribeiro, Antonio Agudo, Marı́a Jesús Costas & José Carlos Cameselle. (1997) Rat liver ADP-ribose pyrophosphatase-I as an in vitro target of the acetaminophen metabolite N-acetyl-p-benzoquinoneimine. Biochimica et Biophysica Acta (BBA) - General Subjects 1336:3, pages 403-408.
Crossref
Crossref
Katherine C. Watt, Charles G. Plopper & Alan R. Buckpitt. (1997) Measurement of Cytochrome P450 2E1 Activity in Rat Tracheobronchial Airways Using High-Performance Liquid Chromatography with Electrochemical Detection. Analytical Biochemistry 248:1, pages 26-30.
Crossref
Crossref
Abdolamir Allameh, Emelin Y Vansoun & Afshin Zarghi. (1997) Role of glutathione conjugation in protection of weanling rat liver against acetaminophen-induced hepatotoxicity. Mechanisms of Ageing and Development 95:1-2, pages 71-79.
Crossref
Crossref
Angeliki P. Kourounakis, Eleni A. Rekka & Panos N. Kourounakis. (2006) Effect of Guaiazulene on Some Cytochrome P450 Activities. Implication in the Metabolic Activation and Hepatotoxicity of Paracetamol. Archiv der Pharmazie 330:1-2, pages 7-11.
Crossref
Crossref
Masato Yonamine, Yoko Aniya, Takahiro Yokomakura, Tomoyuki Koyama, Tatsumi Nagamine & Hisaharu Nakanishi. (1996) Acetaminophen-Derived Activation of Liver Microsomal Glutathione S-Transferase of Rats. Japanese Journal of Pharmacology 72:2, pages 175-181.
Crossref
Crossref