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Research Article

The Role of Covalent Binding to Microsomal Proteins in the Hepatotoxicity of Acetaminophen

Pages 277-297 | Published online: 22 Sep 2008

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S. Palani, S. Raja, R. Naresh & B. Senthil Kumar. (2010) Evaluation of nephroprotective, diuretic, and antioxidant activities of plectranthus amboinicus on acetaminophen-induced nephrotoxic rats. Toxicology Mechanisms and Methods 20:4, pages 213-221.
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Shufeng Zhou, Eli Chan, Wei Duan, Min Huang & Yu-Zong Chen. (2005) Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance. Drug Metabolism Reviews 37:1, pages 41-213.
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P. David Josephy. (2005) The Molecular Toxicology of Acetaminophen. Drug Metabolism Reviews 37:4, pages 581-594.
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Jos G. M. Bessems & Nico P. E. Vermeulen. (2001) Paracetamol (Acetaminophen)-Induced Toxicity: Molecular and Biochemical Mechanisms, Analogues and Protective Approaches. Critical Reviews in Toxicology 31:1, pages 55-138.
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Sasikala M. Chinnappan, Annie George, Praveen Thaggikuppe, YogendraKumar Choudhary, Vandana K. Choudhary, Yesha Ramani & Rashmi Dewangan. (2019) Nephroprotective Effect of Herbal Extract Eurycoma longifolia on Paracetamol-Induced Nephrotoxicity in Rats . Evidence-Based Complementary and Alternative Medicine 2019, pages 1-6.
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Shiyun Pu, Lin Ren, Qinhui Liu, Jiangying Kuang, Jing Shen, Shihai Cheng, Yuwei Zhang, Wei Jiang, Zhiyong Zhang, Changtao Jiang & Jinhan He. (2016) Loss of 5-lipoxygenase activity protects mice against paracetamol-induced liver toxicity. British Journal of Pharmacology 173:1, pages 66-76.
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Michael G. Leeming, Luke F. Gamon, Uta Wille, William A. Donald & Richard A. J. O’Hair. (2015) What Are the Potential Sites of Protein Arylation by N -Acetyl- p -benzoquinone Imine (NAPQI)? . Chemical Research in Toxicology 28:11, pages 2224-2233.
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Jeff B. Helms, Lauren P. Saunders, Jamie Meyer, Charles J. Costa, Eric Plowman, Nick Williford, Matthew Corbitt, Jeremy P. Holden & Craig Gatto. (2015) Kinetic Characterization of Na,K-ATPase Inhibition by the Acetaminophen Metabolite N-Acetylbenzoquinoneimine. Open Journal of Molecular and Integrative Physiology 05:01, pages 1-17.
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Wei Qian & Hitoshi Shichi. (2000) Cataract Formation by a Semiquinone Metabolite of Acetaminophen in Mice: Possible Involvement of Ca2+and Calpain Activation. Experimental Eye Research 71:6, pages 567-574.
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João Meireles Ribeiro, Antonio Agudo, Marı́a Jesús Costas & José Carlos Cameselle. (1997) Rat liver ADP-ribose pyrophosphatase-I as an in vitro target of the acetaminophen metabolite N-acetyl-p-benzoquinoneimine. Biochimica et Biophysica Acta (BBA) - General Subjects 1336:3, pages 403-408.
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CONG ZHAO, YE XIONG & HITOSHI SHICHI. (1997) Acetaminophen Cytotoxicity in Mouse Eye: Mitochondria in Anterior Tissues are the Primary Target. Journal of Ocular Pharmacology and Therapeutics 13:3, pages 269-276.
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