Citations (176)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (20)
Nadda Muhamad & Kesara Na-Bangchang. (2020) Metabolite Profiling in Anticancer Drug Development: A Systematic Review. Drug Design, Development and Therapy 14, pages 1401-1444.
Read now
Read now
Jimmy L. Spearow, Kimberly Gettmann & Michael Wade. (2017) Review: Risk assessment implications of variation in susceptibility to perchloroethylene due to genetic diversity, ethnicity, age, gender, diet and pharmaceuticals. Human and Ecological Risk Assessment: An International Journal 23:6, pages 1466-1492.
Read now
Read now
Lukas Fiebig, Ralf Laux, Rudolf Binder & Thomas Ebner. (2016) In vivo drug metabolite identification in preclinical ADME studies by means of UPLC/TWIMS/high resolution-QTOF MSE and control comparison: cost and benefit of vehicle-dosed control samples. Xenobiotica 46:10, pages 922-930.
Read now
Read now
Andrew Bartholomaeus, Wayne Parrott, Genevieve Bondy & Kate Walker. (2013) The use of whole food animal studies in the safety assessment of genetically modified crops: Limitations and recommendations. Critical Reviews in Toxicology 43:sup2, pages 1-24.
Read now
Read now
Juhyun Kim, Ronghua Wang, Karen A. Veverka & James T. Dalton. (2013) Absorption, distribution, metabolism and excretion of the novel SARM GTx-024 [(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide] in rats. Xenobiotica 43:11, pages 993-1009.
Read now
Read now
Pascal Detampel, Mareike Beck, Stephan Krähenbühl & Jörg Huwyler. (2012) Drug interaction potential of resveratrol. Drug Metabolism Reviews 44:3, pages 253-265.
Read now
Read now
Edward L. LeCluyse, Rafal P. Witek, Melvin E. Andersen & Mark J. Powers. (2012) Organotypic liver culture models: Meeting current challenges in toxicity testing. Critical Reviews in Toxicology 42:6, pages 501-548.
Read now
Read now
Naoki Kamada, Keigo Yamada, Masaaki Odomi, Tadashi Mukai, Toru Nishibayashi, Ken-ichi Ogawara, Toshikiro Kimura & Kazutaka Higaki. (2011) Sex differences in pharmacokinetics of cilostazol in rats. Xenobiotica 41:10, pages 903-913.
Read now
Read now
J.A. Clarkson-Jones, A.S.J. Kenyon & H.K. Tomkinson. (2011) The disposition and metabolism of zibotentan (ZD4054): an oral-specific endothelin A receptor antagonist in mice, rats and dogs. Xenobiotica 41:9, pages 784-796.
Read now
Read now
A.M. Helguera, G. Pérez-Machado, M.N.D.S. Cordeiro & R.D. Combes. (2010) Quantitative structure-activity relationship modelling of the carcinogenic risk of nitroso compounds using regression analysis and the TOPS-MODE approach. SAR and QSAR in Environmental Research 21:3-4, pages 277-304.
Read now
Read now
Katalin Monostory, Jean-Marc Pascussi, László Kóbori & Zdenek Dvorak. (2009) Hormonal regulation of CYP1A expression. Drug Metabolism Reviews 41:4, pages 547-572.
Read now
Read now
Alexandre Pawlik, Paul Delmar, Sebastien Bosse, Laurie Sainz, Cyrille Petat, Genevieve Pietu, Dominique Thierry & Diana Tronik-Le Roux. (2009) Changes in transcriptome after in vivo exposure to ionising radiation reveal a highly specialised liver response. International Journal of Radiation Biology 85:8, pages 656-671.
Read now
Read now
N. N. Patel, C. M. Crincoli, E. L. Kennedy, D. M. Frederick, R. Tchao & P. J. Harvison. (2008) Effect of gender, dose, and time on 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT)-induced hepatotoxicity in Fischer 344 rats. Xenobiotica 38:4, pages 435-449.
Read now
Read now
Susan Hurst, Cho-Ming Loi, Joanne Brodfuehrer & Ayman El-Kattan. (2007) Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans. Expert Opinion on Drug Metabolism & Toxicology 3:4, pages 469-489.
Read now
Read now
G. I. Somers, A. J. Harris, M. K. Bayliss & J. B. Houston. (2007) The metabolism of the 5HT3 antagonists ondansetron, alosetron and GR87442 I: A comparison of and metabolism and enzyme kinetics in rat, dog and human hepatocytes, microsomes and recombinant human enzymes. Xenobiotica 37:8, pages 832-854.
Read now
Read now
Marcella Martignoni, Geny M M Groothuis & Ruben de Kanter. (2006) Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opinion on Drug Metabolism & Toxicology 2:6, pages 875-894.
Read now
Read now
Sean Ekins, Sergey Andreyev, Andy Ryabov, Eugene Kirillov, Eugene A Rakhmatulin, Andrej Bugrim & Tatiana Nikolskaya. (2005) Computational prediction of human drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 1:2, pages 303-324.
Read now
Read now
K. Ohyama, S. Maki, K. Sato & Y. Kato. (2005) Comparative in vitro metabolism of the suspected pro-oestrogenic compound, methoxychlor in precision-cut liver slices from male and female rats. Xenobiotica 35:4, pages 331-342.
Read now
Read now
S. Löfgren, A.-L. Hagbjörk, S. Ekman, R. Fransson-Steen & Y. Terelius. (2004) Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison. Xenobiotica 34:9, pages 811-834.
Read now
Read now
D. C. Mankowski, M. P. Lawton & S. Ekins. (2000) Characterization of transgenic mouse strains using six human hepatic cytochrome P450 probe substrates. Xenobiotica 30:8, pages 745-754.
Read now
Read now
Articles from other publishers (156)
Peng Che, J. Tyler Davidson, Kristina Still, Jeroen Kool & Isabelle Kohler. (2023) In vitro metabolism of cathinone positional isomers: does sex matter?. Analytical and Bioanalytical Chemistry 415:22, pages 5403-5420.
Crossref
Crossref
Maria Norlin & Kjell Wikvall. (2023) Enzymatic activation in vitamin D signaling – Past, present and future. Archives of Biochemistry and Biophysics 742, pages 109639.
Crossref
Crossref
Shayne Cox Gad & Dexter SullivanJr.Jr.. 2023. Drug Safety Evaluation. Drug Safety Evaluation
425
456
.
Antoine Rached, Tarek Mahjoub, Ambre Fafournoux, Brigitte Barbier, Isabelle Fourel, Hervé Caruel, Sébastien Lefebvre & Virginie Lattard. (2023) Interest of the faecal and plasma matrix for monitoring the exposure of wildlife or domestic animals to anticoagulant rodenticides. Environmental Toxicology and Pharmacology 97, pages 104033.
Crossref
Crossref
Derek Simonsen, Jacob Heffelfinger, David M. Cwiertny & Hans-Joachim Lehmler. (2022) Benoxacor is enantioselectively metabolized by microsomes and cytosol from the human liver. Emerging Contaminants, pages 100198.
Crossref
Crossref
Hong Huang, Er-Bing Zhang, Ou-Yang Yi, Han Wu, Guiming Deng, Yu-Ming Huang, Wen-Liang Liu, Jian-Ye Yan & Xiong Cai. (2022) Sex-related differences in safety profiles, pharmacokinetics and tissue distribution of sinomenine hydrochloride in rats. Archives of Toxicology 96:12, pages 3245-3255.
Crossref
Crossref
Derek Simonsen, Jacob Heffelfinger, David M. Cwiertny & Hans-Joachim Lehmler. (2022) The dichloroacetamide safener benoxacor is enantioselectively metabolized by monkey liver microsomes and cytosol. Environmental Toxicology and Pharmacology 96, pages 104008.
Crossref
Crossref
Taisuke Kawamura, Mako Ichikawa, Jo Hatogai, Yuya Koyama, Misa Tachibana, Misaki Kuwahara, Keita Negishi, Miyu Matsumoto, Masafumi Miyazaki & Wataru Ochiai. (2022) Mouse Cyp2c expression and zonation structure in the liver begins in the early neonatal stage. Biopharmaceutics & Drug Disposition 43:4, pages 130-139.
Crossref
Crossref
Partho Sen, Sami Qadri, Panu K. Luukkonen, Oddny Ragnarsdottir, Aidan McGlinchey, Sirkku Jäntti, Anne Juuti, Johanna Arola, Jennifer J. Schlezinger, Thomas F. Webster, Matej Orešič, Hannele Yki-Järvinen & Tuulia Hyötyläinen. (2022) Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease. Journal of Hepatology 76:2, pages 283-293.
Crossref
Crossref
Abdu Hassen Musa, Asfaw Debella Hagos, Girmai Gebru Dimsu, Eyasu Makonnen Eshetu, Mesfin Asefa Tola, Abinet Admas, Abiy Abebe Gelagle & Boki Lengiso Tullu. (2022) Subchronic toxicity study of herbal tea of Moringa stenopetala (Baker f.) Cudof. and Mentha spicata L. leaves formulation in Wistar albino rats. Toxicology Reports 9, pages 797-805.
Crossref
Crossref
Olga Wronikowska, Maria Zykubek, Łukasz Kurach, Agnieszka Michalak, Anna Boguszewska-Czubara & Barbara Budzyńska. (2021) Vulnerability factors for mephedrone-induced conditioned place preference in rats—the impact of sex differences, social-conditioning and stress. Psychopharmacology 238:10, pages 2947-2961.
Crossref
Crossref
Min Yang, Youning Xu, Hailing Ke & Huaqing Chen. (2021) Cumulative Effect and Content Variation of Toxic Trace Elements in Human Hair around Xiaoqinling Gold Mining Area, Northwestern China. International Journal of Environmental Research and Public Health 18:4, pages 2074.
Crossref
Crossref
Tisha Melia & David J. Waxman. (2020) Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice. PLOS ONE 15:12, pages e0242665.
Crossref
Crossref
Farhad Bano & Banalata Mohanty. (2020) Thyroid disrupting pesticides mancozeb and fipronil in mixture caused oxidative damage and genotoxicity in lymphoid organs of mice. Environmental Toxicology and Pharmacology 79, pages 103408.
Crossref
Crossref
Derek Simonsen, David M. Cwiertny & Hans-Joachim Lehmler. (2020) Benoxacor is enantioselectively metabolized by rat liver subcellular fractions. Chemico-Biological Interactions 330, pages 109247.
Crossref
Crossref
André Tadeu Gotardo, Rafael Lanzelloti Fonseca, Fabiano Barreto, Caroline Andrade Tomaszewski, Lucas Suchecki Barnet, Tamara Castilho & Silvana Lima Górniak. (2020) The effect of breed, sex, and drug concentration on the pharmacokinetic profile of ivermectin in cattle. Journal of Veterinary Pharmacology and Therapeutics 43:5, pages 477-484.
Crossref
Crossref
Farhad Bano & Banalata Mohanty. (2020) Thyroxine modulation of immune toxicity induced by mixture pesticides mancozeb and fipronil in mice. Life Sciences 240, pages 117078.
Crossref
Crossref
Yi-Zhong Gu, Xiaoyan Chu, Robert Houle, Katerina Vlasakova, Kenneth A Koeplinger, Isabelle Bourgeois, Kiran Palyada, Kenneth D Anderson, Christopher Brynczka, Bhavana Bhatt, Feifei Chen, Roger Smith, Rupesh Amin, Warren E Glaab, Jose Lebron, Kathleen Cox & Frank D Sistare. (2019) Polyethlyene Glycol 200 Can Protect Rats Against Drug-Induced Kidney Toxicity Through Inhibition of the Renal Organic Anion Transporter 3. Toxicological Sciences 172:1, pages 155-166.
Crossref
Crossref
Vesna Jaćević, Eugenie Nepovimova & Kamil Kuča. (2019) Interspecies and intergender differences in acute toxicity of K-oximes drug candidates. Chemico-Biological Interactions 308, pages 312-316.
Crossref
Crossref
Yue Zhang, Xiao-mei Yuan, Yue-fei Wang, Miao-miao Jiang, Ya-nan Bi, Ying Liu, Wei-ling Pu, Lei Song, Ju-yang Huang, Li-kang Sun, Zhi-xing Zhou & Kun Zhou. (2019) Isopsoralen induces different subchronic toxicities and metabolomic outcomes between male and female Wistar rats. Regulatory Toxicology and Pharmacology 103, pages 1-9.
Crossref
Crossref
Amir Shahsavari, Fatemeh Tabatabaei Yazdi, Zahra Moosavi, Ava Heidari & Pourya Sardari. (2019) A study on the concentration of heavy metals and histopathological changes in Persian jirds (Mammals; Rodentia), affected by mining activities in an iron ore mine in Iran. Environmental Science and Pollution Research 26:12, pages 12590-12604.
Crossref
Crossref
Michael Gerisch, Roland Heinig, Anna Engelen, Dieter Lang, Peter Kolkhof, Martin Radtke, Johannes Platzek, Kai Lovis, Gabriele Rohde & Thomas Schwarz. (2018) Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro. Drug Metabolism and Disposition 46:11, pages 1546-1555.
Crossref
Crossref
Sabine Tejpar, Pu Yan, Hubert Piessevaux, Daniel Dietrich, Peter Brauchli, Dirk Klingbiel, Roberto Fiocca, Mauro Delorenzi, Fred Bosman & Arnaud D. Roth. (2018) Clinical and pharmacogenetic determinants of 5-fluorouracyl/leucovorin/irinotecan toxicity: Results of the PETACC-3 trial. European Journal of Cancer 99, pages 66-77.
Crossref
Crossref
Benoit B. N’guessan, Seth K. Amponsah, George J. Dugbartey, Kwabena D. Awuah, Eunice Dotse, Abigail Aning, Kennedy K. E. Kukuia, Isaac J. Asiedu-Gyekye & Regina Appiah-Opong. (2018) In Vitro Antioxidant Potential and Effect of a Glutathione-Enhancer Dietary Supplement on Selected Rat Liver Cytochrome P450 Enzyme Activity. Evidence-Based Complementary and Alternative Medicine 2018, pages 1-8.
Crossref
Crossref
G.L. Kedderis. 2018. Comprehensive Toxicology. Comprehensive Toxicology
128
142
.
Wenge Chen, Yingying Xiao, Jianzhong Chen, Jian Liu, Jingwei Shao, Tao Li, Yewei Zhu, Ji Ma, Yu Gao, Jichuang Wang, Jianguo Xu, Yusheng Lu & Lee Jia. (2017) Sex-related pharmacokinetic differences and mechanisms of metapristone (RU486 metabolite). Scientific Reports 7:1.
Crossref
Crossref
Simona Pace, Lidia Sautebin & Oliver Werz. (2017) Sex-biased eicosanoid biology: Impact for sex differences in inflammation and consequences for pharmacotherapy. Biochemical Pharmacology 145, pages 1-11.
Crossref
Crossref
Xiao Xiao, Yoo Kim, Daeyoung Kim, Kyong Sup Yoon, John M. Clark & Yeonhwa Park. (2017) Permethrin alters glucose metabolism in conjunction with high fat diet by potentiating insulin resistance and decreases voluntary activities in female C57BL/6J mice. Food and Chemical Toxicology 108, pages 161-170.
Crossref
Crossref
D. K. Gessner, R. Ringseis & K. Eder. (2017) Potential of plant polyphenols to combat oxidative stress and inflammatory processes in farm animals. Journal of Animal Physiology and Animal Nutrition 101:4, pages 605-628.
Crossref
Crossref
Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment
35
76
.
Simon Bucher, Pégah Jalili, Dounia Le Guillou, Karima Begriche, Karine Rondel, Sophie Martinais, Daniel Zalko, Anne Corlu, Marie-Anne Robin & Bernard Fromenty. (2017) Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure. Environmental Toxicology 32:3, pages 1024-1036.
Crossref
Crossref
Lin Li, Yun-Feng Zhou, Yan-Lin Li, Li-Li Wang, Hiderori Arai & Yang Xu. (2017)
In vitro
and
in vivo
antioxidative and hepatoprotective activity of aqueous extract of Cortex Dictamni
. World Journal of Gastroenterology 23:16, pages 2912.
Crossref
Crossref
Cecília R.A. Santos, Ana Catarina Duarte, Telma Quintela, Joana Tomás, Tânia Albuquerque, Fernanda Marques, Joana Almeida Palha & Isabel Gonçalves. (2017) The choroid plexus as a sex hormone target: Functional implications. Frontiers in Neuroendocrinology 44, pages 103-121.
Crossref
Crossref
Shayne Cox Gad. 2016. Drug Safety Evaluation. Drug Safety Evaluation
381
411
.
Moayad Saad, Evy Verbueken, Casper Pype, Christophe Casteleyn, Chris Van Ginneken, Louis Maes, Paul Cos & Steven Van Cruchten. (2016) In vitro CYP1A activity in the zebrafish: temporal but low metabolite levels during organogenesis and lack of gender differences in the adult stage. Reproductive Toxicology 64, pages 50-56.
Crossref
Crossref
Let?cia Martins Rabelo, Bianca Costa e Silva, Sabrina Ferreira de Almeida, Wellington Alves Mizael da Silva, Bruna de Oliveira Mendes, Abra?o Tiago Batista Guimar?es, Anderson Rodrigo da Silva, Andr? Luis da Silva Castro, Aline Sueli de Lima Rodrigues & Guilherme Malafaia. (2016) Memory deficit in Swiss mice exposed to tannery effluent. Neurotoxicology and Teratology 55, pages 45-49.
Crossref
Crossref
Kate McDonnell‐Dowling & John P. Kelly. (2015) Does route of methamphetamine exposure during pregnancy have an impact on neonatal development and behaviour in rat offspring?. International Journal of Developmental Neuroscience 49:1, pages 14-22.
Crossref
Crossref
Maria Margalef, Zara Pons, Lisard Iglesias-Carres, Lluís Arola, Begoña Muguerza & Anna Arola-Arnal. (2016) Gender-related similarities and differences in the body distribution of grape seed flavanols in rats. Molecular Nutrition & Food Research 60:4, pages 760-772.
Crossref
Crossref
Keiyu Oshida, Naresh Vasani, David J. Waxman & J. Christopher Corton. (2016) Disruption of STAT5b-Regulated Sexual Dimorphism of the Liver Transcriptome by Diverse Factors Is a Common Event. PLOS ONE 11:3, pages e0148308.
Crossref
Crossref
Cristina E. Gallegos, Mariana Bartos, Cristina Bras, Fernanda Gumilar, Marta C. Antonelli & Alejandra Minetti. (2016) Exposure to a glyphosate-based herbicide during pregnancy and lactation induces neurobehavioral alterations in rat offspring. NeuroToxicology 53, pages 20-28.
Crossref
Crossref
Sébastien Lefebvre, Benoit Rannou, Stéphane Besse, Etienne Benoit & Virginie Lattard. (2016) Origin of the gender differences of the natural resistance to antivitamin K anticoagulants in rats. Toxicology 344-346, pages 34-41.
Crossref
Crossref
Manoochehr Khazaee, Amir Hossein Hamidian, Afshin Alizadeh Shabani, Sohrab Ashrafi, Seyyed Ali Ashghar Mirjalili & Esmat Esmaeilzadeh. (2015) Accumulation of heavy metals and As in liver, hair, femur, and lung of Persian jird (Meriones persicus) in Darreh Zereshk copper mine, Iran. Environmental Science and Pollution Research 23:4, pages 3860-3870.
Crossref
Crossref
Donald S. Karanewsky, Amy J. Arthur, Hanghui Liu, Bert Chi & Lily Ida. (2016) Toxicological evaluation and metabolism of two N -alkyl benzamide umami flavour compounds: N -(heptan-4-yl)benzo[d][1,3]dioxole-5-carboxamide and ( R )- N -(1-methoxy-4-methylpentan-2-yl)-3,4-dimethylbenzamide. Toxicology Reports 3, pages 841-860.
Crossref
Crossref
Donald S. Karanewsky, Amy J. Arthur, Hanghui Liu, Bert Chi, Lily Ida & Stacy Markison. (2016) Toxicological evaluation of a novel umami flavour compound: 2-(((3-(2,3-Dimethoxyphenyl)-1 H -1,2,4-triazol-5-yl)thio)methyl)pyridine. Toxicology Reports 3, pages 501-512.
Crossref
Crossref
Donald S. Karanewsky, Amy J. Arthur, Hanghui Liu, Bert Chi, Lily Ida & Stacy Markison. (2016) Toxicological evaluation of two novel bitter modifying flavour compounds: 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1 H -pyrazol-4-yl)-1-(3-hydroxybenzyl)imidazolidine-2,4-dione and 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1 H -pyrazol-4-yl)-1-(3-hydroxybenzyl)-5,5-dimethylimidazolidine-2,4-dione. Toxicology Reports 3, pages 310-327.
Crossref
Crossref
Saurabh Kumar Singh, Farhad Bano & Banalata Mohanty. (2016) Vitamin E pretreatment prevents the immunotoxicity of dithiocarbamate pesticide mancozeb in vitro: A comparative age-related assessment in mice and chick. Pesticide Biochemistry and Physiology 126, pages 76-84.
Crossref
Crossref
Shayne Gad & Samantha Gad-McDonald. 2015. Biomaterials, Medical Devices, and Combination Products. Biomaterials, Medical Devices, and Combination Products
469
502
.
Jong-Hwa Lee, Jun-Hyeng Son, Yoon-Jee Chae, Sung Hoon Ahn, Wooin Lee, Dae-Duk Kim & Suk-Jae Chung. (2015) Gender differences in the hepatic elimination and pharmacokinetics of lobeglitazone in rats. Biopharmaceutics & Drug Disposition 36:6, pages 410-415.
Crossref
Crossref
Mariana Bartos, Fernanda Gumilar, Cristina Bras, Cristina E. Gallegos, Leda Giannuzzi, Liliana M. Cancela & Alejandra Minetti. (2015) Neurobehavioural effects of exposure to fluoride in the earliest stages of rat development. Physiology & Behavior 147, pages 205-212.
Crossref
Crossref
Linlin Hu, Janvier Engelbert Agbokponto, Xiaobing Li, Li Ding, Bing Liu, Shuisheng Zhong, Xiaoyu Zhang & Yiwei Du. (2014) In vivo and in vitro evidence of the sex-dependent pharmacokinetics and disposition of G004, a potential hypoglycemic agent, in rats. European Journal of Drug Metabolism and Pharmacokinetics 40:2, pages 187-202.
Crossref
Crossref
Jun-Won Yun, Jung-Hee Yoon, Byeong-Cheol Kang, Nam-Hyuk Cho, Seung Hyeok Seok, Seung-Kee Min, Ji Hyun Min, Jeong-Hwan Che & Young Keun Kim. (2015) The toxicity and distribution of iron oxide-zinc oxide core-shell nanoparticles in C57BL/6 mice after repeated subcutaneous administration. Journal of Applied Toxicology 35:6, pages 593-602.
Crossref
Crossref
Mitchell E. Taub, Eva Ludwig-Schwellinger, Naoki Ishiguro, Wataru Kishimoto, Hongbin Yu, Klaus Wagner & Donald Tweedie. (2015) Sex-, Species-, and Tissue-Specific Metabolism of Empagliflozin in Male Mouse Kidney Forms an Unstable Hemiacetal Metabolite (M466/2) That Degrades to 4-Hydroxycrotonaldehyde, a Reactive and Cytotoxic Species. Chemical Research in Toxicology 28:1, pages 103-115.
Crossref
Crossref
Donald S. Karanewsky, Amy J. Arthur, Hanghui Liu, Bert Chi & Stacy Markison. (2015) Toxicological evaluation of a novel cooling compound: 2-(4-methylphenoxy)- N -(1 H -pyrazol-3-yl)- N -(2-thienylmethyl)acetamide. Toxicology Reports 2, pages 1291-1309.
Crossref
Crossref
Xiao Wu, Jian-Guo Sun, Ying Peng, Yan Liang, Guang-Ji Wang, Hui Chen, Ji-Zhou Wu & Peng Zhang. (2014) Pharmacokinetics, Tissue Distribution and Excretion of Verticinone from F. hupehensis in Rats. Molecules 19:12, pages 20613-20626.
Crossref
Crossref
Kyoko Naramoto, Masashi Kato & Kenji Ichihara. (2014) Effects of an Ethanol Extract of Brazilian Green Propolis on Human Cytochrome P450 Enzyme Activities in Vitro. Journal of Agricultural and Food Chemistry 62:46, pages 11296-11302.
Crossref
Crossref
Bernard Testa. 2014. Drug Metabolism Prediction. Drug Metabolism Prediction
1
26
.
S.R. Crowell, S. Hanson-Drury, D.E. Williams & R.A. Corley. (2014) In vitro metabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes. Toxicology Letters 228:1, pages 48-55.
Crossref
Crossref
J.C.J. van Esterik, M.E.T. Dollé, M.H. Lamoree, S.P.J. van Leeuwen, T. Hamers, J. Legler & L.T.M. van der Ven. (2014) Programming of metabolic effects in C57BL/6JxFVB mice by exposure to bisphenol A during gestation and lactation. Toxicology 321, pages 40-52.
Crossref
Crossref
Lukas Rambousek, Petr Kacer, Kamila Syslova, Jakub Bumba, Vera Bubenikova-Valesova & Romana Slamberova. (2014) Sex differences in methamphetamine pharmacokinetics in adult rats and its transfer to pups through the placental membrane and breast milk. Drug and Alcohol Dependence 139, pages 138-144.
Crossref
Crossref
Flavia Franconi & Ilaria Campesi. (2014) Pharmacogenomics, pharmacokinetics and pharmacodynamics: interaction with biological differences between men and women. British Journal of Pharmacology 171:3, pages 580-594.
Crossref
Crossref
Gro D. Villanger, Kristin M. Gabrielsen, Kit M. Kovacs, Christian Lydersen, Elisabeth Lie, Mahin Karimi, Eugen G. Sørmo & Bjørn M. Jenssen. (2013) Effects of complex organohalogen contaminant mixtures on thyroid homeostasis in hooded seal (Cystophora cristata) mother–pup pairs. Chemosphere 92:7, pages 828-842.
Crossref
Crossref
Kosuke Saito, Masahiko Negishi & E. James Squires. (2013) Sexual dimorphisms in zonal gene expression in mouse liver. Biochemical and Biophysical Research Communications 436:4, pages 730-735.
Crossref
Crossref
C. Demur, B. Métais, C. Canlet, M. Tremblay-Franco, R. Gautier, F. Blas-Y-Estrada, C. Sommer & L. Gamet-Payrastre. (2013) Dietary exposure to a low dose of pesticides alone or as a mixture: The biological metabolic fingerprint and impact on hematopoiesis. Toxicology 308, pages 74-87.
Crossref
Crossref
Rosario Garrido, Tanja S. Zabka, Jianhua Tao, Mark Fielden, Adrian Fretland & Mudher Albassam. (2013) Quantitative Histological Assessment of Xenobiotic-Induced Liver Enzyme Induction and Pituitary-Thyroid Axis Stimulation in Rats Using Whole-Slide Automated Image Analysis. Journal of Histochemistry & Cytochemistry 61:5, pages 362-371.
Crossref
Crossref
Xun Zhang, Choong Yong Ung, Siew Hong Lam, Jing Ma, Yu Zong Chen, Louxin Zhang, Zhiyuan Gong & Baowen Li. (2012) Toxicogenomic Analysis Suggests Chemical-Induced Sexual Dimorphism in the Expression of Metabolic Genes in Zebrafish Liver. PLoS ONE 7:12, pages e51971.
Crossref
Crossref
Shuang Fu, Anthony Rowe & Iqbal Ramzan. (2012) Kavalactone Metabolism in Rat Liver Microsomes. Phytotherapy Research 26:7, pages 1057-1061.
Crossref
Crossref
Joy Simpson, Colin Ryan, Anita Curley, Jeffrey Mulcaire & John P. Kelly. (2012) Sex differences in baseline and drug-induced behavioural responses in classical behavioural tests. Progress in Neuro-Psychopharmacology and Biological Psychiatry 37:2, pages 227-236.
Crossref
Crossref
E. Tovar-S?nchez, L. T. Cervantes, C. Mart?nez, E. Rojas, M. Valverde, M. L. Ortiz-Hern?ndez & P. Mussali-Galante. (2011) Comparison of two wild rodent species as sentinels of environmental contamination by mine tailings. Environmental Science and Pollution Research 19:5, pages 1677-1686.
Crossref
Crossref
Joy Simpson & John P. Kelly. (2012) An investigation of whether there are sex differences in certain behavioural and neurochemical parameters in the rat. Behavioural Brain Research 229:1, pages 289-300.
Crossref
Crossref
Niti N. Patel, Christine M. Crincoli, Douglas M. Frederick, Ruy Tchao & Peter J. Harvison. (2011) Effect of structural modifications on 3‐(3,5‐dichlorophenyl)‐2,4‐thiazolidinedione‐induced hepatotoxicity in Fischer 344 rats. Journal of Applied Toxicology 32:2, pages 108-117.
Crossref
Crossref
Alexander V. LyubimovThomas K. H. Chang & David J. Waxman. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
19
.
D. J. Snodin & A. Suitters. 2011. Stephens' Detection and Evaluation of Adverse Drug Reactions. Stephens' Detection and Evaluation of Adverse Drug Reactions
157
214
.
V. Křížová-Forstová, J. Lamka, V. Cvilink, V. Hanušová & L. Skálová. (2011) Factors affecting pharmacokinetics of benzimidazole anthelmintics in food-producing animals: The consequences and potential risks. Research in Veterinary Science 91:3, pages 333-341.
Crossref
Crossref
Shinsuke Marumoto, Yoshimitsu Oda & Mitsuo Miyazawa. (2011) Antigenotoxic activity of naturally occurring furanocoumarins. Environmental and Molecular Mutagenesis 52:8, pages 646-657.
Crossref
Crossref
Ayman El‐Kattan, Susan Hurst, Joanne Brodfuehrer & Cho‐Ming Loi. 2011. Oral Bioavailability. Oral Bioavailability
253
265
.
MK Rasmussen, G Zamaratskaia & B Ekstrand. (2011) Gender-related Differences in Cytochrome P450 in Porcine Liver - Implication for Activity, Expression and Inhibition by Testicular Steroids. Reproduction in Domestic Animals 46:4, pages 616-623.
Crossref
Crossref
Carol E. Green, Robert Swezey, James Bakke, Walter Shinn, Anna Furimsky, Naveen Bejugam, Gita N. Shankar, Ling Jong & Izet M. Kapetanovic. (2010) Improved oral bioavailability in rats of SR13668, a novel anti-cancer agent. Cancer Chemotherapy and Pharmacology 67:5, pages 995-1006.
Crossref
Crossref
Jun HiraoMasatoshi NishimuraShingo ArakawaNoriyo NiinoKazuhiko MoriTadashi FurukawaAtsushi SanbuisshoSunao ManabeMasugi Nishihara & Yuji Mori. (2011) Sex and circadian modulatory effects on rat liver as assessed by transcriptome analyses. The Journal of Toxicological Sciences 36:1, pages 9-22.
Crossref
Crossref
A. Schmitz, S. Demmel, L. M. Peters, T. Leeb, M. Mevissen & B. Haase. (2010)
Comparative human–horse sequence analysis of the
CYP3A
subfamily gene cluster
. Animal Genetics 41:s2, pages 72-79.
Crossref
Crossref
Lidia Miraglia, Sabrina Pagliarusco, Ellenia Bordini, Silvia Martinucci & Mario Pellegatti. (2010) Metabolic Disposition of Casopitant, a Potent Neurokinin-1 Receptor Antagonist, in Mice, Rats, and Dogs. Drug Metabolism and Disposition 38:10, pages 1876-1891.
Crossref
Crossref
Robert R. Maronpot, Katsuhiko Yoshizawa, Abraham Nyska, Takanori Harada, Gordon Flake, Gundi Mueller, Bhanu Singh & Jerrold M. Ward. (2010) Hepatic Enzyme Induction. Toxicologic Pathology 38:5, pages 776-795.
Crossref
Crossref
. 2010. Drug Safety Evaluation. Drug Safety Evaluation
568
618
.
Li Liu, Zhenzhou Jiang, Jing Liu, Xin Huang, Tao Wang, Jun Liu, Yun Zhang, Zhixing Zhou, Jianlu Guo, Lina Yang, Yun Chen & Luyong Zhang. (2010) Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats. Toxicology 271:1-2, pages 57-63.
Crossref
Crossref
. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia
1
73
.
. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia
1
51
.
Sonu Sundd Singh. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia
1
50
.
Susan R. Crowell, W. Matthew Henderson, Jeffrey W. Fisher & John F. Kenneke. (2010) Gender and species differences in triadimefon metabolism by rodent hepatic microsomes. Toxicology Letters 193:1, pages 101-107.
Crossref
Crossref
Jun HiraoNoriyo NiinoShingo ArakawaShingo Shibata, Kazuhiko MoriYosuke AndoTadashi FurukawaAtsushi SanbuisshoSunao ManabeYuji Mori & Masugi Nishihara. (2010) Circadian modulation of hepatic transcriptome in transgenic rats expressing human growth hormone. The Journal of Toxicological Sciences 35:5, pages 673-685.
Crossref
Crossref
Yoshiji ASAOKA, Hiroki SAKAI, Jun SASAKI, Masanobu GORYO, Tokuma YANAI, Toshiaki MASEGI & Kosuke OKADA. (2010) Changes in the Gene Expression and Enzyme Activity of Hepatic Cytochrome P450 in Juvenile Sprague-Dawley Rats. Journal of Veterinary Medical Science 72:4, pages 471-479.
Crossref
Crossref
G.L. Kedderis. 2010. Comprehensive Toxicology. Comprehensive Toxicology
137
151
.
Cengiz Gokbulut, Ali Bilgili, Basak Hanedan, Dilek Aksit, Ali Metin Aksoy & Cafer Turgut. (2009) Breed-related plasma disposition of ivermectin following subcutaneous administration in Kilis and Damascus goats. Research in Veterinary Science 87:3, pages 445-448.
Crossref
Crossref
Caroline Rouas, Maâmar Souidi, Line Grandcolas, Stephane Grison, Cedric Baudelin, Patrick Gourmelon, Marc Pallardy & Yann Gueguen. (2009) Acetaminophen induces xenobiotic-metabolizing enzymes in rat: Impact of a uranium chronic exposure. Environmental Toxicology and Pharmacology 28:3, pages 363-369.
Crossref
Crossref
Hao-Jie Zhu, David I. Appel, Yan Jiang & John S. Markowitz. (2009) Age- and Sex-Related Expression and Activity of Carboxylesterase 1 and 2 in Mouse and Human Liver. Drug Metabolism and Disposition 37:9, pages 1819-1825.
Crossref
Crossref
Barry Levine. 2009. International Pharmaceutical Product Registration, Second Edition. International Pharmaceutical Product Registration, Second Edition
377
401
.
Cheng Chang, David B Duignan, Kjell D Johnson, Pil H Lee, George S Cowan, Eric M Gifford, Charles J Stankovic, Christopher S Lepsy & Chad L Stoner. (2009) The Development and Validation of a Computational Model to Predict Rat Liver Microsomal Clearance. Journal of Pharmaceutical Sciences 98:8, pages 2857-2867.
Crossref
Crossref
Cengiz Gokbulut, Ali Bilgili, Basak Hanedan, Dilek Aksit, Ali Metin Aksoy & Cafer Turgut. (2009) Sex-related plasma disposition of ivermectin following pour-on administration in goats. Veterinary Parasitology 162:3-4, pages 342-345.
Crossref
Crossref
Z.H. Liu & S. Zeng. (2009) Cytotoxicity of ginkgolic acid in HepG2 cells and primary rat hepatocytes. Toxicology Letters 187:3, pages 131-136.
Crossref
Crossref
G. Zamaratskaia, V. Zlabek, G. Chen & A. Madej. (2009) Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration. Animal 3:8, pages 1124-1132.
Crossref
Crossref
MJ Kennedy. (2008) Hormonal Regulation of Hepatic Drug-Metabolizing Enzyme Activity During Adolescence. Clinical Pharmacology & Therapeutics 84:6, pages 662-673.
Crossref
Crossref
Stefanie D. Krämer & Bernard Testa. (2008) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 5:12, pages 2465-2578.
Crossref
Crossref
David J. Greenblatt & Lisa L. von Moltke. (2008) Gender Has a Small but Statistically Significant Effect on Clearance of CYP3A Substrate Drugs. The Journal of Clinical Pharmacology 48:11, pages 1350-1355.
Crossref
Crossref
Kan Chen, Richard B. Cole, Vicente Santa Cruz, Ernest W. Blakeney, Mary F. Kanz & Tammy R. Dugas. (2008) Characterization of biliary conjugates of 4,4′-methylenedianiline in male versus female rats. Toxicology and Applied Pharmacology 232:2, pages 190-202.
Crossref
Crossref
Luigi Quintieri, Marianna Fantin, Pietro Palatini, Sara De Martin, Antonio Rosato, Michele Caruso, Cristina Geroni & Maura Floreani. (2008) In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: A comparison with human liver microsomes. Biochemical Pharmacology 76:6, pages 784-795.
Crossref
Crossref
Ken Grime, Peter J. H. Webborn & Robert J. Riley. (2008) Functional Consequences of Active Hepatic Uptake on Cytochrome P450 Inhibition in Rat and Human Hepatocytes. Drug Metabolism and Disposition 36:8, pages 1670-1678.
Crossref
Crossref
Wen Huang, Hai Niu & Yinchun Gu. (2008) Metabolic Kinetics of tert-Butylhydroquinone and Its Metabolites in Rat Serum after Oral Administration by LC/ITMS. Lipids 43:8, pages 757-763.
Crossref
Crossref
Paul Baldrick. (2008) Safety evaluation to support First-In-Man investigations I: Kinetic and safety pharmacology studies. Regulatory Toxicology and Pharmacology 51:2, pages 230-236.
Crossref
Crossref
Mette Drude Kjaer Markussen, Ann-Charlotte Heiberg, Merete Fredholm & Michael Kristensen. (2008) Identification of cytochrome P450 differentiated expression related to developmental stages in bromadiolone resistance in rats (Rattus norvegicus). Pesticide Biochemistry and Physiology 91:3, pages 147-152.
Crossref
Crossref
Rochelle W. Tyl, Kevin Crofton, Angelo Moretto, Virginia Moser, Larry P. Sheets & Thomas J. Sobotka. (2008) Identification and interpretation of developmental neurotoxicity effects. Neurotoxicology and Teratology 30:4, pages 349-381.
Crossref
Crossref
Pedro Melo, Maria Dolores Pinazo-Dur?n, Jos? Salgado-Borges & Maria Am?lia Tavares. (2008) Correlation of axon size and myelin occupancy in rats prenatally exposed to methamphetamine. Brain Research 1222, pages 61-68.
Crossref
Crossref
Doreen Mitschke, Andreas Reichel, Gert Fricker & Ursula Moenning. (2008) Characterization of Cytochrome P450 Protein Expression along the Entire Length of the Intestine of Male and Female Rats. Drug Metabolism and Disposition 36:6, pages 1039-1045.
Crossref
Crossref
Leo T.M. Van der Ven, Ton van de Kuil, Pim E.G. Leonards, Wout Slob, Rocío F. Cantón, Silke Germer, Theo J. Visser, Sabina Litens, Helen Håkansson, Dieter Schrenk, Martin van den Berg, Aldert H. Piersma, Josephus G. Vos & Antoon Opperhuizen. (2008) A 28-day oral dose toxicity study in Wistar rats enhanced to detect endocrine effects of decabromodiphenyl ether (decaBDE). Toxicology Letters 179:1, pages 6-14.
Crossref
Crossref
Leo T.M. van der Ven, Ton van de Kuil, Aart Verhoef, Pim E.G. Leonards, Wout Slob, Rocío F. Cantón, Silke Germer, Timo Hamers, Theo J. Visser, Sabina Litens, Helen Håkansson, Yvonne Fery, Dieter Schrenk, Martin van den Berg, Aldert H. Piersma & Josephus G. Vos. (2008) A 28-day oral dose toxicity study enhanced to detect endocrine effects of a purified technical pentabromodiphenyl ether (pentaBDE) mixture in Wistar rats. Toxicology 245:1-2, pages 109-122.
Crossref
Crossref
Mette DK Markussen, Ann-Charlotte Heiberg, Merete Fredholm & Michael Kristensen. (2008) Differential expression of cytochrome P450 genes between bromadiolone-resistant and anticoagulant-susceptible Norway rats: a possible role for pharmacokinetics in bromadiolone resistance. Pest Management Science 64:3, pages 239-248.
Crossref
Crossref
Arlin B. Rogers, Elizabeth J. Theve, Yan Feng, Rebecca C. Fry, Koli Taghizadeh, Kristen M. Clapp, Chakib Boussahmain, Kathleen S. Cormier & James G. Fox. (2007) Hepatocellular Carcinoma Associated with Liver-Gender Disruption in Male Mice. Cancer Research 67:24, pages 11536-11546.
Crossref
Crossref
Raymond Kemper, Johnnie Hayes & Matthew Bogdanffy. 2007. Principles and Methods of Toxicology, Fifth Edition. Principles and Methods of Toxicology, Fifth Edition
103
178
.
R.L. Sprando, T.F.X. Collins, T. Black, N. Olejnik, M. Ramos-Valle & D. Ruggles. (2007) Acute toxicity of sodium arsenite in a complex food matrix. Food and Chemical Toxicology 45:9, pages 1606-1613.
Crossref
Crossref
J B Schwartz. (2007) The Current State of Knowledge on Age, Sex, and Their Interactions on Clinical Pharmacology. Clinical Pharmacology & Therapeutics 82:1, pages 87-96.
Crossref
Crossref
Kazunori Hosoe, Mitsuaki Kitano, Hideyuki Kishida, Hiroshi Kubo, Kenji Fujii & Mikio Kitahara. (2007) Study on safety and bioavailability of ubiquinol (Kaneka QH™) after single and 4-week multiple oral administration to healthy volunteers. Regulatory Toxicology and Pharmacology 47:1, pages 19-28.
Crossref
Crossref
Natasha P. Clayton, Katsuhiko Yoshizawa, Grace E. Kissling, Leo T. Burka, Po-Chuen Chan & Abraham Nyska. (2007) Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract. Experimental and Toxicologic Pathology 58:4, pages 223-236.
Crossref
Crossref
S. Dadashzadeh, B. Javadian & S. Sadeghian. (2006) The effect of gender on the pharmacokinetics of verapamil and norverapamil in human. Biopharmaceutics & Drug Disposition 27:7, pages 329-334.
Crossref
Crossref
M. Dacasto, C. Montesissa & C. Nebbia. (2006) Illegal Drug Treatments and Drug Metabolism: Biomarkers or Not?. Veterinary Research Communications 30:S1, pages 113-119.
Crossref
Crossref
David C. PrydeGraham N. MawSimon PlankenMichelle Y. PlattsVivienne SandersonMartin CorlessAlan StobieChristopher G. BarberRachel RussellLaura FosterLaura BarkerChristopher WaymanPiet Van Der GraafPeter StaceyDebbie MorrenChristopher KohlKevin BeaumontSara CoggonMichael Tute. (2006) Novel Selective Inhibitors of Neutral Endopeptidase for the Treatment of Female Sexual Arousal Disorder. Synthesis and Activity of Functionalized Glutaramides. Journal of Medicinal Chemistry 49:14, pages 4409-4424.
Crossref
Crossref
Julia Ruiz-laguna, Nieves Abril, Tamara GarcÍa-barrera, Jose-luis GÓmez-ariza, Juan LÓpez-barea & Carmen Pueyo. (2006)
Absolute Transcript Expression Signatures of
Cyp
and
Gst
Genes in
Mus spretus
to Detect Environmental Contamination
. Environmental Science & Technology 40:11, pages 3646-3652.
Crossref
Crossref
Mette Gillberg, Mette T. Skaanild & Christian Friis. (2006) Regulation of Gender-Dependent CYP2A Expression in Pigs: Involvement of Androgens and CAR. Basic & Clinical Pharmacology & Toxicology 98:5, pages 480-487.
Crossref
Crossref
Jun Hirao, Shingo Arakawa, Kyoko Watanabe, Kazumi Ito & Tadashi Furukawa. (2006) Effects of Restricted Feeding on Daily Fluctuations of Hepatic Functions Including P450 Monooxygenase Activities in Rats. Journal of Biological Chemistry 281:6, pages 3165-3171.
Crossref
Crossref
Kazutoshi Ohyama, Kiyoshi Sato & Yasuhiro Kato. (2006) Sex- and species-dependent difference of methoxychlor O-demethylation by rat and mouse liver microsomes. Journal of Pesticide Science 31:2, pages 102-109.
Crossref
Crossref
Xin Teng, Alexei Degterev, Prakash Jagtap, Xuechao Xing, Sungwoon Choi, Régine Denu, Junying Yuan & Gregory D. Cuny. (2005) Structure–activity relationship study of novel necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters 15:22, pages 5039-5044.
Crossref
Crossref
Jerold A. Last, Kishorchandra Gohil, Vivek C. Mathrani & Nicholas J. Kenyon. (2005) Systemic responses to inhaled ozone in mice: cachexia and down-regulation of liver xenobiotic metabolizing genes. Toxicology and Applied Pharmacology 208:2, pages 117-126.
Crossref
Crossref
Kim A. Johnson & Chandra Prakash. (2005)
METABOLISM, EXCRETION, AND PHARMACOKINETICS OF (3-{[4-
TERT
-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO]-METHYL}-PHENOXY)-ACETIC ACID, AN EP2 RECEPTOR-SELECTIVE PROSTAGLANDIN E2 AGONIST, IN MALE AND FEMALE SPRAGUE-DAWLEY RATS
. Drug Metabolism and Disposition 33:8, pages 1191-1201.
Crossref
Crossref
Deborah J. Newton, Regina W. Wang & David C. Evans. (2005) Determination of phase I metabolic enzyme activities in liver microsomes of Mrp2 deficient TR− and EHBR rats. Life Sciences 77:10, pages 1106-1115.
Crossref
Crossref
O.N. Mikhailova, L.F. Gulyaeva & M.L. Filipenko. (2005) Gene expression of drug metabolizing enzymes in adult and aged mouse liver: A modulation by immobilization stress. Toxicology 210:2-3, pages 189-196.
Crossref
Crossref
Dale Hattis, Robert Goble & Margaret Chu. (2005) Age-Related Differences in Susceptibility to Carcinogenesis. II. Approaches for Application and Uncertainty Analyses for Individual Genetically Acting Carcinogens. Environmental Health Perspectives 113:4, pages 509-516.
Crossref
Crossref
Monette M Cotreau, Lisa L von Moltke & David J Greenblatt. (2005) The Influence of Age and Sex on the Clearance of Cytochrome P450 3A Substrates. Clinical Pharmacokinetics 44:1, pages 33-60.
Crossref
Crossref
Angéline Gradolatto, Jean-Philippe Basly, Raymond Berges, Caroline Teyssier, Marie-Christine Chagnon, Marie-Héléne Siess & Marie-Chantal Canivenc-Lavier. (2005) PHARMACOKINETICS AND METABOLISM OF APIGENIN IN FEMALE AND MALE RATS AFTER A SINGLE ORAL ADMINISTRATION. Drug Metabolism and Disposition 33:1, pages 49-54.
Crossref
Crossref
Thomas Visalli, Rita Turkall & Mohamed S. Abdel-Rahman. (2005) Gender differences in cocaine pharmacokinetics in CF-1 mice. Toxicology Letters 155:1, pages 35-40.
Crossref
Crossref
. 2005. Drug Metabolism. Drug Metabolism
243
268
.
M. R. Alison, P. Vig, F. Russo, B. W. Bigger, E. Amofah, M. Themis & S. Forbes. (2004) Hepatic stem cells: from inside and outside the liver?. Cell Proliferation 37:1, pages 1-21.
Crossref
Crossref
Brian Chanas, Hongbing Wang & Burhan I Ghanayem. (2003) Differential metabolism of acrylonitrile to cyanide is responsible for the greater sensitivity of male vs female mice: role of CYP2E1 and epoxide hydrolases. Toxicology and Applied Pharmacology 193:2, pages 293-302.
Crossref
Crossref
Renzo Wolbold, Kathrin Klein, Oliver Burk, Andreas K. Nüssler, Peter Neuhaus, Michel Eichelbaum, Matthias Schwab & Ulrich M. Zanger. (2003) Sex is a major determinant of CYP3A4 expression in human liver. Hepatology 38:4, pages 978-988.
Crossref
Crossref
Yukiyoshi Fujita, Yasuhiko Yamada, Makiko Kusama, Toshimasa Yamauchi, Junji Kamon, Takashi Kadowaki & Tatsuji Iga. (2003) Sex differences in the pharmacokinetics of pioglitazone in rats. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 136:1, pages 85-94.
Crossref
Crossref
Mayssa Attar, Dahai Dong, Kah-Hiing John Ling & Diane D-S. Tang-Liu. (2003) Cytochrome P450 2C8 and Flavin-containing Monooxygenases are Involved in the Metabolism of Tazarotenic Acid in Humans. Drug Metabolism and Disposition 31:4, pages 476-481.
Crossref
Crossref
Heather E. Kleiner, Melissa J. Reed & John DiGiovanni. (2003)
Naturally Occurring Coumarins Inhibit Human Cytochromes P450 and Block Benzo[
a
]pyrene and 7,12-Dimethylbenz[
a
]anthracene DNA Adduct Formation in MCF-7 Cells
. Chemical Research in Toxicology 16:3, pages 415-422.
Crossref
Crossref
Monica Lindell, Matti Lang & Hans Lennernäs. (2003) Expression of genes encoding for drug metabolising cytochrome P450 enzymes and P-glycoprotein in the rat small intestine; comparison to the liver. European Journal of Drug Metabolism and Pharmacokinetics 28:1, pages 41-48.
Crossref
Crossref
Donald J. AbrahamBernard Testa & William Soine. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery
431
498
.
Lenka Skálová, Vladimír Wsól, Vendula Baliharová, Radim Král, Barbora Szotáková, Jakub Velík & Jirí Lamka. (2003) Reduction of flobufen in pig hepatocytes: Effect of pig breed (domestic, wild) and castration. Chirality 15:3, pages 213-219.
Crossref
Crossref
Yasumasa GotohYukio Kato, Bruno Stieger, Peter J. Meier & Yuichi Sugiyama. (2002)
Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17β-
d
-glucuronide in rats
. American Journal of Physiology-Endocrinology and Metabolism 282:6, pages E1245-E1254.
Crossref
Crossref
Pailin Ujjin, Soisungwan Satarug, Yuvaree Vanavanitkun, Satoshi Daigo, Noritaka Ariyoshi, Hiroshi Yamazaki, Paul E. B. Reilly, Michael R. Moore & Tetsuya Kamataki. (2002) Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females. Pharmacogenetics 12:3, pages 241-249.
Crossref
Crossref
. 2002. Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists. Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists
121
168
.
Vanina D. Heuser, Juliana da Silva, Heinz‐Jörn Moriske, Johnny F. Dias, Maria Lúcia Yoneama & Thales R.O. de Freitas. (2002)
Genotoxicity biomonitoring in regions exposed to vehicle emissions using the comet assay and the micronucleus test in native rodent
Ctenomys minutus
. Environmental and Molecular Mutagenesis 40:4, pages 227-235.
Crossref
Crossref
Jason R. Baker, Soisungwan Satarug, Paul E.B. Reilly, Robert J. Edwards, Noritaka Ariyoshi, Tetsuya Kamataki, Michael R. Moore & David J. Williams. (2001) Relationships between non-occupational cadmium exposure and expression of nine cytochrome P450 forms in human liver and kidney cortex samples 1 1Abbreviation: CYP, cytochrome P450.. Biochemical Pharmacology 62:6, pages 713-721.
Crossref
Crossref
Michele Poole, Kristie Bridgers, Stefan E.H. Alexson & J.Christopher Corton. (2001) Altered expression of the carboxylesterases ES-4 and ES-10 by peroxisome proliferator chemicals. Toxicology 165:2-3, pages 109-119.
Crossref
Crossref
Sam Kacew. (2001) Confounding factors in toxicity testing. Toxicology 160:1-3, pages 87-96.
Crossref
Crossref
Hirohisa Nagahori, Hiromi Yoshino, Yoshitaka Tomigahara, Naohiko Isobe, Hideo Kaneko & Iwao Nakatsuka. (2000)
Metabolism of Furametpyr. 2.
14
C Excretion,
14
C Concentrations in Tissues, and Amounts of Metabolites in Rats
. Journal of Agricultural and Food Chemistry 48:11, pages 5760-5767.
Crossref
Crossref
Donald R. Buhler, Cristobal L. Miranda, Marilyn C. Henderson, Yea-Huey Yang, Su-Jun Lee & Jun-Lan Wang-Buhler. (2000) Effects of 17β-Estradiol and Testosterone on Hepatic mRNA/Protein Levels and Catalytic Activities of CYP2M1, CYP2K1, and CYP3A27 in Rainbow Trout (Oncorhynchus mykiss). Toxicology and Applied Pharmacology 168:2, pages 91-101.
Crossref
Crossref
Li You, Sanny K. Chan, Jason M. Bruce, Shannon Archibeque-Engle, Mercedes Casanova, J.Christopher Corton & Henry d'A. Heck. (1999) Modulation of Testosterone-Metabolizing Hepatic Cytochrome P-450 Enzymes in Developing Sprague-Dawley Rats Following in Utero Exposure to p,p′-DDE. Toxicology and Applied Pharmacology 158:2, pages 197-205.
Crossref
Crossref
Eun-Jeon Park, Geonil Ko, Jaebaek Kim & Dong Hwan Sohn. (1999) Biotransformation of theophylline in cirrhotic rats induced by biliary obstruction. Archives of Pharmacal Research 22:1, pages 60-67.
Crossref
Crossref