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Hemoglobin
international journal for hemoglobin research
Volume 39, 2015 - Issue 3
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Original Article

Interaction of an α-Globin Gene Triplication with β-Globin Gene Mutations in Iranian Patients with β-Thalassemia Intermedia

Samaneh FarashiKariminejad-Najmabadi Pathology & Genetics Center, Tehran, Iran, ;Genetics Research Center, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran,
,
Nooshin BayatKariminejad-Najmabadi Pathology & Genetics Center, Tehran, Iran,
,
Negin Faramarzi GarousKariminejad-Najmabadi Pathology & Genetics Center, Tehran, Iran,
,
Mehri AshkiKariminejad-Najmabadi Pathology & Genetics Center, Tehran, Iran,
,
Mona Montajabi NiatKariminejad-Najmabadi Pathology & Genetics Center, Tehran, Iran,
,
Shadi VakiliKariminejad-Najmabadi Pathology & Genetics Center, Tehran, Iran,
,
Hashem ImanianKariminejad-Najmabadi Pathology & Genetics Center, Tehran, Iran,
,
Sirous ZeinaliPasteur Institute of Iran, Tehran, Iran,
,
Hossein NajmabadiKariminejad-Najmabadi Pathology & Genetics Center, Tehran, Iran, ;Genetics Research Center, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran,
&
Azita AzarkeivanKariminejad-Najmabadi Pathology & Genetics Center, Tehran, Iran, ;Department of Thalassemia Clinic, Transfusion Research Center Organization, High Institute for Research and Education in Transfusion Medicine, Tehran, IranCorrespondence[email protected]
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Pages 201-206 | Received 07 Aug 2013, Accepted 20 Jan 2015, Published online: 18 Jun 2015

Citations (15)

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Seyedeh Sedigheh Abedini, Fatemeh Forouzesh Pour, Keyvan Karimi, Zhila Ghaderi, Samaneh Farashi, Ameneh Tavakoli Koudehi, Homeira Javadi Pirouz, Seyedeh Bahareh Mobini Nejad, Azita Azarkeivan & Hossein Najmabadi. (2018) Frequency of α-Globin Gene Triplications and Coinheritance with β-Globin Gene Mutations in the Iranian Population. Hemoglobin 42:4, pages 252-256.
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Ebrahim Miri-Moghaddam, Sara Bahrami, Majid Naderi, Ali Bazi & Morteza Karimipoor. (2016) Molecular Characterization of β-Thalassemia Intermedia in Southeast Iran. Hemoglobin 40:3, pages 173-178.
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Samaneh Farashi, Shadi Vakili, Negin Faramarzi Garous, Mehri Ashki, Hashem Imanian, Azita Azarkeivan & Hossein Najmabadi. (2015) Copy number variations of six and seven α-globin genes in a family with intermedia and major thalassemia phenotypes. Expert Review of Hematology 8:5, pages 693-698.
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Articles from other publishers (12)

Nathalie Bonello‐Palot, Audrey Benoit, Imane Agouti, Ilyes Hamouda, Valentine Brousse & Catherine Badens. (2023) Transfusion requirements and complication rate in β‐thalassemia intermedia due to heterozygous β‐globin gene mutation and triplicated α‐globin genes. European Journal of Haematology 111:5, pages 742-747.
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Xinxing Xie, Jinhui Gan, Zezhang Liu, Yulian Zhou, Kun Yuan, Zhigang Chen, Shiping Chen, Rui Zhou, Lipei Liu, Xiaoyan Huang, Yan Zhang, Qian Liu, Wenqian Zhang, Jungao Huang & Junkun Chen. (2023) Prevalence and genetic analysis of triplicated α-globin gene in Ganzhou region using high-throughput sequencing. Frontiers in Genetics 14.
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Shiqiang Luo, Xingyuan Chen, Dingyuan Zeng, Ning Tang, Dejian Yuan, Qingyan Zhong, Aiping Mao, Ruofan Xu & Tizhen Yan. (2021) The value of single-molecule real-time technology in the diagnosis of rare thalassemia variants and analysis of phenotype–genotype correlation. Journal of Human Genetics 67:4, pages 183-195.
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Xi Luo, Xiang-mei Zhang, Liu-song Wu, Jindong Chen & Yan Chen. (2021) Prevalence and clinical phenotype of the triplicated α-globin genes and its ethnic and geographical distribution in Guizhou of China. BMC Medical Genomics 14:1.
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Lauren J. Isley, Aleisha K. Chamberlain, Pamela Callum & Jaime Shamonki. (2021) Comparison of methodologies to detect hemoglobinopathy carriers in a multi‐ethnic sperm donor population. Journal of Genetic Counseling 30:5, pages 1399-1406.
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Mohammad Hamid, Bijan keikhaei, Hamid Galehdari, Alihossein Saberi, Alireza Sedaghat, Gholamreza Shariati & Marziye Mohammadi‐Anaei. (2021) Alpha‐globin gene triplication and its effect in beta‐thalassemia carrier, sickle cell trait, and healthy individual. eJHaem 2:3, pages 366-374.
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Shaema Salih Amin, Sana Dlawar Jalal, Kosar Muhammed Ali, Ali Ibrahim Mohammed, Luqman Khalid Rasool & Tara Jamel Osman. (2020) Beta-Thalassemia Intermedia: A Single Thalassemia Center Experience from Northeastern Iraq. BioMed Research International 2020, pages 1-11.
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Rashail Faraon, Mahmoud Daraghmah, Fekri Samarah & Mahmoud A. Srour. (2019) Molecular characterization of β-thalassemia intermedia in the West Bank, Palestine. BMC Hematology 19:1.
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Anita H. Nadkarni, Ajit C. Gorakshakar, Pratibha M. Sawant, Khushnooma Y. Italia, Dipti S. Upadhye, Manju S. Gorivale, Pallavi R. Mehta, Priya Hariharan, Kanjaksha Ghosh & Roshan B. Colah. (2018) The phenotypic and molecular diversity of hemoglobinopathies in India: A review of 15 years at a referral center. International Journal of Laboratory Hematology 41:2, pages 218-226.
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Orna Steinberg-Shemer, Jacob C. Ulirsch, Sharon Noy-Lotan, Tanya Krasnov, Dina Attias, Orly Dgany, Ruth Laor, Vijay G. Sankaran & Hannah Tamary. (2017) Whole-exome sequencing identifies an α-globin cluster triplication resulting in increased clinical severity of β-thalassemia. Molecular Case Studies 3:6, pages a001941.
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E. I. de-la-Cruz-Salcedo, B. Ibarra, L. C. Rizo-de-la-Torre, J. Y. Sánchez-López, A. González-Mercado, C. L. Harteveld & F. J. Perea-Díaz. (2016) Molecular analysis of complex cases of alpha- and beta-thalassemia in Mexican mestizo patients with microcytosis and hypochromia reveals two novel alpha 0 -thalassemia deletions - - Mex1 and - - Mex2 . International Journal of Laboratory Hematology 38:5, pages 535-542.
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T.-Y. Lee, M.-I. Lai, V. Ramachandran, J. A. M. A. Tan, L.-K. Teh, R. Othman, N. H. Hussein & E. George. (2016) Rapid detection of α-thalassaemia variants using droplet digital PCR. International Journal of Laboratory Hematology 38:4, pages 435-443.
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