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Drug Development and Industrial Pharmacy Volume 36, 2010 - Issue 11
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Original Article

Preparation and characterization of solid dispersion of simvastatin

Taízia D. Silva Department of Pharmaceutical Products, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
,
Valquíria T. Arantes Department of Pharmaceutical Products, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
,
Jackson A.L.C. Resende Department of Physics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;Current address: Department of Inorganic Chemistry, Federal University Fluminense, Niterói, Rio de Janeiro, Brazil.
,
Nivaldo L. Speziali Department of Physics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
,
Renata B. de Oliveira Department of Pharmaceutical Products, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
&
Cristina D. Vianna-Soares Department of Pharmaceutical Products, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, BrazilCorrespondence[email protected]
Pages 1348-1355 | Received 03 Jan 2010, Accepted 22 Mar 2010, Published online: 14 Jun 2010

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Yuanyuan Zhang, Yuxin Liu, Yanfei Luo, Qing Yao, Yue Zhong, Bin Tian & Xing Tang. (2016) Extruded Soluplus/SIM as an oral delivery system: characterization, interactions, in vitro and in vivo evaluations. Drug Delivery 23:6, pages 1902-1911.
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Prateek Dani, Vibha Puri & A. K. Bansal. (2014) Solubility advantage from amorphous etoricoxib solid dispersions. Drug Development and Industrial Pharmacy 40:1, pages 92-101.
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Sheraz Khan, Hannah Batchelor, Peter Hanson, Imran Y. Saleem, Yvonne Perrie & Afzal R. Mohammed. (2013) Dissolution rate enhancement, in vitro evaluation and investigation of drug release kinetics of chloramphenicol and sulphamethoxazole solid dispersions. Drug Development and Industrial Pharmacy 39:5, pages 704-715.
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Srinivasan Shanmugam, Jae-Hyun Park, Sang-Cheol Chi, Chul Soon Yong, Han-Gon Choi & Jong Soo Woo. (2011) Physicochemical stability, pharmacokinetic, and biodistribution evaluation of paclitaxel solid dispersion prepared using supercritical antisolvent process. Drug Development and Industrial Pharmacy 37:6, pages 628-637.
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Articles from other publishers (20)

Sai Krishna Anand Vullendula, Athira R. Nair, Dani Lakshman Yarlagadda, K.S. Navya Sree, Krishnamurthy Bhat & Swapnil J. Dengale. (2022) Polymeric solid dispersion Vs co-amorphous technology: A critical comparison. Journal of Drug Delivery Science and Technology 78, pages 103980.
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Mohammad Mehdi Mahboobian, Simin Dadashzadeh, Mehdi Rezaei, Mojdeh Mohammadi & Noushin Bolourchian. (2022) Simvastatin in ternary solid dispersion formulations: Improved In vitro dissolution and anti-hyperlipidemia efficiency. Journal of Drug Delivery Science and Technology 74, pages 103571.
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Zhou Zhou, Juan Chen, Zhi-xin Zhang, Fang-bin Wang, Lu Wang, Yan Lin, Xian Zhang & Jian Liu. (2022) Solubilization of luteolin in PVP40 solid dispersion improves inflammation-induced insulin resistance in mice. European Journal of Pharmaceutical Sciences 174, pages 106188.
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Barbara Sterle Zorec, Špela Zupančič, Zoran Lavrič & Rok Dreu. (2021) Particle properties and drug metastable solubility of simvastatin containing PVP matrix particles prepared by electrospraying technique. European Journal of Pharmaceutical Sciences 158, pages 105649.
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Xiaoyu Sui, Yan Chu, Jie Zhang, Honglian Zhang, Huiyu Wang, Tingting Liu & Cuiyan Han. (2020) The Effect of PVP Molecular Weight on Dissolution Behavior and Physicochemical Characterization of Glycyrrhetinic Acid Solid Dispersions. Advances in Polymer Technology 2020, pages 1-13.
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Afroditi Kapourani, Melina Chatzitheodoridou, Konstantinos N. Kontogiannopoulos & Panagiotis Barmpalexis. (2020) Experimental, Thermodynamic, and Molecular Modeling Evaluation of Amorphous Simvastatin-Poly(vinylpyrrolidone) Solid Dispersions. Molecular Pharmaceutics 17:7, pages 2703-2720.
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Won Kyung Kim, Jin Su Kim, Myeong Eun Shin, Jong Seon Baek, David Kim, Alessio Bucciarelli, Jeong Eun Song & Gilson Khang. (2020) Sustained-Released Formulation of Nifedipine Solid Dispersion with Various Polymers. Macromolecular Research 28:6, pages 553-557.
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Mitja Pohlen, Zoran Lavrič, Clive Prestidge & Rok Dreu. (2020) Preparation, Physicochemical Characterisation and DoE Optimisation of a Spray-Dried Dry Emulsion Platform for Delivery of a Poorly Soluble Drug, Simvastatin. AAPS PharmSciTech 21:4.
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Paula Eugenia Morales, Jorge Cruz, Cecilia Martínez, Marcelo Videa & Luz María Martínez. (2019) Nano and micro dispersions of two-phase amorphous-amorphous drug formulations as strategy to enhance solubility of pharmaceuticals. Materials Today: Proceedings 13, pages 390-396.
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Mitja Pohlen, Luka Pirker, Matevž Luštrik & Rok Dreu. (2018) A redispersible dry emulsion system with simvastatin prepared via fluid bed layering as a means of dissolution enhancement of a lipophilic drug. International Journal of Pharmaceutics 549:1-2, pages 325-334.
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Xingwang Zhang, Huijie Xing, Yue Zhao & Zhiguo Ma. (2018) Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs. Pharmaceutics 10:3, pages 74.
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Mahendra Singh, Jovita Kanoujia, Pooja Singh, Poonam Parashar, Malti Arya, Chandra Bhushan Tripathi, Vivek R. Sinha & Shubhini A. Saraf. (2016) Development of an α-linolenic acid containing a soft nanocarrier for oral delivery-part II: buccoadhesive gel. RSC Advances 6:103, pages 101602-101612.
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Manish Dhall & A. K. Madan. (2014) Studies on urea co-inclusion complexes of simvastatin for improvement of pharmaceutical characteristics. Journal of Inclusion Phenomena and Macrocyclic Chemistry 81:1-2, pages 105-120.
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Martina Urbanova, Adriana Sturcova, Jana Kredatusova & Jiri Brus. (2015) Structural insight into the physical stability of amorphous Simvastatin dispersed in pHPMA: Enhanced dynamics and local clustering as evidenced by solid-state NMR and Raman spectroscopy. International Journal of Pharmaceutics 478:2, pages 464-475.
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Jung Hwan Lee, Young Lae Kim, So Jin Lee, Jaewon Yang, Jin Young Park, Eun Young Kim, Dongwon Lee & Gilson Khang. (2013) RETRACTED ARTICLE: Preparation/characterization of solid dispersions and enhancement of dissolution rate on celecoxib as BCS II class. Journal of Pharmaceutical Investigation 44:5, pages 399-399.
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Ricardo G. Simões, Carlos E. S. Bernardes, Hermínio P. Diogo, Filipe Agapito & Manuel E. Minas da Piedade. (2013) Energetics and Structure of Simvastatin. Molecular Pharmaceutics 10:7, pages 2713-2722.
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Agata Górniak, Bożena Karolewicz, Ewa Żurawska-Płaksej & Janusz Pluta. (2012) Thermal, spectroscopic, and dissolution studies of the simvastatin–acetylsalicylic acid mixtures. Journal of Thermal Analysis and Calorimetry 111:3, pages 2125-2132.
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P. Subra-Paternault, D. Vrel & C. Roy. (2012) Coprecipitation on slurry to prepare drug?silica-polymer formulations by compressed antisolvent. The Journal of Supercritical Fluids 63, pages 69-80.
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Radheshyam Tiwari & Kamla Pathak. (2011) Nanostructured lipid carrier versus solid lipid nanoparticles of simvastatin: Comparative analysis of characteristics, pharmacokinetics and tissue uptake. International Journal of Pharmaceutics 415:1-2, pages 232-243.
Crossref
Radheshyam Tiwari & Kamla Pathak. (2011) Statins therapy: a review on conventional and novel formulation approaches. Journal of Pharmacy and Pharmacology 63:8, pages 983-998.
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