503
Views
58
CrossRef citations to date
0
Altmetric
Research Article

pH-Sensitive oral insulin delivery systems using Eudragit microspheres

, &
Pages 977-985 | Received 28 Oct 2010, Accepted 04 Jan 2011, Published online: 21 Mar 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (13)

Shiming He, Zhongcheng Liu & Donggang Xu. (2019) Advance in oral delivery systems for therapeutic protein. Journal of Drug Targeting 27:3, pages 283-291.
Read now
Shuangyan Tian, Juan Li, Qi Tao, Yawen Zhao, Zhufen Lv, Fan Yang, Haoyun Duan, Yanzhong Chen, Qingjun Zhou & Dongzhi Hou. (2018) Controlled drug delivery for glaucoma therapy using montmorillonite/Eudragit microspheres as an ion-exchange carrier. International Journal of Nanomedicine 13, pages 415-428.
Read now
Xiaomei Wang, Dan Cheng, Linglin Liu & Xuejun Li. (2018) Development of poly(hydroxyethyl methacrylate) nanogel for effective oral insulin delivery. Pharmaceutical Development and Technology 23:4, pages 351-357.
Read now
Amrita Banerjee, Jessica Wong, Rohan Gogoi, Tyler Brown & Samir Mitragotri. (2017) Intestinal micropatches for oral insulin delivery. Journal of Drug Targeting 25:7, pages 608-615.
Read now
Mayyas Al-Remawi, Amani Elsayed, Ibrahim Maghrabi, Mohammad Hamaidi & Nisrein Jaber. (2017) Chitosan/lecithin liposomal nanovesicles as an oral insulin delivery system. Pharmaceutical Development and Technology 22:3, pages 390-398.
Read now
Arijit Guha, Nikhil Biswas, Kaustav Bhattacharjee, Nityananda Sahoo & Ketousetuo Kuotsu. (2016) pH responsive cylindrical MSN for oral delivery of insulin-design, fabrication and evaluation. Drug Delivery 23:9, pages 3552-3561.
Read now
Yongli Shi, Xiao Wang, Xiuzhen Deng, Ruiqiong Tian, Yuehong Zhang, Qing Shang & Nan Chen. (2016) Release profile of insulin from pH-sensitive hydrogel and its hypoglycemic effect by oral administration. Journal of Biomaterials Science, Polymer Edition 27:1, pages 86-96.
Read now
J. Hecq, F. Siepmann, J. Siepmann, K. Amighi & J. Goole. (2015) Development and evaluation of chitosan and chitosan derivative nanoparticles containing insulin for oral administration. Drug Development and Industrial Pharmacy 41:12, pages 2037-2044.
Read now
F. Cárdenas-Bailón, G. Osorio-Revilla & T. Gallardo-Velázquez. (2015) Microencapsulation of insulin using a W/O/W double emulsion followed by complex coacervation to provide protection in the gastrointestinal tract. Journal of Microencapsulation 32:3, pages 308-316.
Read now
Jin Pei, Qingyuan Lv, Jin Han, Xianyi Li, Shiying Jin, Yajie Huang, Shixiao Jin & Hailong Yuan. (2013) Schisandra lignans-loaded enteric nanoparticles: preparation, characterization, and in vitro–in vivo evaluation. Journal of Drug Targeting 21:2, pages 180-187.
Read now
Viraj Mane & Silvia Muro. (2012) Biodistribution and endocytosis of ICAM-1-targeting antibodies versus nanocarriers in the gastrointestinal tract in mice. International Journal of Nanomedicine 7, pages 4223-4237.
Read now
Vivek S. Dave, Raafat M. Fahmy, Dennis Bensley & Stephen W. Hoag. (2012) Eudragit® RS PO/RL PO as rate-controlling matrix-formers via roller compaction: Influence of formulation and process variables on functional attributes of granules and tablets. Drug Development and Industrial Pharmacy 38:10, pages 1240-1253.
Read now
Raghavendra C. Mundargi, Vidhya Rangaswamy & Tejraj M. Aminabhavi. (2011) Poly(N-vinylcaprolactam-co-methacrylic acid) hydrogel microparticles for oral insulin delivery. Journal of Microencapsulation 28:5, pages 384-394.
Read now

Articles from other publishers (45)

Moses Dele Adams & Ejike Daniel Eze. (2022) Borassus aethiopum (Mart.) ethanol fruit extract reverses alloxan-treatment alterations in experimental animals. Mediterranean Journal of Nutrition and Metabolism 15:3, pages 429-445.
Crossref
Shweta Raj, Santanu Sasidharan, Timir Tripathi & Prakash Saudagar. (2022) Biofunctionalized Chrysin-conjugated gold nanoparticles neutralize Leishmania parasites with high efficacy. International Journal of Biological Macromolecules 205, pages 211-219.
Crossref
Michael K. Danquah & Jaison Jeevanandam. 2022. Emerging Nanomedicines for Diabetes Mellitus Theranostics. Emerging Nanomedicines for Diabetes Mellitus Theranostics 33 57 .
Kanchan Bharti & Brahmeshwar Mishra. 2022. Functional Biomaterials. Functional Biomaterials 37 74 .
Elena V. Grekhnyova, Tatyana N. Kudryavtseva, Sergey A. Efanov & Lyudmila G. Klimova. (2021) Comparative Efficiency of Physical and Physicochemical Microencapsulation of some Medicinal Substances. Key Engineering Materials 899, pages 701-708.
Crossref
Sunil Kumar Jain, Akhlesh K. Jain & Kuldeep Rajpoot. (2020) Expedition of Eudragit® Polymers in the Development of Novel Drug Delivery Systems. Current Drug Delivery 17:6, pages 448-469.
Crossref
Elie Akanny, Sandrine Bourgeois, Anne Bonhommé, Carine Commun, Anne Doleans-Jordheim, François Bessueille & Claire Bordes. (2020) Development of enteric polymer-based microspheres by spray-drying for colonic delivery of Lactobacillus rhamnosus GG. International Journal of Pharmaceutics 584, pages 119414.
Crossref
Dele Moses Adams & Musa Toyin Yakubu. (2020) Aqueous extract of Digitaria exilis grains ameliorate diabetes in streptozotocin-induced diabetic male Wistar rats. Journal of Ethnopharmacology 249, pages 112383.
Crossref
S. J. Owonubi, E. Mukwevho, B. A. Aderibigbe, Neerish Revaprasadu & E. R. Sadiku. (2019) Cytotoxicity and in vitro evaluation of whey protein-based hydrogels for diabetes mellitus treatment. International Journal of Industrial Chemistry 10:3, pages 213-223.
Crossref
Min Jiang, Yan Hong, Zhengbiao Gu, Li Cheng, Zhaofeng Li & Caiming Li. (2019) Preparation of a starch-based carrier for oral delivery of Vitamin E to the small intestine. Food Hydrocolloids 91, pages 26-33.
Crossref
Elena A. Günter, Daria S. Khramova, Pavel A. Markov, Oxana V. Popeyko, Anatoliy K. Melekhin, Vladislav S. Beloserov, Ekaterina A. Martinson, Sergey G. Litvinets & Sergey V. Popov. (2019) Swelling behavior and satiating effect of the gel microparticles obtained from callus cultures pectins. International Journal of Biological Macromolecules 123, pages 300-307.
Crossref
Yongli Shi, Jintao Xue, Yajun Sang, Xiaoqing Xu & Qing Shang. (2019) Insulin-loaded hydroxypropyl methyl cellulose-co-polyacrylamide-co-methacrylic acid hydrogels used as rectal suppositories to regulate the blood glucose of diabetic rats. International Journal of Biological Macromolecules 121, pages 1346-1353.
Crossref
Elena A. Günter, Pavel A. Markov, Anatoliy K. Melekhin, Vladislav S. Belozerov, Ekaterina A. Martinson, Sergey G. Litvinets & Sergey V. Popov. (2018) Preparation and release characteristics of mesalazine loaded calcium pectin-silica gel beads based on callus cultures pectins for colon-targeted drug delivery. International Journal of Biological Macromolecules 120, pages 2225-2233.
Crossref
Xiaoliang Qi, Yue Yuan, Jianfa Zhang, Jeff W. M. Bulte & Wei Dong. (2018) Oral Administration of Salecan-Based Hydrogels for Controlled Insulin Delivery. Journal of Agricultural and Food Chemistry 66:40, pages 10479-10489.
Crossref
Víctor Pérez-Luna & Orfil González-Reynoso. (2018) Encapsulation of Biological Agents in Hydrogels for Therapeutic Applications. Gels 4:3, pages 61.
Crossref
Nemany Hanafy, Alessandra Quarta, Marzia Ferraro, Luciana Dini, Concetta Nobile, Maria De Giorgi, Sonia Carallo, Cinzia Citti, Antonio Gaballo, Giuseppe Cannazza, Rosaria Rinaldi, Gianluigi Giannelli & Stefano Leporatti. (2018) Polymeric Nano-Micelles as Novel Cargo-Carriers for LY2157299 Liver Cancer Cells Delivery. International Journal of Molecular Sciences 19:3, pages 748.
Crossref
Patrícia Batista, Pedro M. Castro, Ana Raquel Madureira, Bruno Sarmento & Manuela Pintado. (2018) Recent insights in the use of nanocarriers for the oral delivery of bioactive proteins and peptides. Peptides 101, pages 112-123.
Crossref
Chun Y. Wong, Hani Al-Salami & Crispin R. Dass. (2018) Microparticles, microcapsules and microspheres: A review of recent developments and prospects for oral delivery of insulin. International Journal of Pharmaceutics 537:1-2, pages 223-244.
Crossref
Li Zhang, Yu-Xiao Zhang, Jia-Ni Qiu, Jian Li, Wuya Chen & Yan-Qing Guan. (2017) Preparation and Characterization of Hypoglycemic Nanoparticles for Oral Insulin Delivery. Biomacromolecules 18:12, pages 4281-4291.
Crossref
Monzer Fanun. 2017. Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 301 311 .
Michael G. Potroz, Raghavendra C. Mundargi, Jurriaan J. Gillissen, Ee-Lin Tan, Sigalit Meker, Jae H. Park, Haram Jung, Soohyun Park, Daeho Cho, Sa-Ik Bang & Nam-Joon Cho. (2017) Plant-Based Hollow Microcapsules for Oral Delivery Applications: Toward Optimized Loading and Controlled Release. Advanced Functional Materials 27:31, pages 1700270.
Crossref
Brajendra Tiwari, Richa Pahuja, Pradeep Kumar, Srikanta Kumar Rath, Kailash Chand Gupta & Neena Goyal. (2017) Nanotized Curcumin and Miltefosine, a Potential Combination for Treatment of Experimental Visceral Leishmaniasis. Antimicrobial Agents and Chemotherapy 61:3.
Crossref
Xiaoliang Qi, Wei Wei, Junjian Li, Gancheng Zuo, Xihao Pan, Ting Su, Jianfa Zhang & Wei Dong. (2017) Salecan-Based pH-Sensitive Hydrogels for Insulin Delivery. Molecular Pharmaceutics 14:2, pages 431-440.
Crossref
Mohammad Reza Nabid & Ismail Omrani. (2016) Facile preparation of pH-responsive polyurethane nanocarrier for oral delivery. Materials Science and Engineering: C 69, pages 532-537.
Crossref
J. Hecq, K. Amighi & J. Goole. (2016) Development and evaluation of insulin-loaded cationic solid lipid nanoparticles for oral delivery. Journal of Drug Delivery Science and Technology 36, pages 192-200.
Crossref
Sonia Barua, Hyeongmin Kim, Kanghee Jo, Chang Won Seo, Tae Jun Park, Kyung Bin Lee, Gyiae Yun, Kyungsoo Oh & Jaehwi Lee. (2016) Drug delivery techniques for buccal route: formulation strategies and recent advances in dosage form design. Journal of Pharmaceutical Investigation 46:7, pages 593-613.
Crossref
Haogang Duan, Shaoyu Lü, Chunmei Gao, Xiao Bai, Hongyan Qin, Yuhui Wei, Xin’an Wu & Mingzhu Liu. (2016) Mucoadhesive microparticulates based on polysaccharide for target dual drug delivery of 5-aminosalicylic acid and curcumin to inflamed colon. Colloids and Surfaces B: Biointerfaces 145, pages 510-519.
Crossref
Jinghua Xu, Wei Li, Zhuo Liu, Jinghan Li, Xiaoyun Zhao, DongYang Li, Shuang Guo & Xiangrong Zhang. (2015) Preparation, characterization and pharmacokinetics evaluation of clarithromycin-loaded Eudragit® L-100 microspheres. European Journal of Drug Metabolism and Pharmacokinetics 41:3, pages 287-293.
Crossref
Monzer Fanun. 2015. Handbook of Encapsulation and Controlled Release. Handbook of Encapsulation and Controlled Release 1111 1126 .
Maryam Mansourpour, Reza Mahjub, Mohsen Amini, Seyed Naser Ostad, Elnaz Sadat Shamsa, Morteza Rafiee- Tehrani & Farid Abedin Dorkoosh. (2015) Development of Acid-Resistant Alginate/Trimethyl Chitosan Nanoparticles Containing Cationic β-Cyclodextrin Polymers for Insulin Oral Delivery. AAPS PharmSciTech 16:4, pages 952-962.
Crossref
Kiran Chaturvedi, Kuntal Ganguly, Anandrao R Kulkarni, Walter E Rudzinski, Leslie Krauss, Mallikarjuna N Nadagouda & Tejraj M Aminabhavi. (2015) Oral insulin delivery using deoxycholic acid conjugated PEGylated polyhydroxybutyrate co-polymeric nanoparticles. Nanomedicine 10:10, pages 1569-1583.
Crossref
Xiaodong She, Lijue Chen, Leonora Velleman, Chengpeng Li, Haijin Zhu, Canzhong He, Tao Wang, Sarah Shigdar, Wei Duan & Lingxue Kong. (2015) Fabrication of high specificity hollow mesoporous silica nanoparticles assisted by Eudragit for targeted drug delivery. Journal of Colloid and Interface Science 445, pages 151-160.
Crossref
Fatemeh Zabihi, Mu Yang, Yuanpeng Leng & Yaping Zhao. (2015) PLGA–HPMC nanoparticles prepared by a modified supercritical anti-solvent technique for the controlled release of insulin. The Journal of Supercritical Fluids 99, pages 15-22.
Crossref
Yan Zhang, Xia Lin, Xuli Du, Sicong Geng, Hongren Li, Hong Sun, Xing Tang & Wei Xiao. (2015) pH-sensitive thiolated nanoparticles facilitate the oral delivery of insulin in vitro and in vivo. Journal of Nanoparticle Research 17:2.
Crossref
Minakshi Kanzarkar, Prem Prakash Pathak, Mandar Vaidya, Charles Brumlik & Abhishek Choudhury. (2015) Oral insulin-delivery system for diabetes mellitus. Pharmaceutical Patent Analyst 4:1, pages 29-36.
Crossref
S. Olya, M. Khorvash, H.R. Rahmani, S. Esmaeilkhanian, B. Olya & H. Sadri. (2014) Oral delivery of insulin-loaded nanoparticles in diabetic rabbits and in sheep. Czech Journal of Animal Science 59:6, pages 251-256.
Crossref
Arun Verma, Nitin Kumar, Rishabha Malviya & Pramod Kumar Sharma. (2014) Emerging Trends in Noninvasive Insulin Delivery. Journal of Pharmaceutics 2014, pages 1-9.
Crossref
M Abhilash & Robin Augustine. 2014. Diabetes Mellitus and Human Health Care. Diabetes Mellitus and Human Health Care 1 129 .
Sae Rom Choi, Dong-Jin Jang, Sanghyun Kim, Sunhyung An, Jinwoo Lee, Euichaul Oh & Jungbae Kim. (2014) Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin. J. Mater. Chem. B 2:6, pages 616-619.
Crossref
Ming-Hung Ling & Mei-Chin Chen. (2013) Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats. Acta Biomaterialia 9:11, pages 8952-8961.
Crossref
Pan He, Huaiyu Liu, Zhaohui Tang, Mingxiao Deng, Yan Yang, Xuan Pang & Xuesi Chen. (2013) Poly(ester amide) blend microspheres for oral insulin delivery. International Journal of Pharmaceutics 455:1-2, pages 259-266.
Crossref
Nadezhda G. Balabushevich, Mikhail A. Pechenkin, Elena D. Shibanova, Dmitry V. Volodkin & Elena V. Mikhalchik. (2013) Multifunctional Polyelectrolyte Microparticles for Oral Insulin Delivery. Macromolecular Bioscience 13:10, pages 1379-1388.
Crossref
Catarina Pinto ReisCatarina Silva, Nuno Martinho & Catarina Rosado. (2013) Drug carriers for oral delivery of peptides and proteins: accomplishments and future perspectives. Therapeutic Delivery 4:2, pages 251-265.
Crossref
Qinhua Zuo, Jianbo Lu, An Hong, Dagen Zhong, Shasha Xie, Quan Liu, Yuexin Huang, Yunfeng Shi, Liumin He & Wei Xue. (2012) Preparation and characterization of PEM-coated alginate microgels for controlled release of protein. Biomedical Materials 7:3, pages 035012.
Crossref
Concetta Giovino, Isaac Ayensu, John Tetteh & Joshua S. Boateng. (2012) Development and characterisation of chitosan films impregnated with insulin loaded PEG-b-PLA nanoparticles (NPs): A potential approach for buccal delivery of macromolecules. International Journal of Pharmaceutics 428:1-2, pages 143-151.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.