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Review Article

Current approaches in tamper-resistant and abuse-deterrent formulations

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Pages 611-624 | Received 01 Jun 2011, Accepted 23 Mar 2012, Published online: 26 Apr 2012

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Beatrice Setnik, Kenneth W. Sommerville, Glenn C. Pixton & Lynn Webster. (2019) Extended-release morphine sulfate and naltrexone hydrochloride (EMBEDA): naltrexone-associated withdrawal and abuse-related effects in patients with chronic pain and recreational opioid users. Current Medical Research and Opinion 35:3, pages 503-512.
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Tiffani D. Eisenhauer, Mike Matchett, Ralph Heasley, Terri Morton, Krishna Devarakonda, Michael Giuliani, Jim L. Young & Thomas Barrett. (2016) Evaluation of the tamper-resistant properties of biphasic immediate-release/extended-release oxycodone/acetaminophen tablets. Drug Development and Industrial Pharmacy 42:1, pages 157-165.
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Lynn R. Webster, Michael J. Brennan, Louis M. Kwong, Richard Levandowski & Jeffrey A. Gudin. (2016) Opioid abuse-deterrent strategies: role of clinicians in acute pain management. Postgraduate Medicine 128:1, pages 76-84.
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Wayne Wakeland, Alexandra Nielsen & Peter Geissert. (2015) Dynamic model of nonmedical opioid use trajectories and potential policy interventions. The American Journal of Drug and Alcohol Abuse 41:6, pages 508-518.
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David J Mastropietro & Hossein Omidian. (2015) Abuse-deterrent formulations: Part 2: commercial products and proprietary technologies. Expert Opinion on Pharmacotherapy 16:3, pages 305-323.
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Michael E Schatman & Beth D Darnall. (2014) A practical and ethical solution to the opioid scheduling conundrum. Journal of Pain Research 7, pages 1-3.
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M. Papadakos, M. Špaglová, M. Čuchorová & M. Hanko. (2023) A Multiple Unit Abuse-deterrent Dosage Form Based on Sodium Alginate. European Pharmaceutical Journal 0:0.
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Dhwani Rana, Sagar Salave & Derajram Benival. (2022) Emerging Trends in Abuse-Deterrent Formulations: Technological Insights and Regulatory Considerations. Current Drug Delivery 19:8, pages 846-859.
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Mori Dhaval, Shweta Sharma, Kiran Dudhat & Jayant Chavda. (2020) Twin-Screw Extruder in Pharmaceutical Industry: History, Working Principle, Applications, and Marketed Products: an In-depth Review. Journal of Pharmaceutical Innovation 17:2, pages 294-318.
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Parmita Phaugat, Suchitra Nishal & Rakhi Dhiman. (2022) Abuse-Deterrent Formulations in Constraining the Abuse Potential of Prescription Medicines: A Myth or Truth. Current Drug Delivery 19:4, pages 466-478.
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Benedikt Fischer. (2020) Some notes on the use, concept and socio-political framing of ‘stigma’ focusing on an opioid-related public health crisis. Substance Abuse Treatment, Prevention, and Policy 15:1.
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Saikishore Meruva, Leyla Rezaei, Prajwal Thool & Maureen D. Donovan. (2020) Use of Drug Release Testing to Evaluate the Retention of Abuse-Deterrent Properties of Polyethylene Oxide Matrix Tablets. AAPS PharmSciTech 21:7.
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Ying Jiang, Kevin S. Murnane, Bruce E. Blough & Ajay K. Banga. (2020) Transdermal Delivery of the Free Base of 3-Fluoroamphetamine: In Vitro Skin Permeation and Irritation Potential. AAPS PharmSciTech 21:3.
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Xin Feng, Ahmed Zidan, Nahid S. Kamal, Xiaoming Xu, Dajun Sun, Ross Walenga, Heather Boyce, Celia N. Cruz & Muhammad Ashraf. (2020) Assessing Drug Release from Manipulated Abuse Deterrent Formulations. AAPS PharmSciTech 21:2.
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Keith Humphreys & Harold A. Pollack. 2020. The Palgrave Handbook of American Mental Health Policy. The Palgrave Handbook of American Mental Health Policy 259 295 .
Jan Kozak, Miloslava Rabiskova & Alf Lamprecht. (2019) Silk Fibroin as a Novel Alcohol-Resistant Excipient for Sustained-Release Tablet Formulation. AAPS PharmSciTech 20:7.
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Saikishore Meruva & Maureen D. Donovan. (2019) Effects of Drug-Polymer Interactions on Tablet Properties During the Development of Abuse-Deterrent Dosage Forms. AAPS PharmSciTech 20:3.
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Benedikt Fischer, Lenka Vojtila & Paul Kurdyak. (2017) ‘Delisting’ OxyContin® to reduce prescription opioid-related harms in Ontario (Canada)-gauging effects 5 years later. Pharmacoepidemiology and Drug Safety 26:9, pages 1040-1043.
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D. Mastropietro, K. Park & H. Omidian. 2017. Comprehensive Biomaterials II. Comprehensive Biomaterials II 430 444 .
Beatrice Setnik, Almasa Bass, Candace Bramson, Naama Levy-Cooperman, Bimal Malhotra, Kyle Matschke, Pierre Geoffroy, Kenneth W. Sommerville & Gernot Wolfram. (2016) Abuse Potential Study of ALO-02 (Extended-Release Oxycodone Surrounding Sequestered Naltrexone) Compared with Immediate-Release Oxycodone Administered Orally to Nondependent Recreational Opioid Users. Pain Medicine, pages pnw178.
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Julien Maincent & Feng Zhang. (2016) Recent advances in abuse-deterrent technologies for the delivery of opioids. International Journal of Pharmaceutics 510:1, pages 57-72.
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Nicole Jedinger, Simone Schrank, Johannes M. Fischer, Karlheinz Breinhälter, Johannes Khinast & Eva Roblegg. (2015) Development of an Abuse- and Alcohol-Resistant Formulation Based on Hot-Melt Extrusion and Film Coating. AAPS PharmSciTech 17:1, pages 68-77.
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Benedikt Fischer, Cayley Russell, Yoko Murphy & Paul Kurdyak. (2015) Prescription opioids, abuse and public health in Canada: is fentanyl the new centre of the opioid crisis?. Pharmacoepidemiology and Drug Safety 24:12, pages 1334-1336.
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Richard L. Rauck, Martin E. Hale, Almasa Bass, Candace Bramson, Glenn Pixton, Jacquelyn G. Wilson, Beatrice Setnik, Paul Meisner, Kenneth W. Sommerville, Bimal K. Malhotra & Gernot Wolfram. (2015) A randomized double-blind, placebo-controlled efficacy and safety study of ALO-02 (extended-release oxycodone surrounding sequestered naltrexone) for moderate-to-severe chronic low back pain treatment. Pain 156:9, pages 1660-1669.
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Bing Cai, Håkan Engqvist & Susanne Bredenberg. (2015) Development and evaluation of a tampering resistant transdermal fentanyl patch. International Journal of Pharmaceutics 488:1-2, pages 102-107.
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Bimal K. Malhotra, Kyle Matschke, Qiang Wang, Candace Bramson & Joanne Salageanu. (2015) Effects of Ethanol on the Pharmacokinetics of Extended-Release Oxycodone with Sequestered Naltrexone (ALO-02). Clinical Drug Investigation 35:4, pages 267-274.
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N. Jedinger, J. Khinast & E. Roblegg. (2014) The design of controlled-release formulations resistant to alcohol-induced dose dumping – A review. European Journal of Pharmaceutics and Biopharmaceutics 87:2, pages 217-226.
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David J. Mastropietro & Hossein Omidian. (2014) ChemInform Abstract: Current Approaches in Tamper‐Resistant and Abuse‐Deterrent Formulations. ChemInform 45:16.
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Bing Cai, Håkan Engqvist & Susanne Bredenberg. (2014) Evaluation of the resistance of a geopolymer-based drug delivery system to tampering. International Journal of Pharmaceutics 465:1-2, pages 169-174.
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Steven D. Passik. (2014) Tamper-Resistant Opioid Formulations in the Treatment of Acute Pain. Advances in Therapy 31:3, pages 264-275.
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Sindhuri Maddineni, Sunil Kumar Battu, Joe Morott, Majumdar Soumyajit & Michael A Repka. (2014) Formulation optimization of hot-melt extruded abuse deterrent pellet dosage form utilizing design of experiments. Journal of Pharmacy and Pharmacology 66:2, pages 309-322.
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Esther Papaseit, Clara Pérez-Mañá, Marta Torrens & Magí Farré. (2013) Reacciones adversas de medicamentos relacionadas con el abuso y formas farmacéuticas disuasorias. Medicina Clínica 141:10, pages 454-458.
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Suzanne K. Vosburg, Jermaine D. Jones, Jeanne M. Manubay, Judy B. Ashworth, Douglas Y. Shapiro & Sandra D. Comer. (2013) A comparison among tapentadol tamper-resistant formulations (TRF) and OxyContin ® (non-TRF) in prescription opioid abusers . Addiction 108:6, pages 1095-1106.
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