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Research Article

Synthesis, characterization and in vitro studies of pegylated melphalan conjugates

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Pages 1053-1062 | Received 10 Nov 2011, Accepted 05 Jun 2012, Published online: 11 Jul 2012

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Amit K. Jain & Sanyog Jain. (2016) Advances in oral delivery of anti-cancer prodrugs. Expert Opinion on Drug Delivery 13:12, pages 1759-1775.
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Amit Alexander, Swarnlata Saraf & Shailendra Saraf. (2015) A comparative study of chitosan and poloxamer based thermosensitive hydrogel for the delivery of PEGylated melphalan conjugates. Drug Development and Industrial Pharmacy 41:12, pages 1954-1961.
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Articles from other publishers (28)

Mohammad Hassan Jamshidi, Neda Hasanzadeh, Hooriye Yahyaei & Amir Bahrami. (2023) The Study of Interaction of Melphalan with SWCNT- BNNT Through Force Fields Molecular Mechanics and Quantum Calculations in Different Solvents and Temperatures. Letters in Organic Chemistry 20:7, pages 657-671.
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Zhimei Lin, Bingyang Chu, Ying Qu, Xue Wei, Jingcao Huang, Fangfang Wang, Yu Feng, Xin Wang, Hongmei Luo, Xinyu Zhai, Juan Xu, Xiang Liu, Li Zhang, Fengjiao Chen, Yu Wu & Yuhuan Zheng. (2022) Liposome-Encapsulated Melphalan Exhibits Potent Antimyeloma Activity and Reduced Toxicity. ACS Omega 8:1, pages 1693-1701.
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Rakesh Pahwa, Jatin Chhabra, Raj Kumar & Rakesh Narang. (2022) Melphalan: Recent insights on synthetic, analytical and medicinal aspects. European Journal of Medicinal Chemistry 238, pages 114494.
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Yu. A. Tereshkina, T. I. Torkhovskaya, M. A. Sanzhakov, L. V. Kostryukova, Yu. Yu. Khudoklinova & E. G. Tikhonova. (2022) The Effect of Lipid Derivative of the Anti-Tumor Drug Sarcolysin Embedded in Phospholipid Nanoparticles in the Experiments in Vivo. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry 16:2, pages 125-133.
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Sunil Kumar Dubey, Tanya Bhatt, Mukta Agrawal, Ranendra Narayan Saha, Swarnlata Saraf, Shailendra Saraf & Amit Alexander. (2022) Application of chitosan modified nanocarriers in breast cancer. International Journal of Biological Macromolecules 194, pages 521-538.
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Galal H. Elgemeie & Reham A. Mohamed-Ezzat. 2022. New Strategies Targeting Cancer Metabolism. New Strategies Targeting Cancer Metabolism 393 505 .
Yu.A. Tereshkina, T.I. Torkhovskaya, M.A. Sanzhakov, L.V. Kostryukova, Yu.Yu. Khudoklinova & E.G. Tikhonova. (2021) The effect of lipid derivative of anti-tumor drug sarcolysin embedded in phospholipid nanoparticles in the experiments in vivo. Biomeditsinskaya Khimiya 67:6, pages 491-499.
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Mukta Agrawal, Eluri Prathyusha, Hafiz Ahmed, Sunil Kumar Dubey, Prashant Kesharwani, Gautam Singhvi, V.G.M. Naidu & Amit Alexander. (2021) Biomaterials in treatment of Alzheimer's disease. Neurochemistry International 145, pages 105008.
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Sunil Kumar Dubey, Shraddha Parab, Neha Dabholkar, Mukta Agrawal, Gautam Singhvi, Amit Alexander, Ranjeet Ajit Bapat & Prashant Kesharwani. (2021) Oral peptide delivery: challenges and the way ahead. Drug Discovery Today 26:4, pages 931-950.
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Pengfei Wang, Qijie Gong, Jiabao Hu, Xiang Li & Xiaojin Zhang. (2020) Reactive Oxygen Species (ROS)-Responsive Prodrugs, Probes, and Theranostic Prodrugs: Applications in the ROS-Related Diseases. Journal of Medicinal Chemistry 64:1, pages 298-325.
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Vikas Pandey, Tanweer Haider, Vishal Gour, Vandana Soni & Prem N. Gupta. 2020. Recent Advancement in Prodrugs. Recent Advancement in Prodrugs 201 225 .
Natalia Oddone, Frank Boury, Emmanuel Garcion, Andreas M. Grabrucker, M. Carmen Martinez, Federica Da Ros, Anna Janaszewska, Flavio Forni, Maria Angela Vandelli, Giovanni Tosi, Barbara Ruozi & Jason T. Duskey. (2020) Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal-Melphalan Prodrug for Glioblastoma Treatment. Frontiers in Pharmacology 11.
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Sunil Kumar Dubey, Amit Alexander, K. Sai Pradhyut, Mukta Agrawal, Rupesh Jain, Ranendra Narayana Saha, Gautam Singhvi, Swarnlata Saraf & Shailendra Saraf. (2020) Recent Avenues in Novel Patient-Friendly Techniques for the Treatment of Diabetes. Current Drug Delivery 17:1, pages 3-14.
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Jie Wu, Ximing Tian, Yihua Yin, Meng He, Weiquan Cai, Guanghua He, Wenjin Xu, Yue Dai, Jiahao Mai, Mengqi Gan & Fengxinjia Zhang. (2020) Melphalan-monomethoxypolyethylene glycol-based pH/enzyme double-response polymer prodrug nanoparticles for enhanced drug stability and anticancer efficacy. European Polymer Journal 122, pages 109350.
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Waleed Mohammed-Saeid, Abdalla H Karoyo, Ronald E Verrall, Lee D Wilson & Ildiko Badea. (2019) Inclusion Complexes of Melphalan with Gemini-Conjugated β-Cyclodextrin: Physicochemical Properties and Chemotherapeutic Efficacy in In-Vitro Tumor Models. Pharmaceutics 11:9, pages 427.
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Kalishwaralal Kalimuthu, Bat-Chen Lubin, Andrii Bazylevich, Gary Gellerman, Ofer Shpilberg, Galia Luboshits & Michael A. Firer. (2018) Gold nanoparticles stabilize peptide-drug-conjugates for sustained targeted drug delivery to cancer cells. Journal of Nanobiotechnology 16:1.
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Junaid Khan, Amit Alexander, Ajazuddin, Swarnlata Saraf & Shailendra Saraf. (2018) Exploring the role of polymeric conjugates toward anti-cancer drug delivery: Current trends and future projections. International Journal of Pharmaceutics 548:1, pages 500-514.
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Waleed Mohammed-Saeid, Deborah Michel, Ildiko Badea & Anas El-Aneed. (2017) Rapid and simple flow injection analysis tandem mass spectrometric method for the quantification of melphalan in a lipid-based drug delivery system. Rapid Communications in Mass Spectrometry 31:18, pages 1481-1490.
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Amit Alexander, Ajazuddin, Ravish J. Patel, Swarnlata Saraf & Shailendra Saraf. (2016) Recent expansion of pharmaceutical nanotechnologies and targeting strategies in the field of phytopharmaceuticals for the delivery of herbal extracts and bioactives. Journal of Controlled Release 241, pages 110-124.
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Hassan M. Badawi & Ibrahim Khan. (2016) A comparative study of the vibrational spectra of the anticancer drug melphalan and its fundamental molecules 3-phenylpropionic acid and l-phenylalanine. Journal of Molecular Structure 1109, pages 171-178.
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Anisha Mazumder, Anupma Dwivedi, Jan L. du Preez & Jeanetta du Plessis. (2016) In vitro wound healing and cytotoxic effects of sinigrin–phytosome complex. International Journal of Pharmaceutics 498:1-2, pages 283-293.
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Gunjan Jeswani, Amit Alexander, Shailendra Saraf, Swarnlata Saraf, Azra Qureshi & Ajazuddin. (2015) Recent approaches for reducing hemolytic activity of chemotherapeutic agents. Journal of Controlled Release 211, pages 10-21.
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Amit Alexander, Ajazuddin, Junaid Khan, Swarnlata Saraf & Shailendra Saraf. (2014) Formulation and evaluation of chitosan-based long-acting injectable hydrogel for PEGylated melphalan conjugate. Journal of Pharmacy and Pharmacology 66:9, pages 1240-1250.
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Anbanandam ParthibanParijat Kanaujia & Ajazuddin. 2014. Synthesis and Applications of Copolymers. Synthesis and Applications of Copolymers 334 371 .
Amit Alexander, Ajazuddin, Junaid Khan, Swarnlata Saraf & Shailendra Saraf. (2013) Poly(ethylene glycol)–poly(lactic-co-glycolic acid) based thermosensitive injectable hydrogels for biomedical applications. Journal of Controlled Release 172:3, pages 715-729.
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Ajazuddin, Amit Alexander, Ajita Khichariya, Saurabh Gupta, Ravish J. Patel, Tapan Kumar Giri & Dulal Krishna Tripathi. (2013) Recent expansions in an emergent novel drug delivery technology: Emulgel. Journal of Controlled Release 171:2, pages 122-132.
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Amit Alexander, Shubhangi Dwivedi, Ajazuddin, Tapan K. Giri, Swarnlata Saraf, Shailendra Saraf & Dulal Krishna Tripathi. (2012) Approaches for breaking the barriers of drug permeation through transdermal drug delivery. Journal of Controlled Release 164:1, pages 26-40.
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Zhimei Lin, Ying Qu, Xue Wei, Jingcao Huang, Fangfang Wang, Yu Feng, Xin Wang, Hongmei Luo, Xinyu Zhai, Juan Xu, Li Zhang, Fengjiao Chen, Yu Wu & Yuhuan Zheng. (2022) Liposome Encapsulated Melphalan Exhibits Potent Anti-Myeloma Activity and Reduced Toxicity. SSRN Electronic Journal.
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