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Drug Development and Industrial Pharmacy Volume 40, 2014 - Issue 7
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Research Article

Evaluation of intratympanic formulations for inner ear delivery: methodology and sustained release formulation testing

Hongzhuo LiuDivision of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati Cincinnati, OHUSA
,
Liang FengDivision of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati Cincinnati, OHUSA
,
Gaurav ToliaDivision of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati Cincinnati, OHUSA
,
Mark R. LiddellDivision of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati Cincinnati, OHUSA
,
Jinsong HaoDivision of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati Cincinnati, OHUSA
&
S. Kevin LiDivision of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati Cincinnati, OHUSACorrespondence[email protected]
Pages 896-903 | Received 20 Jan 2013, Accepted 20 Mar 2013, Published online: 30 Apr 2013

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Xu Liu, Mingshuang Li, Hugh Smyth & Feng Zhang. (2018) Otic drug delivery systems: formulation principles and recent developments. Drug Development and Industrial Pharmacy 44:9, pages 1395-1408.
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Hui Cai, Xingxing Wen, Lu Wen, Nicola Tirelli, Xiao Zhang, Yue Zhang, Huanpeng Su, Fan Yang & Gang Chen. (2014) Enhanced local bioavailability of single or compound drugs delivery to the inner ear through application of PLGA nanoparticles via round window administration. International Journal of Nanomedicine 9, pages 5591-5601.
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Kwadwo Mfoafo, Rahul Mittal, Adrien Eshraghi, Yadollah Omidi & Hossein Omidian. (2023) Improved inner ear drug delivery using hydrogel carriers. Journal of Drug Delivery Science and Technology 79, pages 104086.
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Thu Nhan Nguyen & Jeong-Sook Park. (2022) Intratympanic drug delivery systems to treat inner ear impairments. Journal of Pharmaceutical Investigation 53:1, pages 93-118.
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Shreshtha Dash, Jian Zuo & Peter S. Steyger. (2022) Local Delivery of Therapeutics to the Cochlea Using Nanoparticles and Other Biomaterials. Pharmaceuticals 15:9, pages 1115.
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Kaili Chen, Fei Wang, Rui Ding, Zhengwei Cai, Tianyuan Zou, Andi Zhang, Dongye Guo, Bin Ye, Wenguo Cui & Mingliang Xiang. (2022) Adhesive and Injectable Hydrogel Microspheres for Inner Ear Treatment. Small 18:36, pages 2106591.
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Mario Canales Medina & Mariana Ramirez Gómez. (2022) Tinnitus, Sudden Sensorineural Hearing Loss, and Vestibular Neuritis As Complications of the Astra Zeneca COVID-19 Vaccine. Cureus.
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Zipei Zhang, Xiyu Li, Wei Zhang & Daniel S. Kohane. (2020) Drug Delivery across Barriers to the Middle and Inner Ear. Advanced Functional Materials 31:44, pages 2008701.
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John Garner, Justin Hadar, Sarah Skidmore, Faye Jessmon, Rebecca Immel, Amie Tyler & Kinam Park. (2020) Narrow molecular weight margins for the thermogelling property of polyester–polyether block copolymers in aqueous solutions. Journal of Applied Polymer Science 137:25, pages 48673.
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Ai-Ho Liao, Chih-Hung Wang, Ping-Yu Weng, Yi-Chun Lin, Hao Wang, Hang-Kang Chen, Hao-Li Liu, Ho-Chiao Chuang & Cheng-Ping Shih. (2020) Ultrasound-induced microbubble cavitation via a transcanal or transcranial approach facilitates inner ear drug delivery. JCI Insight 5:3.
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Yu Li, Ru Zhang, Xuanyi Li, Wei Li, Yi Lu & Chunfu Dai. (2020) The preparation of dexamethasone sodium phosphate multivesicular liposomes thermosensative hydrogel and its impact on noise-induced hearing loss in the Guinea pigs. Experimental Cell Research 387:1, pages 111755.
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Caroline R. Anderson, Carol Xie, Matthew P. Su, Maria Garcia, Helen Blackshaw & Anne G. M. Schilder. (2019) Local Delivery of Therapeutics to the Inner Ear: The State of the Science. Frontiers in Cellular Neuroscience 13.
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Anne G.M. Schilder, Matthew P. Su, Rishi Mandavia, Caroline R. Anderson, Evie Landry, Tanjinah Ferdous & Helen Blackshaw. (2019) Early phase trials of novel hearing therapeutics: Avenues and opportunities. Hearing Research 380, pages 175-186.
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Fabiola Paciello, Anna Rita Fetoni, Rolando Rolesi, Matthew B. Wright, Claudio Grassi, Diana Troiani & Gaetano Paludetti. (2018) Pioglitazone Represents an Effective Therapeutic Target in Preventing Oxidative/Inflammatory Cochlear Damage Induced by Noise Exposure. Frontiers in Pharmacology 9.
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Vibhuti Agrahari & Vivek Agrahari. (2018) Advances and applications of block-copolymer-based nanoformulations. Drug Discovery Today 23:5, pages 1139-1151.
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Zuohua Tang, Lingjie Wu, Zebin Xiao, Xiaoyuan Feng, Xinghuai Sun, Weijun Tang, Jie Wang & Lixin Jin. (2017) Manganese-enhanced MRI (ME MRI) in evaluation of the auditory pathway in an experimental rat model. NMR in Biomedicine 30:2, pages e3677.
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Catherine M. Kelso, Hirobumi Watanabe, Joseph M. Wazen, Tizian Bucher, Zhen J. Qian, Elizabeth S. Olson, Jeffrey W. Kysar & Anil K. Lalwani. (2015) Microperforations Significantly Enhance Diffusion Across Round Window Membrane. Otology & Neurotology 36:4, pages 694-700.
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