1,301
Views
51
CrossRef citations to date
0
Altmetric
Review

A review on the taste masking of bitter APIs: hot-melt extrusion (HME) evaluation

, , , &
Pages 145-156 | Received 02 Nov 2012, Accepted 06 May 2013, Published online: 13 Jun 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Bandoo C. Chatale & Mariam S. Degani. (2019) Synthesis and in‐vivo taste assessment of meloxicam pivalate. Drug Development and Industrial Pharmacy 45:10, pages 1590-1598.
Read now
Linda A. Felton. (2018) Use of polymers for taste-masking pediatric drug products. Drug Development and Industrial Pharmacy 44:7, pages 1049-1055.
Read now
Chia Miang Khor, Wai Kiong Ng, Parijat Kanaujia, Kok Ping Chan & Yuancai Dong. (2017) Hot-melt extrusion microencapsulation of quercetin for taste-masking. Journal of Microencapsulation 34:1, pages 29-37.
Read now
Michał Teżyk, Bartłomiej Milanowski, Andrzej Ernst & Janina Lulek. (2016) Recent progress in continuous and semi-continuous processing of solid oral dosage forms: a review. Drug Development and Industrial Pharmacy 42:8, pages 1195-1214.
Read now
Roshan V. Tiwari, Hemlata Patil & Michael A. Repka. (2016) Contribution of hot-melt extrusion technology to advance drug delivery in the 21st century. Expert Opinion on Drug Delivery 13:3, pages 451-464.
Read now
Xin Feng, Xingyou Ye, Jun-Bom Park, Wenli Lu, Joe Morott, Brad Beissner, Zhuoyang John Lian, Elanor Pinto, Vivian Bi, Stu Porter, Tom Durig, Soumyajit Majumdar & Michael A. Repka. (2015) Evaluation of the recrystallization kinetics of hot-melt extruded polymeric solid dispersions using an improved Avrami equation. Drug Development and Industrial Pharmacy 41:9, pages 1479-1487.
Read now
Elena Ravina-Eirin, J. L. Gomez-Amoza & Ramón Martínez-Pacheco. (2015) Drug dispersion degree and drug dissolution rate in Hybrane S1200-based instant-release matricial particles prepared by hot melt extrusion. Drug Development and Industrial Pharmacy 41:6, pages 1000-1005.
Read now

Articles from other publishers (43)

Moaaz Abdelhamid, Carolina Corzo, Ana Belén Ocampo, Mira Maisriemler, Eyke Slama, Carolina Alva, Dirk Lochmann, Sebastian Reyer, Tanja Freichel, Sharareh Salar-Behzadi & Martin Spoerk. (2023) Mechanically promoted lipid-based filaments via composition tuning for extrusion-based 3D-printing. International Journal of Pharmaceutics 643, pages 123279.
Crossref
Kyle Brewer, Todd J. McWhorter, Katherine Moseby, John L. Read, David Peacock & Anton Blencowe. (2023) pH-responsive subcutaneous implants prepared via hot-melt extrusion and fluidised-bed spray coating for targeted invasive predator control. Journal of Drug Delivery Science and Technology 81, pages 104277.
Crossref
Shuqin Hu, Xiaoxuan Liu, Shuangshuang Zhang & Danyi Quan. (2023) An Overview of Taste-Masking Technologies: Approaches, Application, and Assessment Methods. AAPS PharmSciTech 24:2.
Crossref
Laura Andrade Junqueira, Atabak Ghanizadeh Tabriz, Fiona Rousseau, Nádia Rezende Barbosa Raposo, Marcos Antônio Fernandes Brandão & Dennis Douroumis. (2023) Development of printable inks for 3D printing of personalized dosage forms: Coupling of fused deposition modelling and jet dispensing. Journal of Drug Delivery Science and Technology 80, pages 104108.
Crossref
Khater AL-Japairai, Samah Hamed Almurisi, Abd Almonem Doolaanea, Syed Mahmood, Fawaz Alheibshy, Ahmed Alobaida, Nadiya Abdul-Halim & Bappaditya Chatterjee. (2023) A review on taste masked multiparticulate dosage forms for paediatric. International Journal of Pharmaceutics 632, pages 122571.
Crossref
Moaaz Abdelhamid, Ioannis Koutsamanis, Carolina Corzo, Mira Maisriemler, Ana Belén Ocampo, Eyke Slama, Carolina Alva, Dirk Lochmann, Sebastian Reyer, Tanja Freichel, Sharareh Salar-Behzadi & Martin Spoerk. (2022) Filament-based 3D-printing of placebo dosage forms using brittle lipid-based excipients. International Journal of Pharmaceutics 624, pages 122013.
Crossref
Mori Dhaval, Shweta Sharma, Kiran Dudhat & Jayant Chavda. (2020) Twin-Screw Extruder in Pharmaceutical Industry: History, Working Principle, Applications, and Marketed Products: an In-depth Review. Journal of Pharmaceutical Innovation 17:2, pages 294-318.
Crossref
Kai Bin Liew, Long Chiau Ming, Bey-Hing Goh & Kok Khiang Peh. (2022) Fast Melt Cocoa Butter Tablet: Effect of Waxes, Starch, and PEG 6000 on Physical Properties of the Preparation. Molecules 27:10, pages 3128.
Crossref
Janine Boniatti, Patricija Januskaite, Laís B. da Fonseca, Alessandra L. Viçosa, Fábio C. Amendoeira, Catherine Tuleu, Abdul W. Basit, Alvaro Goyanes & Maria-Inês Ré. (2021) Direct Powder Extrusion 3D Printing of Praziquantel to Overcome Neglected Disease Formulation Challenges in Paediatric Populations. Pharmaceutics 13:8, pages 1114.
Crossref
Andrea Aramini, Gianluca Bianchini, Samuele Lillini, Simone Bordignon, Mara Tomassetti, Rubina Novelli, Simone Mattioli, Larisa Lvova, Roberto Paolesse, Michele Remo Chierotti & Marcello Allegretti. (2021) Unexpected Salt/Cocrystal Polymorphism of the Ketoprofen–Lysine System: Discovery of a New Ketoprofen–l-Lysine Salt Polymorph with Different Physicochemical and Pharmacokinetic Properties. Pharmaceuticals 14:6, pages 555.
Crossref
Srushti Tambe, Divya Jain, Yashvi Agarwal & Purnima Amin. (2021) Hot-melt extrusion: Highlighting recent advances in pharmaceutical applications. Journal of Drug Delivery Science and Technology 63, pages 102452.
Crossref
Thomas Kendall, Sam Stratford, Adam R. Patterson, Ruth A. Lunt, Dyanne Cruickshank, Thierry Bonnaud & C. Daniel Scott. 2021. 345 442 .
Suhani Sinha & Rohit Dutt. (2020) Oral Soluble Films: Attributes of the Polymeric Material and Critical Process Parameters for Designing Good Quality Films. Current Applied Polymer Science 3:3, pages 167-188.
Crossref
Honghe Wang, Nagireddy Dumpa, Suresh Bandari, Thomas Durig & Michael A. Repka. (2020) Fabrication of Taste-Masked Donut-Shaped Tablets Via Fused Filament Fabrication 3D Printing Paired with Hot-Melt Extrusion Techniques. AAPS PharmSciTech 21:7.
Crossref
Ioannis Partheniadis, Miltiadis Toskas, Filippos-Michail Stavras, Georgios Menexes & Ioannis Nikolakakis. (2020) Impact of Hot-Melt-Extrusion on Solid-State Properties of Pharmaceutical Polymers and Classification Using Hierarchical Cluster Analysis. Processes 8:10, pages 1208.
Crossref
Zainab H. Mahdi. (2020) Oral Jellies for Improving Oral Drug Delivery in Dysphagia. Al Mustansiriyah Journal of Pharmaceutical Sciences 20:3, pages 94-104.
Crossref
Mingxing Cha, Mengmeng Li & Xiaoqin Wang. (2020) Estimation of Seasonal Evapotranspiration for Crops in Arid Regions Using Multisource Remote Sensing Images. Remote Sensing 12:15, pages 2398.
Crossref
Rishi Thakkar, Eman A. Ashour, Ashay Shukla, Rui Wang, Walter G. Chambliss, Suresh Bandari, Narasimha Murthy & Michael A. Repka. (2020) A Comparison Between Lab-Scale and Hot-Melt-Extruder-Based Anti-inflammatory Ointment Manufacturing. AAPS PharmSciTech 21:5.
Crossref
Rajni Bala, Shivani badjatya & Reecha Madaan. (2020) Strategies practiced to perk up oral palatability and acceptance of bitter drugs. Journal of Drug Delivery Science and Technology 56, pages 101580.
Crossref
Fahad Alqahtani, Peter Belton, Adam Ward, Kofi Asare-Addo & Sheng Qi. (2020) An investigation into the use of low quantities of functional additives to control drug release from hot melt extruded solid dispersions for poorly soluble drug delivery. International Journal of Pharmaceutics 579, pages 119172.
Crossref
Catalina María Álvarez, Laura Restrepo-Uribe, Jorge Andrés López, Omar Augusto Estrada & María del Pilar Noriega. (2019) Improvement of stability and release of (-)-epicatechin by hot melt extrusion. Journal of Polymer Engineering 40:1, pages 75-85.
Crossref
Bartholomew Yir-Erong, Marcel T Bayor, Isaac Ayensu, Stephen Y Gbedema & Joshua S Boateng. (2019) Oral thin films as a remedy for noncompliance in pediatric and geriatric patients. Therapeutic Delivery 10:7, pages 443-464.
Crossref
D. M. More, P. D. Chaudhari & S. D. More. (2019) DESIGNING A PLATFORM TECHNOLOGY FOR AGE APPROPRIATE PEDIATRIC DOSAGE FORM. INDIAN DRUGS 56:05, pages 14-23.
Crossref
Isabelle Nardin & Saskia Köllner. (2019) Successful development of oral SEDDS: screening of excipients from the industrial point of view. Advanced Drug Delivery Reviews 142, pages 128-140.
Crossref
Bazigha K. Abdul Rasool & Aliasgar Shahiwala. 2019. Novel Drug Delivery Technologies. Novel Drug Delivery Technologies 29 71 .
Xiao Zheng, Fei Wu, Yanlong Hong, Lan Shen, Xiao Lin & Yi Feng. (2018) Developments in Taste-Masking Techniques for Traditional Chinese Medicines. Pharmaceutics 10:3, pages 157.
Crossref
Xu Liu, Xiangyu Ma, Eucharist Kun, Xiaodi Guo, Zhongxue Yu & Feng Zhang. (2018) Influence of lidocaine forms (salt vs. freebase) on properties of drug–eudragit® L100-55 extrudates prepared by reactive melt extrusion. International Journal of Pharmaceutics 547:1-2, pages 291-302.
Crossref
Roberta Censi, Maria Gigliobianco, Cristina Casadidio & Piera Di Martino. (2018) Hot Melt Extrusion: Highlighting Physicochemical Factors to Be Investigated While Designing and Optimizing a Hot Melt Extrusion Process. Pharmaceutics 10:3, pages 89.
Crossref
Alison V. Keating, Jessica Soto, Catherine Tuleu, Claire Forbes, Min Zhao & Duncan Q.M. Craig. (2018) Solid state characterisation and taste masking efficiency evaluation of polymer based extrudates of isoniazid for paediatric administration. International Journal of Pharmaceutics 536:2, pages 536-546.
Crossref
Nicolaos Scoutaris, Steven A. Ross & Dennis Douroumis. (2018) 3D Printed “Starmix” Drug Loaded Dosage Forms for Paediatric Applications. Pharmaceutical Research 35:2.
Crossref
Marta Podrażka, Ewa Bączyńska, Magdalena Kundys, Paulina Jeleń & Emilia Witkowska Nery. (2017) Electronic Tongue—A Tool for All Tastes?. Biosensors 8:1, pages 3.
Crossref
Magdalena Münster, Corinna Schoch, Carsten Schmidt & Jörg Breitkreutz. (2017) Multiparticulate system combining taste masking and immediate release properties for the aversive compound praziquantel. European Journal of Pharmaceutical Sciences 109, pages 446-454.
Crossref
Jaywant N. Pawar, Ritesh A. Fule, Mohammed Maniruzzaman & Purnima D. Amin. (2017) Solid crystal suspension of Efavirenz using hot melt extrusion: Exploring the role of crystalline polyols in improving solubility and dissolution rate. Materials Science and Engineering: C 78, pages 1023-1034.
Crossref
Ilhwan Hwang, Chin-Yang Kang & Jun-Bom Park. (2017) Advances in hot-melt extrusion technology toward pharmaceutical objectives. Journal of Pharmaceutical Investigation 47:2, pages 123-132.
Crossref
Roshan V. Tiwari, Ashley N. Polk, Hemlata Patil, Xingyou Ye, Manjeet B. Pimparade & Michael A. Repka. (2015) Rat Palatability Study for Taste Assessment of Caffeine Citrate Formulation Prepared via Hot-Melt Extrusion Technology. AAPS PharmSciTech 18:2, pages 341-348.
Crossref
G. Verstraete, J. Van Renterghem, P.J. Van Bockstal, S. Kasmi, B.G. De Geest, T. De Beer, J.P. Remon & C. Vervaet. (2016) Hydrophilic thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding. International Journal of Pharmaceutics 506:1-2, pages 214-221.
Crossref
Matthew W. Linakis, Jessica K. Roberts, Anita C. Lala, Michael G. Spigarelli, Natalie J. Medlicott, David M. Reith, Robert M. Ward & Catherine M. T. Sherwin. (2015) Challenges Associated with Route of Administration in Neonatal Drug Delivery. Clinical Pharmacokinetics 55:2, pages 185-196.
Crossref
S. A. Ross, D. A. Lamprou & D. Douroumis. (2016) Engineering and manufacturing of pharmaceutical co-crystals: a review of solvent-free manufacturing technologies. Chemical Communications 52:57, pages 8772-8786.
Crossref
J. Thiry, F. Krier & B. Evrard. (2015) A review of pharmaceutical extrusion: Critical process parameters and scaling-up. International Journal of Pharmaceutics 479:1, pages 227-240.
Crossref
Joseph T. Morott, Manjeet Pimparade, Jun-Bom Park, Chelsea P. Worley, Soumyajit Majumdar, Zhuoyang Lian, Elanor Pinto, Yunxia Bi, Thomas Durig & Michael A. Repka. (2015) The Effects of Screw Configuration and Polymeric Carriers on Hot-Melt Extruded Taste-Masked Formulations Incorporated into Orally Disintegrating Tablets. Journal of Pharmaceutical Sciences 104:1, pages 124-134.
Crossref
Anat Levit, Stefanie Nowak, Maximilian Peters, Ayana Wiener, Wolfgang Meyerhof, Maik Behrens & Masha Y. Niv. (2013) The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14. The FASEB Journal 28:3, pages 1181-1197.
Crossref
Mohammed Maniruzzaman, Marion Bonnefille, Attila Aranyos, Martin J Snowden & Dennis Douroumis. (2014) An in-vivo and in-vitro taste masking evaluation of bitter melt-extruded drugs. Journal of Pharmacy and Pharmacology 66:2, pages 323-337.
Crossref
Siva Ram Kiran Vaka, Murali Mohan Bommana, Dipen Desai, Jelena Djordjevic, Wantanee Phuapradit & Navnit Shah. 2014. Amorphous Solid Dispersions. Amorphous Solid Dispersions 123 161 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.