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Research Article

Microemulsion for simultaneous transdermal delivery of benzocaine and indomethacin: in vitro and in vivo evaluation

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Pages 1637-1644 | Received 02 May 2013, Accepted 27 Aug 2013, Published online: 04 Oct 2013

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Read on this site (7)

Yuhang Xu, Ye Cai, Yun Meng, Long Wu, Jingbao Chen, Wenxuan Cao & Xiaoqin Chu. (2022) Liposome and microemulsion loaded with ibuprofen: from preparation to mechanism of drug transport. Journal of Microencapsulation 39:6, pages 539-551.
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Miroslava Špaglová, Mária Čuchorová, Veronika Šimunková, Desana Matúšová, Martina Čierna, Lenka Starýchová & Katarína Bauerová. (2020) Possibilities of the microemulsion use as indomethacin solubilizer and its effect on in vitro and ex vivo drug permeation from dermal gels in comparison with transcutol®. Drug Development and Industrial Pharmacy 46:9, pages 1468-1476.
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Daniele Ribeiro de Araújo, Lígia Nunes de Morais Ribeiro & Eneida de Paula. (2019) Lipid-based carriers for the delivery of local anesthetics. Expert Opinion on Drug Delivery 16:7, pages 701-714.
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Neslihan Üstündağ Okur, Emre Şefik Çağlar, Muhammet Davut Arpa & H. Yeşim Karasulu. (2017) Preparation and evaluation of novel microemulsion-based hydrogels for dermal delivery of benzocaine. Pharmaceutical Development and Technology 22:4, pages 500-510.
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Ran Wen, Qing Zhang, Pan Xu, Jie Bai, Pengyue Li, Shouying Du & Yang Lu. (2016) Xingnaojing mPEG2000-PLA modified microemulsion for transnasal delivery: pharmacokinetic and brain-targeting evaluation. Drug Development and Industrial Pharmacy 42:6, pages 926-935.
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Anna Froelich, Tomasz Osmałek, Paweł Kunstman, Rafał Roszak & Wojciech Białas. (2016) Rheological and textural properties of microemulsion-based polymer gels with indomethacin. Drug Development and Industrial Pharmacy 42:6, pages 854-861.
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Peng Hou, Sali Cao, Jian Ni, Tao Zhang, Zhengjun Cai, Juanjuan Liu, Ye Wang, Penglong Wang, Haimin Lei & Yong Liu. (2015) In-vitro and in-vivo comparison of T-OA microemulsions and solid dispersions based on EPDC. Drug Development and Industrial Pharmacy 41:2, pages 263-271.
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Articles from other publishers (17)

Zaid Majeed Ismaeel, Israa Al-Ani, Maha N. Abu Hajleh & Emad Al-Dujaili. (2023) Formulation and evaluation of retinyl palmitate and vitamin E nanoemulsion for skin care. Pharmacia 70:3, pages 475-483.
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Gamal M. El Maghraby & Mona F. Arafa. 2023. Green Sustainable Process for Chemical and Environmental Engineering and Science. Green Sustainable Process for Chemical and Environmental Engineering and Science 35 54 .
Gamal M. El Maghraby, Mona F. Arafa & Amal A. Sultan. 2023. Advanced and Modern Approaches for Drug Delivery. Advanced and Modern Approaches for Drug Delivery 33 75 .
Lubna M. Abd El Wahab, Ebtessam A. Essa, Gamal M. El Maghraby & Mona F. Arafa. (2022) The Development and Evaluation of Phase Transition Microemulsion for Ocular Delivery of Acetazolamide for Glaucoma Treatment. AAPS PharmSciTech 24:1.
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Rania K. Eid, Mona F. Arafa, Dalia S. Ashour, Ebtessam A. Essa, Hager S. Zoghroban, Yasmine A. Issa, Hanan M. Nomeir, Hend S. Abo Safia & Gamal M. El Maghraby. (2022) Eudragit coated microemulsion for enhanced efficacy of spiramycin against toxoplasmic encephalitis. Journal of Drug Delivery Science and Technology 69, pages 103137.
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Bahjat Alhasso, Muhammad Usman Ghori & Barbara R. Conway. (2022) Systematic Review on the Effectiveness of Essential and Carrier Oils as Skin Penetration Enhancers in Pharmaceutical Formulations. Scientia Pharmaceutica 90:1, pages 14.
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Dalia A. Elmehy, Marwa A. Hasby Saad, Gamal M. El Maghraby, Mona F. Arafa, Nema A. Soliman, Heba H Elkaliny & Dina I. Elgendy. (2021) Niosomal versus nano-crystalline ivermectin against different stages of Trichinella spiralis infection in mice. Parasitology Research 120:7, pages 2641-2658.
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Hadir F. Marei, Mona F. Arafa, Ebtessam A. Essa & Gamal M. El Maghraby. (2021) Lidocaine as eutectic forming drug for enhanced transdermal delivery of nonsteroidal anti-inflammatory drugs. Journal of Drug Delivery Science and Technology 61, pages 102338.
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Gamal M. El Maghraby & Mona F. Arafa. 2019. Natural Polysaccharides in Drug Delivery and Biomedical Applications. Natural Polysaccharides in Drug Delivery and Biomedical Applications 339 361 .
Noha W. El Khayat, Ahmed A. Donia, Omer Y. Mady & Gamal M. El Maghraby. (2018) Optimization of eugenol microemulsion for transdermal delivery of indomethacin. Journal of Drug Delivery Science and Technology 48, pages 311-318.
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Gamal M. El Maghraby, Mona F. Arafa & Ebtessam A. Essa. 2018. Applications of Nanocomposite Materials in Drug Delivery. Applications of Nanocomposite Materials in Drug Delivery 787 803 .
Shannon P. Callender, Jessica A. Mathews, Katherine Kobernyk & Shawn D. Wettig. (2017) Microemulsion utility in pharmaceuticals: Implications for multi-drug delivery. International Journal of Pharmaceutics 526:1-2, pages 425-442.
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Lindi van Zyl, Jan du Preez, Minja Gerber, Jeanetta du Plessis & Joe Viljoen. (2016) Essential Fatty Acids as Transdermal Penetration Enhancers. Journal of Pharmaceutical Sciences 105:1, pages 188-193.
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Dorota Bartusik, David Aebisher & Boguslaw Tomanek. 2016. Emulsions. Emulsions 519 555 .
David Limón, Ezhil Amirthalingam, Mafalda Rodrigues, Lyda Halbaut, Berenice Andrade, María Luisa Garduño-Ramírez, David B. Amabilino, Lluïsa Pérez-García & Ana C. Calpena. (2015) Novel nanostructured supramolecular hydrogels for the topical delivery of anionic drugs. European Journal of Pharmaceutics and Biopharmaceutics 96, pages 421-436.
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Ming-Jun Tsai, Yaw-Bin Huang, Jhih-Wun Fang, Yaw-Syan Fu & Pao-Chu Wu. (2015) Preparation and evaluation of submicron-carriers for naringenin topical application. International Journal of Pharmaceutics 481:1-2, pages 84-90.
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Ming-Jun Tsai, Yaw-Syan Fu, Yu-Hsuan Lin, Yaw-Bin Huang & Pao-Chu Wu. (2014) The Effect of Nanoemulsion as a Carrier of Hydrophilic Compound for Transdermal Delivery. PLoS ONE 9:7, pages e102850.
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