Advanced search
Publication Cover
Drug Development and Industrial Pharmacy Volume 40, 2014 - Issue 12
Submit an article Journal homepage
333
Views
31
CrossRef citations to date
0
Altmetric
Research Article

Lyophilized insulin nanoparticles prepared from quaternized N-aryl derivatives of chitosan as a new strategy for oral delivery of insulin: in vitro, ex vivo and in vivo characterizations

Reza MahjubDepartment of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences TehranIran;School of Pharmacy, Hamedan University of Medical Sciences HamedanIran
,
Moojan RadmehrDepartment of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences TehranIran
,
Farid Abedin DorkooshDepartment of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences TehranIran
,
Seyed Naser OstadDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences TehranIran
&
Morteza Rafiee-TehraniDepartment of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences TehranIran;Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences TehranIranCorrespondence[email protected]
Pages 1645-1659 | Received 04 May 2013, Accepted 29 Aug 2013, Published online: 04 Oct 2013

Citations (31)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (9)

Chun Y. Wong, Hani Al-Salami & Crispin R. Dass. (2021) Fabrication techniques for the preparation of orally administered insulin nanoparticles. Journal of Drug Targeting 29:4, pages 365-386.
Read now
Chun Y. Wong, Hani Al-Salami & Crispin R. Dass. (2020) Current status and applications of animal models in pre-clinical development of orally administered insulin-loaded nanoparticles. Journal of Drug Targeting 28:9, pages 882-903.
Read now
Chun Y. Wong, Jorge Martinez, Jian Zhao, Hani Al-Salami & Crispin R. Dass. (2020) Development of orally administered insulin-loaded polymeric-oligonucleotide nanoparticles: statistical optimization and physicochemical characterization. Drug Development and Industrial Pharmacy 46:8, pages 1238-1252.
Read now
Chun Y. Wong, Hani. Al-Salami & Crispin R. Dass. (2020) Cellular assays and applied technologies for characterisation of orally administered protein nanoparticles: a systematic review. Journal of Drug Targeting 28:6, pages 585-599.
Read now
Bahareh Afra, Mojdeh Mohammadi, Meysam Soleimani & Reza Mahjub. (2020) Preparation, statistical optimization, in vitro characterization, and in vivo pharmacological evaluation of solid lipid nanoparticles encapsulating propolis flavonoids: a novel treatment for skin edema. Drug Development and Industrial Pharmacy 46:7, pages 1163-1176.
Read now
Xiaomei Wang, Dan Cheng, Linglin Liu & Xuejun Li. (2018) Development of poly(hydroxyethyl methacrylate) nanogel for effective oral insulin delivery. Pharmaceutical Development and Technology 23:4, pages 351-357.
Read now
Zhihe Lu, Jingrong Su, Zhengrong Li, Yuzhu Zhan & Decai Ye. (2017) Hyaluronic acid-coated, prodrug-based nanostructured lipid carriers for enhanced pancreatic cancer therapy. Drug Development and Industrial Pharmacy 43:1, pages 160-170.
Read now
J. Hecq, F. Siepmann, J. Siepmann, K. Amighi & J. Goole. (2015) Development and evaluation of chitosan and chitosan derivative nanoparticles containing insulin for oral administration. Drug Development and Industrial Pharmacy 41:12, pages 2037-2044.
Read now
Dalia Mohamed, Ibrahim Elsayed, Aly Fahmy Mohamed & Soad Ali Yehia. (2015) Real time stability and viability prediction of the anticancer BCG after lyophilization. Drug Development and Industrial Pharmacy 41:11, pages 1769-1776.
Read now

Articles from other publishers (22)

Sanchit Arora, Sanat Kumar Dash, Dimple Dhawan, Prabhat Kumar Sahoo, Anil Jindal & Dalapathi Gugulothu. (2023) Freeze-drying revolution: unleashing the potential of lyophilization in advancing drug delivery systems. Drug Delivery and Translational Research.
Crossref
Büşra Arpaç, Burcu Devrim Gökberk, Berrin Küçüktürkmen, Işıl Özakca Gündüz, İsmail Murat Palabıyık & Asuman Bozkır. (2023) Design and in vitro/in vivo Evaluation of Polyelectrolyte Complex Nanoparticles Filled in Enteric-Coated Capsules for Oral Delivery of Insulin. Journal of Pharmaceutical Sciences 112:3, pages 718-730.
Crossref
Alok Ranjan & Prateek K. Jha. (2021) Recent Advances in Dissolution Testing and Their Use to Improve In Vitro–In Vivo Correlations in Oral Drug Formulations. Journal of Pharmaceutical Innovation 17:3, pages 1011-1026.
Crossref
Xueqin Hou, Xinyu Qiu, Yaping Wang, Shuangshuang Song, Yifan Cong & Jifu Hao. (2022) Application and Efficacy of Melatonin Elastic Liposomes in Photoaging Mice. Oxidative Medicine and Cellular Longevity 2022, pages 1-15.
Crossref
Yajie Zhang, Daniel A. Davis, Khaled AboulFotouh, Jieliang Wang, Donna Williams, Akhilesh Bhambhani, Michael Zakrewsky, Mohammed Maniruzzaman, Zhengrong Cui & Robert O. WilliamsIIIIII. (2021) Novel formulations and drug delivery systems to administer biological solids. Advanced Drug Delivery Reviews 172, pages 183-210.
Crossref
Chun Yuen Jerry Wong, Hani Al-Salami & Crispin R Dass. (2021) β-Cyclodextrin-containing chitosan-oligonucleotide nanoparticles improve insulin bioactivity, gut cellular permeation and glucose consumption. Journal of Pharmacy and Pharmacology 73:6, pages 726-739.
Crossref
Reza Mahjub, Farzane K. Najafabadi, Narges Dehkhodaei, Nejat Kheiripour, Amir N. Ahmadabadi, Sara S. Asl, Masomeh Taheri-Azandariani & Akram Ranjbar. (2020) Eudragit L-100 Capsules Aromatize and Quaternerize Chitosan for Insulin Nanoparticle Oral Delivery During Toxic Oxidative Stress in Rat Liver and Kidney. Pharmaceutical Nanotechnology 8:3, pages 239-254.
Crossref
Chun Y. Wong, Hani Al-Salami & Crispin R. Dass. (2020) Formulation and characterisation of insulin-loaded chitosan nanoparticles capable of inducing glucose uptake in skeletal muscle cells in vitro. Journal of Drug Delivery Science and Technology 57, pages 101738.
Crossref
Chun Y. Wong, Hani Al-Salami & Crispin R. Dass. (2020) Lyophilisation Improves Bioactivity and Stability of Insulin-Loaded Polymeric-Oligonucleotide Nanoparticles for Diabetes Treatment. AAPS PharmSciTech 21:3.
Crossref
Chun Y. Wong, Giuseppe Luna, Jorge Martinez, Hani Al-Salami & Crispin R. Dass. (2019) Bio-nanotechnological advancement of orally administered insulin nanoparticles: Comprehensive review of experimental design for physicochemical characterization. International Journal of Pharmaceutics 572, pages 118720.
Crossref
Hans Merzendorfer. 2019. Extracellular Sugar-Based Biopolymers Matrices. Extracellular Sugar-Based Biopolymers Matrices 95 151 .
Giti Kalantarian, Nasrin Ziamajidi, Reza Mahjub, Mohammad Taghi Goodarzi, Massoud Saidijam, Sara Soleimani Asl & Roghayeh Abbasalipourkabir. (2018) Effect of insulin–coated trimethyl chitosan nanoparticles on IGF-1, IGF-2, and apoptosis in the hippocampus of diabetic male rats. Restorative Neurology and Neuroscience 36:4, pages 571-581.
Crossref
Mohammad Jamshidi, Nasrin Ziamajidi, Iraj Khodadadi, Arash Dehghan, Giti Kalantarian & Roghayeh Abbasalipourkabir. (2018) The effect of insulin-loaded trimethylchitosan nanoparticles on rats with diabetes type I. Biomedicine & Pharmacotherapy 97, pages 729-735.
Crossref
Isra Dmour & Mutasem O. Taha. (2017) Novel nanoparticles based on chitosan-dicarboxylate conjugates via tandem ionotropic/covalent crosslinking with tripolyphosphate and subsequent evaluation as drug delivery vehicles. International Journal of Pharmaceutics 529:1-2, pages 15-31.
Crossref
Mahnaz Amiri, Masoud Salavati-Niasari, Abbas Pardakhty, Meysam Ahmadi & Ahmad Akbari. (2017) Caffeine: A novel green precursor for synthesis of magnetic CoFe2O4 nanoparticles and pH-sensitive magnetic alginate beads for drug delivery. Materials Science and Engineering: C 76, pages 1085-1093.
Crossref
Lucia Zakharova, Tatiana Pashirova, Ruslan Kashapov, Dinar Gabdrakhmanov & Oleg Sinyashin. 2017. Nanostructures for Drug Delivery. Nanostructures for Drug Delivery 749 806 .
Giuliana Vozza, Minna Khalid, Hugh J. Byrne, Sinead Ryan & Jesus Frias. 2017. Nutrient Delivery. Nutrient Delivery 1 42 .
Kaihang Chen, Yunzhi Ling, Cong Cao, Xiaoyun Li, Xiao Chen & Xiaoying Wang. (2016) Chitosan derivatives/reduced graphene oxide/alginate beads for small-molecule drug delivery. Materials Science and Engineering: C 69, pages 1222-1228.
Crossref
Reza Mahjub, Robabeh Allahyar, Morteza Rafiee-Tehrani & Farid Abedin Dorkoosh. (2016) Preparation and characterization of nanoparticles composed of methylated N-(4-N,N-dimethyl aminobenzyl) chitosan for oral delivery of cyclosporine A. European Journal of Nanomedicine 8:2, pages 91-99.
Crossref
Ye Tian, Yujiao Sun, Xiaodan Wang, Georgios Kasparis & Shirui Mao. 2016. Nanobiomaterials in Drug Delivery. Nanobiomaterials in Drug Delivery 515 572 .
Yan Chen, Xue-Lian Zheng, Dai-Long Fang, Yang Yang, Jin-Kun Zhang, Hui-Li Li, Bei Xu, Yi Lei, Ke Ren & Xiang-Rong Song. (2014) Dual Agent Loaded PLGA Nanoparticles Enhanced Antitumor Activity in a Multidrug-Resistant Breast Tumor Xenograft Model. International Journal of Molecular Sciences 15:2, pages 2761-2772.
Crossref
Parameswara Rao Vuddanda, Vijayakumar Mahalingam Rajamanickam, Madhu Yaspal & Sanjay Singh. (2014) Investigations on Agglomeration and Haemocompatibility of Vitamin E TPGS Surface Modified Berberine Chloride Nanoparticles. BioMed Research International 2014, pages 1-11.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.