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Drug Development and Industrial Pharmacy Volume 41, 2015 - Issue 3
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Research Article

Preparation of amorphous solid dispersions by rotary evaporation and KinetiSol Dispersing: approaches to enhance solubility of a poorly water-soluble gum extract

Ryan C. BennettDivision of Pharmaceutics, The University of Texas at Austin, Austin, TX, USA, Correspondence[email protected]
,
Chris BroughDisperSol Technologies, Georgetown, TX, USA,
,
Dave A. MillerDisperSol Technologies, Georgetown, TX, USA,
,
Kevin P. O’DonnellThe Dow Chemical Company, Midland, MI, USA, and
,
Justin M. KeenDivision of Pharmaceutics, The University of Texas at Austin, Austin, TX, USA,
,
Justin R. HugheyHovione, LLC, East Windsor, NJ, USA
,
Robert O. Williams IIIDivision of Pharmaceutics, The University of Texas at Austin, Austin, TX, USA,
&
James W. McGinityDivision of Pharmaceutics, The University of Texas at Austin, Austin, TX, USA,
show all
Pages 382-397 | Received 19 Sep 2013, Accepted 06 Nov 2013, Published online: 16 Dec 2013

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Sahar Salehi, Mohammad Sadegh Nourbakhsh, Mardali Yousefpour, Ghadir Rajabzadeh & Sajad Sahab-Negah. (2022) Co-encapsulation of curcumin and boswellic acids in chitosan-coated niosome: an in-vitro digestion study. Journal of Microencapsulation 39:3, pages 226-238.
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Mohamed Ahmed Naseef Soliman, Howida Kamal Ibrahim & Samia Abd El-Kader Nour. (2021) Diacerein solid dispersion loaded tablets for minimization of drug adverse effects: statistical design, formulation, in vitro, and in vivo evaluation. Pharmaceutical Development and Technology 26:3, pages 302-315.
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Scott V. Jermain, Dave Miller, Angela Spangenberg, Xingyu Lu, Chaeho Moon, Yongchao Su & Robert O. Williams. (2019) Homogeneity of amorphous solid dispersions – an example with KinetiSol®. Drug Development and Industrial Pharmacy 45:5, pages 724-735.
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Sophia Yui Kau Fong, Annette Bauer-Brandl & Martin Brandl. (2017) Oral bioavailability enhancement through supersaturation: an update and meta-analysis. Expert Opinion on Drug Delivery 14:3, pages 403-426.
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Mohammad A. Altamimi & Steven H. Neau. (2016) Use of the Flory–Huggins theory to predict the solubility of nifedipine and sulfamethoxazole in the triblock, graft copolymer Soluplus. Drug Development and Industrial Pharmacy 42:3, pages 446-455.
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Emilie Gue, Susanne Muschert, Jean-Francois Willart, Florence Danede, Elisabeth Delcourt-Debruyne, Marc Descamps & Juergen Siepmann. (2015) Accelerated ketoprofen release from spray-dried polymeric particles: importance of phase transitions and excipient distribution. Drug Development and Industrial Pharmacy 41:5, pages 838-850.
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Arif Budiman, Annisa Luthfiyah Handini, Mutia Nur Muslimah, Neng Vera Nurani, Eli Laelasari, Insan Sunan Kurniawansyah & Diah Lia Aulifa. (2023) Amorphous Solid Dispersion as Drug Delivery Vehicles in Cancer. Polymers 15:16, pages 3380.
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Guoliang Wang, Yanchao Li, Zhiguo Qin & Tao Liu. (2022) Nanosizing Coamorphous Drugs Using Top-Down Approach: The Effect of Particle Size Reduction on Dissolution Improvement. AAPS PharmSciTech 24:1.
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Sana Inam, Muhammad Irfan, Noor ul ain Lali, Haroon Khalid Syed, Sajid Asghar, Ikram Ullah Khan, Salah-Ud-Din Khan, Muhammad Shahid Iqbal, Imran Zaheer, Ahmed Khames, Heba A. Abou-Taleb & Mohammad A. S. Abourehab. (2022) Development and Characterization of Eudragit® EPO-Based Solid Dispersion of Rosuvastatin Calcium to Foresee the Impact on Solubility, Dissolution and Antihyperlipidemic Activity. Pharmaceuticals 15:4, pages 492.
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Daniel A. DavisJr.Jr., Rishi Thakkar, Mohammed Maniruzzaman, Dave A. Miller & Robert O. WilliamsIIIIII. 2022. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 599 650 .
Wenjing Zhu, Wenling Fan, Xiaotong Zhang & Meiqi Gao. (2021) Sustained-Release Solid Dispersion of High-Melting-Point and Insoluble Resveratrol Prepared through Hot Melt Extrusion to Improve Its Solubility and Bioavailability. Molecules 26:16, pages 4982.
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May Kyaw Oo, Syed Mahmood, Wong Tin Wui, Uttam Kumar Mandal & Bappaditya Chatterjee. (2019) Effects of Different Formulation Methods on Drug Crystallinity, Drug-Carrier Interaction, and Ex Vivo Permeation of a Ternary Solid Dispersion Containing Nisoldipine. Journal of Pharmaceutical Innovation 16:1, pages 26-37.
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Scott V. Jermain, Michael B. Lowinger, Daniel J. Ellenberger, Dave A. Miller, Yongchao Su & Robert O. WilliamsIIIIII. (2020) In Vitro and In Vivo Behaviors of KinetiSol and Spray-Dried Amorphous Solid Dispersions of a Weakly Basic Drug and Ionic Polymer . Molecular Pharmaceutics 17:8, pages 2789-2808.
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Ahmad Ziaee, Stephen O'Dea, Aoise Howard-Hildige, Luis Padrela, Catherine Potter, Javed Iqbal, Ahmad B. Albadarin, Gavin Walker & Emmet J. O'Reilly. (2019) Amorphous solid dispersion of ibuprofen: A comparative study on the effect of solution based techniques. International Journal of Pharmaceutics 572, pages 118816.
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Aniket Sabnis, Niten Jadav, Tim Gough, Adrian Kelly & Anant Paradkar. 2019. Innovative Dosage Forms. Innovative Dosage Forms 281 329 .
Neelam Sharma & Sukhbir Singh. (2019) Central composite designed ezetimibe solid dispersion for dissolution enhancement: synthesis and in vitro evaluation . Therapeutic Delivery 10:10, pages 643-658.
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Phuong Tran, Yong-Chul Pyo, Dong-Hyun Kim, Sang-Eun Lee, Jin-Ki Kim & Jeong-Sook Park. (2019) Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs. Pharmaceutics 11:3, pages 132.
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Huner K. Omer, Nozad R. Hussein, Amina Ferraz, Mohammad Najlah, Waqar Ahmed, Kevin M. G. Taylor & Abdelbary M. A. Elhissi. (2018) Spray-Dried Proliposome Microparticles for High-Performance Aerosol Delivery Using a Monodose Powder Inhaler. AAPS PharmSciTech 19:5, pages 2434-2448.
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Daniel J. Ellenberger, Dave A. Miller & Robert O. WilliamsIIIIII. (2018) Expanding the Application and Formulation Space of Amorphous Solid Dispersions with KinetiSol®: a Review. AAPS PharmSciTech 19:5, pages 1933-1956.
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Siyuan Huang & Robert O. WilliamsIIIIII. (2017) Effects of the Preparation Process on the Properties of Amorphous Solid Dispersions. AAPS PharmSciTech 19:5, pages 1971-1984.
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Tao Liu, Rainer H. Müller & Jan P. Möschwitzer. (2018) Consideration of the solid state for resveratrol nanocrystal production. Powder Technology 332, pages 63-69.
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Rahul Maheshwari, Yashu Chourasiya, Shantanu Bandopadhyay, Prashant K. Katiyar, Piyoosh Sharma, Pran Kishore Deb & Rakesh K. Tekade. 2018. Dosage Form Design Parameters. Dosage Form Design Parameters 1 30 .
Khadijah Edueng, Denny Mahlin & Christel A. S. Bergström. (2017) The Need for Restructuring the Disordered Science of Amorphous Drug Formulations. Pharmaceutical Research 34:9, pages 1754-1772.
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Weifeng Li, Sun Qing, Wenbing Zhi, Huan Yao, Chenglong Fu & Xiaofeng Niu. (2017) The pharmacokinetics and anti-inflammatory effects of chelerythrine solid dispersions in vivo. Journal of Drug Delivery Science and Technology 40, pages 51-58.
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Dave A Miller, Justin M Keen, Chris Brough, Daniel J Ellenberger, Marshall Cisneros, Robert O Williams & James W McGinity. (2016) Bioavailability enhancement of a BCS IV compound via an amorphous combination product containing ritonavir. Journal of Pharmacy and Pharmacology 68:5, pages 678-691.
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Justin S. LaFountaine, James W. McGinity & Robert O. WilliamsIIIIII. (2015) Challenges and Strategies in Thermal Processing of Amorphous Solid Dispersions: A Review. AAPS PharmSciTech 17:1, pages 43-55.
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Leena Kumari Prasad, Justin R. Hughey, James W. McGinity, Dave A. Miller & Robert O. WilliamsIIIIII. 2016. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 691 740 .
Dave A. Miller & Justin M. Keen. 2014. Amorphous Solid Dispersions. Amorphous Solid Dispersions 567 577 .

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