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Drug Development and Industrial Pharmacy Volume 41, 2015 - Issue 8
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Research Article

Effect of CYP2C9 genetic polymorphism on the metabolism of flurbiprofen in vitro

Li WangDepartment of Pharmacology, School of Pharmacy of Wenzhou Medical University, Wenzhou, Zhejiang, China,
,
Shi-Hui BaoThe Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China, and
,
Pei-Pei PanDepartment of Pharmacology, School of Pharmacy of Wenzhou Medical University, Wenzhou, Zhejiang, China,
,
Meng-Ming XiaDepartment of Pharmacology, School of Pharmacy of Wenzhou Medical University, Wenzhou, Zhejiang, China,
,
Meng-Chun ChenDepartment of Pharmacology, School of Pharmacy of Wenzhou Medical University, Wenzhou, Zhejiang, China,
,
Bing-Qing LiangDepartment of Pharmacology, School of Pharmacy of Wenzhou Medical University, Wenzhou, Zhejiang, China,
,
Da-Peng DaiThe Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China
,
Jian-Ping CaiThe Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China
&
Guo-Xin HuDepartment of Pharmacology, School of Pharmacy of Wenzhou Medical University, Wenzhou, Zhejiang, China, Correspondence[email protected]
 show all
Pages 1363-1367 | Received 03 Jun 2014, Accepted 27 Jul 2014, Published online: 21 Aug 2014

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Peng-fei Tang, Xiang Zheng, Xiao-xia Hu, Cheng-cheng Yang, Zhe Chen, Jian-chang Qian, Jian-ping Cai & Guo-xin Hu. (2020) Functional Measurement of CYP2C9 and CYP3A4 Allelic Polymorphism on Sildenafil Metabolism. Drug Design, Development and Therapy 14, pages 5129-5141.
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Jingru Zhang, Hong Zhang, Libo Zhao, Jian Gu, Yi Feng & Haiyan An. (2018) Population pharmacokinetic modeling of flurbiprofen, the active metabolite of flurbiprofen axetil, in Chinese patients with postoperative pain. Journal of Pain Research 11, pages 3061-3070.
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Articles from other publishers (12)

Chang-Keun Cho, Pureum Kang, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee & Chang-Ik Choi. (2023) Physiologically based pharmacokinetic (PBPK) modeling to predict the pharmacokinetics of irbesartan in different CYP2C9 genotypes. Archives of Pharmacal Research.
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Sang-Sup Whang, Chang‑Keun Cho, Eui Hyun Jung, Pureum Kang, Hye-Jung Park, Yun Jeong Lee, Chang-Ik Choi, Jung‑Woo Bae, Hyung Sik Kim, Choon-Gon Jang & Seok-Yong Lee. (2022) Physiologically based pharmacokinetic (PBPK) modeling of flurbiprofen in different CYP2C9 genotypes. Archives of Pharmacal Research 45:8, pages 584-595.
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Maor Wanounou, Chanan Shaul, Zahi Abu Ghosh, Shoshana Alamia & Yoseph Caraco. (2022) The Impact of CYP2C9*11 Allelic Variant on the Pharmacokinetics of Phenytoin and ( S )‐Warfarin . Clinical Pharmacology & Therapeutics 112:1, pages 156-163.
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Chang‑Keun Cho, Pureum Kang, Hye-Jung Park, Eunvin Ko, Chou Yen Mu, Yun Jeong Lee, Chang-Ik Choi, Hyung Sik Kim, Choon-Gon Jang, Jung‑Woo Bae & Seok-Yong Lee. (2022) Physiologically based pharmacokinetic (PBPK) modeling of piroxicam with regard to CYP2C9 genetic polymorphism. Archives of Pharmacal Research 45:5, pages 352-366.
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Miriam Dawidowicz, Agnieszka Kula, Paweł Świętochowski & Zofia Ostrowska. (2020) Assessment of the impact of PTGS1, PTGS2 and CYP2C9 polymorphisms on pain, effectiveness and safety of NSAID therapies. Postępy Higieny i Medycyny Doświadczalnej 74, pages 504-516.
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Ioannis Loisios-Konstantinidis, Rodrigo Cristofoletti, Masoud Jamei, David Turner & Jennifer Dressman. (2020) Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Predict the Impact of CYP2C9 Genetic Polymorphisms, Co-Medication and Formulation on the Pharmacokinetics and Pharmacodynamics of Flurbiprofen. Pharmaceutics 12:11, pages 1049.
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Matthew G. McDonald, Lindsay M. Henderson, Sutapa Ray, Catherine K. Yeung, Amanda L. Johnson, John P. Kowalski, Helmut Hanenberg, Constanze Wiek, Kenneth E. Thummel & Allan E. Rettie. (2020) Heterologous Expression and Functional Characterization of Novel CYP2C9 Variants Identified in the Alaska Native People. Journal of Pharmacology and Experimental Therapeutics 374:2, pages 233-240.
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Ryo Kunimoto & Jürgen Bajorath. (2018) Design of a tripartite network for the prediction of drug targets. Journal of Computer-Aided Molecular Design 32:2, pages 321-330.
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Ankit Srivastava, Debleena Guin, Ritushree Kukreti & Divya Vohora. 2018. Pharmaceutical Medicine and Translational Clinical Research. Pharmaceutical Medicine and Translational Clinical Research 107 127 .
Xiang Zheng, Ping Fang, Su-su Bao, Dan Lin, Jian-ping Cai & Guo-xin Hu. (2017) Function of 38 variants CYP2C9 polymorphism on ketamine metabolism in vitro. Journal of Pharmacological Sciences 135:1, pages 8-13.
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Adriana Isvoran, Maxime Louet, Diana Larisa Vladoiu, Dana Craciun, Marie-Anne Loriot, Bruno O. Villoutreix & Maria A. Miteva. (2017) Pharmacogenomics of the cytochrome P450 2C family: impacts of amino acid variations on drug metabolism. Drug Discovery Today 22:2, pages 366-376.
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Lian-Guo Chen, Zhe Wang, Yuan Zhu, Jian-Hua Xiong, Li-Rong Sun, Da-Peng Dai, Jian-Ping Cai & Guo-Xin Hu. (2016) In vitro metabolism of phenytoin in 36 CYP2C9 variants found in the Chinese population. Chemico-Biological Interactions 253, pages 93-99.
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