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Review Article

Twin screw granulation – review of current progress

Pages 1223-1231 | Received 25 Aug 2014, Accepted 29 Oct 2014, Published online: 17 Nov 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Marcel Franke, Thomas Riedel, Robin Meier, Carsten Schmidt & Peter Kleinebudde. (2023) Scale-up in twin-screw wet granulation: impact of formulation properties. Pharmaceutical Development and Technology 0:0, pages 1-14.
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Yi Zhang, Tongzhou Liu, Shahab Kashani-Rahimi & Feng Zhang. (2021) A review of twin screw wet granulation mechanisms in relation to granule attributes. Drug Development and Industrial Pharmacy 47:3, pages 349-360.
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Sandeep Sarabu, Suresh Bandari, Venkata Raman Kallakunta, Roshan Tiwari, Hemlata Patil & Michael A Repka. (2019) An update on the contribution of hot-melt extrusion technology to novel drug delivery in the twenty-first century: part II. Expert Opinion on Drug Delivery 16:6, pages 567-582.
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Shankali U. Pradhan, Maitraye Sen, Jiayu Li, Ian Gabbott, Gavin Reynolds, James D. Litster & Carl R. Wassgren. (2018) Characteristics of multi-component formulation granules formed using distributive mixing elements in twin screw granulation. Drug Development and Industrial Pharmacy 44:11, pages 1826-1837.
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Michał Teżyk, Bartłomiej Milanowski, Andrzej Ernst & Janina Lulek. (2016) Recent progress in continuous and semi-continuous processing of solid oral dosage forms: a review. Drug Development and Industrial Pharmacy 42:8, pages 1195-1214.
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Articles from other publishers (49)

Jiangtao Yu, Jie Zhu, Linlin Chen, Yanhong Chao, Wenshuai Zhu & Zhichang Liu. (2023) A review of adsorption materials and their application of 3D printing technology in the separation process. Chemical Engineering Journal 475, pages 146247.
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Lalith Kotamarthy, Ashley Dan, Subhodh Karkala, Sania Parvani, Andrés D. Román-Ospino & Rohit Ramachandran. (2023) Twin-screw granulation: Mechanistic understanding of the effect of material properties on key granule quality attributes through the analysis of mixing dynamics and granulation rate mechanisms. Advanced Powder Technology 34:9, pages 104137.
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Seung-Dong Yoo, Ji Yeon Kim, Sung-Kyun Han, Byung-Hoon Lee, Du Hyung Choi & Eun-Seok Park. (2023) Development of prediction model with machine learning in continuous twin screw granulation. Journal of Pharmaceutical Investigation.
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H.A. Abdulhussain & M.R. Thompson. (2023) Considering inelasticity in the real-time monitoring of particle size for twin-screw granulation via acoustic emissions. International Journal of Pharmaceutics 639, pages 122949.
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Daniel Zakowiecki, Margarethe Richter, Ceren Yuece, Annika Voelp, Maximilian Ries, Markos Papaioannou, Peter Edinger, Tobias Hess, Krystyna Mojsiewicz-Pieńkowska & Krzysztof Cal. (2023) Towards the Continuous Manufacturing of Liquisolid Tablets Containing Simethicone and Loperamide Hydrochloride with the Use of a Twin-Screw Granulator. Pharmaceutics 15:4, pages 1265.
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Abbe Haser, Nada Kittikunakorn, Erin Dippold, James C DiNunzio & William Blincoe. (2023) Continuous Twin-Screw wet granulation process with In-Barrel drying and NIR setup for Real-Time Moisture Monitoring. International Journal of Pharmaceutics 630, pages 122377.
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Jasim Ahmed, Bhupendra Raj Giri, Linu Thomas, Hasan Al-Attar & Mohammed Maniruzzaman. (2022) Continuous manufacturing of vitamin D3 and iron enriched granules by means of a novel twin-screw dry granulation process. Powder Technology 412, pages 117975.
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Lalith Kotamarthy, Chaitanya Sampat & Rohit Ramachandran. (2022) Development of a Granule Growth Regime Map for Twin Screw Wet Granulation Process via Data Imputation Techniques. Pharmaceutics 14:10, pages 2211.
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Shankali U. Pradhan, Joseph W. Bullard, Steven Dale, Peter Ojakovo & Alexandre Bonnassieux. (2022) A scaled down method for identifying the optimum range of L/S ratio in twin screw wet granulation using a regime map approach. International Journal of Pharmaceutics 616, pages 121542.
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Kyann De Smit, Tom Wieme, Yoshi W. Marien, Paul H. M. Van Steenberge, Dagmar R. D'hooge & Mariya Edeleva. (2022) Multi-scale reactive extrusion modelling approaches to design polymer synthesis, modification and mechanical recycling. Reaction Chemistry & Engineering 7:2, pages 245-263.
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L. Vandevivere, E. Van Wijmeersch, O. Häusler, T. De Beer, C. Vervaet & V. Vanhoorne. (2022) The effect of screw configuration and formulation variables on liquid requirements and granule quality in a continuous twin screw wet granulation process. Journal of Drug Delivery Science and Technology 68, pages 103042.
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Rajat Radhakrishna Rao, Abhijeet Pandey, Aswathi R. Hegde, Vijay Induvadan Kulkarni, Chetan Chincholi, Vinay Rao, Indu Bhushan & Srinivas Mutalik. (2021) Metamorphosis of Twin Screw Extruder-Based Granulation Technology: Applications Focusing on Its Impact on Conventional Granulation Technology. AAPS PharmSciTech 23:1.
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Uttom Nandi, Tumpa Dey & Dennis Douroumis. 2022. Optimization of Pharmaceutical Processes. Optimization of Pharmaceutical Processes 135 169 .
John P. Morrissey, Kevin J. Hanley & Jin Y. Ooi. (2021) Conceptualisation of an Efficient Particle-Based Simulation of a Twin-Screw Granulator. Pharmaceutics 13:12, pages 2136.
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Christoph Portier, Tamas Vigh, Giustino Di Pretoro, Jan Leys, Didier Klingeleers, Thomas De Beer, Chris Vervaet & Valérie Vanhoorne. (2021) Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying – A QbD approach. International Journal of Pharmaceutics: X 3, pages 100077.
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Lalith Kotamarthy & Rohit Ramachandran. (2021) Mechanistic understanding of the effects of process and design parameters on the mixing dynamics in continuous twin-screw granulation. Powder Technology 390, pages 73-85.
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Ivana Cotabarren, Thamer A. Omar & Fernando J. Muzzio. (2021) Binder-free twin-screw melt granulation: An effective approach to manufacture high-dose API formulations. International Journal of Pharmaceutics 606, pages 120886.
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A. Ryckaert, D. Van Hauwermeiren, J. Dhondt, A. De Man, A. Funke, D. Djuric, C. Vervaet, I. Nopens & T. De Beer. (2021) TPLS as predictive platform for twin-screw wet granulation process and formulation development. International Journal of Pharmaceutics 605, pages 120785.
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Seth P. Forster & David B. Lebo. (2021) Continuous Melt Granulation for Taste-Masking of Ibuprofen. Pharmaceutics 13:6, pages 863.
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Christoph Portier, Chris Vervaet & Valérie Vanhoorne. (2021) Continuous Twin Screw Granulation: A Review of Recent Progress and Opportunities in Formulation and Equipment Design. Pharmaceutics 13:5, pages 668.
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Seth P. Forster, Erin Dippold & Tiffany Chiang. (2021) Twin-Screw Melt Granulation for Oral Solid Pharmaceutical Products. Pharmaceutics 13:5, pages 665.
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Uttom Nandi, Vivek Trivedi, Steven A. Ross & Dennis Douroumis. (2021) Advances in Twin-Screw Granulation Processing. Pharmaceutics 13:5, pages 624.
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Pallavi Pawar, Don Clancy, Lee Gorringe, Steve Barlow, Alex Hesketh & Richard Elkes. (2020) Development and Scale-Up of Diversion Strategy for Twin Screw Granulation in Continuous Manufacturing. Journal of Pharmaceutical Sciences 109:11, pages 3439-3450.
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Kaisa M. Kyttä, Satu Lakio, Håkan Wikström, Anisa Sulemanji, Magnus Fransson, Jarkko Ketolainen & Pirjo Tajarobi. (2020) Comparison between twin-screw and high-shear granulation - The effect of filler and active pharmaceutical ingredient on the granule and tablet properties. Powder Technology 376, pages 187-198.
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Christoph Portier, Charlotte De Vriendt, Tamas Vigh, Giustino Di Pretoro, Thomas De Beer, Chris Vervaet & Valérie Vanhoorne. (2020) Continuous twin screw granulation: Robustness of lactose/MCC-based formulations. International Journal of Pharmaceutics 588, pages 119756.
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Victoria R. Kitching, Nejat Rahmanian, Nurul Hanis Jamaluddin & Adrian Kelly. (2020) Influence of type of granulators on formation of seeded granules. Chemical Engineering Research and Design 160, pages 154-161.
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Li Ge Wang, Shankali U. Pradhan, Carl Wassgren, Dana Barrasso, David Slade & James D. Litster. (2020) A breakage kernel for use in population balance modelling of twin screw granulation. Powder Technology 363, pages 525-540.
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Christoph Portier, Tamas Vigh, Giustino Di Pretoro, Thomas De Beer, Chris Vervaet & Valérie Vanhoorne. (2020) Continuous twin screw granulation: Impact of binder addition method and surfactants on granulation of a high-dosed, poorly soluble API. International Journal of Pharmaceutics 577, pages 119068.
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Christoph Portier, Kenny Pandelaere, Urbain Delaet, Tamas Vigh, Giustino Di Pretoro, Thomas De Beer, Chris Vervaet & Valérie Vanhoorne. (2020) Continuous twin screw granulation: A complex interplay between formulation properties, process settings and screw design. International Journal of Pharmaceutics 576, pages 119004.
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Christoph Portier, Kenny Pandelaere, Urbain Delaet, Tamas Vigh, Ashish Kumar, Giustino Di Pretoro, Thomas De Beer, Chris Vervaet & Valérie Vanhoorne. (2020) Continuous twin screw granulation: Influence of process and formulation variables on granule quality attributes of model formulations. International Journal of Pharmaceutics 576, pages 118981.
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Arwa El Hagrasy, Li Ge Wang & Jim Litster. 2020. Continuous Pharmaceutical Processing. Continuous Pharmaceutical Processing 269 300 .
Gabriella Dahlgren, Pirjo Tajarobi, Eric Simone, Brendon Ricart, Jason Melnick, Vibha Puri, Courtney Stanton & Gurjit Bajwa. (2019) Continuous Twin Screw Wet Granulation and Drying—Control Strategy for Drug Product Manufacturing. Journal of Pharmaceutical Sciences 108:11, pages 3502-3514.
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Yeom, Ha, Kim, Jeong, Hwang & Choi. (2019) Application of the Discrete Element Method for Manufacturing Process Simulation in the Pharmaceutical Industry. Pharmaceutics 11:8, pages 414.
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Prakash Thapa, Julu Tripathi & Seong Hoon Jeong. (2019) Recent trends and future perspective of pharmaceutical wet granulation for better process understanding and product development. Powder Technology 344, pages 864-882.
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Shankali U. Pradhan, Yiyun Zhang, Jiayu Li, James D. Litster & Carl R. Wassgren. (2019) Tailored granule properties using 3D printed screw geometries in twin screw granulation. Powder Technology 341, pages 75-84.
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Ankita V. Shah & Abu T.M. Serajuddin. 2019. Handbook of Pharmaceutical Wet Granulation. Handbook of Pharmaceutical Wet Granulation 791 823 .
Saeed Shirazian, Jacek Zeglinski, Shaza Darwish, Manuel Kuhs, Ahmad B. Albadarin, Denise M. Croker & Gavin M. Walker. (2018) Continuous twin screw wet granulation: The combined effect of process parameters on residence time, particle size, and granule morphology. Journal of Drug Delivery Science and Technology 48, pages 319-327.
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Adrian Schmidt, Hans de Waard, Klaus-Peter Moll, Peter Kleinebudde & Markus Krumme. (2018) Simplified end-to-end continuous manufacturing by feeding API suspensions in twin-screw wet granulation. European Journal of Pharmaceutics and Biopharmaceutics 133, pages 224-231.
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N. Willecke, A. Szepes, M. Wunderlich, J.P. Remon, C. Vervaet & T. De Beer. (2018) A novel approach to support formulation design on twin screw wet granulation technology: Understanding the impact of overarching excipient properties on drug product quality attributes. International Journal of Pharmaceutics 545:1-2, pages 128-143.
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Y. Liu, M.R. Thompson & K.P. O’Donnell. (2018) Impact of non-binder ingredients and molecular weight of polymer binders on heat assisted twin screw dry granulation. International Journal of Pharmaceutics 536:1, pages 336-344.
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P. Suresh, I. Sreedhar, R. Vaidhiswaran & A. Venugopal. (2017) A comprehensive review on process and engineering aspects of pharmaceutical wet granulation. Chemical Engineering Journal 328, pages 785-815.
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Y. Liu, M. R. Thompson, K. P. O'Donnell & S. Ali. (2017) Heat assisted twin screw dry granulation. AIChE Journal 63:11, pages 4748-4760.
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Maxim Verstraeten, Daan Van Hauwermeiren, Kai Lee, Neil Turnbull, David Wilsdon, Mary am Ende, Pankaj Doshi, Chris Vervaet, Davinia Brouckaert, Séverine T.F.C. Mortier, Ingmar Nopens & Thomas De Beer. (2017) In-depth experimental analysis of pharmaceutical twin-screw wet granulation in view of detailed process understanding. International Journal of Pharmaceutics 529:1-2, pages 678-693.
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Haoyu Wang, Ahmad Mustaffar, Anh N. Phan, Vladimir Zivkovic, David Reay, Richard Law & Kamelia Boodhoo. (2017) A review of process intensification applied to solids handling. Chemical Engineering and Processing: Process Intensification 118, pages 78-107.
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Mohammed Maniruzzaman, Steven A. Ross, Tumpa Dey, Arun Nair, Martin J. Snowden & Dennis Douroumis. (2017) A quality by design (QbD) twin—Screw extrusion wet granulation approach for processing water insoluble drugs. International Journal of Pharmaceutics 526:1-2, pages 496-505.
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N. Willecke, A. Szepes, M. Wunderlich, J.P. Remon, C. Vervaet & T. De Beer. (2017) Identifying overarching excipient properties towards an in-depth understanding of process and product performance for continuous twin-screw wet granulation. International Journal of Pharmaceutics 522:1-2, pages 234-247.
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L.J. Gorringe, G.S. Kee, M.F. Saleh, N.H. Fa & R.G. Elkes. (2017) Use of the channel fill level in defining a design space for twin screw wet granulation. International Journal of Pharmaceutics 519:1-2, pages 165-177.
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Juan G. Osorio, Ridade Sayin, Arjun V. Kalbag, James D. Litster, Laura Martinez-MarcosDimitrios A. LamprouGavin W. Halbert. (2017) Scaling of continuous twin screw wet granulation. AIChE Journal 63:3, pages 921-932.
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Y. Liu, M.R. Thompson, K.P. O'Donnell & N.S. Grasman. (2016) Effect of temperature on the wetting behavior of hydroxypropyl methylcellulose in a twin-screw granulator. Powder Technology 302, pages 63-74.
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