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Drug Development and Industrial Pharmacy Volume 12, 1986 - Issue 11-13
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Research Article

Continuous Extrusion Using a Raker Perkins MP50 (Multipurpose) Extruder

M. J. Gamlen Pharmaceutical Development Laboratories, Wellcome Foundation Limited, Dartford, DA1 5AH, UK
&
C. Eardley Baker Perkins Chemical Machinery Ltd Cooper St., Hanley, Stoke on Trent, ST1 4DW, UK
Pages 1701-1713 | Published online: 20 Oct 2008

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Margot Fonteyne, Jurgen Vercruysse, Damián Córdoba Díaz, Delphine Gildemyn, Chris Vervaet, Jean Paul Remon & Thomas De Beer. (2013) Real-time assessment of critical quality attributes of a continuous granulation process. Pharmaceutical Development and Technology 18:1, pages 85-97.
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M. R. Thompson, S. Weatherley, R. N. Pukadyil & P. J. Sheskey. (2012) Foam granulation: new developments in pharmaceutical solid oral dosage forms using twin screw extrusion machinery. Drug Development and Industrial Pharmacy 38:7, pages 771-784.
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Dejan Djuric & Peter Kleinebudde. (2010) Continuous granulation with a twin-screw extruder: Impact of material throughput. Pharmaceutical Development and Technology 15:5, pages 518-525.
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R. M. Iyer, L. L. Augsburger, D. G. Pope & R. D. Shah. (1996) Extrusion/Spheronization—Effect of Moisture Content and Spheronization Time on Pellet Characteristics. Pharmaceutical Development and Technology 1:4, pages 325-331.
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Articles from other publishers (46)

Daniel Nesges, Tom Lang, Thomas Birr, Markus Thommes & Jens Bartsch. (2023) Planetary roller melt granulation (PRMG) – A new continuous method for powder processing. Powder Technology 427, pages 118728.
Crossref
Abbe Haser, Nada Kittikunakorn, Erin Dippold, James C DiNunzio & William Blincoe. (2023) Continuous Twin-Screw wet granulation process with In-Barrel drying and NIR setup for Real-Time Moisture Monitoring. International Journal of Pharmaceutics 630, pages 122377.
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Petra Záhonyi, Edina Szabó, András Domokos, Anna Haraszti, Martin Gyürkés, Erzsébet Moharos & Zsombor K. Nagy. (2022) Continuous integrated production of glucose granules with enhanced flowability and tabletability. International Journal of Pharmaceutics 626, pages 122197.
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Rajat Radhakrishna Rao, Abhijeet Pandey, Aswathi R. Hegde, Vijay Induvadan Kulkarni, Chetan Chincholi, Vinay Rao, Indu Bhushan & Srinivas Mutalik. (2021) Metamorphosis of Twin Screw Extruder-Based Granulation Technology: Applications Focusing on Its Impact on Conventional Granulation Technology. AAPS PharmSciTech 23:1.
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Uttom Nandi, Tumpa Dey & Dennis Douroumis. 2022. Optimization of Pharmaceutical Processes. Optimization of Pharmaceutical Processes 135 169 .
John P. Morrissey, Kevin J. Hanley & Jin Y. Ooi. (2021) Conceptualisation of an Efficient Particle-Based Simulation of a Twin-Screw Granulator. Pharmaceutics 13:12, pages 2136.
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Uttom Nandi, Vivek Trivedi, Steven A. Ross & Dennis Douroumis. (2021) Advances in Twin-Screw Granulation Processing. Pharmaceutics 13:5, pages 624.
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Nada Kittikunakorn, Tongzhou Liu & Feng Zhang. (2020) Twin-screw melt granulation: Current progress and challenges. International Journal of Pharmaceutics 588, pages 119670.
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Shahab Kashani Rahimi, Shubhajit Paul, Changquan Calvin Sun & Feng Zhang. (2020) The role of the screw profile on granular structure and mixing efficiency of a high-dose hydrophobic drug formulation during twin screw wet granulation. International Journal of Pharmaceutics 575, pages 118958.
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Annika Wilms, Klaus Knop & Peter Kleinebudde. (2019) Combination of a rotating tube sample divider and dynamic image analysis for continuous on-line determination of granule size distribution. International Journal of Pharmaceutics: X 1, pages 100029.
Crossref
Martin Warman. 2019. Chemical Engineering in the Pharmaceutical Industry. Chemical Engineering in the Pharmaceutical Industry 527 546 .
Nada Kittikunakorn, J. Joseph KolengIIIIII, Tony Listro, Changquan Calvin Sun & Feng Zhang. (2019) Effects of thermal binders on chemical stabilities and tabletability of gabapentin granules prepared by twin-screw melt granulation. International Journal of Pharmaceutics 559, pages 37-47.
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Wei Meng, Kallakuri Suparna Rao, Ronald D. Snee, Rohit Ramachandran & Fernando J. Muzzio. (2019) A comprehensive analysis and optimization of continuous twin-screw granulation processes via sequential experimentation strategy. International Journal of Pharmaceutics 556, pages 349-362.
Crossref
Ankita V. Shah & Abu T.M. Serajuddin. 2019. Handbook of Pharmaceutical Wet Granulation. Handbook of Pharmaceutical Wet Granulation 791 823 .
Wei Meng, Sarang Oka, Xue Liu, Thamer Omer, Rohit Ramachandran & Fernando J. Muzzio. (2017) Effects of Process and Design Parameters on Granule Size Distribution in a Continuous High Shear Granulation Process. Journal of Pharmaceutical Innovation 12:4, pages 283-295.
Crossref
P. Suresh, I. Sreedhar, R. Vaidhiswaran & A. Venugopal. (2017) A comprehensive review on process and engineering aspects of pharmaceutical wet granulation. Chemical Engineering Journal 328, pages 785-815.
Crossref
Rupinder Singh, Sunpreet Singh & Mohammed S.J. Hashmi. 2017. Encyclopedia of Materials: Composites. Encyclopedia of Materials: Composites 691 705 .
R. Singh, G. Dhuria & A. Batish. 2017. Reference Module in Materials Science and Materials Engineering. Reference Module in Materials Science and Materials Engineering.
B. Chen, L. Zhu, F. Zhang & Y. Qiu. 2017. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 821 868 .
R. Meier, M. Thommes, N. Rasenack, K.-P. Moll, M. Krumme & P. Kleinebudde. (2016) Granule size distributions after twin-screw granulation – Do not forget the feeding systems. European Journal of Pharmaceutics and Biopharmaceutics 106, pages 59-69.
Crossref
Hemlata Patil, Roshan V. Tiwari & Michael A. Repka. (2015) Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation. AAPS PharmSciTech 17:1, pages 20-42.
Crossref
Tim Chan Seem, Neil A. Rowson, Andy Ingram, Zhenyu Huang, Shen Yu, Marcel de Matas, Ian Gabbott & Gavin K. Reynolds. (2015) Twin screw granulation — A literature review. Powder Technology 276, pages 89-102.
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Maiju A. Järvinen, Marko Paavola, Sami Poutiainen, Päivi Itkonen, Ville Pasanen, Katja Uljas, Kauko Leiviskä, Mikko Juuti, Jarkko Ketolainen & Kristiina Järvinen. (2015) Comparison of a continuous ring layer wet granulation process with batch high shear and fluidized bed granulation processes. Powder Technology 275, pages 113-120.
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Shen Yu, Gavin K. Reynolds, Zhenyu Huang, Marcel de Matas & Agba D. Salman. (2014) Granulation of increasingly hydrophobic formulations using a twin screw granulator. International Journal of Pharmaceutics 475:1-2, pages 82-96.
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Kai T. Lee, Andy Ingram & Neil A. Rowson. (2013) Comparison of granule properties produced using Twin Screw Extruder and High Shear Mixer: A step towards understanding the mechanism of twin screw wet granulation. Powder Technology 238, pages 91-98.
Crossref
A.S. El Hagrasy, J.R. Hennenkamp, M.D. Burke, J.J. Cartwright & J.D. Litster. (2013) Twin screw wet granulation: Influence of formulation parameters on granule properties and growth behavior. Powder Technology 238, pages 108-115.
Crossref
Wei-Da Tu, Andy Ingram & Jonathan Seville. (2013) Regime map development for continuous twin screw granulation. Chemical Engineering Science 87, pages 315-326.
Crossref
Kai T. Lee, Andy Ingram & Neil A. Rowson. (2012) Twin screw wet granulation: The study of a continuous twin screw granulator using Positron Emission Particle Tracking (PEPT) technique. European Journal of Pharmaceutics and Biopharmaceutics 81:3, pages 666-673.
Crossref
Spencer D. Schaber, Dimitrios I. Gerogiorgis, Rohit Ramachandran, James M. B. Evans, Paul I. Barton & Bernhardt L. Trout. (2011) Economic Analysis of Integrated Continuous and Batch Pharmaceutical Manufacturing: A Case Study. Industrial & Engineering Chemistry Research 50:17, pages 10083-10092.
Crossref
P Kleinebudde, A J Sølvberg & H Lindner. (1994) The Power-consumption-controlled Extruder: A Tool for Pellet Production. Journal of Pharmacy and Pharmacology 46:7, pages 542-546.
Crossref
L Baert, D Fanara, P De Baets & J P Remon. (1991) Instrumentation of a Gravity Feed Extruder and the Influence of the Composition of Binary and Ternary Mixtures on the Extrusion Forces. Journal of Pharmacy and Pharmacology 43:11, pages 745-749.
Crossref
Martin Warman. 2010. Chemical Engineering in the Pharmaceutical Industry. Chemical Engineering in the Pharmaceutical Industry 837 851 .
Hideki Yano & Peter Kleinebudde. (2010) Improvement of Dissolution Behavior for Poorly Water-Soluble Drug by Application of Cyclodextrin in Extrusion Process: Comparison between Melt Extrusion and Wet Extrusion. AAPS PharmSciTech 11:2, pages 885-893.
Crossref
M.R. Thompson & J. Sun. (2010) Wet Granulation in a Twin‐Screw Extruder: Implications of Screw Design. Journal of Pharmaceutical Sciences 99:4, pages 2090-2103.
Crossref
Dejan Djuric & Peter Kleinebudde. (2008) Impact of screw elements on continuous granulation with a twin-screw extruder. Journal of Pharmaceutical Sciences 97:11, pages 4934-4942.
Crossref
B. Van Melkebeke, C. Vervaet & J.P. Remon. (2008) Validation of a continuous granulation process using a twin-screw extruder. International Journal of Pharmaceutics 356:1-2, pages 224-230.
Crossref
Richard (Ruey-ching) Hwang & Nitin Pathak. 2008. Water-Insoluble Drug Formulation, Second Edition. Water-Insoluble Drug Formulation, Second Edition 637 661 .
Barbara Van Melkebeke, Brenda Vermeulen, Chris Vervaet & Jean Paul Remon. (2006) Melt granulation using a twin-screw extruder: A case study. International Journal of Pharmaceutics 326:1-2, pages 89-93.
Crossref
Chris Vervaet & Jean Paul Remon. (2005) Continuous granulation in the pharmaceutical industry. Chemical Engineering Science 60:14, pages 3949-3957.
Crossref
Herbert StickerHerbert Sticker. 2003. Arzneiformen-Entwicklung. Arzneiformen-Entwicklung 73 96 .
E.I Keleb, A Vermeire, C Vervaet & J.P Remon. (2002) Continuous twin screw extrusion for the wet granulation of lactose. International Journal of Pharmaceutics 239:1-2, pages 69-80.
Crossref
E.I Keleb, A Vermeire, C Vervaet & J.P Remon. (2001) Cold extrusion as a continuous single-step granulation and tabletting process. European Journal of Pharmaceutics and Biopharmaceutics 52:3, pages 359-368.
Crossref
Ramarao Chatlapalli & Bhagwan D Rohera. (1998) Physical characterization of HPMC and HEC and investigation of their use as pelletization aids. International Journal of Pharmaceutics 161:2, pages 179-193.
Crossref
Chris Vervaet, Lieven Baert & Jean Paul Remon. (1995) Extrusion-spheronisation A literature review. International Journal of Pharmaceutics 116:2, pages 131-146.
Crossref
Chris Vervaet, Lieven Baert, Peter A. Risha & Jean-Paul Remon. (1994) The influence of the extrusion screen on pellet quality using an instrumented basket extruder. International Journal of Pharmaceutics 107:1, pages 29-39.
Crossref
Peter Kleinebudde & Hans Lindner. (1993) Experiments with an instrumented twin-screw extruder using a single-step granulation/extrusion process. International Journal of Pharmaceutics 94:1-3, pages 49-58.
Crossref

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