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Drug Development and Industrial Pharmacy Volume 12, 1986 - Issue 11-13
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Research Article

Water Uptake and Disintegrating Force Measurements: Towards a General Understanding of Disintegration Mechanisms

C. Caramella Dipartimento di Chimica, Farmaceutica - Università di Pavia, Italy
,
P. Colombo Dipartimento di Chimica, Farmaceutica - Università di Pavia, Italy
,
U. Conte Dipartimento di Chimica, Farmaceutica - Università di Pavia, Italy
,
F. Ferrari Dipartimento di Chimica, Farmaceutica - Università di Pavia, Italy
,
A. La Manna Dipartimento di Chimica, Farmaceutica - Università di Pavia, Italy
,
H. V. Van Kamp Laboratory for Pharmaceutical Technology and Dispensing - University of Groningen, The Netherlands
&
G. K. Bolhuis Laboratory for Pharmaceutical Technology and Dispensing - University of Groningen, The Netherlands
 show all
Pages 1749-1766 | Published online: 20 Oct 2008

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Ting Wang, Ahmed Ibrahim & Stephen W. Hoag. (2020) Understanding the impact of magnesium stearate variability on tableting performance using a multivariate modeling approach. Pharmaceutical Development and Technology 25:1, pages 76-88.
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Kamran Zaheer & Peter Langguth. (2018) Formulation strategy towards minimizing viscosity mediated negative food effect on disintegration and dissolution of immediate release tablets. Drug Development and Industrial Pharmacy 44:3, pages 444-451.
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Julian Quodbach & Peter Kleinebudde. (2016) A critical review on tablet disintegration. Pharmaceutical Development and Technology 21:6, pages 763-774.
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Christine Hersen-Delesalle, Bernard Leclerc, Guy Couarraze, Virginie Busignies & Pierre Tchoreloff. (2007) The Effects of Relative Humidity and Super-Disintegrant Concentrations on the Mechanical Properties of Pharmaceutical Compacts. Drug Development and Industrial Pharmacy 33:12, pages 1297-1307.
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Jia Ai Allen Zhang & J. Mark Christensen. (1996) Effect of Superdisintegrant on Antigen Release from Enteric-Coated Antigen Microspheres. Drug Development and Industrial Pharmacy 22:8, pages 833-839.
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C. Caramella, F. Ferrari, M. C. Bonferoni & M. Ronchi. (1990) Disintegrants in Solid Dosage Forms. Drug Development and Industrial Pharmacy 16:17, pages 2561-2577.
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C. Caramella, F. Ferrari, A. Gazzaniga, U. Conte, A. La Manna & M. Geddo. (1988) A New Computer-Aided Apparatus for Simultaneous Measurements of Water Uptake and Swelling Force in Tablets. Drug Development and Industrial Pharmacy 14:15-17, pages 2167-2177.
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C. Caramella, P. Colombo, U. Conte & A. La Manna. (1987) Tablet Disintegration Update: The Dynamic Approach. Drug Development and Industrial Pharmacy 13:12, pages 2111-2145.
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Articles from other publishers (38)

Claudia Köster & Peter Kleinebudde. (2023) Evaluation of binders in twin-screw wet granulation – Optimal combination of binder and disintegrant. European Journal of Pharmaceutics and Biopharmaceutics 186, pages 55-64.
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Pauline H.M. Janssen, Alberto Berardi, Jurjen H. Kok, Anthony W. Thornton & Bastiaan H.J. Dickhoff. (2022) The impact of lactose type on disintegration: An integral study on porosity and polymorphism. European Journal of Pharmaceutics and Biopharmaceutics 180, pages 251-259.
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Alberto Berardi, Pauline H.M. Janssen & Bastiaan H.J. DickhoffPhDPhD. (2022) Technical insight into potential functional-related characteristics (FRCs) of sodium starch glycolate, croscarmellose sodium and crospovidone. Journal of Drug Delivery Science and Technology 70, pages 103261.
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Lena Ritters, Yuanyuan Tian & Stephan Reichl. (2021) Spray-Dried Paracetamol/Polyvinylpyrrolidone Amorphous Solid Dispersions: Part I—Stability of Powders and Tablets. Pharmaceutics 13:11, pages 1938.
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Cedrine de Backere, Thomas De Beer, Chris Vervaet & Valérie Vanhoorne. (2021) Effect of binder type and lubrication method on the binder efficacy for direct compression. International Journal of Pharmaceutics 607, pages 120968.
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Sonja Bauhuber, Gernot Warnke & Alberto Berardi. (2021) Disintegrant Selection in Hydrophobic Tablet Formulations. Journal of Pharmaceutical Sciences 110:5, pages 2028-2037.
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Alberto Berardi, Sonja Bauhuber, Obada Sawafta & Gernot Warnke. (2021) Alginates as tablet disintegrants: Understanding disintegration mechanisms and defining ranges of applications. International Journal of Pharmaceutics 601, pages 120512.
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Daniel Markl, Natalie Maclean, James Mann, Helen Williams, Alexander Abbott, Heather Mead & Ibrahim Khadra. (2021) Tablet disintegration performance: Effect of compression pressure and storage conditions on surface liquid absorption and swelling kinetics. International Journal of Pharmaceutics 601, pages 120382.
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Jan Lenz, Heike Bunjes, Arno Kwade & Michael Juhnke. (2021) An improved method for the simultaneous determination of water uptake and swelling of tablets. International Journal of Pharmaceutics 595, pages 120229.
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Anne Linnet Skelbæk-Pedersen, Mohammed Al-Sharabi, Thomas Kvistgaard Vilhelmsen, Jukka Rantanen & J. Axel Zeitler. (2020) Effect of particle size and deformation behaviour on water ingress into tablets. International Journal of Pharmaceutics 587, pages 119645.
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Kamran Zaheer & Peter Langguth. (2019) Designing robust immediate release tablet formulations avoiding food effects for BCS class 3 drugs. European Journal of Pharmaceutics and Biopharmaceutics 139, pages 177-185.
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Daniel Markl, Parry Wang, Cathy Ridgway, Anssi-Pekka Karttunen, Prince Bawuah, Jarkko Ketolainen, Patrick Gane, Kai-Erik Peiponen & J. Axel Zeitler. (2018) Resolving the rapid water absorption of porous functionalised calcium carbonate powder compacts by terahertz pulsed imaging. Chemical Engineering Research and Design 132, pages 1082-1090.
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JinZhi Li, LiJie Zhao, Xiao Lin, Lan Shen & Yi Feng. (2017) Co-spray Drying with HPMC as a Platform to Improve Direct Compaction Properties of Various Tablet Fillers. AAPS PharmSciTech 18:8, pages 3105-3115.
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M. Sacchetti, R. Teerakapibal, K. Kim & E. J. ElderJr.Jr.. (2017) Role of Water Sorption in Tablet Crushing Strength, Disintegration, and Dissolution. AAPS PharmSciTech 18:6, pages 2214-2226.
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Doaa Ahmed El-Setouhy, Emad B. Basalious & Nevine Shawky Abdelmalak. (2017) Effect of Different Meltable Binders on the Disintegration and Dissolution Behavior of Zolmitriptan Oromucosal Fast Melt Tablets. Journal of Pharmacy and Nutrition Sciences 7:1, pages 13-23.
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Julian Quodbach & Peter Kleinebudde. (2014) Systematic classification of tablet disintegrants by water uptake and force development kinetics. Journal of Pharmacy and Pharmacology 66:10, pages 1429-1438.
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Keita Kondo, Toshiyuki Niwa & Kazumi Danjo. (2012) Evaluation of Disintegration Properties of Orally Rapidly Disintegrating Tablets Using a Novel Disintegration Tester. Chemical and Pharmaceutical Bulletin 60:10, pages 1240-1248.
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