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Research Article

Retardation of Polymeric Carrier Dissolution by Dispersed Drugs: Factors Influencing the Dissolution of Solid Dispersions Containing Polyethlene Glycols

Pages 1777-1793 | Published online: 20 Oct 2008

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Tu Van Duong & Guy Van den Mooter. (2016) The role of the carrier in the formulation of pharmaceutical solid dispersions. Part I: crystalline and semi-crystalline carriers. Expert Opinion on Drug Delivery 13:11, pages 1583-1594.
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D. H. Doshi, W. R. Ravis & G. V. Betageri. (1997) Carbamazepine and Polyethylene Glycol Solid Dispersions: Preparation, in Vitro Dissolution, and Characterization. Drug Development and Industrial Pharmacy 23:12, pages 1167-1176.
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F. C. Millar & O. I. Corrigan. (1991) Influence of Sodium Caseinate on the Dissolution Rate of Hydrochlorothiazide and Chlorothiazide. Drug Development and Industrial Pharmacy 17:12, pages 1593-1607.
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Rayan Sabra, Akshay Narula, Lynne S. Taylor & Na Li. (2022) Comparisons of in Vitro Models to Evaluate the Membrane Permeability of Amorphous Drug Nanoparticles . Molecular Pharmaceutics 19:9, pages 3412-3428.
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Jeong-Soo Kim, Heejun Park, Eun-Sol Ha, Kyu-Tae Kang, Min-Soo Kim & Sung-Joo Hwang. (2021) Preparation and Characterization of Fenofibrate Microparticles with Surface-Active Additives: Application of a Supercritical Fluid-Assisted Spray-Drying Process. Pharmaceutics 13:12, pages 2061.
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Sugandha Saboo, Naila A. Mugheirbi, Dmitry Y. Zemlyanov, Umesh S. Kestur & Lynne S. Taylor. (2019) Congruent release of drug and polymer: A “sweet spot” in the dissolution of amorphous solid dispersions. Journal of Controlled Release 298, pages 68-82.
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Laura Modica de Mohac, Alison Keating, Maria de Fátima Pina & Bahijja Raimi-Abraham. (2018) Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery. Pharmaceutics 11:1, pages 7.
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Kateřina Punčochová, Branko Vukosavljevic, Jaroslav Hanuš, Josef Beránek, Maike Windbergs & František Štěpánek. (2016) Non-invasive insight into the release mechanisms of a poorly soluble drug from amorphous solid dispersions by confocal Raman microscopy. European Journal of Pharmaceutics and Biopharmaceutics 101, pages 119-125.
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Kenjirou Higashi, Hiroki Hayashi, Keiji Yamamoto & Kunikazu Moribe. (2015) The effect of drug and EUDRAGIT® S 100 miscibility in solid dispersions on the drug and polymer dissolution rate. International Journal of Pharmaceutics 494:1, pages 9-16.
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Manoela Klüppel Riekes, Gislaine Kuminek, Gabriela Schneider Rauber, Carlos Eduardo Maduro de Campos, Adailton João Bortoluzzi & Hellen Karine Stulzer. (2014) HPMC as a potential enhancer of nimodipine biopharmaceutical properties via ball-milled solid dispersions. Carbohydrate Polymers 99, pages 474-482.
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Hywel D. Williams, Natalie L. Trevaskis, Susan A. Charman, Ravi M. Shanker, William N. Charman, Colin W. Pouton & Christopher J. H. Porter. (2013) Strategies to Address Low Drug Solubility in Discovery and Development. Pharmacological Reviews 65:1, pages 315-499.
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David E. Alonzo, Yi Gao, Deliang Zhou, Huaping Mo, Geoff G.Z. Zhang & Lynne S. Taylor. (2011) Dissolution and Precipitation Behavior of Amorphous Solid Dispersions. Journal of Pharmaceutical Sciences 100:8, pages 3316-3331.
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Sandrien Janssens & Guy Van den Mooter. (2009) Review: physical chemistry of solid dispersions. Journal of Pharmacy and Pharmacology 61:12, pages 1571-1586.
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Shyam Sunder Bansal, Aditya Mohan Kaushal & Arvind Kumar Bansal. (2007) Molecular and Thermodynamic Aspects of Solubility Advantage from Solid Dispersions. Molecular Pharmaceutics 4:5, pages 794-802.
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Evangelos Karavas, Georgios Ktistis, Aristotelis Xenakis & Emmanouel Georgarakis. (2006) Effect of hydrogen bonding interactions on the release mechanism of felodipine from nanodispersions with polyvinylpyrrolidone. European Journal of Pharmaceutics and Biopharmaceutics 63:2, pages 103-114.
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Solmaz Esnaashari, Yousef Javadzadeh, Hannah K. Batchelor & Barbara R. Conway. (2005) The use of microviscometry to study polymer dissolution from solid dispersion drug delivery systems. International Journal of Pharmaceutics 292:1-2, pages 227-230.
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Duncan Q.M Craig. (2002) The mechanisms of drug release from solid dispersions in water-soluble polymers. International Journal of Pharmaceutics 231:2, pages 131-144.
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Roberto Frontini & Jobst B. Mielck. (1997) Interactions between bendroflumethiazide and water soluble polymers. I. Solubility of bendroflumethiazide in water from solid dispersions and formation of associates under climatic stress. European Journal of Pharmaceutics and Biopharmaceutics 43:2, pages 185-191.
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M. Kuhnert-Brandstätter & U. J. Griesser. (1995) Ungewöhnliche Phasendiagramme der Polyethylenglykole 6000 und 4000 mit Harnstoff. Journal of Thermal Analysis 45:3, pages 559-572.
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D.Q.M. Craig & J.M. Newton. (1991) Characterisation of polyethylene glycols using differential scanning calorimetry. International Journal of Pharmaceutics 74:1, pages 33-41.
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